LOCUS       NM_025407               1665 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus ubiquinol-cytochrome c reductase core protein 1
            (Uqcrc1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025407
VERSION     NM_025407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Milenkovic,D., Misic,J., Hevler,J.F., Molinie,T., Chung,I.,
            Atanassov,I., Li,X., Filograna,R., Mesaros,A., Mourier,A.,
            Heck,A.J.R., Hirst,J. and Larsson,N.G.
  TITLE     Preserved respiratory chain capacity and physiology in mice with
            profoundly reduced levels of mitochondrial respirasomes
  JOURNAL   Cell Metab 35 (10), 1799-1813 (2023)
   PUBMED   37633273
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Yi,T., Chen,H., Zhan,J., Li,Y., Long,Z., Wu,Z., Yang,M., Peng,T.
            and Li,H.
  TITLE     Ubiquinol-cytochrome c reductase core protein 1 contributes to
            cardiac tolerance to acute exhaustive exercise
  JOURNAL   Exp Biol Med (Maywood) 247 (2), 165-173 (2022)
   PUBMED   34648372
  REMARK    GeneRIF: Ubiquinol-cytochrome c reductase core protein 1
            contributes to cardiac tolerance to acute exhaustive exercise.
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1665)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1665)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
REFERENCE   9  (bases 1 to 1665)
  AUTHORS   Wittenburg,H., Lammert,F., Wang,D.Q., Churchill,G.A., Li,R.,
            Bouchard,G., Carey,M.C. and Paigen,B.
  TITLE     Interacting QTLs for cholesterol gallstones and gallbladder mucin
            in AKR and SWR strains of mice
  JOURNAL   Physiol Genomics 8 (1), 67-77 (2002)
   PUBMED   11842132
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1665)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB649589.1, BY260300.1, AK010553.1 and AI462428.1.
            
            On Apr 27, 2004 this sequence version replaced NM_025407.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013128.1, AK160337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BB649589.1         1-71
            72-368              BY260300.1         45-341
            369-1636            AK010553.1         309-1576
            1637-1665           AI462428.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..1665
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /note="ubiquinol-cytochrome c reductase core protein 1"
                     /db_xref="GeneID:22273"
                     /db_xref="MGI:MGI:107876"
     exon            1..140
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            141..281
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..368
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..498
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..697
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..777
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            778..893
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1037
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1198
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1284
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1373
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1449
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1656
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="Uqcrc1"
                     /gene_synonym="1110032G10Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttacagcgct tgcgcctcag actccgctct gcgcatgcgc agcgcggctc tacactgacg
       61 gaagttagaa gatggcggcg tccgcagtct gccgagcggc ctgctccggg acgcaagtgc
      121 tacttcgcac ccgccgctcg ccggccctgc tgaggttacc tgccttgcgg ggtaccgcaa
      181 ccttcgccca ggccctccag agcgtgccgg agacccaggt cagcatcttg gacaacgggc
      241 tgcgtgtggc ctcggagcag tcctcgcatg ctacctgcac ggtgggagtg tggattgacg
      301 ctggcagtcg ctatgagact gagaagaaca atggagcagg ctactttttg gaacatctgg
      361 ctttcaaggg aacaaagaat cggcctggca atgccttaga gaaggaggta gagagtattg
      421 gggctcatct taatgcctac agcactcgag agcacactgc ttacctcatc aaggcactgt
      481 ccaaggacct gccaaaagtt gtggagctcc tggcagatat cgtgcagaac agtagtctgg
      541 aagactcaca gatcgagaag gaacgagatg tgatcctgcg ggagatgcag gaaaatgacg
      601 cctccatgca gaacgtggtc tttgattacc tgcatgcgac agcattccag ggcacacctc
      661 tagcccaggc tgtggagggg cccagtgaga acgtcaggag gctgtcgcgc acagacttga
      721 ctgactacct caacagacat tacaaagccc cccggatggt gctggctgca gctggaggtg
      781 tggaacacca gcagctgctg gaccttgccc agaaacactt gagcagtgtc tcccgagtgt
      841 atgaagaaga tgccgtgcct ggtctcactc catgtcgctt cactggcagt gagatccgcc
      901 atcgcgatga cgccctgcct ttggcccacg tggccattgc agtagaggga cctggctggg
      961 ctaacccaga caacgtgacc ctccaagtgg ccaatgccat cataggccac tatgactgca
     1021 cttacggtgg tggagtgcac ctgtcaagcc cgctggcttc cgttgctgtg gctaacaagc
     1081 tttgccagag tttccagacc ttcaacatct cctactctga tactgggctg ctgggcgcac
     1141 actttgtctg tgatgccatg agtatcgatg acatggtctt cttcctgcaa ggccagtgga
     1201 tgcgcctatg taccagtgct acagagagtg aggtgactcg gggcaaaaac atccttagga
     1261 atgctttggt gtctcatttg gatggcacca cccctgtgtg tgaagacatt ggtcgcagtc
     1321 tcctgactta tggccgccgc atccctctgg ctgagtggga gagccggatt caggaggtgg
     1381 atgcccagat gctgcgtgac atttgctcca agtactttta tgaccaatgt ccagcagtgg
     1441 ctggctatgg ccccatcgag cagctcccag actacaaccg gatccgcagt ggcatgttct
     1501 ggctgcgctt ctaggcagga agtctgcaca ggcaggcagg agggcggggc cgggcacccg
     1561 gggtccctgc cacagacata ccactcctgc tgctcagctg tgtgcagcca gttaccccca
     1621 ataaagccct attgagaact gtgttgtcct tccttaaaaa aaaaa
//
