LOCUS       NP_079628                 82 aa            linear   ROD 15-APR-2025
DEFINITION  cytochrome b-c1 complex subunit 8 [Mus musculus].
ACCESSION   NP_079628
VERSION     NP_079628.1
DBSOURCE    REFSEQ: accession NM_025352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 82)
  AUTHORS   Stoolman,J.S., Grant,R.A., Poor,T.A., Weinberg,S.E.,
            D'Alessandro,K.B., Tan,J., Hu,J.Y., Zerrer,M.E., Wood,W.A.,
            Harding,M.C., Soni,S., Ridge,K.M., Schumacker,P.T., Budinger,G.R.S.
            and Chandel,N.S.
  TITLE     Mitochondrial respiration in microglia is essential for response to
            demyelinating injury but not proliferation
  JOURNAL   Nat Metab 6 (8), 1492-1504 (2024)
   PUBMED   39048801
REFERENCE   2  (residues 1 to 82)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (residues 1 to 82)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 82)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 82)
  AUTHORS   Wang,D., Li,H., Chandel,N.S., Dou,Y. and Yi,R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 82)
  AUTHORS   Sadakata,T. and Furuichi,T.
  TITLE     Identification and mRNA expression of Ogdh, QP-C, and two predicted
            genes in the postnatal mouse brain
  JOURNAL   Neurosci Lett 405 (3), 217-222 (2006)
   PUBMED   16901643
REFERENCE   7  (residues 1 to 82)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   8  (residues 1 to 82)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (residues 1 to 82)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (residues 1 to 82)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB950804.1, AK007982.1, AK005374.1 and AL592489.13.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005374.1, EH100397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..82
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.94 cM"
     Protein         1..82
                     /product="cytochrome b-c1 complex subunit 8"
                     /EC_number="7.1.1.8"
                     /note="complex III subunit VII; low molecular mass
                     ubiquinone-binding protein (Qpc-pending); complex III
                     subunit 8; complex III subunit VIII; ubiquinol-cytochrome
                     c reductase complex 9.5 kDa protein; ubiquinol-cytochrome
                     c reductase complex ubiquinone-binding protein QP-C;
                     ubiquinol-cytochrome c reductase binding protein"
                     /calculated_mol_wt=9637
     Region          4..79
                     /region_name="UcrQ"
                     /note="UcrQ family; pfam02939"
                     /db_xref="CDD:460757"
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14949; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ69.3)"
     Site            33
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ69.3)"
     Site            44..62
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQ69.3)"
     CDS             1..82
                     /gene="Uqcrq"
                     /gene_synonym="1100001F06Rik; 1500040F11Rik;
                     5830407L17Rik; 9.5kDa; c1502; QP-C; Qpc; Uqcrb"
                     /coded_by="NM_025352.3:143..391"
                     /db_xref="CCDS:CCDS36151.1"
                     /db_xref="GeneID:22272"
                     /db_xref="MGI:MGI:107807"
ORIGIN      
        1 mgrefgnlar irhvisysls pfeqrafpsy fskgipnvlr rtrerilrva ppfvvvyliy
       61 twgnqefeqs krknpamyen dk
//
