LOCUS       NM_027604              11564 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 15 (Usp15), transcript
            variant 1, mRNA.
ACCESSION   NM_027604
VERSION     NM_027604.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11564)
  AUTHORS   Baek,J.H., Kim,M.S., Jung,H.R., Hwang,M.S., Lee,C.H., Han,D.H.,
            Lee,Y.H., Yi,E.C., Im,S.S., Hwang,I., Kim,K., Chung,J.Y. and
            Chun,K.H.
  TITLE     Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty
            liver disease and nonalcoholic steatohepatitis
  JOURNAL   Exp Mol Med 55 (7), 1520-1530 (2023)
   PUBMED   37394587
REFERENCE   2  (bases 1 to 11564)
  AUTHORS   Wu,Z., Zhu,L., Nie,X., Wei,L. and Qi,Y.
  TITLE     USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner
  JOURNAL   Exp Mol Med 55 (1), 183-195 (2023)
   PUBMED   36635430
  REMARK    GeneRIF: USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner.
REFERENCE   3  (bases 1 to 11564)
  AUTHORS   Li,L., Luo,J., Zhu,Z., Xu,Q., Wang,P., Chang,B., Wang,D., Yu,L.,
            Lu,X., Zhou,J., Zuo,D. and Chen,Q.
  TITLE     SRA Suppresses Antiviral Innate Immune Response in Macrophages by
            Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15
  JOURNAL   Microbiol Spectr 10 (6), e0202822 (2022)
   PUBMED   36342281
  REMARK    GeneRIF: SRA Suppresses Antiviral Innate Immune Response in
            Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase
            USP15.
REFERENCE   4  (bases 1 to 11564)
  AUTHORS   Tian,X., Zhao,Y., Yang,Z., Lu,Q., Zhou,L. and Zheng,S.
  TITLE     USP15 regulates p66Shc stability associated with Drp1 activation in
            liver ischemia/reperfusion
  JOURNAL   Cell Death Dis 13 (9), 823 (2022)
   PUBMED   36163170
  REMARK    GeneRIF: USP15 regulates p66Shc stability associated with Drp1
            activation in liver ischemia/reperfusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11564)
  AUTHORS   van den Berk,P., Lancini,C., Company,C., Serresi,M.,
            Sanchez-Bailon,M.P., Hulsman,D., Pritchard,C., Song,J.Y.,
            Schmitt,M.J., Tanger,E., Popp,O., Mertins,P., Huijbers,I.J.,
            Jacobs,H., van Lohuizen,M., Gargiulo,G. and Citterio,E.
  TITLE     USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity
            in Hematopoietic Stem Cells and Leukemia Cells
  JOURNAL   Cell Rep 33 (13), 108533 (2020)
   PUBMED   33378683
  REMARK    GeneRIF: USP15 Deubiquitinase Safeguards Hematopoiesis and Genome
            Integrity in Hematopoietic Stem Cells and Leukemia Cells.
REFERENCE   6  (bases 1 to 11564)
  AUTHORS   Zou,Q., Jin,J., Hu,H., Li,H.S., Romano,S., Xiao,Y., Nakaya,M.,
            Zhou,X., Cheng,X., Yang,P., Lozano,G., Zhu,C., Watowich,S.S.,
            Ullrich,S.E. and Sun,S.C.
  TITLE     USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit
            antitumor T cell responses
  JOURNAL   Nat Immunol 15 (6), 562-570 (2014)
   PUBMED   24777531
REFERENCE   7  (bases 1 to 11564)
  AUTHORS   Eichhorn,P.J., Rodon,L., Gonzalez-Junca,A., Dirac,A., Gili,M.,
            Martinez-Saez,E., Aura,C., Barba,I., Peg,V., Prat,A., Cuartas,I.,
            Jimenez,J., Garcia-Dorado,D., Sahuquillo,J., Bernards,R.,
            Baselga,J. and Seoane,J.
  TITLE     USP15 stabilizes TGF-beta receptor I and promotes oncogenesis
            through the activation of TGF-beta signaling in glioblastoma
  JOURNAL   Nat Med 18 (3), 429-435 (2012)
   PUBMED   22344298
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 11564)
  AUTHORS   Isumi,Y., Hirata,T., Saitoh,H., Miyakawa,T., Murakami,K., Kudoh,G.,
            Doi,H., Ishibashi,K. and Nakajima,H.
