LOCUS       NM_001301414            3608 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ubiquitin specific peptidase 1 (Usp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001301414 XM_006502938
VERSION     NM_001301414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Zhao,X., Ni,W., Zheng,W., Ni,W., Sun,C., Gu,Y. and Gu,Z.
  TITLE     Multi-regulatory potency of USP1 on inflammasome components
            promotes pyroptosis in thyroid follicular cells and contributes to
            the progression of Hashimoto's thyroiditis
  JOURNAL   Mol Med 30 (1), 121 (2024)
   PUBMED   39134949
  REMARK    GeneRIF: Multi-regulatory potency of USP1 on inflammasome
            components promotes pyroptosis in thyroid follicular cells and
            contributes to the progression of Hashimoto's thyroiditis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Hu,Y., Li,X., Zhang,J., Liu,D., Lu,R. and Li,J.D.
  TITLE     A genome-wide CRISPR screen identifies USP1 as a novel regulator of
            the mammalian circadian clock
  JOURNAL   FEBS J 291 (3), 445-457 (2024)
   PUBMED   37909373
  REMARK    GeneRIF: A genome-wide CRISPR screen identifies USP1 as a novel
            regulator of the mammalian circadian clock.
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Yu,Z., Tong,L., Ma,C., Song,H., Wang,J., Chai,L., Wang,C., Wang,M.,
            Wang,C., Yan,R., Fu,Y., Jia,M., Zhao,W. and Zhao,C.
  TITLE     The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses
  JOURNAL   J Immunol 212 (2), 295-301 (2024)
   PUBMED   38054892
  REMARK    GeneRIF: The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses.
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Kim,M.S., Baek,J.H., Lee,J., Sivaraman,A., Lee,K. and Chun,K.H.
  TITLE     Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta
            (C/EBPbeta) stability and accelerates adipogenesis and lipid
            accumulation
  JOURNAL   Cell Death Dis 14 (11), 776 (2023)
   PUBMED   38012162
  REMARK    GeneRIF: Deubiquitinase USP1 enhances CCAAT/enhancer-binding
            protein beta (C/EBPbeta) stability and accelerates adipogenesis and
            lipid accumulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Cataldo,F., Peche,L.Y., Klaric,E., Brancolini,C., Myers,M.P.,
            Demarchi,F. and Schneider,C.
  TITLE     CAPNS1 regulates USP1 stability and maintenance of genome integrity
  JOURNAL   Mol Cell Biol 33 (12), 2485-2496 (2013)
   PUBMED   23589330
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Piatkov,K.I., Colnaghi,L., Bekes,M., Varshavsky,A. and Huang,T.T.
  TITLE     The auto-generated fragment of the Usp1 deubiquitylase is a
            physiological substrate of the N-end rule pathway
  JOURNAL   Mol Cell 48 (6), 926-933 (2012)
   PUBMED   23159736
  REMARK    GeneRIF: Autocleaved Usp1 remains a deubiquitylase because its
            fragments remain associated with Uaf1, an enhancer of Usp1
            activity, until the C-terminal fragment is selectively destroyed by
            the Arg/N-end rule pathway.
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Williams,S.A., Maecker,H.L., French,D.M., Liu,J., Gregg,A.,
            Silverstein,L.B., Cao,T.C., Carano,R.A. and Dixit,V.M.
  TITLE     USP1 deubiquitinates ID proteins to preserve a mesenchymal stem
            cell program in osteosarcoma
  JOURNAL   Cell 146 (6), 918-930 (2011)
   PUBMED   21925315
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Parmar,K., Kim,J., Sykes,S.M., Shimamura,A., Stuckert,P., Zhu,K.,
            Hamilton,A., Deloach,M.K., Kutok,J.L., Akashi,K., Gilliland,D.G.
            and D'andrea,A.
  TITLE     Hematopoietic stem cell defects in mice with deficiency of Fancd2
            or Usp1
  JOURNAL   Stem Cells 28 (7), 1186-1195 (2010)
   PUBMED   20506303
  REMARK    GeneRIF: Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited
            marked hematopoietic defects.
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Kim,J.M., Parmar,K., Huang,M., Weinstock,D.M., Ruit,C.A.,
            Kutok,J.L. and D'Andrea,A.D.
  TITLE     Inactivation of murine Usp1 results in genomic instability and a
            Fanconi anemia phenotype
  JOURNAL   Dev Cell 16 (2), 314-320 (2009)
   PUBMED   19217432
  REMARK    GeneRIF: mouse Usp1 functions downstream in the Fanconi anemia
            pathway, and its deubiquitination is required for Fancd2 nuclear
            foci assembly
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK080882.1, BY713495.1 and
            BG083613.1.
            
            On Aug 22, 2014 this sequence version replaced XM_006502938.1.
