LOCUS       NM_001305677            1863 bp    mRNA    linear   ROD 30-DEC-2022
DEFINITION  Mus musculus upstream transcription factor 1 (Usf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001305677 XM_006496748
VERSION     NM_001305677.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Sideromenos S, Nikou M, Czuczu B, Thalheimer N, Gundacker A,
            Horvath O, Cuenca Rico L, Stohrmann P, Niello M, Partonen T and
            Pollak DD.
  TITLE     The metabolic regulator USF-1 is involved in the control of
            affective behaviour in mice
  JOURNAL   Transl Psychiatry 12 (1), 497 (2022)
   PUBMED   36450713
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Hoekstra M, Ren B, Laurila PP, Hildebrand RB, Soronen J, Frodermann
            V, Li Z, Boon MR, Geerling JJ, Rensen PCN, Jauhiainen M and Van Eck
            M.
  TITLE     Hematopoietic upstream stimulating factor 1 deficiency is
            associated with increased atherosclerosis susceptibility in LDL
            receptor knockout mice
  JOURNAL   Sci Rep 11 (1), 16419 (2021)
   PUBMED   34385562
  REMARK    GeneRIF: Hematopoietic upstream stimulating factor 1 deficiency is
            associated with increased atherosclerosis susceptibility in LDL
            receptor knockout mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Faisal I, Cisneros-Montalvo S, Hamer G, Tuominen MM, Laurila PP,
            Tumiati M, Jauhiainen M, Kotaja N, Toppari J, Makela JA and Kauppi
            L.
  TITLE     Transcription Factor USF1 Is Required for Maintenance of Germline
            Stem Cells in Male Mice
  JOURNAL   Endocrinology 160 (5), 1119-1136 (2019)
   PUBMED   30759202
  REMARK    GeneRIF: Data suggest that the that the upstream transcription
            factor 1 (USF1) is indispensable for the proper maintenance of
            mammalian spermatogenesis.
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttila J, Metso J,
            Lee-Rueckert M, Taskinen MR, Kovanen PT, Oorni K, Olkkonen VM,
            Jauhiainen MS and Laurila PP.
  TITLE     USF1 deficiency alleviates inflammation, enhances cholesterol
            efflux and prevents cholesterol accumulation in macrophages
  JOURNAL   Lipids Health Dis 17 (1), 285 (2018)
   PUBMED   30545366
  REMARK    GeneRIF: Our findings identify USF1 as a novel factor regulating
            HDL functionality, showing that USF1 inactivation boosts
            cholesterol efflux, reduces macrophage inflammation and attenuates
            macrophage cholesterol accumulation, linking improved macrophage
            cholesterol metabolism and inflammatory pathways to the
            antiatherogenic function of USF1 deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Sirito M, Lin Q, Deng JM, Behringer RR and Sawadogo M.
  TITLE     Overlapping roles and asymmetrical cross-regulation of the USF
            proteins in mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3758-3763 (1998)
   PUBMED   9520440
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Aperlo C, Boulukos KE, Sage J, Cuzin F and Pognonec P.
  TITLE     Complete sequencing of the murine USF gene and comparison of its
            genomic organization to that of mFIP/USF2
  JOURNAL   Genomics 37 (3), 337-344 (1996)
   PUBMED   8938446
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Henrion AA, Vaulont S, Raymondjean M and Kahn A.
  TITLE     Mouse USF1 gene cloning: comparative organization within the c-myc
            gene family
  JOURNAL   Mamm Genome 7 (11), 803-809 (1996)
   PUBMED   8875887
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Henrion AA, Martinez A, Mattei MG, Kahn A and Raymondjean M.
  TITLE     Structure, sequence, and chromosomal location of the gene for USF2
            transcription factors in mouse
  JOURNAL   Genomics 25 (1), 36-43 (1995)
   PUBMED   7774954
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Nishimura T, Hanada K, Maeda Y, Song CZ, Hisatake K and Muramatsu
            M.
  TITLE     Regulation of mouse UBF gene by multiple growth-related control
            elements
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1217-1225 (1994)
   PUBMED   7802653
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Lin Q, Luo X and Sawadogo M.
  TITLE     Archaic structure of the gene encoding transcription factor USF
  JOURNAL   J Biol Chem 269 (39), 23894-23903 (1994)
   PUBMED   7523363
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ050979.1, AK142437.1,
            AW555090.2 and BE995823.1.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_001305677.2.
            
            On Mar 30, 2015 this sequence version replaced XM_006496748.2.
