LOCUS       NM_029497               7381 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
            (Urb1), mRNA.
ACCESSION   NM_029497 XM_489612 XM_904396
VERSION     NM_029497.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7381)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7381)
  AUTHORS   Shan,L., Xu,G., Yao,R.W., Luan,P.F., Huang,Y., Zhang,P.H.,
            Pan,Y.H., Zhang,L., Gao,X., Li,Y., Cao,S.M., Gao,S.X., Yang,Z.H.,
            Li,S., Yang,L.Z., Wang,Y., Wong,C.C.L., Yu,L., Li,J., Yang,L. and
            Chen,L.L.
  TITLE     Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome
            surveillance
  JOURNAL   Nature 615 (7952), 526-534 (2023)
   PUBMED   36890225
  REMARK    GeneRIF: Nucleolar URB1 ensures 3' ETS rRNA removal to prevent
            exosome surveillance.
REFERENCE   3  (bases 1 to 7381)
  AUTHORS   Liu,C., Morishima,M., Yu,T., Matsui,S., Zhang,L., Fu,D., Pao,A.,
            Costa,A.C., Gardiner,K.J., Cowell,J.K., Nowak,N.J., Parmacek,M.S.,
            Liang,P., Baldini,A. and Yu,Y.E.
  TITLE     Genetic analysis of Down syndrome-associated heart defects in mice
  JOURNAL   Hum Genet 130 (5), 623-632 (2011)
   PUBMED   21442329
  REMARK    Erratum:[Hum Genet. 2011 Nov;130(5):633. Nowak, Normal J [corrected
            to Nowak, Norma J]]
REFERENCE   4  (bases 1 to 7381)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 7381)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   6  (bases 1 to 7381)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 7381)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658427.1, AK050735.1, CD541646.1, BX522964.1, CF534743.1,
            BU058447.1, CK391060.1, AK220219.1 and BE943636.1.
            
            On or before Aug 30, 2009 this sequence version replaced
            XM_904396.3, XM_489612.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BB658427.1         1-21
            22-1281             AK050735.1         2-1261
            1282-1282           CD541646.1         214-214
            1283-1726           AK050735.1         1263-1706
            1727-2232           BX522964.1         8-513
            2233-2552           CF534743.1         1-320
            2553-3079           BU058447.1         6-532
            3080-3522           CK391060.1         1-443
            3523-7364           AK220219.1         1-3842
            7365-7381           BE943636.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..7381
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.92 cM"
     gene            1..7381
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /note="URB1 ribosome biogenesis 1 homolog (S. cerevisiae)"
                     /db_xref="GeneID:207932"
                     /db_xref="MGI:MGI:2146468"
     exon            1..215
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..6907
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /note="nucleolar preribosomal-associated protein 1"
                     /codon_start=1
                     /product="nucleolar pre-ribosomal-associated protein 1"
                     /protein_id="NP_083773.1"
                     /db_xref="CCDS:CCDS49905.1"
                     /db_xref="GeneID:207932"
                     /db_xref="MGI:MGI:2146468"
                     /translation="MGVPKRKASEGPSSAASPAGTVKRTRAEEFTGVRFKTLLKDAQG
                     PGPALEAFVSAAKKLPQEDMCDVVEGYIKISMECAEIFQLLSGEKRPESEMLLIFQAF
                     EAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTAMVTQ
                     GPEAARDVCSSLDLNKKALFALVTKRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVL
                     EIKEFIPCIFSSGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAA
                     LYNWNGITDVTPEKPESAAISAEEAGKAMVRDLVHNFLMDLCCSRKHGISFYDASLGT
                     SGRGGNLTLLHFLLSLKTAAGDDLVASLVVSILKVCPDLLTKYFKEVTFSFLPRVKST
                     WLNNVKLLNKIYEAQPEISPAFWTREFIPLPRLLAMVMVTTVPLVCNKIMFTQALNLD
                     SIPVKHSALSLISDILKRALKTVDHCLDKETWQDSDVYTAEMMEEFVQLFREALGKIL
                     PDLNTVIWVWQSFKKQEIKEDHEKGKKSSSKTPAVSKAAQHDVAETILLKSVLLQVIC
                     LYQQVVPHVIMQYNFDFSKLLKGIISEQGPSQEVPPILQHHMLKVALELPANKFLWLK
                     AQEGPEAEIIGGERSVFYLLMKMFVNSNHLQLKSSTKLLIMKILRDTGVFEHTWRELE
                     LWLEHLDSTAEERKEAVIQFLERILLTLVMNPYSYTDKASEFVQEASTLQASMGKQDA
                     DDVSIPISHIDDVLDMVDVLVEGSEGLDEDIGFLLNEDMILLTFPFSALVPAALEARN
                     KLLLGTDCEAGESIMAYMTAVLTDLLHTQRDPLALCLLLQSYDKFEPVSLLCGQQLAQ
                     FHRYYSLWIPAQAQEALPLQVSSSSGPCTLPPSSCFSTLLQTAYESQTLGDKSVQAQL
                     LAAVPSLALQHMLRSAKQVLLYLKSTVENFSQLGRSVGPALLQSLLGLLKQLVIHAER
                     LDAQNQQKLEAARAESDLFLDMESVASLELATDKTIEELLLAILKHPTLETWFLALEQ
                     KALPPHTLSPILVKLLAAHFSAGVLQLLVASSPILHKLGQLGLLAKYSEAITQSVLIE
                     LRTRTLNSTSTPKTLPQLEALRELHPYMEGVQIREVTLALLALPEAHLLTQQGTQSLG
                     KERHLSSLGKTLVQLLASSHQDQLQSSELLWCAEYVRGLGALLPTLAEHELDTVFLQT
                     LQKDPVLAPVVPEGVLEYCLARRTQTALGIASLLLQYSGTHLVKFELWCGQPGVGPTL
                     QEHLDDFFPLIHVYLQHRAQGSFMRPTGVSSAVTPVLKALWRQVRDRFFHITGPSKDA
                     LHLEALAQLIPFARTKDLHVLMDHLPNTLRTLSNHKSWTLADSVSAALAESAEELGSW
                     RKTLLRSCIQWLAVSFSGREPEDENTQEHEKAMLVRLSELLHAVKEVDPGDWQQFVKT
                     GLKFRYHDLTFLKTLLSATKLLYGPESSGRTKLVQLSVVHMMLTQHSLFLPTMLSSEE
                     EETPDSGVKETLLDLMSTVVRLCPSVCQSSHFAVLLGTYSATLSVLDQKILLLLRAYE
                     QNNLSLISFRVLLWGPAAVEHHKTCRSLGKSLWQQPSVGDILRLLDPDRMMQTILHFP
                     QYRKLLPTEDTGEPLVFKDKTARVDLDSLYDPCFLLHLFGELTRPEFVVDCRKFLDSN
                     ALGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRTPNL
                     RLPFTVALFIAKAAVQILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQK
                     TEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNSPLCDEVAQNWILEILQNVAH
                     ITRSAYEVIRDYSLLTWVLHILESRFVETQLLSNVISLLHTLWVTNLGNKAPEERSQP
                     PGQVGSQESEKMLALHMVSEFLYVLIALTKHLRPTLASAQLMNFFWTLESVLSYRATI
                     IKLFKDMGRFTVNKVALSTKDVLILLHKWSLIERDTKLQGELKAVIEQHQAKDLMKML
                     KDKSRPVVAAQARGPRGRKRRHGGLEETAEPQLEASCLEKCKDLLRATLTHWGPGDPL
                     PGPTQGSVGQTIPKSKTLSSAHAAVSLVASWVLRSLAERPVSRAEVTRLLDWLKSHIL
                     PQPMVVADLLGDSAVKTGIFKLYNHHCSAQGLVGPAQDVACKFSTVMLQLLVAQGRKE
                     SPFHSVAEALCLDSLNEKEEAKRAPAAFLVSLYVKDMWLGAQQPDTFLAHIRMVCEAA
                     KDVPLDEPEAIVVLCRNVDSSAQCLTRSR"
     exon            216..355
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            356..507
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            508..640
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            641..737
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            738..823
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            824..958
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1083
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1279
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1417
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1591
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1721
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1838
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1951
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2071
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2188