            
            Summary: This gene encodes a member of the ubiquitin-specific
            peptidase family. The encoded protein acts as a catalytic subunit
            in a heterodimeric deubiquitinating enzyme complex that
            deubiquitinates Fanconi anemia, complementation group D2, and plays
            a role in homologous recombination-mediated DNA repair. Disruption
            of this gene is associated with a Fanconi anemia-like phenotype and
            genomic instability. Alternative splicing results in multiple
            transcript variants. Pseudogenes of this gene have been defined on
            chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020007.1, SRR1660811.244822.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AK080882.1         2-132
            132-673             BY713495.1         1-542
            674-3586            AK080882.1         656-3568
            3587-3608           BG083613.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.6 cM"
     gene            1..3608
                     /gene="Usp1"
                     /note="ubiquitin specific peptidase 1"
                     /db_xref="GeneID:230484"
                     /db_xref="MGI:MGI:2385198"
     exon            1..434
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..673
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2858
                     /gene="Usp1"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin specific protease 1; ubiquitin carboxyl-terminal
                     hydrolase 1; ubiquitin thioesterase 1; deubiquitinating
                     enzyme 1; ubiquitin-specific-processing protease 1;
                     ubiquitin thiolesterase 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 1 isoform
                     1"
                     /protein_id="NP_001288343.1"
                     /db_xref="CCDS:CCDS18381.1"
                     /db_xref="GeneID:230484"
                     /db_xref="MGI:MGI:2385198"
                     /translation="MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQE
                     NEEKTSEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFC
                     PGFKTGVKHLFNIISRKKEALKDDSNQKDKGSCKEESLASYELICSLQSLIISVEQLQ
                     ASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGFLQHDAQEVLQCILGNIQETCQLL
                     KKEEIKNLAELSGKVEEQSLQKEETGGITSTEIDSMRNTEDVKEQLPKGNWKRKSDSE
                     SSNVKKKVKLSRESQPLEENQRQTRSKRKAIGDTLEAAPKIIPKCVSESESAKPSQKK
                     SKVKINWLKPSTKQPSILSKFCSLGKITTNQRSKGQPKEKEGDVEEDLEKYGSDHTAN
                     GGPESPGSSVTPVDSSEAKSGNKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERRE
                     DFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENC
                     HHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEW
                     STKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDEGNFVVDQMCELGKPE
                     PLTEEQARGTAGNYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELYNKA
                     SNPDKVVGTPFTDNRNSETNDTTNGTHESDRNKESSDQTGVNMNGLENKISYVVQSLK
                     EYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL"
     exon            674..794
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..899
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1060
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1749
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1920
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2122
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..3596
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3568..3573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Usp1"
                     /note="hexamer: AATAAA"
     polyA_site      3596
                     /gene="Usp1"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgcgcgg cggctcgcgc ctttcgcgcc tctgcaacgt ggagaggaga accggcactt
       61 tccgtggacg ccacctccag ccgcgacgct ggcgcgggcg ggggttcact cgcgggggtc
      121 ctgagactga ggaaaacgcg ccaagttccc cctcggcggc cgtgcgggga ccctgcggct
      181 cgggagcgcc gccaccgctg tgcgcccgta gccttcccgg ccgggctgcg ccggggatgt
      241 agtggtgccg cggcgggcag gaccgagcgg cggcccggct cccgctccgc ggacgaatgg
