LOCUS       NM_011274               3424 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus URI1, prefoldin-like chaperone (Uri1), transcript
            variant 1, mRNA.
ACCESSION   NM_011274
VERSION     NM_011274.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   de la Rosa,S., Del Mar Rigual,M., Vargiu,P., Ortega,S. and
            Djouder,N.
  TITLE     Endogenous retroviruses shape pluripotency specification in mouse
            embryos
  JOURNAL   Sci Adv 10 (4), eadk9394 (2024)
   PUBMED   38266080
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Bernard,H., Teijeiro,A., Chaves-Perez,A., Perna,C., Satish,B.,
            Novials,A., Wang,J.P. and Djouder,N.
  TITLE     Coxsackievirus B Type 4 Infection in beta Cells Downregulates the
            Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1
            Silencing
  JOURNAL   Cell Rep Med 1 (7), 100125 (2020)
   PUBMED   33205075
  REMARK    GeneRIF: Coxsackievirus B Type 4 Infection in beta Cells
            Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like
            Diabetes via Pdx1 Silencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Chaves-Perez,A., Yilmaz,M., Perna,C., de la Rosa,S. and Djouder,N.
  TITLE     URI is required to maintain intestinal architecture during ionizing
            radiation
  JOURNAL   Science 364 (6443) (2019)
   PUBMED   31147493
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 3424)
  AUTHORS   Hao,L., Vassena,R., Wu,G., Han,Z., Cheng,Y., Latham,K.E. and
            Sapienza,C.
  TITLE     The unfolded protein response contributes to preimplantation mouse
            embryo death in the DDK syndrome
  JOURNAL   Biol Reprod 80 (5), 944-953 (2009)
   PUBMED   19129515
REFERENCE   8  (bases 1 to 3424)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 3424)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3424)
  AUTHORS   Van Leuven,F., Torrekens,S., Moechars,D., Hilliker,C., Buellens,M.,
            Bollen,M. and Delabie,J.
  TITLE     Molecular cloning of a gene on chromosome 19q12 coding for a novel
            intracellular protein: analysis of expression in human and mouse
            tissues and in human tumor cells, particularly Reed-Sternberg cells
            in Hodgkin disease
  JOURNAL   Genomics 54 (3), 511-520 (1998)
   PUBMED   9878255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163447.5.
            
            On Feb 28, 2023 this sequence version replaced NM_011274.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166566.1, AK155994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               AC163447.5         98137-98552         c
            417-451             AC163447.5         75714-75748         c
            452-530             AC163447.5         61897-61975         c
            531-666             AC163447.5         60638-60773         c
            667-758             AC163447.5         48633-48724         c
            759-816             AC163447.5         48407-48464         c
            817-985             AC163447.5         46348-46516         c
            986-1334            AC163447.5         44258-44606         c
            1335-1474           AC163447.5         42420-42559         c
            1475-1718           AC163447.5         41493-41736         c
            1719-3424           AC163447.5         39019-40724         c
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 25.29 cM"
     gene            1..3424
