LOCUS       NM_025352               1525 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus ubiquinol-cytochrome c reductase, complex III subunit
            VII (Uqcrq), transcript variant 1, mRNA.
ACCESSION   NM_025352
VERSION     NM_025352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Wang,D., Li,H., Chandel,N.S., Dou,Y. and Yi,R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Wculek,S.K., Heras-Murillo,I., Mastrangelo,A., Mananes,D.,
            Galan,M., Miguel,V., Curtabbi,A., Barbas,C., Chandel,N.S.,
            Enriquez,J.A., Lamas,S. and Sancho,D.
  TITLE     Oxidative phosphorylation selectively orchestrates tissue
            macrophage homeostasis
  JOURNAL   Immunity 56 (3), 516-530 (2023)
   PUBMED   36738738
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Sadakata,T. and Furuichi,T.
  TITLE     Identification and mRNA expression of Ogdh, QP-C, and two predicted
            genes in the postnatal mouse brain
  JOURNAL   Neurosci Lett 405 (3), 217-222 (2006)
   PUBMED   16901643
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1525)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1525)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB950804.1, AK007982.1, AK005374.1 and AL592489.13.
            
            On May 21, 2016 this sequence version replaced NM_025352.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005374.1, EH100397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CB950804.1         4-43
            41-494              AK007982.1         2-455
            495-1488            AK005374.1         477-1470
            1489-1489           AL592489.13        137212-137212       c
            1490-1525           AK005374.1         1471-1506
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.94 cM"
     gene            1..1525
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /note="ubiquinol-cytochrome c reductase, complex III
                     subunit VII"
                     /db_xref="GeneID:22272"
                     /db_xref="MGI:MGI:107807"
     exon            1..296
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..391
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /EC_number="7.1.1.8"
                     /note="complex III subunit VII; low molecular mass
                     ubiquinone-binding protein (Qpc-pending); complex III
                     subunit 8; complex III subunit VIII; ubiquinol-cytochrome
                     c reductase complex 9.5 kDa protein; ubiquinol-cytochrome
                     c reductase complex ubiquinone-binding protein QP-C;
                     ubiquinol-cytochrome c reductase binding protein"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 8"
                     /protein_id="NP_079628.1"
                     /db_xref="CCDS:CCDS36151.1"
                     /db_xref="GeneID:22272"
                     /db_xref="MGI:MGI:107807"
                     /translation="MGREFGNLARIRHVISYSLSPFEQRAFPSYFSKGIPNVLRRTRE
                     RILRVAPPFVVVYLIYTWGNQEFEQSKRKNPAMYENDK"
     exon            297..1525
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      473..478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /note="hexamer: AATAAA"
     polyA_site      494
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /note="major polyA site"
ORIGIN      
        1 tcctcccgga agtgacgggc gaaagccggc tcagagctct ggaggtagag gtgaccgatc
       61 ctgggggtcg gtgttaggcc gtgggaggtt tttcgcgaga ctgagccacg cgtctatctt
      121 ctgtcccagg gccgccgtca ccatgggccg cgagtttggg aacctggcgc ggatacggca
      181 cgtgatctcc tacagcttgt cgccctttga gcagcgcgcc ttcccaagct atttcagcaa
      241 aggcatcccc aacgtgctgc gccgcactcg cgagcgcatc ctgcgcgtgg cgccgccgtt
      301 tgtagtggtc tacctgatct acacatgggg caaccaggag tttgagcagt cgaaaaggaa
      361 gaatccagcc atgtatgaaa atgacaagta gacggcctgc acctgggtga cagtcccctg
      421 cctctgaaag acccttctct gggagaggaa tccacactgt agtcttgaag acaataaact
      481 acttatggac ttccctttgt gactttgtgt gcttagtttg agacaaggtc tcactgtgtg
      541 tccctgactg gcctgcgtct cctgagaaat ctgcctgcct ctgcctgcta tgtcatggcg
      601 atcaccacca tgcccagcac aacgttgttt tggcaatatg caagttcatg acaatccctt
      661 tctcagcaca agccctgcag gggctgtggt agctatgcat agcgtggaac ctggagtgca
      721 gggtcccaac cctctgctcc catcacatcc ttaaggtcta gggacaacac tgtaatcagg
      781 gtgtcaggtg gacttgctag acacagatga acttttaact cggcagcctt tgaagtaagc
      841 attctaatcc ctttgctgat gaggaatcag agtttaagta ctttgcccag aatcatatga
      901 ctgagttggt agagccaggt accagtgtgt gatcttaaaa gcaagccatg ctgccttcct
      961 taggtaggga aggccttcct tagcctaagg gatttcatct ttgaaaggaa agcatgagac
     1021 attcccttga ctgctacagc caaggtcagg caaccatggt tggttatctg tcatgttgcc
     1081 aatccaacag tggcttttag tcatatgtgg accacagagg ctgaaaagat ctatcacttt
     1141 gtggaaaaga tataccacct gctctagata tacacctttg ggtgtcttta gtttctcctc
     1201 acctagagat gatagggtgg gtgtggttgg caatcctgag ctggccctgt catttggtta
     1261 aggactgtag caatttacag tccagtcgga ctctgagact tttttgcctg atgatcgcta
     1321 gctagtacta aaagttctca gaagagagca aatgacttcc aacaatagtt gcttagactg
     1381 tgaggcaaat gggaaatagc tatgtctgac agtcatacac ccacaccctt agaacactgg
     1441 ttctcaacct ccctaattca agcctttaat acagttcttc atgtggtggt gaccccaacc
     1501 ataaaattat tttggttgct acttc
//
