LOCUS       NM_025917                874 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus unconventional SNARE in the ER 1 homolog (S.
            cerevisiae) (Use1), transcript variant 1, mRNA.
ACCESSION   NM_025917
VERSION     NM_025917.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 874)
  AUTHORS   Nieradka,A., Ufer,C., Thiadens,K., Grech,G., Horos,R., van
            Coevorden-Hameete,M., van den Akker,E., Sofi,S., Kuhn,H. and von
            Lindern,M.
  TITLE     Grsf1-induced translation of the SNARE protein Use1 is required for
            expansion of the erythroid compartment
  JOURNAL   PLoS One 9 (9), e104631 (2014)
   PUBMED   25184340
  REMARK    GeneRIF: Grsf1 controls translation of the protein Use1, possibly
            by positioning the 40S ribosomal subunit and associated translation
            factors in front of the translation start site.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 874)
  AUTHORS   Lee,P.C., Dodart,J.C., Aron,L., Finley,L.W., Bronson,R.T.,
            Haigis,M.C., Yankner,B.A. and Harper,J.W.
  TITLE     Altered social behavior and neuronal development in mice lacking
            the Uba6-Use1 ubiquitin transfer system
  JOURNAL   Mol Cell 50 (2), 172-184 (2013)
   PUBMED   23499007
  REMARK    GeneRIF: Uba6 and Use1 promote proteasomal turnover of Ube3a in
            mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation
            in vitro.
REFERENCE   3  (bases 1 to 874)
  AUTHORS   Hatsuzawa,K., Hashimoto,H., Hashimoto,H., Arai,S., Tamura,T.,
            Higa-Nishiyama,A. and Wada,I.
  TITLE     Sec22b is a negative regulator of phagocytosis in macrophages
  JOURNAL   Mol Biol Cell 20 (20), 4435-4443 (2009)
   PUBMED   19710423
  REMARK    GeneRIF: Domain analyses of Sec22b revealed that the R-SNARE motif,
            a selective domain for forming a SNARE complex with syntaxin18
            and/or D12, was responsible for the inhibition of phagocytosis.
REFERENCE   4  (bases 1 to 874)
  AUTHORS   Uemura,T., Sato,T., Aoki,T., Yamamoto,A., Okada,T., Hirai,R.,
            Harada,R., Mori,K., Tagaya,M. and Harada,A.
  TITLE     p31 deficiency influences endoplasmic reticulum tubular morphology
            and cell survival
  JOURNAL   Mol Cell Biol 29 (7), 1869-1881 (2009)
   PUBMED   19188447
  REMARK    GeneRIF: p31 is an essential molecule involved in the maintenance
            of endoplasmic reticulum (ER) morphology and that its deficiency
            leads to ER stress-induced apoptosis.
REFERENCE   5  (bases 1 to 874)
  AUTHORS   Duan,J.Z., Zhang,J.P. and Zhu,S.X.
  TITLE     mED2--a novel gene involved in mouse embryonic development
  JOURNAL   Yi Chuan Xue Bao 33 (8), 692-701 (2006)
   PUBMED   16939003
REFERENCE   6  (bases 1 to 874)
  AUTHORS   Okumura,A.J., Hatsuzawa,K., Tamura,T., Nagaya,H., Saeki,K.,
            Okumura,F., Nagao,K., Nishikawa,M., Yoshimura,A. and Wada,I.
  TITLE     Involvement of a novel Q-SNARE, D12, in quality control of the
            endomembrane system
  JOURNAL   J Biol Chem 281 (7), 4495-4506 (2006)
   PUBMED   16354670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286283.1, AK160726.1 and BC075695.1.
            
            On Mar 11, 2009 this sequence version replaced NM_025917.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF353245.1, CA786863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY286283.1         275-282
            9-844               AK160726.1         2-837
            845-874             BC075695.1         964-993
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..874
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /note="unconventional SNARE in the ER 1 homolog (S.
                     cerevisiae)"
                     /db_xref="GeneID:67023"
                     /db_xref="MGI:MGI:1914273"
     exon            1..153
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..831
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vesicle transport protein USE1; embryonic development
                     factor 2; USE1-like protein"
                     /codon_start=1
                     /product="vesicle transport protein USE1 isoform 1"
                     /protein_id="NP_080193.1"
                     /db_xref="CCDS:CCDS22390.1"
                     /db_xref="GeneID:67023"
                     /db_xref="MGI:MGI:1914273"
                     /translation="MAQAEGAYHRPLATSRLELNLVRLLCRCESMAAEKREPDEWRLE
                     KYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLA
                     PGRVPTTAKERVPATKTVHLQSRARYTSEMRSELLGMEPSGECEVDMRKRAAKGSRPA
                     DERQSASELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKM
                     ADQNLEKLKLESERLEQHAQKSVNWLLWAMLIVVCFVFISMILFIRIMPRLK"
     exon            154..203
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            204..282
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            283..435
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            436..448
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            449..476
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            477..648
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     exon            649..854
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /inference="alignment:Splign:2.1.0"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /note="hexamer: AAGAAA"
     polyA_site      853
                     /gene="Use1"
                     /gene_synonym="2010315L10Rik; 5730403H22Rik; D12; Ed2;
                     p31; Q-snare"
                     /note="major polyA site"
ORIGIN      
        1 cttccgccct tttctaagat ggcgcaggcg gaaggagcct atcatcgccc gctggcgacg
       61 tcgcggttgg agttgaacct ggtacggctg ctttgtcgct gtgagtcgat ggcggcagaa
      121 aaacgagaac cggacgagtg gcgactggag aagtatgtgg gtgccctgga agacatgctg
      181 caggccctga aagttcaagc aagtaaaccg gcctcagaag tgatcagcga gtactcccgc
      241 aaagtggact ttctgaaggg catgctgcag gccgagaagt tgacctcctc ctctgaaaaa
      301 gctctagcta accagttcct ggctcctggc cgcgtgccca ccacagccaa ggagcgggtg
      361 cctgccacca agactgtaca tttgcagtct agggcacgtt acaccagtga gatgcggagt
      421 gagctgttgg gcatggaacc atctggagaa tgtgaggtgg acatgaggaa acgagctgcg
      481 aaggggtcca gacctgcaga tgagaggcag tcagcatccg agctagacct cgtcctccag
      541 aggcaccagg gcctccagga aaagctggct gaggagatgc taggcctggc ccgcagcctc
      601 aagaccaaca cactggctgc ccagagtgtc atcaagaagg acaatcagac cctgtcacat
      661 tcactcaaga tggcagacca gaacctggag aagctgaagc tggagtcgga gagattggag
      721 cagcatgcac agaagtcagt gaactggctg ctgtgggcca tgctcattgt cgtgtgcttc
      781 gtgttcatca gcatgatcct gtttatccga atcatgccca ggctgaaata aaacaagaaa
      841 gcctgcacac caacaaaaaa aaaaaaaaaa aaaa
//