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2327
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2498
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2692
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2911
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3091
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3944
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4143
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4330
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4389
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4583
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4584..4694
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4758
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4930
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5039
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..5200
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5201..5312
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5313..5419
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5563
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5564..5673
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5674..5871
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            5872..6113
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            6114..6713
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     exon            6714..7365
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7345..7350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /note="hexamer: AATAAA"
     polyA_site      7365
                     /gene="Urb1"
                     /gene_synonym="4921511H13Rik; 5730405K23Rik; mKIAA0539"
                     /note="major polyA site"
ORIGIN      
        1 ttccttgccg ccggtgcttc cggtcgcgtg ggttttccga gggtgccgtt ttgctggccc
       61 ggtggtttgg gccatggggg tccccaagag gaaggcgtca gagggtccca gcagcgcggc
      121 gtcccccgct ggcacagtca agcgaacgcg agcggaggag ttcacgggcg tgcggttcaa
      181 gaccctgctg aaggatgcgc agggcccagg accggctttg gaagccttcg tctctgctgc
      241 caagaagcta ccgcaggaag acatgtgtga tgttgtcgag ggctacatca agatttccat
      301 ggaatgtgca gagattttcc agctcctgag tggggagaag cggcccgaga gtgaaatgct
      361 gttaatattt caagctttcg aggccatatt actgaggaca gccagtgatc ttacgcattt
      421 ccacgtggtg ggtgccaaca ttgtgaagaa gctgctgtac aaccacatga agctcctctg
      481 tgagtccctg tatgcgtctg gttacaggat ggctcgagcc tgcctggacc tgatgactgc
      541 catggtgacc cagggtcctg aagctgccag agatgtgtgc agctctttgg atttgaataa
      601 aaaagccttg tttgccttgg tgaccaagag ggattcaaag ggagtgcatg acgtccggct
      661 ggcctacatc cagtttgccc tttccttcct aattgcgggt gatgacaaca ccattggaca
      721 agtcctggag ataaaagaat ttatcccctg catctttagc tcaggtataa aggaggataa
      781 gatttctacc atcaacattt tattgtccac actgaaaaca aaggtgattc acaataaaaa
      841 catcacgaaa acccagaagg tgcgtttctt tactgggcag tttctgaacc atatagctgc
      901 tctctacaac tggaacggga tcacagatgt cactccagaa aagccagaaa gtgctgcgat
      961 atcagctgaa gaggcgggga aagccatggt gagggacctc gttcataact tcctgatgga
     1021 tctctgctgt tctcgaaagc atgggattag tttttatgat gcctctttgg gaacttctgg
     1081 cagaggaggc aacctgacac tcttgcactt cttgttgagt ttgaaaactg cagctggtga
     1141 tgacctggtg gcctcacttg tggtgagcat tctgaaggtg tgcccggacc tgctgaccaa
     1201 atacttcaag gaagtcacat tttcctttct cccaagagtg aagtccactt ggctaaacaa
     1261 cgtgaagctg ctaaacaaga tctatgaggc ccagccagag atttccccgg ccttttggac
     1321 cagagagttt atcccattgc caaggctcct ggcgatggtg atggtgacca cagtgcctct
     1381 ggtgtgcaat aagatcatgt tcactcaggc attaaatttg gacagcatac ctgtaaaaca
     1441 ctcagcatta tcccttattt cggacatttt gaagagagca ttaaaaacag ttgaccactg
     1501 tctggacaaa gagacatggc aagattcaga cgtgtacaca gctgagatga tggaagaatt
