LOCUS       NM_011669               4274 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 12 (Usp12), mRNA.
ACCESSION   NM_011669 XM_904614 XM_918916 XM_918924 XM_918931
VERSION     NM_011669.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4274)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4274)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   3  (bases 1 to 4274)
  AUTHORS   Sheng,B., Wei,Z., Wu,X., Li,Y. and Liu,Z.
  TITLE     USP12 promotes breast cancer angiogenesis by maintaining midkine
            stability
  JOURNAL   Cell Death Dis 12 (11), 1074 (2021)
   PUBMED   34759262
  REMARK    GeneRIF: USP12 promotes breast cancer angiogenesis by maintaining
            midkine stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4274)
  AUTHORS   Fu,Y., Wang,P., Zhao,J., Tan,Y., Sheng,J., He,S., Du,X., Huang,Y.,
            Yang,Y., Li,J., Cai,Y., Liu,Y. and Hu,S.
  TITLE     USP12 promotes CD4+ T cell responses through deubiquitinating and
            stabilizing BCL10
  JOURNAL   Cell Death Differ 28 (10), 2857-2870 (2021)
   PUBMED   33941870
  REMARK    GeneRIF: USP12 promotes CD4(+) T cell responses through
            deubiquitinating and stabilizing BCL10.
REFERENCE   5  (bases 1 to 4274)
  AUTHORS   Lu,P., Xu,Y., Sheng,Z.Y., Peng,X.G., Zhang,J.J., Wu,Q.H., Wu,Y.Q.,
            Cheng,X.S. and Zhu,K.
  TITLE     De-ubiquitination of p300 by USP12 Critically Enhances METTL3
            Expression and Ang II-induced cardiac hypertrophy
  JOURNAL   Exp Cell Res 406 (1), 112761 (2021)
   PUBMED   34339675
  REMARK    GeneRIF: De-ubiquitination of p300 by USP12 Critically Enhances
            METTL3 Expression and Ang II-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4274)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4274)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 4274)
  AUTHORS   Baek,K.H., Park,K.H., Kim,Y.S., Kim,M.S. and Choi,H.K.
  TITLE     Molecular cloning and complete cDNA sequence of UBH1 in mouse
            testis
  JOURNAL   DNA Seq 13 (3), 145-148 (2002)
   PUBMED   12391724
  REMARK    GeneRIF: Product has deubiquitinating enzyme activity and sequence
            analysis showed 98.3% amino acid identity with human UBH1.
REFERENCE   9  (bases 1 to 4274)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 4274)
  AUTHORS   Hansen-Hagge,T.E., Janssen,J.W., Hameister,H., Papa,F.R.,
            Zechner,U., Seriu,T., Jauch,A., Becke,D., Hochstrasser,M. and
            Bartram,C.R.
  TITLE     An evolutionarily conserved gene on human chromosome 5q33-q34,
            UBH1, encodes a novel deubiquitinating enzyme
  JOURNAL   Genomics 49 (3), 411-418 (1998)
   PUBMED   9615226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124828.14
            and AC127589.4.
            
            On Nov 17, 2006 this sequence version replaced NM_011669.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068136.1, AK167153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC124828.14        23688-24029         c
            343-423             AC127589.4         190401-190481       c
            424-637             AC127589.4         184665-184878       c
            638-867             AC127589.4         175834-176063       c
            868-944             AC127589.4         173357-173433       c
            945-1028            AC127589.4         173159-173242       c
            1029-1226           AC127589.4         161758-161955       c
            1227-1305           AC127589.4         160564-160642       c
            1306-4274           AC127589.4         156276-159244       c
FEATURES             Location/Qualifiers
     source          1..4274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.0 cM"
     gene            1..4274
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /note="ubiquitin specific peptidase 12"
