LOCUS       NM_021522               4185 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 14 (Usp14), transcript
            variant 1, mRNA.
ACCESSION   NM_021522
VERSION     NM_021522.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Li,M., Zhao,Y., Zhang,J., Jiang,W., Peng,S., Hu,J. and Shen,Y.
  TITLE     Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits
            the NOD2 pathway mediated inflammatory response in vitro
  JOURNAL   Eur J Histochem 68 (3), 4101 (2024)
   PUBMED   39252535
  REMARK    GeneRIF: Deubiquitinase USP14 is upregulated in Crohn's disease and
            inhibits the NOD2 pathway mediated inflammatory response in vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Wei,D., Tian,X., Ren,Z., Liu,Z. and Sun,C.
  TITLE     Mechanistic insights into the role of USP14 in adipose tissue
            macrophage recruitment and insulin resistance in obesity
  JOURNAL   Int J Biol Macromol 267 (Pt 2), 131645 (2024)
   PUBMED   38631582
  REMARK    GeneRIF: Mechanistic insights into the role of USP14 in adipose
            tissue macrophage recruitment and insulin resistance in obesity.
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Wei,D., Tian,X., Zhu,L., Wang,H. and Sun,C.
  TITLE     USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease
            through deubiquitination and stabilization of HSP90AA1
  JOURNAL   Cell Death Dis 14 (8), 566 (2023)
   PUBMED   37633951
  REMARK    GeneRIF: USP14 governs CYP2E1 to promote nonalcoholic fatty liver
            disease through deubiquitination and stabilization of HSP90AA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Lane,P.W., Searle,A.G., Beechey,C.V. and Eicher,E.
  TITLE     Chromosome 18 of the house mouse
  JOURNAL   J Hered 72 (6), 409-412 (1981)
   PUBMED   6949984
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Burt,A.M.
  TITLE     Morphologic abnormalities in the postnatal differentiation of CA1
            pyramidal cells and granule cells in the hippocampal formation of
            the ataxic mouse
  JOURNAL   Anat Rec 196 (1), 61-69 (1980)
   PUBMED   7416502
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Weber,M.B.
  TITLE     A study of brain lipids, nucleic acids and proteins in the ataxic
            (axJ) mouse
  JOURNAL   Neurology 18 (3), 243-249 (1968)
   PUBMED   5689664
REFERENCE   10 (bases 1 to 4185)
  AUTHORS   D'Amato,C.J. and Hicks,S.P.
  TITLE     Neuropathologic alterations in the ataxia (paralytic) mouse
  JOURNAL   Arch Pathol 80 (6), 604-612 (1965)
   PUBMED   5855800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ161902.1, AK011322.1, AK029977.1 and AC163451.2.
            
            On May 12, 2006 this sequence version replaced NM_021522.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170933.1, AK172477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CJ161902.1         2-66
            66-1256             AK011322.1         2-1192
            1257-2368           AK029977.1         1186-2297
            2369-4185           AC163451.2         53606-55422
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     gene            1..4185
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="ubiquitin specific peptidase 14"
                     /db_xref="GeneID:59025"
                     /db_xref="MGI:MGI:1928898"
     exon            1..237
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1703
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dUB-type TGT for deubiquitinating enzyme; ubiquitin
                     carboxyl-terminal hydrolase 14; ubiquitin thioesterase 14;
                     deubiquitinating enzyme 14; ubiquitin-specific-processing
                     protease 14; ubiquitin thiolesterase 14; ubiquitin
                     specific protease 14; ataxia"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 14 isoform
                     1"
