LOCUS       NM_025899               1882 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ubiquinol cytochrome c reductase core protein 2
            (Uqcrc2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025899
VERSION     NM_025899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Diaz,F., Thomas,C.K., Garcia,S., Hernandez,D. and Moraes,C.T.
  TITLE     Mice lacking COX10 in skeletal muscle recapitulate the phenotype of
            progressive mitochondrial myopathies associated with cytochrome c
            oxidase deficiency
  JOURNAL   Hum Mol Genet 14 (18), 2737-2748 (2005)
   PUBMED   16103131
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Baumgart,E., Vanhorebeek,I., Grabenbauer,M., Borgers,M.,
            Declercq,P.E., Fahimi,H.D. and Baes,M.
  TITLE     Mitochondrial alterations caused by defective peroxisomal
            biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout
            mouse)
  JOURNAL   Am J Pathol 159 (4), 1477-1494 (2001)
   PUBMED   11583975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074691.1, AK005151.1 and AK075856.1.
            
            On Apr 18, 2006 this sequence version replaced NM_025899.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075856.1, SRR1660811.14551.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                CJ074691.1         2-86
            86-1519             AK005151.1         70-1503
            1520-1882           AK075856.1         1465-1827
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.9 cM"
     gene            1..1882
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /note="ubiquinol cytochrome c reductase core protein 2"
                     /db_xref="GeneID:67003"
                     /db_xref="MGI:MGI:1914253"
     exon            1..134
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1463
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /EC_number="7.1.1.8"
                     /note="cytochrome b-c1 complex subunit 2, mitochondrial;
                     core protein II; complex III subunit 2;
                     ubiquinol-cytochrome-c reductase complex core protein 2"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 2, mitochondrial
                     precursor"
                     /protein_id="NP_080175.1"
                     /db_xref="CCDS:CCDS21795.1"
                     /db_xref="GeneID:67003"
                     /db_xref="MGI:MGI:1914253"
                     /translation="MKLLSRAGSFSRFYSLKVAPKVKTSAAPGGVPLQPQDLEFTKLP
                     NGLVIASLENYAPLSRIGLFVKAGSRYEDSNNLGTSHLLRLASSLTTKGASSFKITRG
                     IEAVGGKLSVTATRENMAYTVEGIRSDIEILMEFLLNVTTAPEFRRWEVAALRSQLKI
                     DKAVAFQNSQTRIIENLHDVAYKNALANPLYCPDYRMGKITSEELHYFVQNHFTSARM
                     ALVGLGVSHSVLKQVAEQFLNMRGGLGLAGAKAKYRGGEIREQNGDNLVHAAIVAESA
                     AIGNAEANAFSVLQHLLGAGPHIKRGNNTTSLLSQSVAKGSHQPFDVSAFNASYSDSG
                     LFGIYTISQAAAAGEVINAAYNQVKAVAQGNLSSADVQAAKNKLKAGYLMSVETSEGF
                     LSEIGSQALAAGSYMPPSTVLQQIDSVADADVVKAAKKFVSGKKSMAASGNLGHTPFL
                     DEL"
     exon            135..218
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            219..368
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..433
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            434..490
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            491..615
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            616..713
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..771
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..867
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1067
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1148
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1225
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1379
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1882
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1633
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /note="major polyA site"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1696
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1840
                     /gene="Uqcrc2"
                     /gene_synonym="1500004O06Rik"
ORIGIN      
        1 gtgggcaagc tcgcagtgca caccgggaaa ctcggtcctc cgaccccatc ttgctttgct
       61 gtctgcagcg gtgaccgtgg gaaagggcaa ctgctagagc catgaagctc ctcagcaggg
      121 ccgggtcctt ctcgagattt tattccctca aagttgcccc gaaggttaaa acttcagcag
      181 cccctggagg agtgcctctg cagcctcagg atcttgagtt taccaaatta ccaaatggtt
      241 tggtgattgc ttctctggaa aactatgctc ctctgtcaag aatcggcttg ttcgttaaag
      301 caggcagtag atatgaggac tccaacaact tgggaacctc acatttacta cgtcttgcat
      361 ctagtttgac taccaaagga gcttcatctt tcaagataac ccgtgggatt gaagcagttg
      421 gtggtaaatt aagtgtgact gcaacaaggg aaaacatggc gtacactgta gaaggcattc
      481 ggagtgatat tgagatcctc atggagttcc tgctcaatgt caccacagca cccgagtttc
      541 gccgttggga agtagctgcc ctgcggtctc agctaaagat tgacaaagct gttgcctttc
      601 agaattcaca gacccgtatc attgagaact tgcatgatgt tgcctacaag aatgccttgg
      661 ctaatccttt gtactgtcct gactatagga tggggaagat aacatcagag gaattacatt
      721 actttgttca gaaccacttc acaagtgcaa gaatggctct ggttggactt ggtgtgagtc
      781 attctgtctt aaagcaggtg gctgaacaat ttctcaacat gaggggtggc cttggtttag
      841 ctggtgcaaa agccaaatac cgtggaggtg aaattagaga gcagaatgga gacaacctgg
      901 tccatgctgc tattgttgca gaaagtgctg ccattggaaa tgcagaggca aatgcattca
      961 gtgtacttca gcatcttctt ggtgctggac cacatatcaa aaggggcaac aacaccacca
     1021 gcctcctgag ccagagtgtt gccaaaggaa gtcaccagcc ttttgatgtt tctgcattta
     1081 atgccagtta ctcagactct gggctctttg gaatttacac tatttcccag gctgcagctg
     1141 ctggagaggt tatcaatgct gcctacaacc aagtcaaagc agttgctcaa ggaaaccttt
     1201 ccagtgcaga tgtccaagct gccaagaaca agctaaaagc tggatatcta atgtctgtgg
     1261 agacgtcaga gggcttcctg agtgaaattg ggtcacaggc tctagctgca ggttcttata
     1321 tgccaccttc taccgtcctt caacagattg actccgtggc tgatgctgat gttgtaaagg
     1381 ctgcaaaaaa gtttgtttct ggcaagaagt caatggcagc gagtggaaac ttgggacata
     1441 cgccttttct cgacgagtta taacacatgc gtgtatttaa agctcagccc agaccagcaa
     1501 gcacatcaaa gtcaggtctc ttaataatta attaatgtta attcaacatt ttctcaatga
     1561 agtaaaaaaa aaaaaaactt aaaagcatag tgactcccag ctgtcctagt gtcaataaag
     1621 cattgtgtgt aaatgttctt cttgcattct ttctaagcag tcagcaagta tttattaaat
     1681 gctttaagga aaacaataat agagtaattt ttgagttcgc caattacatc aattaagaaa
     1741 tttcagaaac tgttaaaatt gaggctaagc agctttaaaa gtaaaaattc cagattatta
     1801 ctggtggctt tttaaaataa aaacaacttt aacacttgaa cagcctggat tttgccccat
     1861 gtacagtaaa cctgcgtttc tg
//
