LOCUS       NP_663603                921 aa            linear   ROD 28-APR-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 11 isoform 1 [Mus musculus].
ACCESSION   NP_663603
VERSION     NP_663603.3
DBSOURCE    REFSEQ: accession NM_145628.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 921)
  AUTHORS   Qian,T., Bai,F., Zhang,S., Xu,Y., Wang,Y., Yuan,S., Liu,X., Du,Y.,
            Peng,B., Zhu,W.G., Xu,X. and Pei,X.H.
  TITLE     USP11 deubiquitinates E-cadherin and maintains the luminal fate of
            mammary tumor cells to suppress breast cancer
  JOURNAL   J Biol Chem 300 (10), 107768 (2024)
   PUBMED   39270819
REFERENCE   2  (residues 1 to 921)
  AUTHORS   Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J.,
            Cao,J. and Jiao,Y.
  TITLE     USP11 Exacerbates Radiation-Induced Pneumonitis by Activating
            Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
  JOURNAL   Int J Radiat Oncol Biol Phys 119 (4), 1261-1274 (2024)
   PUBMED   38364946
  REMARK    GeneRIF: USP11 Exacerbates Radiation-Induced Pneumonitis by
            Activating Endothelial Cell Inflammatory Response via OTUD5-STING
            Signaling.
REFERENCE   3  (residues 1 to 921)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 921)
  AUTHORS   Wang,R., Wu,D., Dai,J., Shen,J., Rong,J., Chen,Z., Jiao,Y. and
            Qi,X.
  TITLE     USP11 plays a critical role in the onset and progression of acute
            graft-versus-host diseaseNovel target for precision therapeutics
  JOURNAL   Pharmacol Res 189, 106707 (2023)
   PUBMED   36822452
  REMARK    GeneRIF: USP11 plays a critical role in the onset and progression
            of acute graft-versus-host diseaseNovel target for precision
            therapeutics.
REFERENCE   5  (residues 1 to 921)
  AUTHORS   Shi,Y., Tao,M., Chen,H., Ma,X., Wang,Y., Hu,Y., Zhou,X., Li,J.,
            Cui,B., Qiu,A., Zhuang,S. and Liu,N.
  TITLE     Ubiquitin-specific protease 11 promotes partial
            epithelial-to-mesenchymal transition by deubiquitinating the
            epidermal growth factor receptor during kidney fibrosis
  JOURNAL   Kidney Int 103 (3), 544-564 (2023)
   PUBMED   36581018
  REMARK    GeneRIF: Ubiquitin-specific protease 11 promotes partial
            epithelial-to-mesenchymal transition by deubiquitinating the
            epidermal growth factor receptor during kidney fibrosis.
REFERENCE   6  (residues 1 to 921)
  AUTHORS   Vlasschaert,C., Xia,X., Coulombe,J. and Gray,D.A.
  TITLE     Evolution of the highly networked deubiquitinating enzymes USP4,
            USP15, and USP11
  JOURNAL   BMC Evol Biol 15, 230 (2015)
   PUBMED   26503449
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 921)
  AUTHORS   Werber,M., Wittler,L., Timmermann,B., Grote,P. and Herrmann,B.G.
  TITLE     The tissue-specific transcriptomic landscape of the mid-gestational
            mouse embryo
  JOURNAL   Development 141 (11), 2325-2330 (2014)
   PUBMED   24803591
REFERENCE   8  (residues 1 to 921)
  AUTHORS   Al-Salihi,M.A., Herhaus,L., Macartney,T. and Sapkota,G.P.
  TITLE     USP11 augments TGFbeta signalling by deubiquitylating ALK5
  JOURNAL   Open Biol 2 (6), 120063 (2012)
   PUBMED   22773947
  REMARK    GeneRIF: USP11 augments TGFbeta signalling by deubiquitylating
            ALK5.
REFERENCE   9  (residues 1 to 921)
  AUTHORS   Maertens,G.N., El Messaoudi-Aubert,S., Elderkin,S., Hiom,K. and
            Peters,G.