  TITLE     Transgenic overexpression of USP15 in the heart induces cardiac
            remodeling in mice
  JOURNAL   Biochem Biophys Res Commun 405 (2), 216-221 (2011)
   PUBMED   21219870
REFERENCE   9  (bases 1 to 11564)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   10 (bases 1 to 11564)
  AUTHORS   Angelats,C., Wang,X.W., Jermiin,L.S., Copeland,N.G., Jenkins,N.A.
            and Baker,R.T.
  TITLE     Isolation and characterization of the mouse ubiquitin-specific
            protease Usp15
  JOURNAL   Mamm Genome 14 (1), 31-46 (2003)
   PUBMED   12532266
  REMARK    GeneRIF: Both mouse and human have 22 exons with identical splice
            sites and an exon/intron structure identical to the mouse Usp4
            gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB857893.1, BB843959.1,
            AK145749.1, AK161771.1, AC153021.2 and AW490591.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_027604.5.
            
            On Aug 23, 2014 this sequence version replaced NM_027604.3.
            
            Summary: The protein encoded by this gene is a member of the large
            ubiquitin specific protease (Usp) family of proteins. These
            proteins are known to cleave ubiquitin, and contain a conserved
            cysteine residue (Cys box) and two conserved histidine residues
            (His box) that are thought to form part of the active site of the
            protease. This protein has been shown to cleave both the
            ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This
            protein is thought to regulate many cellular processes through its
            deubiquitination activity, including the transforming growth factor
            beta (TGF-beta) pathway. Cardiac-specific overexpression of the
            human ortholog of this gene in mice causes enlargement of the heart
            that is more pronounced in the atrium than in the ventricle. This
            gene has two pseudogenes on chromosome 14. Alternative splicing
            results in multiple transcript variants that encode multiple
            protein isoforms.[provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145749.1, AF468037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BB857893.1         2-86
            86-96               BB843959.1         62-72
            97-3325             AK145749.1         1-3229
            3326-4818           AK161771.1         1197-2689
            4819-11381          AC153021.2         177561-184123       c
            11382-11564         AW490591.1         1-183               c
FEATURES             Location/Qualifiers
     source          1..11564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 72.31 cM"
     gene            1..11564
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /note="ubiquitin specific peptidase 15"
                     /db_xref="GeneID:14479"
                     /db_xref="MGI:MGI:101857"
     exon            1..193
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            194..321
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            322..452
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            453..579
