LOCUS       NM_181418               3549 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus USH1 protein network component harmonin binding
            protein 1 (Ushbp1), mRNA.
ACCESSION   NM_181418
VERSION     NM_181418.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3549)
  AUTHORS   Young,T., Poobalan,Y., Ali,Y., Siew Tein,W., Sadasivam,A., Ee
            Kim,T., Erica Tay,P. and Dunn,N.R.
  TITLE     Mutated in colorectal cancer (Mcc), a candidate tumor suppressor,
            is dynamically expressed during mouse embryogenesis
  JOURNAL   Dev Dyn 240 (9), 2166-2174 (2011)
   PUBMED   22016184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY241807.1, AK043798.1 and AK084049.1.
            
            On Mar 26, 2008 this sequence version replaced NM_181418.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026453.1, SRR7345562.3264866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               BY241807.1         17-441
            426-1036            AK043798.1         416-1026
            1037-1088           AK084049.1         484-535
            1089-3549           AK043798.1         1027-3487
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..3549
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /note="USH1 protein network component harmonin binding
                     protein 1"
                     /db_xref="GeneID:234395"
                     /db_xref="MGI:MGI:1922920"
     exon            1..88
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            89..218
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2207
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /note="AIE-75 binding protein; usher syndrome type-1C
                     protein-binding protein 1; USH1C-binding protein 1; Usher
                     syndrome 1C binding protein 1"
                     /codon_start=1
                     /product="harmonin-binding protein USHBP1"
                     /protein_id="NP_852083.2"
                     /db_xref="CCDS:CCDS22393.1"
                     /db_xref="GeneID:234395"
                     /db_xref="MGI:MGI:1922920"
                     /translation="MSARATRPRSRRGRHPLPGELDPVAESSEEVDANNGRFETKPEL
                     HQEYLGPGLQSPRNWIKEGCDVGSHAVLSLSPEEQCEPEVEAHQVLQEAPLDSGPAEI
                     SVPSVYETLQCRLSSLEAVVAALRHHSLSFPKSVEAEDRDQGAPGPFGDEKEDAGPGQ
                     QEAARLIERNAWLRLALCNREDELACTQASLQDAQAEKETLQRQVQELEDSLMQMEAS
                     PPTPILRAGRRNSNSSTSGAERRPWVPQDSSMAHPFLQRLRSDSSTQSFGCLSTQHPA
                     PETYLMEDQMGQLQGSIEKLKCFNRLLLAVLQGYKGRCESLSIKLAKREAEATALRLA
                     LQYSEDCEEVYEVLLALKMAGLGTGVGTTKGDLQAAEKEASRLLMKKEATMEVETPQP
                     SSEGSGVDKPTPEELASQLHGYVQHLRERWALVKIPEELGPVTAPKATMPHAEATVQA
                     ILEIQPGPTLPHLEKSQIQQDLAATRDRLADLVLRLQLTQREKRGLELREAALRAQGP
                     AHQLLLQQLRWERAHFAGDGSSGGSSEDPSSEEEAGEDRQQHYQGPLALLDGQMGKVW
                     DSENVSQELSASLARAIDLRAQLQSLRQQLEQVTQKGRTRRVQSAELSRELCKAHSAL
                     ALAFRGAHRKQEEQRLKLEQQVARLQAQQAEELAVLTATARALGKPGAPQPAQTFL"
     exon            219..340
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..776
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..902
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1036
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1177
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1342
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1592
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1820
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1906
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2029
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..3549
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2454
                     /gene="Ushbp1"
                     /gene_synonym="2210404N08Rik; 9430064H24; AIEBP; MCC2"
                     /note="major polyA site"
ORIGIN      
        1 gaatggcttg agatatgccc tggatctcag gcctttccca aggtgctctg gagaagcaga
       61 gaagagcgca gcagggtcaa cccccaggga aacaaaaaaa caaaaaacaa ggattctaag
      121 gtgacgaagg caagaactga aagcagactg tagtgacaga ggcaatgagt gcccgggcca
      181 cacggccccg aagccgtcga gggaggcatc ctctgcctgg ggagctagac cctgtagctg
