LOCUS       NP_067497                493 aa            linear   ROD 28-APR-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 14 isoform 1 [Mus musculus].
ACCESSION   NP_067497
VERSION     NP_067497.2
DBSOURCE    REFSEQ: accession NM_021522.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Li,M., Zhao,Y., Zhang,J., Jiang,W., Peng,S., Hu,J. and Shen,Y.
  TITLE     Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits
            the NOD2 pathway mediated inflammatory response in vitro
  JOURNAL   Eur J Histochem 68 (3), 4101 (2024)
   PUBMED   39252535
  REMARK    GeneRIF: Deubiquitinase USP14 is upregulated in Crohn's disease and
            inhibits the NOD2 pathway mediated inflammatory response in vitro.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Wei,D., Tian,X., Ren,Z., Liu,Z. and Sun,C.
  TITLE     Mechanistic insights into the role of USP14 in adipose tissue
            macrophage recruitment and insulin resistance in obesity
  JOURNAL   Int J Biol Macromol 267 (Pt 2), 131645 (2024)
   PUBMED   38631582
  REMARK    GeneRIF: Mechanistic insights into the role of USP14 in adipose
            tissue macrophage recruitment and insulin resistance in obesity.
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Wei,D., Tian,X., Zhu,L., Wang,H. and Sun,C.
  TITLE     USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease
            through deubiquitination and stabilization of HSP90AA1
  JOURNAL   Cell Death Dis 14 (8), 566 (2023)
   PUBMED   37633951
  REMARK    GeneRIF: USP14 governs CYP2E1 to promote nonalcoholic fatty liver
            disease through deubiquitination and stabilization of HSP90AA1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Lane,P.W., Searle,A.G., Beechey,C.V. and Eicher,E.
  TITLE     Chromosome 18 of the house mouse
  JOURNAL   J Hered 72 (6), 409-412 (1981)
   PUBMED   6949984
REFERENCE   8  (residues 1 to 493)
  AUTHORS   Burt,A.M.
  TITLE     Morphologic abnormalities in the postnatal differentiation of CA1
            pyramidal cells and granule cells in the hippocampal formation of
            the ataxic mouse
  JOURNAL   Anat Rec 196 (1), 61-69 (1980)
   PUBMED   7416502
REFERENCE   9  (residues 1 to 493)
  AUTHORS   Weber,M.B.
  TITLE     A study of brain lipids, nucleic acids and proteins in the ataxic
            (axJ) mouse
  JOURNAL   Neurology 18 (3), 243-249 (1968)
   PUBMED   5689664
REFERENCE   10 (residues 1 to 493)
  AUTHORS   D'Amato,C.J. and Hicks,S.P.
  TITLE     Neuropathologic alterations in the ataxia (paralytic) mouse
  JOURNAL   Arch Pathol 80 (6), 604-612 (1965)
   PUBMED   5855800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ161902.1, AK011322.1, AK029977.1 and AC163451.2.
            
            On Jun 10, 2003 this sequence version replaced NP_067497.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170933.1, AK172477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     Protein         1..493
                     /product="ubiquitin carboxyl-terminal hydrolase 14 isoform
                     1"
                     /EC_number="3.4.19.12"
                     /note="dUB-type TGT for deubiquitinating enzyme; ubiquitin
                     carboxyl-terminal hydrolase 14; ubiquitin thioesterase 14;
                     deubiquitinating enzyme 14; ubiquitin-specific-processing
                     protease 14; ubiquitin thiolesterase 14; ubiquitin
                     specific protease 14; ataxia"
                     /calculated_mol_wt=55871
     Region          4..76
                     /region_name="Ubl_USP14_like"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin
                     carboxyl-terminal hydrolase 14 (USP14) and similar
                     proteins; cd16104"
                     /db_xref="CDD:340521"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Region          106..480
                     /region_name="Peptidase_C19A"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyse bonds involving the carboxyl...; cd02657"
                     /db_xref="CDD:239122"
     Site            order(109,114,434,451)
                     /site_type="active"
                     /db_xref="CDD:239122"
     Site            143
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            148
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            235
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P54578; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            237
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54578; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54578; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54578; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     Site            448
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P54578; propagated from
                     UniProtKB/Swiss-Prot (Q9JMA1.3)"
     CDS             1..493
                     /gene="Usp14"
                     /gene_synonym="2610005K12Rik; 2610037B11Rik; ax; nmf375"
                     /coded_by="NM_021522.4:222..1703"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37735.1"
                     /db_xref="GeneID:59025"
                     /db_xref="MGI:MGI:1928898"
ORIGIN      
        1 mplysvtvkw gkekfegvel ntdeppmvfk aqlfaltgvq parqkvmvkg gtlkdddwgn
       61 ikmkngmtvl mmgsadalpe epsaktvfve dmteeqlata melpcgltnl gntcymnatv
      121 qcirsvpelk dalkryagal rasgemasaq yitaalrdlf dsmdktsssi ppiillqflh
      181 mafpqfaekg eqgqylqqda necwiqmmrv lqqkleaied dsgretdsss apavtpskkk
      241 slidqyfgve fettmkctes eeeevtkgke nqlqlscfin qevkylftgl klrlqeeitk
      301 qsptlqrnal yiksskisrl payltiqmvr ffykekesvn akvlkdvkfp lmldvyelct
      361 pelqekmvsf rskfkdledk kvnqqpnand knsppkeiky epfsfaddig snncgyydlq
      421 avlthqgrss ssghyvswvr rkqdewikfd ddkvsivtpe dilrlsgggd whiayvllyg
      481 prrveimeee seq
//