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            580..725
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            726..787
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            788..874
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1019
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1193
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1352
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1577
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1661
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1756
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1948
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2064
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2337
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2408
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2524
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2674
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2778
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2867
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..11549
                     /gene="Usp15"
                     /gene_synonym="4921514G19Rik; E430033I05Rik; Gcap18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtacagacc tgccggcggg gcggggccgg ggacgccatt cccacaatgc tccggggcgt
       61 gccgccgccg tcgccgccgc ctccgctacg gctagtggaa gaagatggcg gaaggcggag
      121 cggcggacct ggacacccag cgttctgaca tcgcgacgct gctcaaaacc tcgctccgga
      181 aaggggacac ctggtatcta gtagatagtc ggtggttcaa acagtggaaa aaatatgttg
      241 gctttgacag ctgggacaaa taccagatgg gagatcaaaa tgtctatcct ggacccatcg
      301 ataactctgg acttctcaaa gatggcgacg cgcagtcact taaggagcac cttattgatg
      361 agttggatta catactcttg ccaactgagg gctggaataa acttgtcagc tggtacacac
      421 tgatggaggg ccaggagcca atagcaagaa aggtggtaga acagggtatg tttgtaaagc
      481 actgcaaagt agaagtctac ctcacagaac tgaagctctg tgagaacggg aacatgaaca
      541 atgttgtaac tcggaggttt agcaaagctg acacaataga tacgattgag aaggaaataa
      601 gaaaaatctt caatattcca gatgagaagg aggccagact gtggaacaag tatatgagca
      661 acacatttga accactgaat aagccagaca gcaccatcca ggatgccggc ctataccaag
      721 gacaggtgtt agtgatagag caaaaaaatg aagatggaac gtggcccagg ggtccctcta
      781 ctcctaagtc cccaggtgca tccaattttt caactttacc aaagatctct ccttcatctc
      841 tatcaaataa ttataacaac atcaacaaca gaaatgtgaa aaactcaaat tattgtctcc
      901 cgtcatatac tgcttataag aactatgatt attcagaacc tggaagaaac aatgaacagc
      961 caggcctgtg tggcttaagt aacttgggaa atacgtgttt catgaactca gccattcagt
     1021 gtttgagcaa cacacctcca cttactgaat atttcctcaa tgataagtac caagaagagc
     1081 tgaattttga caatccctta ggaatgagag gtgaaatagc taaatcatac gctgaactca
     1141 tcaagcagat gtggtctgga aagtttagct acgtcactcc aagagcattc aagacacagg
     1201 tagggcgctt cgcacctcag ttctctggat atcaacagca ggactgccaa gaactactgg
     1261 ctttcctgtt ggatggactg cacgaggacc tgaatagaat taggaaaaaa ccctatatcc
     1321 agttaaaaga tgctgatggc aggccagaca aggtggttgc tgaagaagcc tgggagaacc
     1381 atttaaagcg aaatgattcc atcatagtag acatattcca tggccttttc aagtctacgt
     1441 tagtgtgtcc tgagtgtgct aagatctcgg tgacctttga ccctttctgt tacttgactc