      301 tcactccccc gcgggaggcg cccaccagcg atccctctcc cgggacggcg gccgggctca
      361 cctgtcgcgc ccgcactctg cccggctggt ctccccggcg gcggcgccgc ggactcgcga
      421 agggccatga ccggatttaa ttggtgatta cagcttcctt caataagtta attctcgtca
      481 actccttgca attttgaaag aaaatgcctg gcgtcatacc tagtgaaagt aatgggcttt
      541 caagaggcag tccatccaag aaaaacagac tgtctctgaa gttttttcag aaaaaggaaa
      601 ctaaaagagc cttagacttt actgattctc aagaaaatga agaaaaaact tctgaatata
      661 gaggatctga gattgaccaa gttgttcctg ctgcacagtc ctccccagta agctgcgaga
      721 agagagagaa cttgttacca tttgtgggat tgaataacct tggcaacact tgttatctga
      781 atagtattct tcaggtgtta tacttttgtc ctggctttaa gactggagtg aagcacttat
      841 ttaatattat ttcaaggaag aaagaagctc tgaaggatga ctctaatcag aaggataagg
      901 gaagctgcaa agaagagtct ttggcaagtt atgagcttat atgtagttta cagtccttaa
      961 taatttcagt tgaacagctt caggctagtt ttctcttaaa tccagagaaa tatacagatg
     1021 aacttgctac acagccaagg cgactgctga acacactcag ggaactcaac cctatgtatg
     1081 aaggatttct acagcatgat gcacaggaag tgctacagtg tattctggga aacattcaag
     1141 aaacatgcca actcctaaaa aaagaagaaa taaaaaacct ggctgaatta tccggcaagg
     1201 ttgaagaaca atctcttcag aaagaggaaa caggtggaat taccagcaca gagattgaca
     1261 gtatgaggaa tacggaggac gtcaaagagc agctccccaa agggaactgg aaaagaaaaa
     1321 gtgacagtga gtcgagtaac gtgaagaaaa aggttaaact gtccagggaa tcccagccat
     1381 tggaagaaaa ccagagacaa accagatcca agagaaaagc tatcggagac acactagagg
     1441 ctgctcctaa gatcatcccc aagtgtgttt ctgaaagtga gagtgcaaag ccctcacaga
     1501 agaaatcaaa agttaaaata aattggttaa agccatccac taagcaaccc agcattcttt
     1561 ccaagttctg tagtcttgga aaaataacaa ctaaccagcg ctccaaagga caacctaagg
     1621 aaaaggaggg tgatgttgaa gaggacttgg agaagtacgg aagtgaccac acagctaatg
     1681 gtggacccga atctccagga agtagcgtca cacctgtgga cagcagtgaa gccaagtccg
     1741 gaaacaaagg tgctgaacag attggctttg agctagtaga gaaactgttt caaggtcagc
     1801 tcgtgttaag gactcggtgt ttggaatgtg aaagcttaac agaaagaaga gaagatttcc
     1861 aggatattag tgttccagtg caagaagatg agctttccaa ggtcgaggag agctctgaaa
     1921 tttctccaga gccaaaaaca gaaatgaaga ccttgagatg ggcaatttca cagtttgctt
     1981 cagtggagag aattgtagga gaggataaat acttctgtga aaattgccat cattatacgg
     2041 aagcagagcg aagtctcctg tttgataaaa tgcctgaagt tatcactatt catctgaagt
     2101 gctttgctgc tagtggcttg gagtttgact gttacggtgg tggactttcc aagatcaaca
     2161 ctcctttatt gacacctctt aaactgtcac tagaagaatg gagcacaaag ccgacgaatg
     2221 acagctatgg attatttgcc gttgtgatgc acagtggcat tactattagt agtgggcact
     2281 ataccgcatc tgttaaagtc actgacctta acagtctaga gctcgatgag gggaattttg
     2341 tggttgacca gatgtgtgaa ctaggtaagc cagagccact gaccgaggag caagcaaggg
     2401 ggacggctgg gaactacgac gatgaagtat caattagagt tggtggaaat gcccagccaa
     2461 gtaaagtttt gaacaaaaaa aatgtagaag gtattggact tctcggtgga caaaagagca
     2521 aagcagatta tgagctgtac aacaaagcat ctaatcctga taaggtggtt gggacaccat
     2581 tcaccgacaa tagaaattct gaaactaatg atactactaa tgggacccac gaatctgaca
     2641 ggaacaagga atccagtgac caaacaggcg ttaacatgaa cggacttgag aacaaaattt
     2701 cctatgtagt gcaaagctta aaggagtacg aggggaagtg gttgctcttt gacgattctg
     2761 aggtaaaagt gacagaagag aaagactttc tgaattctct ctccccttct acatccccta
     2821 cgtctactcc ctacttgcta ttctataaaa aattatagtg agtatatttc ccctgtaaat
     2881 attaaacaga cctggacaga tgttggtaaa gttgattaca tctaagagtc tttagtttat
     2941 cttttgaagc tattggatat tattggtctc tctaggcttt tatataaata gtgagatttt
     3001 aaatactgaa aaccatgtta atttttagaa tcattttcct tagtagagac tagtgatgga
     3061 tgagctggga acaaacttgt gtagattcta aatgatccaa aatggaagct tgacacagtt
     3121 aacacttgga tttacatgat cttttgtgtt tgctttttaa aataaagtgc ttgtatttgt
     3181 attctccata ttctggagta attatctact tgatgtttat aggtctggct ttttcaccca
     3241 agaaacaatc tcattcagta tatttagttt tataatagtc atgaagccaa atctctgcgc
     3301 tgtatcagag gcacaaagtc tagaatatgt atattcacaa tggtgtatat tttgtgcctt
     3361 gaataacttt ggaaagtgtc tcagaaaacc tggcaatccc ctctatcttc ataagaattt
     3421 tatatgtatt tatgaagatg gctctgtact ctagtcaatc tttttggcat gactaatttg
     3481 tatctcttca tactctttct gcacgatctg tacatagaac atcaacttag atgtgtgacc
     3541 tttaactttt ttaaaaactg ggaggtcaat aaaatttaag ctgtttaaca accaaaaaaa
     3601 aaaaaaaa
//