                     /db_xref="GeneID:22217"
                     /db_xref="MGI:MGI:1270128"
     exon            1..342
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1407
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 12; ubiquitin
                     thiolesterase 12; ubiquitin thioesterase 12;
                     deubiquitinating enzyme 12; ubiquitin-hydrolyzing enzyme
                     1; ubiquitin-specific-processing protease 12"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 12"
                     /protein_id="NP_035799.1"
                     /db_xref="CCDS:CCDS39395.1"
                     /db_xref="GeneID:22217"
                     /db_xref="MGI:MGI:1270128"
                     /translation="MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNF
                     GNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKENLLTCLADLFHSIATQKKKVGVIP
                     PKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLRNGDVDN
                     EDNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRG
                     FSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPLILALHLKRFKYMDQLHRYTKLSY
                     RVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDD
                     IVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD"
     exon            343..423
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..637
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..867
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..944
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1028
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1226
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1305
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..4274
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1642..1647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /note="hexamer: AGTAAA"
     polyA_site      1660
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /note="major polyA site"
     polyA_site      1695
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
     regulatory      4242..4247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
                     /note="hexamer: ATTAAA"
     polyA_site      4262
                     /gene="Usp12"
                     /gene_synonym="Ubh1"
ORIGIN      
        1 ccagcgcgct gggcggggtg tgctgtgagc ggcttcccgg gcaggcgcgg gccctgaggc
       61 ggcggctgcg ccgtgcgccg gggcggagcc gggggcgggc gggcggccgg cgggcggggg
      121 ctgggccgga ggaagcctga gcgcccgcgg cgacgacggc agcggcggcc cagcaggcta
      181 gaagcgtggg tcggcggcgg ctccgggtgc ggccgcgggc tgcggagcga gcgggcggcc
      241 cggctccccg cgtcccccgc ccgccgcgac tgtctggaag atggcgccgg gcggatggaa
      301 atcctaatga cagtctccaa attcgcctcc atctgtacca tgggcgccaa tgcctcggca
      361 ttagagaaag agattggtcc agaacagttt ccggtcaacg agcactattt tggattagtc
      421 aattttggga atacctgcta ctgcaactca gttcttcaag cactttattt ttgtcgtcca
      481 tttcgggaaa aagttctagc atacaaaagt cagcccagaa aaaaggagaa ccttctcacc
      541 tgcctggcag acctcttcca cagcatagcc acccagaaga agaaggtcgg cgtgatcccg
      601 cccaagaagt tcatcacaag gttgcggaaa gaaaacgagc tgtttgacaa ctacatgcaa
      661 caagatgccc atgaattctt aaattaccta ctcaatacaa ttgctgatat tctacaagaa
      721 gaaagaaaac aggagaagca aaatggccga ttacggaacg gagacgtgga caacgaggat
      781 aacaacagca caccagaccc aacctgggtc cacgagatct ttcagggaac attaactaat
      841 gaaaccaggt gtcttacttg tgaaactata agcagcaaag atgaagattt tttagacctt
      901 tctgttgacg tggaacaaaa cacatcaatt actcactgct taagagggtt cagtaacaca
      961 gaaactctgt gcagtgaata taagtactac tgtgaagagt gccggagcaa gcaggaagca
     1021 cacaagcgga tgaaggttaa gaaactgccc ctgatcctgg ctctgcacct gaagaggttt
     1081 aagtatatgg accagcttca ccggtacacg aagctttctt atcgcgtggt ctttccttta
     1141 gagctccgtc tgttcaacac gtcaggagat gcgaccaacc ctgacagaat gtatgacctg
