LOCUS       NM_009462               3745 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 10 (Usp10), transcript
            variant 1, mRNA.
ACCESSION   NM_009462
VERSION     NM_009462.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Zhou,L., Mu,S., Zhang,Y. and Song,H.
  TITLE     USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis
            by controlling CST3 expression
  JOURNAL   Biochem Pharmacol 229, 116519 (2024)
   PUBMED   39236936
  REMARK    GeneRIF: USP10-mediated deubiquitination of NR3C1 regulates bone
            homeostasis by controlling CST3 expression.
REFERENCE   2  (bases 1 to 3745)
  AUTHORS   Mushajiang,M., Li,Y., Sun,Z., Liu,J., Zhang,L. and Wang,Z.
  TITLE     USP10 alleviates Nepsilon-carboxymethyl-lysine-induced vascular
            calcification and atherogenesis in diabetes mellitus by promoting
            AMPK activation
  JOURNAL   Cell Signal 120, 111211 (2024)
   PUBMED   38705504
  REMARK    GeneRIF: USP10 alleviates Nepsilon-carboxymethyl-lysine-induced
            vascular calcification and atherogenesis in diabetes mellitus by
            promoting AMPK activation.
REFERENCE   3  (bases 1 to 3745)
  AUTHORS   Zhao,M., Zheng,Z., Peng,S., Xu,Y., Zhang,J., Liu,J., Pan,W.,
            Yin,Z., Xu,S., Wei,C., Wang,M., Wan,J. and Qin,J.J.
  TITLE     Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3
            Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting
            Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination
  JOURNAL   J Am Heart Assoc 13 (6), e031283 (2024)
   PUBMED   38456416
  REMARK    GeneRIF: Epidermal Growth Factor-Like Repeats and Discoidin I-Like
            Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by
            Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4
            Deubiquitination.
REFERENCE   4  (bases 1 to 3745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3745)
  AUTHORS   Tang,X., Weng,R., Guo,G., Wei,J., Wu,X., Chen,B., Liu,S., Zhong,Z.
            and Chen,X.
  TITLE     USP10 regulates macrophage inflammation responses via stabilizing
            NEMO in LPS-induced sepsis
  JOURNAL   Inflamm Res 72 (8), 1621-1632 (2023)
   PUBMED   37436447
  REMARK    GeneRIF: USP10 regulates macrophage inflammation responses via
            stabilizing NEMO in LPS-induced sepsis.
REFERENCE   6  (bases 1 to 3745)
  AUTHORS   Takahashi,M., Higuchi,M., Matsuki,H., Yoshita,M., Ohsawa,T., Oie,M.
            and Fujii,M.
  TITLE     Stress granules inhibit apoptosis by reducing reactive oxygen
            species production
  JOURNAL   Mol Cell Biol 33 (4), 815-829 (2013)
   PUBMED   23230274
REFERENCE   7  (bases 1 to 3745)
  AUTHORS   Boulkroun,S., Ruffieux-Daidie,D., Vitagliano,J.J., Poirot,O.,
            Charles,R.P., Lagnaz,D., Firsov,D., Kellenberger,S. and Staub,O.
  TITLE     Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC
            cell surface expression by deubiquitylating and stabilizing sorting
            nexin 3
  JOURNAL   Am J Physiol Renal Physiol 295 (4), F889-F900 (2008)
   PUBMED   18632802
  REMARK    GeneRIF: vasopressin-induced Usp10 deubiquitylates and stabilizes
            endogenous SNX3 and consequently promotes cell surface expression
            of ENaC in kidney
REFERENCE   8  (bases 1 to 3745)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3745)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3745)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153675.1, DV650223.1, AK077453.1 and AI846788.1.