     1501 ttccattgcc tatgaaaaaa gaacgtagct tggaagttta tttagttaga atggatccac
     1561 ttgctaaacc tatgcaatac aaagttattg tgcccaaaat tggaaatata ctagatcttt
     1621 gtacagcgct gtctgctttg tcgggagtac ctgcagataa gatgatagtc actgacatat
     1681 acaatcatag atttcacagg atatttgccg tggatgaaaa cctgagtagt attatggagc
     1741 gggatgatat ttacgtgttt gaaattaaca tcaacagggc agaagacaca gagcatgtag
     1801 ttatccctgt ctgcctaaga gaaaaattca gacactcaag ttacactcac cacactggct
     1861 cttcactgtt cggccagcct tttcttatgg ctataccacg aaacaatact gaagataaac
     1921 tctataatct tctactcttg agaatgtgcc ggtatgtcaa aatgtctact gaaactgagg
     1981 aaacagatgg acacctacgt tgctgtgagg accagaatat taatgggaat gggccaaatg
     2041 gcctacatga agagggttca ccaagtgaga tggaaaccga cgagccagat gacgagtcca
     2101 gccaggatca agagcttccc tcagagaacg agaacagtca gtctgaagat tcagtcggag
     2161 gagataacga ttctgaaaat ggattgtgca ctgaagaaac atgcaaaggt caacttacgg
     2221 gacacaaaaa gcgcttgttt acattccagt tcaacaactt aggcaacaat gacatcaact
     2281 acatcaaaga cgacaccagt cacatccgat tcgatgacag gcagcttcgg ctggacgaaa
     2341 gatcttttct cgctttggac tgggaccctg acttgaagaa gagatacttt gatgagaatg
     2401 ctgcagagga ttttgaaaaa catgaaagtg tggaatacaa acctccaaaa aggccctttg
     2461 tgaagttaaa agactgcatt gagctcttca ccaccaagga gaagctgggt gctgaggacc
     2521 cctggtattg tccaaattgt aaagagcatc agcaagccac aaagaaatta gatctgtggt
     2581 ccctgcctcc agttcttgtg gtgcatctca agagattctc ctatagtcgc tacatgagag
     2641 acaagctaga tacattagtc gattttccca tcagtgactt ggatatgtca gaattcctaa
     2701 ttaacccaaa tgcaggtcct tgccgctata atttgattgc tgtttccaac cactatggag
     2761 ggatgggagg aggacattat actgcttttg caaaaaacaa agatgatggg aagtggtact
     2821 atttcgatga cagtagcgtc tccactgcat ctgaagacca aatcgtgtcc aaggcagcgt
     2881 acgtgctctt ctaccagaga caggacactt tcagtgggac tggcttcttc cctcttgacc
     2941 gagaaactaa aggtgcttca gctgccacag gtatccccct ggaaagtgac gaagacagca
     3001 atgataatga caatgaccta gaaaatgaaa actgtatgca cactaattaa cgaaagtgca
     3061 agaagccata ggagagactt tcctgctggt ggtgtctatg gagatgaagt tatcaccaca
     3121 tgaaacagaa gtctgagatg aggagtttca gatacccgaa tgtaaatcct ttatcagatt
     3181 ttaacttgtg cagtacttga agtgaaacac aatgaaaact ttaacagaaa ttgtctctta
     3241 atacatttac agtcttgtat ttacaagcta aatatatata ggaaatcaca aataaatccc
     3301 ttttaagttt gctgctgttt tgatgaatta tgttttcttt aattttttgg atgtgactta
     3361 attgatgaca aatgttaaat ttgtggatgt tggtcattaa ttttgctcta ataatactgc
     3421 aagaaaacca tggctgaact tagttcttgg gtaatctagt tcctgcgcgt taggctgcct
     3481 gtctgcgcca tccgggtact tagctgctgt gtcggtgtgg ctcaaatact gcagtgtcct
     3541 tggtacacca gattctctga tctgtccctg gtaatcagtg tgggtctgtt cccaccacgt
     3601 gaggaacagt cttgaggaag ttcccttttg ttgtctcatt aaagtgcagg ccatgacatt
     3661 gacttccctc gctgtgggaa cgaacgcctt ctagatttca catgccatca gaatcatttt
     3721 cagctacatg tatgtatttt tcactgcaat tggaatctat ttaaattttt caattttgtt
     3781 ttggtttaga atgcttatct tcactccact gttggttcaa tattaaaggt ttttgctatt
     3841 agtccctact ccattttggt aatttggcaa ctttttagct ctcccagtta ctgtagcttt
     3901 aaggcgggct ggttagtact ctgtatctgt agtaagaatt gcatcacagt taggcgaggc
     3961 tttctgttca cgtactagcc tttaactcat cgataactgg gctatagagg taggtctgtt
