LOCUS       NM_145628               3464 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 11 (Usp11), transcript
            variant 1, mRNA.
ACCESSION   NM_145628
VERSION     NM_145628.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3464)
  AUTHORS   Qian,T., Bai,F., Zhang,S., Xu,Y., Wang,Y., Yuan,S., Liu,X., Du,Y.,
            Peng,B., Zhu,W.G., Xu,X. and Pei,X.H.
  TITLE     USP11 deubiquitinates E-cadherin and maintains the luminal fate of
            mammary tumor cells to suppress breast cancer
  JOURNAL   J Biol Chem 300 (10), 107768 (2024)
   PUBMED   39270819
REFERENCE   2  (bases 1 to 3464)
  AUTHORS   Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J.,
            Cao,J. and Jiao,Y.
  TITLE     USP11 Exacerbates Radiation-Induced Pneumonitis by Activating
            Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
  JOURNAL   Int J Radiat Oncol Biol Phys 119 (4), 1261-1274 (2024)
   PUBMED   38364946
  REMARK    GeneRIF: USP11 Exacerbates Radiation-Induced Pneumonitis by
            Activating Endothelial Cell Inflammatory Response via OTUD5-STING
            Signaling.
REFERENCE   3  (bases 1 to 3464)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3464)
  AUTHORS   Wang,R., Wu,D., Dai,J., Shen,J., Rong,J., Chen,Z., Jiao,Y. and
            Qi,X.
  TITLE     USP11 plays a critical role in the onset and progression of acute
            graft-versus-host diseaseNovel target for precision therapeutics
  JOURNAL   Pharmacol Res 189, 106707 (2023)
   PUBMED   36822452
  REMARK    GeneRIF: USP11 plays a critical role in the onset and progression
            of acute graft-versus-host diseaseNovel target for precision
            therapeutics.
REFERENCE   5  (bases 1 to 3464)
  AUTHORS   Shi,Y., Tao,M., Chen,H., Ma,X., Wang,Y., Hu,Y., Zhou,X., Li,J.,
            Cui,B., Qiu,A., Zhuang,S. and Liu,N.
  TITLE     Ubiquitin-specific protease 11 promotes partial
            epithelial-to-mesenchymal transition by deubiquitinating the
            epidermal growth factor receptor during kidney fibrosis
  JOURNAL   Kidney Int 103 (3), 544-564 (2023)
   PUBMED   36581018
  REMARK    GeneRIF: Ubiquitin-specific protease 11 promotes partial
            epithelial-to-mesenchymal transition by deubiquitinating the
            epidermal growth factor receptor during kidney fibrosis.
REFERENCE   6  (bases 1 to 3464)
  AUTHORS   Vlasschaert,C., Xia,X., Coulombe,J. and Gray,D.A.
  TITLE     Evolution of the highly networked deubiquitinating enzymes USP4,
            USP15, and USP11
  JOURNAL   BMC Evol Biol 15, 230 (2015)
   PUBMED   26503449
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3464)
  AUTHORS   Werber,M., Wittler,L., Timmermann,B., Grote,P. and Herrmann,B.G.
  TITLE     The tissue-specific transcriptomic landscape of the mid-gestational
            mouse embryo
  JOURNAL   Development 141 (11), 2325-2330 (2014)
   PUBMED   24803591
REFERENCE   8  (bases 1 to 3464)
  AUTHORS   Al-Salihi,M.A., Herhaus,L., Macartney,T. and Sapkota,G.P.
  TITLE     USP11 augments TGFbeta signalling by deubiquitylating ALK5
  JOURNAL   Open Biol 2 (6), 120063 (2012)
   PUBMED   22773947
  REMARK    GeneRIF: USP11 augments TGFbeta signalling by deubiquitylating
            ALK5.
REFERENCE   9  (bases 1 to 3464)
  AUTHORS   Maertens,G.N., El Messaoudi-Aubert,S., Elderkin,S., Hiom,K. and
            Peters,G.