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /note="URI1, prefoldin-like chaperone"
                     /db_xref="GeneID:19777"
                     /db_xref="MGI:MGI:1342294"
     exon            1..416
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1901
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /note="isoform a is encoded by transcript variant 1;
                     unconventional prefoldin RPB5 interactor; RNA polymerase
                     II subunit 5-mediating protein; RPB5-mediating protein;
                     protein phosphatase 1 regulatory subunit 19"
                     /codon_start=1
                     /product="unconventional prefoldin RPB5 interactor isoform
                     a"
                     /protein_id="NP_035404.4"
                     /db_xref="CCDS:CCDS21157.1"
                     /db_xref="GeneID:19777"
                     /db_xref="MGI:MGI:1342294"
                     /translation="MEPPSEPEPEPQPLAEASAAAPLRAPEVARLREEQEKVVTNCQE
                     KIQHWEKVDNDYSALQERLRTLPDKLSYDVMVPFGPLAFMPGKLVHTNEVTVLLGDNW
                     FAKCSAKQAVGLVEHRKEHVRKTIDDFKKVLKNFESRVEFTEDLQKMSDAAGDFVDIR
                     EEIKSDFEFKGKQRIAHKPHSKPKTSDIFEADFENGVKPKNTFDADELWARLEELERQ
                     EELLGELESKPDTVIANGEDRVSSEEEKEGADTGVNVVSPVTDSSAASSCKRRAGNAG
                     LPNGQVNSLNYSVNGSNSYHSNKDDDEEEEDDDDDDDEDDDNESDHAISADNSIPTIY
                     FSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKSGAGSHATHELPAIKSPADIYRVF
                     VDVVNGEYVPRKSILKSRSRENSVCSDTSESSAADVEDRRGLLRSTSSEEAVATEAGG
                     SSLDELQENHPKKPLPSGVSEAFSGTVIEKEFLSPSLAPYSAIAHHALPTIPERKEVP
                     SEVSEEPTKRVSKFRAARLQQRS"
     exon            417..451
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            452..530
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            531..666
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            667..758
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            759..816
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            817..985
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1334
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1474
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1718
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..3424
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3396..3401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /note="hexamer: ATTAAA"
     polyA_site      3424
                     /gene="Uri1"
                     /gene_synonym="NNX3; Rmp"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggga cgctaagctg ggcccggttg cgggagaaga gcgtggcgcg cctggtgtag
       61 ggcctgctgc tccgaggcgg cggcggcggc ggcggcggcg gtatgcgcgt gtgagatgcg
      121 gccgcgggta gcccggacgc gagcggcggc ccccggggca gcggcgaaag tgagcgcggc
      181 ctcttcagag agaggcgtgc agtgcatgag ggcgagcgcg cgggcgctgg gcatccgccg
      241 gccacgccgt ctccataaac acttgtttag gacttgttcg cctcgctgag gctgcggcgc
      301 cgggcatgga gcccccgtcc gaacccgagc ccgagcccca gccccttgca gaggcctcag
      361 ccgccgctcc gctgcgcgca ccagaggtgg cgcggcttcg cgaggagcag gaaaaggtgg
      421 tcactaactg ccaagagaaa atccagcatt gggagaaagt agacaatgac tacagtgctc
      481 ttcaagagag gctgaggacc ttgcctgaca agctgtctta cgacgtcatg gtaccattcg
      541 gccctcttgc cttcatgcca ggaaaactag tccacactaa tgaagtcact gttttacttg
      601 gcgacaactg gtttgcaaag tgctcagcca agcaggctgt gggtttagtt gagcatcgga