  TITLE     Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation
            of the INK4a tumour suppressor
  JOURNAL   EMBO J 29 (15), 2553-2565 (2010)
   PUBMED   20601937
REFERENCE   10 (residues 1 to 921)
  AUTHORS   Ideguchi,H., Ueda,A., Tanaka,M., Yang,J., Tsuji,T., Ohno,S.,
            Hagiwara,E., Aoki,A. and Ishigatsubo,Y.
  TITLE     Structural and functional characterization of the USP11
            deubiquitinating enzyme, which interacts with the RanGTP-associated
            protein RanBPM
  JOURNAL   Biochem J 367 (Pt 1), 87-95 (2002)
   PUBMED   12084015
  REMARK    GeneRIF: structural and functional characterization of the USP11
            deubiquitinating enzyme
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY272535.1, AK031767.1, AK049053.1 and AK169116.1.
            
            On Jan 12, 2008 this sequence version replaced NP_663603.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031767.1, SRR1660815.12858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.2 cM"
     Protein         1..921
                     /product="ubiquitin carboxyl-terminal hydrolase 11 isoform
                     1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin carboxyl-terminal hydrolase 11; ubiquitin
                     thioesterase 11; deubiquitinating enzyme 11;
                     ubiquitin-specific-processing protease 11; ubiquitin
                     thiolesterase 11"
                     /calculated_mol_wt=105254
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99K46.4)"
     Region          23..888
                     /region_name="UBP12"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; COG5560"
                     /db_xref="CDD:227847"
     Site            194
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q99K46.4)"
     Region          593..668
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99K46.4)"
     Site            596
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q99K46.4)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5D006; propagated from
                     UniProtKB/Swiss-Prot (Q99K46.4)"
     Region          893..921
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99K46.4)"
     Site            906
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q99K46.4)"
     CDS             1..921
                     /gene="Usp11"
                     /gene_synonym="6230415D12Rik; mKIAA4085"
                     /coded_by="NM_145628.4:60..2825"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS53015.1"
                     /db_xref="GeneID:236733"
                     /db_xref="MGI:MGI:2384312"
ORIGIN      
        1 maavaadpaa aavpasaedr dtqpeampdl deqwrqigng rerplrages wflvekhwyk
       61 qwevyvkggd qdastfpgci nnaglfedqi swhlrerlle gddyvllpap awnymvswyg
      121 lmdgqppier kvielpgirk vevyplelll vqhsdmetal tiqfsytdsv elvlqtareq
      181 flvepqedtr lwtknsegsl drlcntqitl ldacletgql vimetrnkdg twpsaqlcgm
      241 nnipdededf qgqpgicglt nlgntcfmns alqclsnvpq lteyflnnry leelnfrnpl
      301 gmkgelaeay adlvkqtwsg yhrsivpnvf knkvghfasq flgyqqhdsq ellsflldgl
      361 hedlnrvkkk eyvelcngag rpdlevaqea wqnhkrrnds vivdtfhglf kstlvcpdcg
      421 nvsvtfdpfc ylsvplpvcs rrvlevffvp mdprrkpeqh rvvvpkkgni sdlcvalsth
      481 tsvapdkmiv advfshrfyk lyqledplsg ildrddifvy evtgriepve gsrddivvpv
      541 ylrertpsrd ynnsyyglil fghpllvsvp rdrfswegly nilmyrlsry vtkptsdedd
      601 gdekvdeded edveddssse eekeemsapt vndgtreaeq eqagtssgvt ercpslldns
      661 lrasqwpprr rrkqlftlqt vnsngtsdrt tspeemqtqp yiamdwepdm krryydevea
      721 egyvkhdcvg ymlkkspvql keciklfttv etlekenpwy cssckqhqla tkkldlwmlp
      781 evliihlkrf sfskisrekl dtlvqfpird ldfsefvikp knesspdlyk ydliavsnhy
      841 ggmrdghytt facnkdsgqw hyfddnsvsp vnenqieska ayvlfyqrqd vgrrqsqtss
      901 sdtpaspvss stpnsdimdi n
//