  TITLE     Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation
            of the INK4a tumour suppressor
  JOURNAL   EMBO J 29 (15), 2553-2565 (2010)
   PUBMED   20601937
REFERENCE   10 (bases 1 to 3464)
  AUTHORS   Ideguchi,H., Ueda,A., Tanaka,M., Yang,J., Tsuji,T., Ohno,S.,
            Hagiwara,E., Aoki,A. and Ishigatsubo,Y.
  TITLE     Structural and functional characterization of the USP11
            deubiquitinating enzyme, which interacts with the RanGTP-associated
            protein RanBPM
  JOURNAL   Biochem J 367 (Pt 1), 87-95 (2002)
   PUBMED   12084015
  REMARK    GeneRIF: structural and functional characterization of the USP11
            deubiquitinating enzyme
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY272535.1, AK031767.1, AK049053.1 and AK169116.1.
            
            On Jan 12, 2008 this sequence version replaced NM_145628.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031767.1, SRR1660815.12858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY272535.1         2-24
            24-388              AK031767.1         2-366
            389-873             AK031767.1         368-852
            874-1822            AK049053.1         1288-2236
            1823-3121           AK031767.1         1802-3100
            3122-3462           AK169116.1         1945-2285
            3463-3464           AK031767.1         3442-3443
FEATURES             Location/Qualifiers
     source          1..3464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.2 cM"
     gene            1..3464
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /note="ubiquitin specific peptidase 11"
                     /db_xref="GeneID:236733"
                     /db_xref="MGI:MGI:2384312"
     exon            1..211
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            212..321
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            322..452
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            453..570
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            571..716
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            717..778
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            779..878
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1052
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1211
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1436
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1520
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1615
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1822
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1872
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2151
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2222
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2335
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2485
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2601
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2690
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..3464
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /note="hexamer: CATAAA"
     polyA_site      3216
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /note="major polyA site"
ORIGIN      
        1 agttgagggt cgtcttccta tcttcagttg cgtcggcagt tggaggagga cagacggtga
       61 tggcggcggt cgcagcggac ccagctgcag ctgccgtccc ggcctctgct gaggaccgag
      121 acacacagcc cgaggcaatg ccagacctgg atgaacagtg gcgccaaatc gggaatgggc
      181 gagagcgtcc actgcgagct ggcgaaagct ggttccttgt ggagaaacac tggtataaac
      241 agtgggaggt gtacgtgaag ggaggggatc aagatgctag cacctttcct ggctgtatca
      301 acaatgctgg gctctttgaa gatcagataa gctggcatct cagggagaga ctgctagaag
      361 gagatgatta tgtgctgctc ccagcgcctg cttggaacta catggtcagc tggtatggct
      421 taatggatgg ccagccacct attgagcgca aggtaataga acttcctggc attcggaagg