      661 aagaacatgt aagaaaaaca atagatgatt ttaaaaaagt gttgaaaaat tttgaatcca
      721 gagttgaatt cacagaagat ttgcagaaga tgagtgatgc tgcaggtgat tttgttgaca
      781 taagagaaga aattaaaagt gactttgaat ttaaaggaaa acaacgaatt gctcacaaac
      841 ctcattccaa accaaaaact tcagatattt ttgaagcaga ttttgaaaat ggtgtaaaac
      901 ccaagaatac atttgatgct gatgaactgt gggctcgact tgaagagctg gagagacaag
      961 aagaactgct gggtgaactt gaaagtaaac ctgatactgt gattgcaaat ggagaagaca
     1021 gagtgtcttc tgaggaggaa aaggaaggtg cagacacagg tgtgaatgtg gtgtctccag
     1081 tgacagactc ctctgccgcc agcagctgta aaaggcgtgc tggaaatgca ggactcccta
     1141 atggtcaagt caatagtctg aactattcag tgaatggctc aaattcttac cacagcaaca
     1201 aagatgatga tgaagaagaa gaagatgacg atgatgatga tgatgaagat gacgataatg
     1261 aaagtgacca tgctatttca gcagataatt ctattccaac aatatatttc tctcatactg
     1321 ttgaacctaa aagggttcga ataaatactg ggaaaaatac cactttaaag ttcagtgaga
     1381 agaaagagga agccaaacgg aaacgaaaga gtggtgccgg cagtcacgct acccacgagc
     1441 tgcctgccat caagagtcct gctgatattt acagagtctt cgtggatgtt gtgaatggag
     1501 aatatgttcc tcgcaagtca atcctcaagt ctcgcagccg agagaacagc gtgtgcagcg
     1561 acacaagtga gagcagcgct gccgatgtgg aggaccggcg ggggctcctg cggagcacca
     1621 gctctgagga ggccgtggct accgaggccg gcgggagcag tttggacgaa ctccaagaga
     1681 accaccccaa gaagcctttg ccctcaggag tgtctgaggc tttttctgga actgtaatag
     1741 aaaaagaatt tttatcaccc tccctagcac catactcagc cattgctcac catgccctcc
     1801 ccaccattcc agagcgaaaa gaagttccat cagaagtatc agaggaaccc acaaagaggg
     1861 tgtcaaagtt cagagctgcc cgattgcagc agagaagcta gagggctccg cctgcagctc
     1921 cagctgcgct ttaggacatg cggcggattc ggccatggag ttgggacggc gtcctgcttg
     1981 gctgggcaga gctctctcac ctttatcagt ggcattggga aagtcaaagt aaatgtttga
     2041 atgctgtaat gttctgctgg cttcgttaat tctgtgacta ctgtctaatt ggccttagga
     2101 tgcaggaata gcgttttgag ttacttttca aagaatcctg tcatatattg tttgtgtgtt
     2161 ttcaactaaa cacaggcagt ttcgtaccag ctgtgatgtt gtgctttcca tatggaccat
     2221 gttaaagaca cttttaaaat ctcaaataga ttcaacaatt atattacttg cttttacatt
     2281 ttaaaggcac tttaaaaaaa tctacatttc ttgtaggttt cacagctgta tggttctttg
     2341 aaaaattctt cctttgaatg tcatactgta atctttaagg caaaaagcta cacaaaccct
     2401 ttgggaaaat ttgactagaa gaagaatatt ttgtacaact tttttttttt tggaagtaaa
     2461 atttttatga aacttggttt ctaaaatgtt gtgaacttcc tggtttagat tgtgtataaa
     2521 atgtctttga tttgtgtata ggccacacca cagattttca aagttttcaa gtcccacgag
     2581 cacctcctct ccccatacac acagttgtca ttggcaccat tctttggggg gaaaaagttt
     2641 gtctagatgc tttaacactt tgttaaagca caggcctttt gtttgtttgt ttgtttgttt
     2701 tacatttcaa tcttcctcac attttcattc ttcaaggatg ctttcctacc agtaaaaaaa
     2761 aagaaagaaa gaaatattat attatattta cttgtagcca aactccttaa agagacattc
     2821 agtctcaggt tgaccattac agtgcaagtg ttgatcatta gcttgatgca tgctaaaatg
     2881 tagcttttaa aaagcattcc gcatcagtac taaaataagc catcaacccc agtccaccct
     2941 ctattcacgg ctaaatagtt agaggttatt tatagcttct ttaatgaatt cttgcttaaa
     3001 caaagtgaaa ttatgtccta gaaaagtcgc agctgtaact agagcagtgc cactgtcaga
     3061 gttttatgaa atacatgctt taatggtaaa atggtatgct agggtccatg ctagttaatg
     3121 gataatgcag aacaggggac tgaattggaa aggctgccta aaaatataat agctcggttt
     3181 ttctagccgt tgttgatcat ctgtacacat attttgtact taaaaaccac ttttctttcc
     3241 aatcacctac tctcaaccag actatcccat cacaccgact ctaggcacac cctgctcctt
     3301 ctccctatga gaggcgtcct gtgctaacct cctcctgatg caagcctcct tgtggaactg
     3361 ttggatcttc agatgtgtaa cttaagtgtg ctgttattaa acactttcta tgttcatgaa
     3421 ctta
//