                     /protein_id="NP_067497.2"
                     /db_xref="CCDS:CCDS37735.1"
                     /db_xref="GeneID:59025"
                     /db_xref="MGI:MGI:1928898"
                     /translation="MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQ
                     KVMVKGGTLKDDDWGNIKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAME
                     LPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLF
                     DSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAI
                     EDDSGRETDSSSAPAVTPSKKKSLIDQYFGVEFETTMKCTESEEEEVTKGKENQLQLS
                     CFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYK
                     EKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNANDKN
                     SPPKEIKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVRRKQDEWIKFD
                     DDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ"
     exon            238..383
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            384..416
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            417..521
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            522..625
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            626..684
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            685..815
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            816..896
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            897..982
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1097
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1163
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1256
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1385
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1443
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1551
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..4185
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="major polyA site"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="hexamer: AATAAA"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="hexamer: AATAAG"
     polyA_site      2363
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
     polyA_site      2367
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
     regulatory      4157..4162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /note="hexamer: AATAAA"
     polyA_site      4178
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
ORIGIN      
        1 tgccccgtgc tgctctcccc cgcacctccc cgcggtggct tcttgggcga acagcgtgcg
       61 gctgcgtcat cgccagtggc cggtttgaat gaggcttgtc gcaccggagc tgccgcctcc
      121 acctcgcttc caccccggcc gcctccacga gttgcttcgt attcctcggc tgcccttgtc
      181 agacccagcc tcccgcgcct tttcttcctt cctgcctcgc catgccactc tactctgtta
      241 cagtaaaatg gggaaaggag aagtttgaag gtgtagaatt gaatactgat gaacctccaa
      301 tggtgttcaa agcccagctt tttgcattga ctggagtcca gccagccaga caaaaagtta
      361 tggtgaaagg aggaaccctg aaggatgatg actggggaaa catcaaaatg aaaaatggaa
      421 tgactgtact aatgatgggg tcagcagatg ctcttccaga agaaccctct gctaaaactg
      481 tcttcgtaga agacatgaca gaagaacagt tagcaaccgc tatggaattg ccatgtggat
      541 tgacaaacct tggtaacact tgttacatga atgctacagt tcagtgtatt cgttctgtgc
      601 ctgaactcaa agatgccctt aaaaggtatg caggtgcgtt gagagcttca ggagaaatgg
      661 cttcagcaca gtatattact gcagctctta gagatttgtt tgattccatg gataaaactt
      721 cttctagtat cccacctatt attctgctgc agtttctgca catggccttt ccacagtttg
      781 cagagaaggg cgaacaaggg cagtatcttc agcaggatgc taacgaatgc tggatacaaa
      841 tgatgagagt cctgcaacag aaactagaag ccatagagga tgattctggt agagagacgg
      901 attcttcatc tgcaccagcg gtgacacctt ctaaaaagaa aagcttaatt gatcaatatt
      961 ttggtgttga gtttgaaact accatgaaat gtacagaatc tgaagaagaa gaggtcacca
     1021 aaggaaagga aaatcaactt caacttagtt gtttcattaa ccaggaagtg aagtatcttt
     1081 tcacagggct gaaattgcga cttcaggaag aaattactaa acagtctcca acactgcaga