            
            Summary: This protein encoded by this gene is a member of the
            basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes
            a protein that can act as a transcription factor. Studies indicate
            that the basic region interacts with DNA at E-Box motifs, while the
            helix-loop-helix and leucine zipper domains are involved in
            dimerization with different partners. This protein is involved in a
            wide array of biological pathways, including cell cycle regulation,
            immune response, and responses to ultraviolet radiation. Mice
            lacking most of the coding exons of this gene often lacked both
            whiskers and nasal fur, and were prone to epileptic seizures, while
            mice lacking both this gene and another family member, Usf2,
            displayed embryonic lethality (PMID:9520440). Mutations in the
            human ortholog of this gene have been associated with Familial
            Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene
            are found on chromosome 11 and the X chromosome. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2, and 3
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK142437.1, SRR1660811.154340.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               CJ050979.1         2-570
            570-1579            AK142437.1         492-1501
            1580-1847           AW555090.2         1-268               c
            1848-1863           BE995823.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.4 cM"
     gene            1..1863
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /note="upstream transcription factor 1"
                     /db_xref="GeneID:22278"
                     /db_xref="MGI:MGI:99542"
     exon            1..128
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            129..285
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            286..335
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            336..451
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            452..553
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            554..749
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            750..837
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            838..896
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1120
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1848
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1848
                     /gene="Usf1"
                     /gene_synonym="bHLHb11"
ORIGIN      
        1 acacttccgc ccctcaccaa catggccgca ggctgggact gcgcatgagc agctgtctat
       61 ggagagacct agatccaaag acggagaagg ctgccggggg aaatcggcga ctgaagcggc
      121 ctggcccggt tctagaacct ggaaagctgt tcagttgcct ggcctcactg caaactctgt
      181 ggtttccacc aggacttagc attcaggcct ttgagttggg agatacaaag tcctccgaaa
      241 aaagaccggc gcctcggatg agccccctca cagagagatg aaggggcagc agaaaacagc
      301 tgaaaccgaa gagggaacag tgcagattca ggaaggcgca gtggctactg gagaggaccc
      361 aactagtgta gctatcgcca gcatccagtc agctgccact tttcctgacc ccaacgtcaa
      421 gtacgtcttc cgaactgaga atgggggcca ggtgatgtac agggtgatcc aggtgtcaga
      481 ggggcagctg gatggccaga cagagggctc tggcgccatc agtggttacc ctgccactca
      541 gtctatgacc caggcagtga tccagggagc tttcaccagt gacgatgccg ttgacacgga
      601 gggagcagct gctgagacac attatacata tttccccagc accgcagtgg gagatgggtc
      661 agggggtacc acatctggga gtactacagc tgttgttacc acccagggct cagaggcact
      721 actggggcag gcaaccccgc ccagcacagg tcaattcttt gtgatgatgt caccacaaga
      781 agtattgcag ggagggagcc agcgatcgat tgcccccagg acccaccctt attccccgaa
      841 gtcagaggct cccaggacaa ctcgagatga gaaacggagg gctcaacata acgaagtgga
      901 gcgccgccgc cgggacaaga tcaacaactg gattgtacag ctgtccaaaa tcatcccaga
      961 ctgctctatg gagagcacca agtctggcca gagtaaaggt ggaatcctgt ccaaagcctg
     1021 tgattatatc caggagctgc ggcagagcaa ccaccggctg tctgaagagc tgcaggggtt
     1081 agatcagttg cagctggaca acgatgtgct ccggcaacag gtggaagatc tcaagaacaa
     1141 gaacctgctc ctgcgagctc agcttcggca ccacggactc gaggtcgtca tcaagaatga
     1201 cagcaactaa ctctggggac tcaggggctt tgggccaagg actgcagccg gcccaggagc
     1261 aacaggctaa ccccatgccc ctctccttca ctgcctcctc tggcatggga ctcgggggag
     1321 tttggcaagt gtgtttttga actgaggccc tgtggcgtgg cagtctgcag tgagtggtgt
     1381 gaaacaaaca gtgtgggcgt gcactgacag cccggcctgc tccctctgtg cagtccccgg
     1441 gtctggtgcg ccttcggcac actgcatgtg ctgtctcctt gctggacact ggacacactg
     1501 aatctgggct tgccgtgtgc tcgcttggag tgcctgagag agggactgcg ggcctagtac
     1561 ttccactggc tcttcctttc tctggagcag aagttaagat gcgtacctga gtactctggg
     1621 aagcaggctt actcaagagg tgggaaagga tgctagctgg ctgctatccc aggagtagaa
     1681 gggggcccaa tgagcagccg aggcccctac ggaaggctct ggagccaggg agaactgtag
     1741 gcaggggtgg gttcactgag agccttccct gctccaggga tgggtctttt tatttctttc
     1801 cttttttttt tttttttttt tttaaagata aaattgttta gagccacaaa aaaaaaaaaa
     1861 aaa
//