     4021 aactttctct gtgtgttcct gatggaattc accatagcct tacagctttt ctcggaaggt
     4081 aacctgtata agagaaatag cgtttgcatg ttccagagtc agaaccttgc agcacatgac
     4141 gcacacaaac cttgggtttc atttagcttc tcacagtcaa ggatccaaga cgccaaatct
     4201 atgtgtgagc atttgacaca ttctcatttg ctgcttctct ctccctctga tccagttgaa
     4261 ggaatgtatg ggtgactggc aggcagtgct gccttcaata ggaaactaaa cgctggggcc
     4321 catctcccac ccgactacct gagaaaccgc tttgtgtccc actgttacta aagcagaaag
     4381 tatagtgttc ttcacttgaa ctaatcaaat acaatagatt ataaattgtg tattgtaaat
     4441 aaaagttcac tctgtgagtg cacattttgg taaattattt atttatgtta acattataaa
     4501 agaaagggaa aaaatgcatt tggccaggat aagtaaggta tgttggtcat ggctttgctt
     4561 tatatcttga tattaaagct ggtttttgat cctggtcttt taaaagctgc tttaggtatc
     4621 gattcttttt tttttttttt ttctgttctt tctctttttt cttttttttt tctttctctc
     4681 tctctctctt tttttaaatg taaactgacc tcctgcatga cagaggttaa tattttgtct
     4741 gcacttgggt tcacttgagt ttacatttga aatgtgcatg tttatttata cagatttcaa
     4801 taaagctatt gacggcctta tttagtcttt tatttcttac tctgaaacca ctgaagtaaa
     4861 tccagttttc tgcatagacg acttgactgt acagtgacat tatagttagt attacaaagg
     4921 gaatcaaatc ctattgagga tgttttaaac ttgggtcggt gttgttttaa ctcacatact
     4981 cattgagcag acagtgcagt tttctgcttg cctttggagc atgtattcgt tctgccctta
     5041 aacttacttt catatgttta aagtccatgt taacttctca tagacctaga ttatagtatc
     5101 caccctgact catttgcttt ctgttgtatt ttgtttgtgt tgtttacttc ctaatccatt
     5161 tgcttggcta ttgagagggt cttaggctga ccttcaccgc ccctgaagcc caggccaggc
     5221 tcaaagtctt gatcatcctg cctaggcctc tgaaatgccg ggactgcaga tgagaaccac
     5281 catgccctga ctcagaccac atcctttcaa tgcatgccat caagtccttt tctcactgag
     5341 aagaaacatt tagagaatgc tgtggatgcc gttgagtctg tcagacgatc gcttcatctg
     5401 caaaaattaa ccttgtagca taaaaaaaaa aagaactaaa gagatgttca tatggaatac
     5461 agggtcatta ggaatagatt tagattagaa ttctactggt aactttgcct gttagtaatt
     5521 gtatgatttt gaacttactc tttcttagcc tgtctcttga cctataaagt aatgacaact
     5581 ccagtagcag ctgtttatgg agggcttgct ctaaaccagt cactctatta aaatgtgtgt
     5641 gtgtgtgtgt gtgcgcgcgc gcacattctc ccatctcatc cctcaagagc tgtgtggtag
     5701 ggaccagacc attcattatc ttcacctccc atacgttgtg tcccaaagtt ctcacagtta
     5761 ttgtgtggtg acgtccgcat cgtcccctca gacacatacc gcctcactgt gtcacagtgc
     5821 ctttctcacc acacaactca aatgaggtca tctcgtcttc cagcaggcag gcttttgtga
     5881 acaatgtggc acttgttgct gattgcttct gtctgcgtgg aaagtgctgt tgttagagaa
     5941 tttagcttcc agtaggaaga gtagcagctg gtacacttag cctttcacct ttcattccac
     6001 aatgaacttt atcgacgtat cacactattc gctattttga ttgcatgtta aatattacgt
     6061 ggtatatgat ttaaaccatt cccctaattt caacctgaat ttcaagtctc tttaattttt
     6121 tttaacttca catgtaattt ctctattata tttcacttta tttgggaagg agagtgcatg
     6181 tcatggcacg tgtggagatc aaaggacaac ttgcagaact gtggtctcct ctcctaccac
     6241 gtgggcccct tgagatcgat ggaagtgcct ttacctgctg agccatctta ccttaattgt
     6301 tttgttagtt cagggaaggg cacaggtata ctatggtgag cacagggtgg ctagaggatt
     6361 agtggcatct tttctctcct tccagagatc gaacttggaa catcagggtt tcatagggag
     6421 cgcctttacc cactgagcca tctcacaggc cctgtgttta tatttaaatg acctctgaca
     6481 aagctgtagc ctggtgcttt taagtaatcc ttgctttggc ttataatctg attttagtaa
