LOCUS       NM_025641                562 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus ubiquinol-cytochrome c reductase hinge protein
            (Uqcrh), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025641
VERSION     NM_025641.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 562)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 562)
  AUTHORS   Jacobs,H.T., Szibor,M., Rathkolb,B., da Silva-Buttkus,P.,
            Aguilar-Pimentel,J.A., Amarie,O.V., Becker,L., Calzada-Wack,J.,
            Dragano,N., Garrett,L., Gerlini,R., Holter,S.M., Klein-Rodewald,T.,
            Kraiger,M., Leuchtenberger,S., Marschall,S., Ostereicher,M.A.,
            Pfannes,K., Sanz-Moreno,A., Seisenberger,C., Spielmann,N.,
            Stoeger,C., Wurst,W., Fuchs,H., Hrabe de Angelis,M. and
            Gailus-Durner,V.
  TITLE     AOX delays the onset of the lethal phenotype in a mouse model of
            Uqcrh (complex III) disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166760 (2023)
   PUBMED   37230398
  REMARK    GeneRIF: AOX delays the onset of the lethal phenotype in a mouse
            model of Uqcrh (complex III) disease.
REFERENCE   3  (bases 1 to 562)
  AUTHORS   Spielmann,N., Schenkl,C., Komlodi,T., da Silva-Buttkus,P.,
            Heyne,E., Rohde,J., Amarie,O.V., Rathkolb,B., Gnaiger,E.,
            Doenst,T., Fuchs,H., Gailus-Durner,V., de Angelis,M.H. and
            Szibor,M.
  TITLE     Knockout of the Complex III subunit Uqcrh causes bioenergetic
            impairment and cardiac contractile dysfunction
  JOURNAL   Mamm Genome 34 (2), 229-243 (2023)
   PUBMED   36565314
  REMARK    GeneRIF: Knockout of the Complex III subunit Uqcrh causes
            bioenergetic impairment and cardiac contractile dysfunction.
REFERENCE   4  (bases 1 to 562)
  AUTHORS   Vidali,S., Gerlini,R., Thompson,K., Urquhart,J.E.,
            Meisterknecht,J., Aguilar-Pimentel,J.A., Amarie,O.V., Becker,L.,
            Breen,C., Calzada-Wack,J., Chhabra,N.F., Cho,Y.L., da
            Silva-Buttkus,P., Feichtinger,R.G., Gampe,K., Garrett,L.,
            Hoefig,K.P., Holter,S.M., Jameson,E., Klein-Rodewald,T.,
            Leuchtenberger,S., Marschall,S., Mayer-Kuckuk,P., Miller,G.,
            Oestereicher,M.A., Pfannes,K., Rathkolb,B., Rozman,J., Sanders,C.,
            Spielmann,N., Stoeger,C., Szibor,M., Treise,I., Walter,J.H.,
            Wurst,W., Mayr,J.A., Fuchs,H., Gartner,U., Wittig,I., Taylor,R.W.,
            Newman,W.G., Prokisch,H., Gailus-Durner,V. and Hrabe de Angelis,M.
  TITLE     Characterising a homozygous two-exon deletion in UQCRH: comparing
            human and mouse phenotypes
  JOURNAL   EMBO Mol Med 13 (12), e14397 (2021)
   PUBMED   34750991
  REMARK    GeneRIF: Characterising a homozygous two-exon deletion in UQCRH:
            comparing human and mouse phenotypes.
REFERENCE   5  (bases 1 to 562)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   6  (bases 1 to 562)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 562)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   8  (bases 1 to 562)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   9  (bases 1 to 562)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 562)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY138998.1 and BY702808.1.
            
            On Sep 6, 2006 this sequence version replaced NM_025641.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ748215.1, CD768312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               BY138998.1         1-345
            346-562             BY702808.1         319-535
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.1 cM"
     gene            1..562
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /note="ubiquinol-cytochrome c reductase hinge protein"
                     /db_xref="GeneID:66576"
                     /db_xref="MGI:MGI:1913826"
     exon            1..155
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..371
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /EC_number="7.1.1.8"
                     /note="complex III subunit VIII; mitochondrial hinge
                     protein; cytochrome C1, nonheme 11 kDa protein; complex
                     III subunit 6; cytochrome c1 non-heme 11 kDa protein;
                     ubiquinol-cytochrome c reductase complex 11 kDa protein"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 6,
                     mitochondrial"
                     /protein_id="NP_079917.1"
                     /db_xref="CCDS:CCDS38846.1"
                     /db_xref="GeneID:66576"
                     /db_xref="MGI:MGI:1913826"
                     /translation="MGLEDERKMLTGSGDPKEEEEEELVDPLTTVREHCEQLEKCVKA
                     RERLELCDNRVSSRSQTEEDCTEELFDFLHARDHCVAHKLFKNLK"
     exon            156..176
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            177..338
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..546
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      545
                     /gene="Uqcrh"
                     /gene_synonym="2210416J04Rik; 2310021J10Rik;
                     2610041P16Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgccgga tatccgtcga gtgaccctta ctagtccttc ttaaacctga agtggagtac
       61 tactctggtt gcgcttgttg gatcccaaac cggctcccga catgggacta gaggacgaac
      121 gaaagatgct cactggatct ggagacccca aagaggaaga agaggaagaa ctagtggacc
      181 ccctaacaac agtgagagag cactgtgaac agctggagaa gtgtgtaaag gcccgggaac
      241 gactagagtt gtgtgataat cgcgtgtctt cccggtcaca gacagaagag gattgtacag
      301 aggagctctt tgacttcttg catgcacggg accactgtgt ggcccacaag ctctttaaaa
      361 acttgaagta aatgtgcaga ttcgtcctcc tcagccttgt cactgggaat caggaacagt
      421 tccttgtggt tctggacgtc ggtgtctgat ggagtgagtt ctcgagaacc tcactgactt
      481 tggcggtagc ttctcttctg tgtgactagc agtgacttca tcttaataaa ctgatctgca
      541 aacttgaaaa aaaaaaaaaa aa
//