            
            On Jul 16, 2015 this sequence version replaced NM_009462.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153675.1, AK157970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1975              AK153675.1         1-1975
            1976-1976           DV650223.1         287-287
            1977-3060           AK153675.1         1977-3060
            3061-3724           AK077453.1         2591-3254
            3725-3745           AI846788.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.61 cM"
     gene            1..3745
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /note="ubiquitin specific peptidase 10"
                     /db_xref="GeneID:22224"
                     /db_xref="MGI:MGI:894652"
     exon            1..580
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..2941
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquintin c-terminal hydrolase related polypeptide;
                     ubiquitin specific protease 10; ubiquitin
                     carboxyl-terminal hydrolase 10; ubiquitin thioesterase 10;
                     deubiquitinating enzyme 10; ubiquitin-specific-processing
                     protease 10; ubiquitin thiolesterase 10"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 10 isoform
                     1"
                     /protein_id="NP_033488.1"
                     /db_xref="CCDS:CCDS40495.1"
                     /db_xref="GeneID:22224"
                     /db_xref="MGI:MGI:894652"
                     /translation="MALHNPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTLCSIQAE
                     DELPDAGQEHQRIEFGVDEVIEPSEGLPPTPSYSISSTLNPQAPEFILGCTTSKKIPE
                     AVEKDETYSSIDQYPASALALESNSNAEAETLENDSGAGGLGQRERKKKKKRPPGYYS
                     YLKDGGEDSASPATLVNGHATSVGTSGEAVEDAEFMDVLPPVMPRTCDSPQNPVDFIS
                     GPVPDSPFPRTLGGDARTAGLCEGCHEADFEQPCLPADSLLRTAGTQPYVGTDTTENF
                     AVANGKILESPGEDTAANGAELHTDEGADLDPAKPESQSPPAESALSASGAIPISQPA
                     KSWASLFHDSKPSASSPMAYVETKCSPPVPSPLASEKQMEVKEGLVPVSEDPVAIKIA
                     ELLETVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRP
                     CTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVIKS
                     SLSEKGRQEDAEEYLGFILNGLHEEMLSLKKLLSPTHEKHSVSNGPRSDLIEDEELED
                     TGKGSEDEWEQVGPKNKTSITRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQLFF
                     TLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEVSRRVTLEKLPPVLVLHLK
                     RFVYEKTGGCQKLVKNIDYPVDLEISRELLSPGIKNKNFKCQRTYRLFAVVYHHGNSA
                     TGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPPADRTAYLLYYRRVDLL"
     exon            581..649
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            650..707
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1736
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1828
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1938
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..1994
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2098
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2198
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2376
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2542
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2687
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2753
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..3731
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /note="hexamer: AATAAA"
     polyA_site      3731
                     /gene="Usp10"
                     /gene_synonym="2610014N07Rik; mKIAA0190; UBPO; Uchrp"
                     /note="major polyA site"
ORIGIN      
        1 atttggtcct caagggtaca ggaggcaggg ctccgttacc cgctgagtca tctcactagc
       61 tccttcaacg tttactttta tgttttacaa agaaaaaaaa aatctttttt tccccaatgc
      121 caggtaaaac aagctagtga agagaatgaa gagtgaagga atgaatgaat gaacgaacgg
      181 tcagaagagc gcgctccata gggtaaggga tccttggaga tctccagcgg agatcccagg
      241 gcggagctca ggcggaccca gcgcagtaac cactccggaa ctccaccttg cagccccagg
      301 gtgcctggcc agctccatcc tcacgccctc gcctggagca gccgccctcg gcgcgctggg
      361 gacagaaggg tcgccggccc ggggcgcacg cccacctgtc gcgcgcaggc gcagaacgcc