      481 tggaagtgta cccactagag ctactgctcg ttcagcacag tgatatggaa acagctctca
      541 ccattcagtt tagctatact gattctgtgg aactagtctt gcaaacagct cgggagcagt
      601 ttctggtaga gcctcaggaa gacacgcgcc tctggaccaa gaactcagag ggctctttgg
      661 atcgactgtg taatacacag atcacgctgc ttgatgcctg ccttgagact gggcagttgg
      721 tcatcatgga gactcgaaac aaagatggca cttggcccag tgctcagctg tgtggcatga
      781 acaacatacc ggacgaggat gaggacttcc aggggcaacc gggcatctgt ggccttacca
      841 atctgggcaa cacatgcttc atgaactcgg ccctacagtg cctgagcaat gtgccacagc
      901 tgacagagta ctttctcaac aatcgctacc tagaggagct caacttccgg aaccctctag
      961 gcatgaaggg tgagcttgct gaggcctatg cagatctggt aaagcagact tggtctggct
     1021 accaccgctc cattgtgcca aatgtgttca agaacaaggt tggccatttt gcatcccagt
     1081 ttctgggcta ccagcagcat gactcacagg aactactgtc attcctcctg gatgggctac
     1141 atgaggatct caatcgggtc aaaaagaaag aatatgttga gctatgcaat ggtgctgggc
     1201 ggcctgatct ggaagtggct caggaagcct ggcagaacca taaacgacga aatgattctg
     1261 tgatcgtgga cactttccat ggcctcttca agtccaccct ggtgtgccct gattgtggca
     1321 atgtttctgt gacctttgac cccttctgct acctcagtgt cccactgcct gtctgctcca
     1381 ggagggtctt ggaagtcttc tttgtcccca tggatccccg ccgcaagcca gaacagcacc
     1441 gggttgtagt ccccaagaag ggcaatatct cagatctgtg tgtggctctg tccacgcata
     1501 caagtgttgc accagacaag atgatagtag ctgatgtctt cagtcaccga ttctataagc
     1561 tttaccagct ggaggatcct ctgagtggca tcttggatcg tgatgatatc tttgtatatg
     1621 aggtgactgg tcggattgag ccggttgagg gttcaagaga tgatattgtg gtacctgttt
     1681 acttgcggga gcgcacccca tccagagact acaacaactc ctactatggt ctgatacttt
     1741 ttgggcaccc tctcctggtg tcagtgcccc gggaccggtt ctcctgggag ggcctatata
     1801 acatcttgat gtaccgactt tcacgatatg tgaccaaacc cacctcagat gaggatgatg
     1861 gggatgagaa agttgatgaa gatgaggatg aggatgtgga agatgacagc agcagtgagg
     1921 aggaaaagga ggaaatgtct gcgcccactg ttaatgatgg gacccgagaa gcagagcagg
     1981 agcaggctgg gaccagctct ggggtcactg agagatgccc atccctctta gacaacagcc
     2041 tccgcgcatc gcagtggccc ccaaggcgac gacgaaagca gctgtttact ctgcagacgg
     2101 tgaactccaa tggaaccagt gaccggacca cttcccctga agaaatgcaa acccagccat
     2161 acattgccat ggattgggaa ccagatatga agaggcgtta ttatgacgaa gtggaggctg
     2221 agggctatgt gaagcatgac tgtgtgggct acatgctgaa gaaaagtcca gtgcagctga
     2281 aggagtgcat caaactcttc accactgtgg aaaccctgga gaaggagaac ccctggtact
     2341 gctcctcctg caagcagcac cagctggcca ccaagaaact ggacctctgg atgctacccg
     2401 aagttctcat tatccacctg aagcgttttt cattttccaa aatttcccgg gagaagctgg
     2461 acaccctggt gcagtttcct atccgggacc tggatttctc tgagtttgtc atcaaaccaa
     2521 agaatgagtc ttctccagac ctctacaaat atgatctcat cgcagtttcc aaccattatg
     2581 gtggcatgcg tgatggacac tatacaacat ttgcctgcaa caaggacagt ggccagtggc
     2641 actactttga tgacaatagt gtctcacctg tgaatgagaa tcagattgag tccaaggcag
     2701 cctatgtctt gttctatcag cgccaagatg tgggtcgacg ccagtcccag acttcttcat
     2761 ctgacactcc tgcctctcct gtctccagtt ctacacccaa ctctgacatc atggatatca
     2821 actaaggagc cctagaacct accatggaga aggaagcccc ctttgccact ctctcctgtc
     2881 taccccctct ctttcctgtg tttatcgccc ccctctgccc ccccagacat tgcaggctta
     2941 gtctgtggct actgttctct tgtaccgctg tattactctc tcagaaagaa gaggccctat
     3001 gcccctggca gtgtgcccct gcctgtgtgt gcccgtacag cagtgacttc ctctcctagt
     3061 cttatttatg ctccccctcc ctcttttcct catgccaaag tgttcttagt ggctgatact
     3121 ggggtttaca tgaacacaga gtgtattttc ttattgagac cataccttct tctctgtgtt
     3181 aagtatccat aaaaagctcc agattcccat gttcaacagt gtggctttgt ttcttcatat
     3241 gtacttacta tgtaccagtc atatgtcttt gttcagttga cttactgaag gtcaagtatg
     3301 gtatgtagtt gatgctgtcc tgagtgggtt tgttgttttt gagacaggat ctgtctgtgt
     3361 agctcttggg tgtcctggaa ctcactgtgt ggatcaggct ggcctttaac tcagagattg
     3421 tacctctgcc tcctaagtgc tggcattaaa agcatgacca ccac
//