     6541 ttcttgtgtt tttccttgca tggcagacaa caaggtatta agaaccacac aaaacattga
     6601 gttcagcata aagaaaacca actcgtacct aaattagatg ttgcacaagg gcagcgcttt
     6661 ttgtggctat cttattagaa gaaagccacg agagattctg agagaaggtg agcgttgcat
     6721 accaaaggag aaagtcaaag aagagcctgc ctgaaaggag gcagttccca cctgtggcca
     6781 tgctcagcac tggtacccag ccgattttca gtcaggcttt ctgcctttca actctacggg
     6841 ctgctgtttg acggctgccc gctcccggtc ccgctgtttg tccgggtgca cagttgcaca
     6901 ggttagattc tcttgccagt gtcactaaga taggaatgtg aagagacctt gtgtcccatt
     6961 gaggagtcgg gtcctccaaa agattgaatg ccaccttgtc tgaagccaaa gaacagtagt
     7021 agtcttccta gttcttactc tataacagaa ttgatttctt ttactgcctg aagaatttta
     7081 aaatagtttc ttttaaaaat aatgttgatg cttccaggta attcttttga gtgctgcttg
     7141 accagaagat aaagaaaaaa accaagtgtg tttataccct tggtggtgca ggtgcaggtg
     7201 tgtgttatat attgtttcgt ggccagattt tcctaatgag aaaaaaatat ttttcttaag
     7261 cattccagat ttgggacatt ttgattcagt atgtatatgc tttgtgtatt taattcatat
     7321 ttactataaa ttacagaaga aattgctaaa tagtttagat ggcatgtttg tttagagcta
     7381 aatatattaa atttttataa gggacatggt ttccaaaata gcagatttgg gaaaataaaa
     7441 tatatgtata gtaaaaattc aaatactaag caagccttgt tttcactatt agaaagatca
     7501 ggaaatcttg tctttaaaga aatggctaat ataaaacaca gtccaaagat tatttgtggc
     7561 gaatacaagc actgagatac atacctgtat catactgtgc tctcatgatt ccccagctat
     7621 ttggggctcc tgcaactagc cagagtagtt gaagggaaag accctaaatt actatctgaa
     7681 ttcaaaagta gataaactac taaaaaatca agttgttttt tggacaagag tttcaagaaa
     7741 taaaggaaaa aaaaacaaaa aacagtcaga tgggtttcac tattggtttg ttgttgaggt
     7801 ctggtcccct gccaaatttt gcaaaggtgc taaaaataca accatctctt tgggaatggt
     7861 attttaaata gtactgtaaa aataaagcta catttttaaa taatttttta tatctctgtg
     7921 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtggtgcat gccacacgtg
     7981 tggggaaatc catggaggcc agaagaaggc attgggtgcc ctggagctgg agttacaggt
     8041 gcttgctgga aactgagtat ctggaagagc tggaagtgct ctgttaactg ctgagccctc
     8101 tttctagccc caagactgca tttttaatat gcacaaaatc aaatactctg aatgtttacg
     8161 ttgttttggc agctgactgt tcttcagtag gaaagcttgc caggtttgtg gcttattttg
     8221 ctaatgtttt ccccccgcat atcagcaatt tatagcttca tcggtttaat tgggtggggg
     8281 gtgggggcta agtttcatct tctgtgacct ttcagatttg cttgtggcta acatacttgt
     8341 ctgactcctc acacagtcaa gagagcaggg aacagcctgc ctgctgtccc tgtttataag
     8401 gcctcgtaat gtaaccttag ccatttcagc gtaagggtta ctgaacggca gcctgtggca
     8461 taagctccat ctttagaaag gtctgctctc taggattgta tcgctcagcc cagttcctgc
     8521 cacctcggtg cattctctgt tctaccagag tgccctctat caagttttga tcttaacgtt
     8581 ctcttttaac ctctgtcttc agattctcca cagaaacaag accaataggc tgtacaacta
     8641 gaaagtttct gtgactgaag ctgacaactt ctaagaccca cagttatcaa gccagaccca
     8701 agaatgcaca gacaacctag aaagccaggg acaatcttcc agcctaaaag ccagcaagct
     8761 tgagaacaag aagagccagt tcccttttga atccagagga cagagaggac aggggtgcca
     8821 gcgcagggca gtcaagcaca aggggagaca tgtccctttc tttcatgctg acctttattt
     8881 agttgggatg agactcaaca ctgggaaggc aagcatattc accgtccata cttaatgctc
     8941 atctcgtcca agaagatgct cggaagcagc caaaatagtt gggtactctg tacccaggct
     9001 agtagatata aaccccttca cgtgtaagtg tgcattagac acagggctag accactggtg
