LOCUS       NM_029821                913 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus urate (5-hydroxyiso-) hydrolase (Urah), transcript
            variant 2, mRNA.
ACCESSION   NM_029821 XM_001000224 XM_001000233 XM_001000250 XM_001000264
            XM_133915 XM_900078 XM_900080 XM_900083 XM_917938 XM_925372
            XM_925374 XM_925375
VERSION     NM_029821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Lu,J., Dalbeth,N., Yin,H., Li,C., Merriman,T.R. and Wei,W.H.
  TITLE     Mouse models for human hyperuricaemia: a critical review
  JOURNAL   Nat Rev Rheumatol 15 (7), 413-426 (2019)
   PUBMED   31118497
  REMARK    Review article
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Baey,C., Yang,J., Ronchese,F. and Harper,J.L.
  TITLE     Hyperuricaemic UrahPlt2/Plt2 mice show altered T cell proliferation
            and defective tumor immunity after local immunotherapy with Poly
            I:C
  JOURNAL   PLoS One 13 (11), e0206827 (2018)
   PUBMED   30383838
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Stevenson,W.S., Hyland,C.D., Zhang,J.G., Morgan,P.O., Willson,T.A.,
            Gill,A., Hilton,A.A., Viney,E.M., Bahlo,M., Masters,S.L.,
            Hennebry,S., Richardson,S.J., Nicola,N.A., Metcalf,D., Hilton,D.J.,
            Roberts,A.W. and Alexander,W.S.
  TITLE     Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and
            hepatocellular carcinoma in mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (38), 16625-16630 (2010)
   PUBMED   20823251
  REMARK    GeneRIF: Substitution of cysteine for tyrosine in a conserved
            helical region of HIU hydrolase resulted in undetectable protein
            expression. Homozygotes for the mutation had elevated platelet
            counts secondary to excess thrombopoietin production and
            hepatomegaly.
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Lee,Y., Park,B.C., Lee,D.H., Bae,K.H., Cho,S., Lee,C.H., Lee,J.S.,
            Myung,P.K. and Park,S.G.
  TITLE     Mouse transthyretin-related protein is a hydrolase which degrades
            5-hydroxyisourate, the end product of the uricase reaction
  JOURNAL   Mol Cells 22 (2), 141-145 (2006)
   PUBMED   17085964
  REMARK    GeneRIF: Study provides evidence that mouse transthyretin-related
            protein facilitates the hydrolysis of 5-hydroxyisourate, the end
            product of the uricase reaction.
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Ramazzina,I., Folli,C., Secchi,A., Berni,R. and Percudani,R.
  TITLE     Completing the uric acid degradation pathway through phylogenetic
            comparison of whole genomes
  JOURNAL   Nat Chem Biol 2 (3), 144-148 (2006)
   PUBMED   16462750
  REMARK    GeneRIF: Identified as the gene encoding the enzyme catalyzing the
            second step of the pathway from uric acid to S-allantoin.
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Trams,E.G. and Lauter,C.J.
  TITLE     Adenosine deaminase of cultured brain cells
  JOURNAL   Biochem J 152 (3), 681-687 (1975)
   PUBMED   16742956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004470.1, BY145477.1, AK013117.1 and BP776625.1.
            
            On Jan 13, 2018 this sequence version replaced NM_029821.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY704695.1, AK004470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AK004470.1         2-54
            54-82               BY145477.1         50-78
            83-217              AK004470.1         84-218
            218-892             AK013117.1         3-677
            893-913             BP776625.1         27-47               c
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.03 cM"
     gene            1..913
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /note="urate (5-hydroxyiso-) hydrolase"
                     /db_xref="GeneID:76974"
                     /db_xref="MGI:MGI:1916142"
     exon            1..473
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..699
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /EC_number="3.5.2.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     5-hydroxyisourate hydrolase; HIU hydrolase;
                     transthyretin-related protein"
                     /codon_start=1
                     /product="5-hydroxyisourate hydrolase isoform 2"
                     /protein_id="NP_084097.1"
                     /db_xref="CCDS:CCDS21986.1"
                     /db_xref="GeneID:76974"
                     /db_xref="MGI:MGI:1916142"
                     /translation="MATESSPLTTHVLDTASGLPAQGLCLRLSRLEAPCQQWMELRTS
                     YTNLDGRCPGLLTPSQIKPGTYKLFFDTERYWKERGQESFYPYVEVVFTITKETQKFH
                     VPLLLSPWSYTTYRGS"
     exon            474..609
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /inference="alignment:Splign:2.1.0"
     exon            610..895
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /note="hexamer: AATAAA"
     polyA_site      895
                     /gene="Urah"
                     /gene_synonym="1190003J15Rik; 2810420C16Rik; HIUHase"
                     /note="major polyA site"
ORIGIN      
        1 atacttaagg agacagagac ggaagagtgt gtgggagctt gggagcaagg gtgttgctag
       61 gagtcagagg cacgggagag ctgggttctg ggacactaaa gccaccgatc agctgaaact
      121 gaaggtctca tacaagggag aggggtggtg cccaggcagg ggcaaaggag ggcacaggtc
      181 agctttgttt agcacttggc accccatcct gccgctcagc agttcagcct gcctcggggc
      241 agtgcggccc tttgtttgct ctcctcagaa ctagatcgaa gacgcacttg ggcctctacg
      301 gactggctga tcactctcac tctctctgca caggctggca acatggctac cgagagcagt
      361 cccctgacta ctcacgttct agacactgcc tcagggctcc ctgcccaagg cctctgcctc
      421 cggctgtccc gcctggaggc cccctgccag cagtggatgg agctgaggac aagctacaca
      481 aacctggacg gtcgctgtcc tgggctcctg acaccaagcc agataaagcc aggcacctat
      541 aagctgttct tcgacacaga gcgctactgg aaagagcggg gtcaagagag cttttacccc
      601 tatgtagagg tggttttcac tattacaaag gagacccaga agttccacgt acctctgctg
      661 ctgagcccat ggtcctacac cacctaccgg gggagttaaa gtgatgtgtt acctgaagaa
      721 agccatctat ctgcctgttt ctttcccaga cttagccacc cacacaaatc atgggctttg
      781 ttctcatcaa aggacatgaa gttgctgctt gctgaagata ttctagctgc cctggagttt
      841 cataatggga agctgtgact tgggtgtcaa taaagagagt ttcaacacct gccaaaaaaa
      901 aaaaaaaaaa aaa
//