     1561 tgttcagctc ttcagagaag ccttgggcaa gattttgcca gatctgaaca ctgttatttg
     1621 ggtttggcag tcatttaaaa agcaagagat taaggaggac catgagaaag ggaagaagag
     1681 cagcagcaag actcctgctg tctctaaagc tgcccagcat gatgttgcag aaacaattct
     1741 tctgaaatca gttctgctcc aggtcatatg cctctaccag caggtcgttc cccacgtgat
     1801 catgcagtac aactttgact tcagcaagct cctaaaaggc atcatctctg agcagggccc
     1861 ttctcaggag gtcccgccca tcctgcagca ccacatgctc aaggtggccc tggaactgcc
     1921 tgctaacaag tttttgtggc taaaggcaca ggaaggcccc gaggcagaaa tcattggagg
     1981 agaacgctcg gttttttacc tgctgatgaa gatgtttgtg aatagtaacc atttgcagct
     2041 caagtcctcc actaagcttc tgatcatgaa gatcctccgg gacacgggtg tgttcgagca
     2101 cacgtggaga gagctggagc tctggctgga gcacctggac agcactgcag aggagcgcaa
     2161 ggaagccgtc attcagttcc tggagcggat tttactgaca ctggtgatga atccttactc
     2221 atacacggac aaagcttctg agtttgtcca agaagccagc accctgcagg cctctatggg
     2281 gaagcaagat gcagatgatg tcagcatccc catctcccat attgatgatg tgctggacat
     2341 ggtggacgtc ctggtggaag gcagcgaggg cctggacgag gatattgggt tcttgttaaa
     2401 tgaagacatg attctgctca ccttcccctt cagtgctctg gtccctgcag ctctggaagc
     2461 caggaataag ctgctccttg ggacagactg tgaagcaggg gaaagcatca tggcatatat
     2521 gactgcagtg ttgaccgacc ttctccatac ccagagggac cccctagctc tgtgtcttct
     2581 gctccagtct tacgacaagt ttgagcctgt tagcctgctc tgcggtcagc agcttgccca
     2641 gtttcacaga tactacagtc tctggattcc tgcgcaagcc caagaggcct tgccgctgca
     2701 ggtgtccagc agctcaggac catgtacact cccgccatct tcctgcttct ccacgctgct
     2761 gcaaacagcc tatgaaagcc agacacttgg ggataagagt gttcaggcac agcttctcgc
     2821 cgctgtccca agcctggctc tgcagcacat gctgcgctca gccaagcagg tactgctgta
     2881 cctcaagagc accgtggaga acttcagcca gctgggcaga agtgtgggcc cagctctgct
     2941 tcagtccctc ctgggcctcc ttaagcagct ggtcatccac gctgagcggc tggacgccca
     3001 gaaccagcag aagctagagg ctgcccgggc cgagtcggat ctctttttgg acatggagtc
     3061 tgtggcttcc cttgagttgg ctactgacaa gacgatagag gagctgctgc tggctatcct
     3121 taaacatccc acactggaga cttggtttct cgccctggag cagaaagcct tgccccccca
     3181 cacgctcagc cctattcttg tgaagctcct agcagcccac ttcagtgcag gggttcttca
     3241 gctactggtg gcaagttccc caattctcca taaactgggc cagttgggcc ttctggcaaa
     3301 gtactcagaa gccatcactc aaagtgtgct gatagagctc cgcacaagga ctctgaactc
     3361 aacctcaacg cccaagactc tgcctcagct ggaggccctg cgagagctgc acccgtacat
     3421 ggaaggtgtc cagattcgag aagtcaccct ggccctactg gccctgccag aggcccacct
     3481 gctgacccag caaggcacac agtctcttgg gaaggagaga cacttaagca gtcttggaaa
     3541 gaccctggta caactgctgg caagcagcca ccaggatcag ctgcagagca gtgagctact
     3601 ctggtgcgcc gagtatgtgc gaggcctggg ggctctgctc cccactctgg ctgagcatga
     3661 gctggacacg gtattccttc agactcttca gaaagacccc gtgctggccc ctgtggtccc
     3721 cgagggcgtg cttgagtact gcctggcccg acggacacag acagccctgg gcattgccag
     3781 cctcctgctt cagtacagcg gcacccacct tgtgaagttt gagctgtggt gtgggcagcc
     3841 tggtgtgggg cccaccttgc aggagcacct agatgacttc ttccccctta tccatgtgta
     3901 cctccagcac agggcgcaag gaagcttcat gcggccaaca ggagtatcct ctgctgtcac
     3961 tcctgtcttg aaggccctgt ggagacaagt gcgagacagg ttctttcata tcactgggcc
     4021 ttccaaagat gcgctgcatc tggaggccct ggcccagctc attccatttg caagaaccaa
     4081 ggatctgcat gtcctcatgg accatttacc caacacgctt cggactctga gtaatcacaa
     4141 gagttggacc ctggctgact ctgtctcagc agccttggca gagtcagcag aagagctggg
     4201 ctcctggagg aagaccctcc tgcggtcctg tatacagtgg ctggctgtgt ccttcagtgg
     4261 cagggagcca gaagatgaaa acacccagga gcacgagaag gcaatgctgg tccggttaag
     4321 cgagttgttg catgcggtta aggaggttga ccctggtgac tggcagcagt ttgtgaagac
     4381 aggactcaaa tttcggtacc atgacctcac ctttttgaag actctgctca gtgccacaaa