     1141 gaaatgcttt gtacatcaaa tcttctaaga tcagccggct acctgcttac ttaactattc
     1201 aaatggttcg atttttttat aaagagaaag aatctgtgaa cgccaaagtt cttaaggatg
     1261 ttaagtttcc tcttatgttg gatgtgtatg aactctgcac accagaactt caagagaaaa
     1321 tggtctcttt tcggtcaaaa ttcaaggatc tagaagataa aaaagtgaat cagcaaccaa
     1381 atgcaaatga caagaatagt cctccgaaag agattaagta tgaacccttt tcatttgctg
     1441 acgatattgg ctccaataat tgtggctact atgacttaca agcagtgtta actcaccagg
     1501 gaagatctag ttcttcaggt cattatgtat catgggtgag aagaaaacaa gatgaatgga
     1561 tcaaatttga tgatgataag gtcagcattg taaccccaga agatattctg cggctgtctg
     1621 gtggtggaga ctggcacatt gcttatgttc tactttatgg gcctcgaaga gttgaaataa
     1681 tggaagaaga aagtgaacag taatcttcaa tttagctatt tatgcttagg tgtgaatgtt
     1741 tttgttgttg ttgttgaaca tttctataat cttgagctct aaagaaaatg agaacagaac
     1801 caagccactt gtgcatcttc aatcttaaga ctacgggaaa ttacgtttgg gtcctacctt
     1861 gtatagaggt agcttcaaga cattctttaa aaatctcatt ttttgcatta atccttagaa
     1921 attcttggct gaaatccatt ttatcccttg ccttttcagc ccaagcttta gcagtgatgt
     1981 ttattgcaca cctatctgtt gttcttgcat ggttactatc accttcagta gctgcccgtc
     2041 ctctgcctta tctaaccaat atttttctag gaaggtggaa aagtgttgct ctcttcgtgt
     2101 aactcagtgc tgctgtccac atcccatcaa ctgggtgcaa tcaagtattg tccagactga
     2161 ctgttgctgg cctttcatga ctttacaata aattgtgatc aataagaaca cacttgatta
     2221 tacacttatt attgtgtctc taatgtactg tggtttatat gttaaacttt gcattggttt
     2281 ttgtagtaat cataatgtgt aaacaagctc tggttgcttg gaaaccaagg atatttaata
     2341 ataaaaataa ggaaaaagag ggattaacaa cttttgacat ttctttttag tattagagct
     2401 tggcttaaga gtcaaatgaa ttcagtacta tacagtttct gcaaatggct aataatgcta
     2461 agcagtcaag gatctattta aaatacaaga aactttagct tgtccagtgt tattacaaaa
     2521 gaaatacaaa gtagtaaagg tgatgagttc ctttggacag tgaattctgt gatcagtttc
     2581 attccctcac acgtttgttg tttctatttt ctttcccaaa gtctttgtgc ccatcttgaa
     2641 agttactgat ttttaagatt aaggtataca ttaccaagag tattgtttat taatctattg
     2701 actacccagt gagtaagtcc ttagatgttt caggaacttt agcaatctaa ggaaaggatg
     2761 aagtgttgaa tattcgtgat ctggtctgat ttgagttgac taggaatgtc aggaatatca
     2821 tgacatcttc cacctcatgt tttaatgctc tgtaaagtac ccaagattcc tataggataa
     2881 taaatctgta atagtgtggg taagtcagca ttttaggttt gtaaatagtt tgctaactta
     2941 aacattatta gcagttaaga cgccttacaa tggggagtga aacatggaat gaaacagtgc
     3001 tgtgtgtact gtaatagttt gtgtcatgac ccctgggatt cagtgttatt tgctagaaca
     3061 gttgtagaac gaaggaattt ggcacctgtg ttttcctact aaaccaggtg aggtagattt
     3121 agaacaaata tgccaaaact atgtttagaa tgcattaaga aaactattat acaaaaagtg
     3181 tggtgatagt ttatttgacc taaaaaggca ttccaaaaat aattctttaa agtagaaatt
     3241 ggacttccat cattttgttt taaataaggt gttaagtgtt ttagaatgag gtaaaaaaac
     3301 attctcctcc ctttcaatcc ctgaacttgc cttaatttgc ttaatgcaga agacatctgg
     3361 aggccagggt tgtgcttagt cactgcttcc ccagctagta gagtgcagtt caagcaagaa
     3421 cacttaacag tggtctgccc agtcgccctt cactagtata ctaaacaccc acaggaaatg
     3481 ctgtatggga ctagaacacg aacatcttaa ccgtcagcca gtaccacaca tgctctgcta
     3541 catatagggt attttcacat ctcaagtgaa ctgacaggaa tccctgggtg tttaaagact
     3601 taaggaggtc aagtaatctt tgtaaagcta aaggagtagt tgggtcttag actccacttc
     3661 atataaactt agagctagca aacaaacatt ttctgttttg gacaaacagc taatgatttg
     3721 gtttttgcag gcccctggct atcagtttga actctttgct attgtagtgt cagcatgtca
     3781 gagtgccagg aaaacactta aaactatcca tggtttgctg atcctcttct ctccagtcct
     3841 aaggtttcag aagtgtcatc ttgtaatttc agaataaaat tttataaccg atagcatgca
     3901 ggaaactaat ttgggacagt actgttagta gtactcattt aacttcactg tagaaatact
     3961 taacaaaaat tggtgtgatc ttgaggtcct tttactttgt tttcccaccc tgttctccac
     4021 tccaatgcct gttctgtatg tggtttttgg agcaccagcc aactgtacaa tagctgttat
     4081 aaaagtgttt attgtttacc aaaaccagtg aaccttttat caaatgctgc ttggtaacaa
     4141 aatcttatca ctgtttaata aaaaagaaaa gaaaggaaga aagct
//