      241 agagctcaga ggaagtagat gccaacaatg gacgcttcga gactaaacct gagctgcatc
      301 aggaatacct tggtcctggc cttcagagcc caaggaactg gatcaaggag ggttgtgatg
      361 tgggatccca tgcggttcta tccttgagcc cagaagaaca gtgcgagcct gaggtggaag
      421 cccaccaggt cctgcaagaa gcccccctgg atagtggccc tgctgagata tcagtaccca
      481 gtgtgtatga gaccttgcag tgcaggctga gctcccttga ggcagttgta gctgccttgc
      541 gccaccactc gctaagcttt ccaaagtcag tggaagcaga agacagagac cagggggctc
      601 cggggccctt tggtgatgag aaagaagacg caggacctgg acagcaggag gctgctcgcc
      661 tcatagagag gaacgcctgg ctgcggctag ccctgtgcaa ccgggaggat gagctggcat
      721 gcactcaggc ttcactgcag gacgcccagg cagagaagga gactctgcag agacaggtac
      781 aggagctgga ggattccctg atgcagatgg aggcctcccc acctaccccc atcctcagag
      841 cagggcgtag aaacagcaac tccagtactt ctggggcaga aaggagaccc tgggtacctc
      901 aggactcttc catggctcac ccctttctcc aacgcctccg gagtgactcc agcacccaga
      961 gctttgggtg cctttccaca cagcatccag ccccagagac gtacctcatg gaagaccaga
     1021 tggggcagct ccaggggagc attgagaagt tgaagtgctt caaccgtctt cttctggctg
     1081 tgctccaggg ctacaagggc cgttgtgaga gcctcagcat taagctggcc aagcgggaag
     1141 ccgaggccac agccctgcgc ctggctctgc agtatagtga ggactgtgag gaggtgtatg
     1201 aggtgctgct agctctgaag atggctggcc taggaactgg agttggaact accaagggtg
     1261 acctgcaggc tgctgagaag gaggcctcta ggctgctgat gaagaaggaa gcaaccatgg
     1321 aggtagagac accccagccc agctcagagg gcagtggtgt ggacaagcct acaccagagg
     1381 aactggcctc tcagctccat ggctatgtcc agcatctccg ggaacgctgg gctctggtga
     1441 agatccccga agaacttggc cctgtcactg cacccaaggc cactatgccc catgcagaag
     1501 caacagtgca ggccattctg gagatacaac ctggccccac cttgccccat ctggagaagt
     1561 ctcagatcca gcaggaccta gcagctactc gggacaggct ggctgatctg gtgctgaggc
     1621 tgcagctaac acaacgagag aagcgtgggt tggagctgcg ggaggctgca ctgcgggccc
     1681 agggccctgc ccaccagcta ctcctgcagc agcttcgctg ggagcgggct cactttgcgg
     1741 gtgatggcag cagtggaggc agtagcgagg acccaagcag cgaggaggag gctggggagg
     1801 acagacagca gcactaccag ggccctcttg ccctcctgga tggtcagatg ggcaaagtgt
     1861 gggactctga gaatgtgtcc caggaactgt cagcgtcctt ggcccgggca atagacctgc
     1921 gggcacagct gcagtccctg cggcagcagc tggaacaggt gactcagaag ggccgaacca
     1981 gacgtgttca gagtgccgag ctgtccagag aactgtgcaa ggctcacagt gctctggcct
     2041 tggccttcag aggagcccac cggaagcagg aagagcaacg cctgaagttg gagcagcagg
     2101 tggctcggtt gcaggctcag caggcagaag agctggcagt gctgacagcc accgctaggg
     2161 ccctggggaa gcctggggca ccccagccag cccagacttt cctgtagggc ccggaccacg
     2221 tttgcttgtg acacagaggt ggctggagtg tcacagtgtc ctgtggtggg cggagaggtg
     2281 gtccaacaac taagagcagg gtctccaatt gcgggcactt gagtttaatt gccagcctca
     2341 gcagccatgg cgcctgtgac tccgggtcaa ggagatctgg cacccccttc tggcctctgc
     2401 aggctctgta ctaatgttcc ctcacacatg taattagaca aagtaactta caaacctgtc
     2461 ctttgtccct ggcacctgga gcgtctcttc aagaggggac tgaggtggga cgggcttagc
     2521 ttaagggtgt ggcagggagg cttgttccca gggagaggaa ccccaggctg ctttagaacc
     2581 agcatttaca ggaagtagag ggctggtggt tgctcagcag tagggcacct gctgagattg
     2641 tttgaagccc tcagagctgt ctctgtgtgc tcccaacagc ctgcactaag gaggcctgca
     2701 ttggtcccag cccttataga acatgtggga gtcttctgca gaatacatgg agtggggtgg
     2761 ggggaaacaa aggccttggt gggtggagta taggcctagc acgcacaggg ccctgagttc
     2821 caaacccagt gacatataca cctggaagtc tgtggctgcc tgtgatgcca gcactcagag
     2881 cctaaggcta tccctgacta cacagtgtgt ttaaggccag cctggacttc ttgagacagt
     2941 atcagagaaa gaagttaatg aggggctgga gacaaggctc agtggttagg agcactggct
     3001 ctcttgcaga gggcctggga tccatttcca gcacccaacg tggcagctca caactgtctg
     3061 taactccagt tccaggggtc cagtaccctt ttctggcttc tgtggacatc aggtagacac
     3121 attacatgga cacaaatgca gacaaaacac acctaaatat aaaaacaaaa tgaatgaatg
     3181 agaaaagtgt aaccagagag atggctgact gggcaagggt gcttattgcg gagtgacaat
     3241 ttgaggtctg cattcaattc ccagctccca cataaaggtg gaatgaggat ggacgccaca
     3301 aagttgtcct ctgacatcca caatatcacc cgttgttact gttgttaaat tgagagtcag
     3361 aggagatacc tcagcagtta agagcactta ctgctctaga ggaggaccag agtccagttc
     3421 ccagcaccca tagtagctca cagccacctg taattccagc tctaggggat ctgatgcttc
     3481 tggccgccta ggacgcccac acacagatac acatgattga aaatggtaag aataaaactt
     3541 aatgtactg
//