     4441 gctcctgtat ggtccagaaa gctctgggcg cacgaaactt gtccagcttt cagtggtcca
     4501 catgatgctc acccagcact ctctgttttt gccaaccatg ttgtcatctg aagaagagga
     4561 aactccagac agtggagtaa aagaaaccct gctggacctg atgtccacag tggtgaggct
     4621 gtgcccttct gtctgtcaga gcagccactt tgctgtgcta cttgggacct acagtgccac
     4681 cctcagtgtg ctggaccaga agattttact tctcctccgt gcatatgaac agaacaacct
     4741 cagcctcatc agtttcaggg ttctgctgtg gggcccagca gcagtggaac atcacaagac
     4801 atgccggagc ctgggcaagt cactttggca gcagccaagc gttggggaca tcctccgcct
     4861 gctggaccca gaccggatga tgcagaccat cctgcacttc ccgcagtacc ggaagctgct
     4921 gcccacggag gacacagggg agccactggt gtttaaggac aagactgcga gagtggacct
     4981 cgacagcctc tatgacccct gctttcttct ccatctcttt ggggaactga ccaggccaga
     5041 gtttgtggtg gattgtcgaa aatttttgga ctcaaacgcc ctgggtttaa ctgtggcagc
     5101 cctcagcagc tacgaccccc agatgcgagc tgcagcctac tatgtcctcg cagcctacta
     5161 ctcacacctg gagggagctc gcttccggga acagtcccaa gttctgtacc tgctcgatgt
     5221 tgtccgcaat gggattagaa ctccaaacct gaggctccct ttcaccgtgg cccttttcat
     5281 cgccaaggca gccgtgcaga tcttgaaacc agaggagcac atgtactgga agatcagcaa
     5341 gttcctgctg tcacacgaga acttgaacat ggacaaactg ccaggcttct accagttctt
     5401 ctacagctct gacttccagc aaaaaactga acaagaatgg gtgttggaaa ttctacggca
     5461 ggggattaga gacaagcact gctatgagct atgctctaga agaggcgtgt tccacatcat
     5521 cctgtccttc ttcaatagcc ccttgtgtga cgaagttgct cagaattgga ttctggaaat
     5581 cctgcagaat gttgcccaca tcaccagatc tgcctatgaa gtcatacgtg actatagcct
     5641 tttaacgtgg gttttacaca tccttgagag cagatttgta gagactcagc tgctgtccaa
     5701 cgtgatctcc ttgttacaca ccctgtgggt gaccaacctg ggcaacaaag cgccggagga
     5761 gagaagccag ccacctggcc aggtcggctc ccaggaatcc gagaagatgc ttgccttgca
     5821 catggtcagt gagttcctgt atgtcctcat tgcgcttaca aagcacctga ggcccacctt
     5881 ggcttctgcc cagctgatga acttcttttg gacacttgaa tctgtgctga gttatcgggc
     5941 caccatcata aaattattca aggacatggg ccgattcact gtgaacaagg tggcactttc
     6001 taccaaagat gtcctgatcc tcttacacaa gtggagcctc attgaaagag acacgaagct
     6061 ccaaggagag ctgaaagcag tcattgagca gcaccaagcc aaggacctaa tgaaaatgct
     6121 caaggataag agcaggcctg tggtagctgc ccaggcccga ggcccacgag gccggaagag
     6181 gaggcatgga gggctggagg agactgctga gccccagctg gaagcatctt gcttggagaa
     6241 atgcaaggac ctcctgaggg ccacactgac ccactggggg cccggtgacc ccttgcctgg
     6301 tcccacacag gggtctgtgg gccagactat ccccaagagt aaaacactga gctctgcgca
     6361 tgctgctgtt tctttggtgg ccagctgggt gcttcggtca ttggctgagc gccctgtcag
     6421 cagggcagag gtcacaagac tccttgactg gctcaagagc cacattttgc cacagccaat
     6481 ggtagtagct gaccttctcg gggacagcgc cgtgaagact ggcatcttta agctgtataa
     6541 tcatcactgc agtgcccagg gcctcgtggg acctgcacag gatgtggcct gcaagttcag
     6601 cacggtcatg ctgcagttgt tggtggccca gggccggaaa gagagccctt tccactcggt
     6661 ggcagaggcc ctgtgccttg attctctgaa tgaaaaggaa gaagccaaac gagctcctgc
     6721 agcgttcctg gtgtctctgt atgttaagga catgtggctg ggggcccagc agccagatac
     6781 cttccttgct cacatccgaa tggtctgtga ggctgcaaag gacgtgccac ttgatgagcc
     6841 cgaggccatt gttgtgctct gcaggaacgt ggactcctca gcccagtgct tgactcgctc
     6901 ccgctgaaca gagccccagc gggttccagg aagcttaagt gggttccgag acagacataa
     6961 actgatacat gcaactattt tccagcaaga aagctaagag gactttattc agctgaccaa
     7021 caagtaagcc cttatagtca gatctagtga ctgaggcact gccaggccgt gaggaccatg
     7081 gaggtctcag atgtctgccg tcccctcccc tgaaggccct gacagaggag ctaggtgctg
     7141 gttggtcatg gattggtatt aaaactgaaa tgtgaaagct cttgtgtctt cggttgtaca
     7201 tgacacatgt gtaaagttgc ctctctttgc tgttttattt aagaatgttg agtccctaag
     7261 gtagaaacct ctactttggg aagacatcct atttttttaa agttatattt caaagaggat
     7321 ttttgagttt tataatgttt tgataataaa tagctatttt tgtgaaaaaa aaaaaaaaaa
     7381 a
//
