LOCUS       NM_009478               1489 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus uroporphyrinogen decarboxylase (Urod), mRNA.
ACCESSION   NM_009478
VERSION     NM_009478.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Phillips JD, Kushner JP, Bergonia HA and Franklin MR.
  TITLE     Uroporphyria in the Cyp1a2-/- mouse
  JOURNAL   Blood Cells Mol Dis 47 (4), 249-254 (2011)
   PUBMED   21880518
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner
            BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL and Perkins AC.
  TITLE     A global role for KLF1 in erythropoiesis revealed by ChIP-seq in
            primary erythroid cells
  JOURNAL   Genome Res 20 (8), 1052-1063 (2010)
   PUBMED   20508144
  REMARK    Erratum:[Genome Res. 2010 Dec;20(12):1748]
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Smith AG and Elder GH.
  TITLE     Complex gene-chemical interactions: hepatic uroporphyria as a
            paradigm
  JOURNAL   Chem Res Toxicol 23 (4), 712-723 (2010)
   PUBMED   20099833
  REMARK    Review article
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Arch DD, Bergeron M, Hathaway L, Kushner JP, Phillips JD and
            Franklin MR.
  TITLE     Longitudinal study of a mouse model of familial porphyria cutanea
            tarda
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 55 (2), 46-54 (2009)
   PUBMED   19656451
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Phillips JD, Bergonia HA, Reilly CA, Franklin MR and Kushner JP.
  TITLE     A porphomethene inhibitor of uroporphyrinogen decarboxylase causes
            porphyria cutanea tarda
  JOURNAL   Proc Natl Acad Sci U S A 104 (12), 5079-5084 (2007)
   PUBMED   17360334
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Phillips JD, Jackson LK, Bunting M, Franklin MR, Thomas KR, Levy
            JE, Andrews NC and Kushner JP.
  TITLE     A mouse model of familial porphyria cutanea tarda
  JOURNAL   Proc Natl Acad Sci U S A 98 (1), 259-264 (2001)
   PUBMED   11134514
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Lyu MS, Rhee SG, Chae HZ, Lee TH, Adamson MC, Kang SW, Jin DY,
            Jeang KT and Kozak CA.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Wu C, Xu W, Kozak CA and Desnick RJ.
  TITLE     Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and
            mapping
  JOURNAL   Mamm Genome 7 (5), 349-352 (1996)
   PUBMED   8661721
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Bahary N, Zorich G, Pachter JE, Leibel RL and Friedman JM.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Romana M, Le Boulch P and Romeo PH.
  TITLE     Rat uroporphyrinogen decarboxylase cDNA: nucleotide sequence and
            comparison to human uroporphyrinogen decarboxylase
  JOURNAL   Nucleic Acids Res 15 (17), 7211 (1987)
   PUBMED   3658690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY266170.1, AK002844.1,
            AK007470.1 and AL671671.5.
            
            [WARNING] On Nov 29, 2023 this sequence was replaced by
            NM_009478.5.
            
            On Aug 18, 2015 this sequence version replaced NM_009478.3.
            
            Summary: This gene encodes an enzyme that catalyzes the conversion
            of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate
            step in heme biosynthesis. Homozygous knockout mice for this gene
            exhibit embryonic lethality. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007470.1, BC008109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY266170.1         2-27
            27-49               BY266170.1         29-51
            50-897              AK002844.1         2-849
            898-1192            AK007470.1         851-1145
            1193-1489           AL671671.5         74103-74399         c
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.41 cM"
     gene            1..1489
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /note="uroporphyrinogen decarboxylase"
                     /db_xref="GeneID:22275"
                     /db_xref="MGI:MGI:98916"
     exon            1..83
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1167
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /EC_number="4.1.1.37"
                     /codon_start=1
                     /product="uroporphyrinogen decarboxylase"
                     /protein_id="NP_033504.2"
                     /db_xref="CCDS:CCDS18521.1"
                     /db_xref="GeneID:22275"
                     /db_xref="MGI:MGI:98916"
                     /translation="MEANGFGLQNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
                     EFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVP
                     GKGPSFPEPLREERDLERLRDPAAAASELGYVFQAITLTRQRLAGRVPLIGFAGAPWT
                     LMTYMVEGGSSSTMAQAKRWLYQRPQASHKLLGILTDVLVPYLIGQVAAGAQALQLFE
                     SHAGHLGTELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMIIFAKDGHFALEELAQAG
                     YEVVGLDWTVAPKKARERVGKAVTLQGNLDPCALYASEEEIGRLVQQMLDDFGPQRYI
                     ANLGHGLYPDMDPERVGAFVDAVHKHSRLLRQN"
     exon            84..196
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            197..276
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            277..339
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            340..537
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            538..699
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            700..837
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            838..938
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1005
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1489
                     /gene="Urod"
                     /gene_synonym="UPD; Uro-d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggactggg gtgtcggggc ggagcctcag attaaagcgg agaccgctca gttactgttt
       61 accatggagg cgaacgggtt cggactccag aatttcccgg agctgaagaa tgacacgttc
      121 ctgagagcag cctggggaga ggaaacagac tatactcccg tttggtgcat gagacaggca
      181 ggccgctact taccagagtt tagggaaacc agggctgccc aggacttctt cagcacctgc
      241 cgatctcccg aggcttgctg tgaactgact ctacagccac tacgaaggtt tcctctggat
      301 gctgccataa ttttctctga catccttgtt gtaccccagg cattgggcat ggaggtgacc
      361 atggtacctg gcaaaggacc cagctttcca gagccattaa gagaagagcg ggacttagag
      421 cgtctacggg atccagcagc agcggcttca gagttaggct atgtgttcca agccatcacc
      481 cttactcgac aacggctggc cggacgtgtg ccactaattg gctttgctgg tgctccgtgg
      541 accctaatga catacatggt tgaaggcggc agttcaagca ccatggctca ggccaaacga
      601 tggctctacc aaaggccaca ggccagtcac aagctgcttg gcatactcac tgatgttctg
      661 gtcccatacc taataggaca agtggctgct ggtgctcagg cattgcagct ctttgagtcc
      721 cacgcaggac atcttggcac cgagctcttc agcaagtttg cactgcccta cattcgtgat
      781 gtggccaagc gagtgaaggc tgggttgcag aaggcaggcc tggcaccagt gcccatgatc
      841 atctttgcta aggatggaca ttttgccctg gaagagctgg cccaggctgg ctatgaggta
      901 gttggacttg actggacagt ggctccaaag aaagcccggg aacgtgtcgg gaaggcagtg
      961 accctgcagg ggaacctgga tccctgtgcc ttgtatgcat ctgaggaaga gatcggtcgg
     1021 ctggtgcagc aaatgctgga tgactttggg cctcaacgct acattgccaa cctagggcat
     1081 gggctttacc ctgacatgga cccagaacgt gtaggagcct ttgtggatgc tgtacacaaa
     1141 cattcacgcc tgcttcgaca gaattgagta catgcctttc tgctcaagtg ccaccaacag
     1201 agattgtttc caggagaata aaacttccag agttggagtc tagcatgttc ttttgtaaag
     1261 gcttatgtcc tgatcctcag ttctttctga agccccctcc tttcctgccc agcccccccc
     1321 cgtttctctc tctctctctc tctctctctc tctctctctc tctctctctc acacacacac
     1381 acacacacac acacacacac acacacacac acacacacac acacgacctc aaactcacaa
     1441 agatccacct acctgcctct caagtgctgg aattaaaggc ggtaccagc
//