     9061 gtgtgggcct accacttgtg tgcactcatc tctctctctc tcttgattta taaagtaggg
     9121 caagtccaga atctcctcaa aaagtactta gaccgagata gatgttaatt agaagacaga
     9181 aatctggtct atgaaaactg tttgcttagc caaccagtga aatgccttca gatgtcccgt
     9241 tctaatgttg gggaccagtg tggaaaccac agtcccccgt gcaccagact ccggccccag
     9301 cactaatgaa ctcccttgag atagatccta aggcttggat tgtcttaagc tttataaagg
     9361 gtgcaacggg tgtttttact aaggaaacag acacagggta atcaatagtt gctagaacca
     9421 tgtcgtctgc tacgatcatg cttgaggaaa aagattaaga actacctcca tccaacttct
     9481 tacctttcct caaatgcatt cttcagcttt accatcccta tagggctttc ccatgcattc
     9541 tccttgcctg gtctgtttgc tctactgcca gacacatcta tccaaagggc agtcccctat
     9601 cttttcagtc gctcgctgca ctggctataa gtcacgagtc cgtcctcccc cactacacct
     9661 gatagaacat agtgggatcg agtatttctg tacataaact gtcttcacac agacatttcc
     9721 tcacagcgac cctgtactcc catcccacga ggctgggaca ggaacagaag gatcatacat
     9781 ttaaggacct tctgagctac agactgagtt caagtccaga ctttaaactt cgggaagaac
     9841 ccgtcttcag catagaaaat gcaggctggg ggcgtcgctt agtggtagag catttgcttc
     9901 agcctccagc acacacacaa gctttctcaa gcatcgctgc ccttgtggtt ttatgtttct
     9961 agcattaatg agcacacgct ttaagtttta aacgtaaata ctctttttgg gtgtgcatta
    10021 aaaaatagtg tagggctagg aatcccctgt gtccccagta tgggatgggg gttgggaggt
    10081 agatgctagg tgaggtaaca ttttaaatcc agtacgttta ggacattcgg aatattcaaa
    10141 cttggacgta tattgatttt cactcagatt aacttcccta cagtccaaag cgctgtgcct
    10201 gtctgtacac tttcccgaga tgctgttcag gttcccgttt gcatgtttat ggatttacag
    10261 cttagtacat gggttttttt tttttttttt tggtttttta ataatgctct cagtgtaagc
    10321 ttttatgttt ttcaggaagg tgtatgttgg actcaaagta aaatagagta tgtagtaagt
    10381 agctgttatt aaatggttct tatttcatgt agattttcta ggggactttt actgtaagga
    10441 attctttgtt ctaataaaga catgctgcta tcttttggtc ttatcagaga tcaacccaga
    10501 tttccatttg tgtggggccc tctttccata tggacagccc tgtctggaag cagccaagca
    10561 tcgccttttt aatctgaaac atctctccgc tgtgctcaga tagttaacgt gattcagctc
    10621 ctctgtgctc agatagtcag gtggttcagt ttcctggttt tacttctggg ggttttcttg
    10681 tgacttgttt gcctcaatca tgtacatagg acgttaggaa atgtttagat gacagaagtg
    10741 aactgtcatc tacgactgtt gagatggcta atgggtaagg gccctagcct gtaagcctat
    10801 gaccctagtt ccatccatgg ggcccacatg gtggacggag agaaacaatt tctgtcaatt
    10861 tgtattgata gtcctttaaa aacttgtcag tttggaatat tctagtactt ctctgcaaat
    10921 tctggatttt ttttaaaaaa aagtaaattc tacttgtgcc cgtgttttac attgagttag
    10981 acctgctgga gccggggtcc agaagggtgg tcagctggca gacttttaga aagtggaggg
    11041 tctttcttta acaaaagctc tgttcagttt ttctcaaaag ccacaaagtg gcatcttgaa
    11101 actggggtga gaacccagag gtgtcacatc agctgtgatc atcctctcag tctttgtgac
    11161 cagtgtccaa gattagagtc ctcagagcca agagtatgtc cttccatctc ttaaacccac
    11221 aagctttgtc tcgggaagtt tgaacttgga aagtaagaaa aacagaattt ttttaactct
    11281 agcacaaagc tcttgctcat gaaattcaca atccggggac cttttctttc ttttcaggtg
    11341 ctatggctcg aacccagggc ctcacacacg gtaggcaaac accccccccc ccttcagctc
    11401 cattctcact ctccggcgct atcgtatcaa gtgacatgtt tcacagtata gatgaatgta
    11461 cactatgtaa acagccactg catttgcaat gtatgaaatt gccctttgta atatcaataa
    11521 atgtaataaa catgttttgg tcaatcgaaa aaaaaaaaaa aaaa
//