      421 gcctggctct cccgcggcgc agtcagtgcg caggcgcggc ggccgctgcg agtgtgtctg
      481 tgcggcgaga agatggcggc gacgggagac gcggcgtgag aagccggagc agcaccgaac
      541 ctcattgaga cgggccgcca tggccctcca caacccacag tatatctttg gcgatttcag
      601 ccctgatgaa ttcaatcagt tttttgtgac tccccgctct tctgttgagc tccctccata
      661 cagtgggact ctgtgtagca tacaggctga agatgaactg ccagatgcag gacaggagca
      721 ccagaggatc gagtttggtg tagatgaagt catcgaacct agtgaggggc tgccgccaac
      781 tcctagctac agtatttcaa gcaccttgaa cccccaggca cccgaattta tccttggttg
      841 tacgacttct aaaaagatcc ctgaagccgt tgaaaaagat gagacctaca gctccattga
      901 ccagtacccc gcctcggcct tggctctgga aagcaactct aacgcagagg ctgagaccct
      961 ggagaacgac agtggtgccg gcggccttgg tcagagggaa cggaaaaaga agaagaagcg
     1021 gccccctggg tactacagtt atttgaaaga tggcggtgag gacagtgctt ccccagccac
     1081 cctggtcaac ggccatgcca cctcagtggg cacgagcggc gaggctgtgg aggacgccga
     1141 gttcatggac gtgcttcctc cagtcatgcc caggacttgt gacagccctc agaatcctgt
     1201 ggacttcatc agtggccctg tccctgacag tccgttcccc aggacactag gaggcgatgc
     1261 caggactgca gggctgtgtg agggctgcca tgaagctgac tttgagcagc cctgcctccc
     1321 tgcagacagc ctgctaagga cagctgggac gcagccctac gttggcaccg atactactga
     1381 gaacttcgca gttgctaatg ggaaaatact tgaatccccg ggcgaggaca ctgctgccaa
     1441 cggggcagaa ctgcacaccg acgagggtgc agacctggac cctgcgaagc cggagagcca
     1501 gtcacctcct gccgaaagtg cgctctctgc ctctggcgcc atccccatta gccagcctgc
     1561 aaagtcctgg gctagtctct ttcatgattc taagccctct gcctcctcac ccatggcgta
     1621 tgtggaaact aagtgttccc cccctgtccc atcccccctg gcctctgaaa aacagatgga
     1681 agtcaaagaa gggcttgttc cagtgtcaga ggatcctgta gccataaaga ttgcagagtt
     1741 attggagact gtaaccctaa tacataagcc agtgtcattg caaccccgtg ggctgatcaa
     1801 taaaggaaac tggtgctaca ttaatgccac cctgcaggca ttggtggctt gccctccgat
     1861 gtatcacctg atgaagttca ttcctctgta ctcaaaagtg cagcggcctt gcacatcaac
     1921 gcccatgata gatagctttg ttcggctcat gaatgagttc actaacatgc cagtgcctcc
     1981 caaaccccgc caagctctcg gggataaaat cgtgagagat atccgcccag gggctgcctt
     2041 tgaacccaca tacatataca gactcctgac agtcatcaag tcgagcctgt ctgaaaaggg
     2101 ccggcaggag gacgcagagg agtatctagg tttcatcctc aatggactcc atgaagagat
     2161 gctgagcctg aagaagctac tctcacccac gcacgaaaaa cactctgttt ccaatgggcc
     2221 cagaagcgac ttgatagagg acgaggagct ggaagacacg ggcaagggca gcgaggacga
     2281 gtgggagcaa gtgggtccca agaataagac gtccatcacc cggcaggcgg acttcgtcca
     2341 gacgcccatc actggcattt ttgggggaca catcaggtct gtggtctacc agcagagttc
     2401 caaagagtca gctactctgc aactgttttt cacgctgcag ttggacatcc agtctgacaa
     2461 gatacgcaca gtccaggatg cgctggagag cttggtggcc agggagtctg tccaaggtta
     2521 caccaccaaa accaagcagg aggttgaggt gagccgcaga gtgactctgg agaagctgcc
     2581 ccctgtcctc gtgctccacc tgaagcgctt tgtctatgag aagacaggtg gatgccagaa
     2641 gctggtcaag aacattgact accctgtgga cttggagatc agcagagaac tactttctcc
     2701 aggcatcaaa aataaaaatt ttaaatgcca gagaacctat aggctgtttg cagtggtcta
     2761 ccaccatggc aacagcgcta caggcggcca ctacactacg gacgtcttcc agattgggct
     2821 taatggctgg ctacgaatcg atgaccaaac ggtcaaggtt attaaccagt accaggtggt
     2881 gaaaccgcct gccgaccgca cagcctacct cctatattac cgccgcgtgg acctgctgta
     2941 accgtgcccg tgtgcccgtg tgtgcctgac gctgcttcct acagttccca actcactcac
     3001 tacccacctc tctagtggct ctgtagagag actccctctg cgcccgtggg cttggatgga
     3061 aggtgcctga gggcccgcac agcgcagctc gtgctgactg acttcagaag ctggactgtt
     3121 gcctgggtga gggcacacga gagccgccgc ttctgaagaa ccgctggttc ccgggcggag
     3181 gaggcggctc gcaccgtgtc ccagtctgat cgcgtagtgg aataagtccc gcaccagcag
     3241 ctcttgtaaa tttgtgaaaa tgaattttat ctttccttaa aaaaataatt tttttaattc
     3301 atcacactct cctcctttac cctgtagttt ttgataaatg acaaaaacga gccagtcgtc
     3361 attagagatc gctcttactt caaaaggaaa taaatacaaa aaaaacttgt tgctggttcc
     3421 taataggaaa cacattttaa cgattacgag agggaaaccg ctgacgtaga caccgcgggt
     3481 cagacatgtg ggtagacgtc aggctgcaga ggtgggtgat tgtaacttta ttaccctgaa
     3541 aagatttcaa atcacattca tgctgtgtac acatgaacag tgggcacaat gatggactga
     3601 caattcccag tgtctgctgt gtaatctccc gccacgcctc tctgatgccg tgtcccccac
     3661 gtacacagtg tattgattcc taggagtata aagttgtcac ccatcaataa agatcacaaa
     3721 gttggtttaa aaaaaaaaaa aaaaa
//