     1201 gtcgccgttg tggttcactg tggaagtggt cccaaccgag gccattatat tgcaatagtt
     1261 aagagtcatg atttctggct gttgtttgat gatgacattg tagaaaaaat cgatgcccaa
     1321 gctattgaag aattctacgg attgacatct gacatctcca agaactcgga gtctggctac
     1381 atccttttct atcagtctcg ggactgagag gagccacggt ggggagaagc ttctacaagc
     1441 ttctctggtt gtttcagaaa ggatcgagcg gatgttcaag aagagaaagc gagacagaca
     1501 gacagacagc cacaggacgc tcagggcagt agctcacttt gcatacgata aagcaaagac
     1561 tgtggattaa catgcccttc cggttacagt agttgaattt tttgctcagg aatcatgctg
     1621 tctgtgcagt tcacacaagg aagtaaaatc agagatacca gctctcgtgt aaagcagctg
     1681 ccagctgcca acacattttc tgtagtaatt gcaccaatga tgatttgagt tcctcgggag
     1741 ggcagtggaa gaattagatg tgctagtctg attgagcaca ctgcactgtg tgccagcgtg
     1801 cgggatgcgt acactgtgca tgggagcagt ggcggtcttg tcaagcatcc cggaaagtac
     1861 ctttgggccc aacccttgca gttgccttcc tgacgcacag agcacagaca cagagcccag
     1921 tgtcaggagg tcaaagataa ccctgcttct ctggagaagc gtgtgatcat atacagtgta
     1981 tgtacatgga gggaacagct ggtcaaaact ggcttcttga ttccccaagg ggaaagactg
     2041 cctttgtaat gatctttttt tccttattta ttttacttaa actggttgag tctaagcatt
     2101 gtgtgaagtg ccagtgactc taccagcaag tcttagcata ttttattagt ttgtcagctg
     2161 aagtagtcct gttgttcgtt tctgttttca aggtgaactg aaaattctag ctaaaatcac
     2221 taagataatc atgagatgat tgcaagattg cagtgagcgg ggtcagtgct gtcaggaggg
     2281 actgtctctc tctggctgag catttcctct ttggttatag tttgtcactt tttttaaagc
     2341 tttaatttca gtaaagtagg aattccctgt tgctagaatg ataaaggaag ccgcagcgtg
     2401 aagccggcat tcttgccagc cagaacccca ggaccgtgca cagctgcggc ggtggcatgg
     2461 cgtgttcttc cggtctcttt ttagccttgg gaagggctag tagagcagcc agaaccccgg
     2521 cagcagggca gcgcacgccc tttggaagat tacgttttgg tgaagtagta atctcgaaaa
     2581 gaagcccctc cctcccctcc cgacctgatc gtcctattgg agcagtgtgt tcagacgctt
     2641 acaactaggt ctgttgggag tttaaggaac agtacgggga gtctccatgt cccgccaggc
     2701 atcaagtggt atgacagtgg ctgaatgtaa cttgcagaaa gtggatgagg attctagtcg
     2761 aagctgtcag actctgggta gcctcacact gccctccgca tgccgtggtg gtggtggcct
     2821 gttgataaag cccctggttt tctattttac taaaactgtt gactgagaag caaacagcaa
     2881 aaagaaatgt ttttgtgctg ctatgattaa catttatttt ctacctttag ctcaggaaat
     2941 gacttcatct attcatccca taggcagatt tgtggcgggg tcacttagct aatcgggctt
     3001 cgtggacaga tgtgctggga gaaaaagatg gcctttgaca aactctttct gatagtttct
     3061 gaagccttac cctggctggg tttgtgatct gccagcatcg cacagagaac cacaaccaag
     3121 agcatgggag gtagagccag gagcacaggc ctgcgagggc ctacgccaga ttgtgttgga
     3181 attaagacat gccacggctg cagccttggg ttcagagaca aggcatacag tgcggctggg
     3241 tcctccaggc ggccttgtgc agcactgaat actgtgtttg cttgcacaca catttttgaa
     3301 gttaaaacat agcaggaaaa acctagttaa gttctccatg aggtgaggtg tagcatggga
     3361 gccaacctcc gggcgagcag gcctgcttgg ctcaggtctg cgctggacgg tttgcagggg
     3421 aagggctcct gggtgttggc tcctaattta ctttttattt atagtgcaga tggatctgag
     3481 gaagacattt tgaattttat cagagactca gtaaacttaa aaagcataca gggtttgggt
     3541 tggggactgg ggaaggcagg tatggggagt gagaaagaaa ggtgacaaag gtgacccgcc
     3601 cagcacacac ttcaggggat tgtcgtttgt ttgcctgcga ttatgatgag ggcagatgca
     3661 agtttcagac aaggctagct gctgtgttat tatgtacatg tttgcttggg cagctgtccc
     3721 agattttgta tattagaaca aaagtttcta tgaattagca taactaaaag taaatattgt
     3781 aagtgaagcc cacttctgag ccatgcggct tctgtcatgg ggatttcgcc tttagaaggt
     3841 tactcaagac aggagccgag tggcttaggc cgggccagga aatgtgctat ggcgtcagcc
     3901 atcagcatcg ggtttttctt tccatgatgg ccgtaggaag acctcacttt cataacacgc
     3961 tcctcctgat actttgtgta aagatacttt tcattaaaga ttctctcagg agggatgtgg
     4021 ctgggagctg ggaggcaagg tgctggagtc ctcattctcc agtgagctta gctgtgtgac
     4081 cttgggcaag tcacctaacc tctctgtgct tcagtctccc tcttgtcaat gggagtaata
     4141 cctacctcac agggttgttg tggggattaa ttagagagga agtctgtaaa gcatttaaaa
     4201 ggttcttgaa gaaggcgcta tataaataca aaataatatc tattaaagtt ggcttatttg
     4261 tgcttgttgg tttt
//
