LOCUS       NM_026219                548 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ubiquinol-cytochrome c reductase binding protein
            (Uqcrb), mRNA.
ACCESSION   NM_026219
VERSION     NM_026219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 548)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 548)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 548)
  AUTHORS   Ma,W., Tian,Y., Shi,L., Liang,J., Ouyang,Q., Li,J., Chen,H.,
            Sun,H., Ji,H., Liu,X., Huang,W., Gao,X., Jin,X., Wang,X., Liu,Y.,
            Yu,Y., Guo,X., Tian,Y., Yang,F., Li,F., Wang,N. and Cai,B.
  TITLE     N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of
            ac4C modification to promote heart regeneration
  JOURNAL   Nat Commun 15 (1), 2137 (2024)
   PUBMED   38459019
  REMARK    GeneRIF: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb
            independently of ac4C modification to promote heart regeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 548)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     Structure and assembly of the mammalian mitochondrial supercomplex
            CIII2CIV
  JOURNAL   Nature 598 (7880), 364-367 (2021)
   PUBMED   34616041
REFERENCE   6  (bases 1 to 548)
  AUTHORS   Sadakata,T. and Furuichi,T.
  TITLE     Identification and mRNA expression of Ogdh, QP-C, and two predicted
            genes in the postnatal mouse brain
  JOURNAL   Neurosci Lett 405 (3), 217-222 (2006)
   PUBMED   16901643
  REMARK    GeneRIF: In the postnatal mouse brain ,c1502/QP-C mRNA was
            localized at high levels in the olfactory bulb, cerebral cortex,
            hippocampus, thalamus, tegmentum (red nucleus), cerebellum
            (Purkinje and granule cells), and pons.
REFERENCE   7  (bases 1 to 548)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 548)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   9  (bases 1 to 548)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 548)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008945.1 and AC124433.4.
            
            On Apr 14, 2018 this sequence version replaced NM_026219.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008945.1, BY708830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AK008945.1         1-503
            504-548             AC124433.4         14779-14823         c
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..548
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /note="ubiquinol-cytochrome c reductase binding protein"
                     /db_xref="GeneID:67530"
                     /db_xref="MGI:MGI:1914780"
     exon            1..58
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..375
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /EC_number="7.1.1.8"
                     /note="complex III subunit 7; complex III subunit VII;
                     ubiquinol-cytochrome c reductase complex 14 kDa protein"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 7"
                     /protein_id="NP_080495.1"
                     /db_xref="CCDS:CCDS26610.1"
                     /db_xref="GeneID:67530"
                     /db_xref="MGI:MGI:1914780"
                     /translation="MAGRSAVSASSKWLDGFRKWYYNAAGFNKLGLMRDDTLHETEDV
                     KEAIRRLPEDLYNDRMFRIKRALDLTMRHQILPKDQWTKYEEDKFYLEPYLKEVIRER
                     KEREEWAKK"
     exon            59..130
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /inference="alignment:Splign:2.1.0"
     exon            131..297
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /inference="alignment:Splign:2.1.0"
     exon            298..548
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      485..490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /note="hexamer: AATAAA"
     regulatory      496..501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /note="hexamer: ATTATA"
     polyA_site      505
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
                     /note="major polyA site"
     polyA_site      527
                     /gene="Uqcrb"
                     /gene_synonym="2210415M14Rik; QP-C; QPC; UQBC; UQBP; UQPC"
ORIGIN      
        1 ggacttaccc agaaggcagc gcttcactct caggtcaaaa tggcgggccg atctgctgtt
       61 tcagcatcaa gcaagtggct ggatggtttt cgaaagtggt attataatgc tgcaggattc
      121 aataaactgg ggttaatgcg agatgataca ctacatgaaa ctgaagatgt aaaagaagcc
      181 ataagaaggc ttcctgagga cctttataat gacaggatgt ttcgaattaa gagagccctg
      241 gacctgacta tgaggcatca gatcttgcct aaggatcagt ggacaaaata tgaggaggac
      301 aaattctacc ttgaacccta tctaaaagag gttattcggg aaagaaagga gagagaagag
      361 tgggcaaaga agtgatcttt tagttaagat ctgtgggtgt gcctggtctc accatacttt
      421 tacaaagtta tttcaaccca aatcacaatt taagaattat ttgttctacc tatgccacac
      481 tttaaataaa tgtctattat aaccatggtt ggattatttg aattcaattc aaacgcctac
      541 tgtcataa
//
