LOCUS       NM_018888               2668 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquinol-cytochrome c reductase complex assembly
            factor 1 (Uqcc1), transcript variant 1, mRNA.
ACCESSION   NM_018888
VERSION     NM_018888.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Vetter,K. and Wurst,W.
  TITLE     Expression of a novel mouse gene 'mbFZb' in distinct regions of the
            developing nervous system and the adult brain
  JOURNAL   Mech Dev 100 (1), 123-125 (2001)
   PUBMED   11118897
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Kunst,C.B., Messer,L., Gordon,J., Haines,J. and Patterson,D.
  TITLE     Genetic mapping of a mouse modifier gene that can prevent ALS onset
  JOURNAL   Genomics 70 (2), 181-189 (2000)
   PUBMED   11112346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139488.1 and BB761198.1.
            
            On May 6, 2010 this sequence version replaced NM_018888.3.
            
            Transcript Variant: This variant (1) uses an alternate splice
            junction in the 5' end compared to variant 4. The resulting isoform
            (a) has a shorter and distinct N-terminus compared to isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139488.1, BC050884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18614015; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2633              AK139488.1         1-2633
            2634-2668           BB761198.1         441-475
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..2668
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /note="ubiquinol-cytochrome c reductase complex assembly
                     factor 1"
                     /db_xref="GeneID:56046"
                     /db_xref="MGI:MGI:1929472"
     exon            1..298
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1162
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /note="isoform a is encoded by transcript variant 1; basic
                     FGF repressed, zinc binding protein; ubiquinol-cytochrome
                     c reductase complex chaperone, CBP3 homolog; basic
                     FGF-repressed Zic-binding protein"
                     /codon_start=1
                     /product="ubiquinol-cytochrome c reductase complex
                     assembly factor 1 isoform a"
                     /protein_id="NP_061376.2"
                     /db_xref="CCDS:CCDS16957.2"
                     /db_xref="GeneID:56046"
                     /db_xref="MGI:MGI:1929472"
                     /translation="MALLVRVLRNQTSISQWVPVCSQLVSVSPTQRQWSSTSQWLQKN
                     QSRVCLGSEQTVGADTAQNRKYHNTSKLLTTQDFPQPVEEKVGPFTKIIEAMGFTGPL
                     KYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQE
                     GRTGKYMCRIIVHFMWEDVEQRGRVMGVNSYILKKNMALMTNNFYAAILGYDEGILSD
                     DHGLAAALWRTFFNQKCEDPRQLELLVEYVRKQMQYLDSMNGEDLLLTGEVRWRPLVE
                     KNPQSILKPHAPTYNDEGL"
     exon            299..391
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            392..487
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            488..595
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            596..668
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            669..726
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            727..835
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            836..913
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1027
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2668
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="Uqcc1"
                     /gene_synonym="2310079L17Rik; 2410003P15Rik;
                     3110038N19Rik; Bfzb; Bfzp; Cbp3; Uqcc"
                     /note="major polyA site"
ORIGIN      
        1 gagagggatg tgagaggcca ggccggggtg tgtgtagagg aagaacgtga gcccttgtga
       61 cgcgcagcag cgacttaaga ccggcgagga gtctcgcgtc ctggaacctc attcagatcc
      121 acggcaggaa aaccgcgggt gcgcagttgc gaaaactacg cctgcgccgc ctccagagcc
      181 tgactacctt tagcaagggg acagcggctg agtgggtggt gacaatcggg attccggaag
      241 cccacctttc acccggaaat gattgtggag gaacatggcg ttgctggtgc gagtccttag
      301 gaaccagact agcatctctc agtgggttcc agtatgcagc caactggtat cagtgtctcc
      361 tacccaaaga cagtggagca gcacttccca gtggctccag aagaatcagt ctcgagtgtg
      421 tttgggatca gaacagactg ttggagcgga cacagcgcag aataggaaat accacaacac
      481 aagtaagctt cttactaccc aagatttccc acagcctgtt gaagagaagg tcggtccctt
      541 cacgaagata atagaagcca tgggattcac tggacctttg aaatacagta aatggaagat
      601 caagatcgcg gccctccgca tgtacacgag ctgcgtggag aagactgact tcgaggagtt
      661 ctttctgagg tgtcagatgc ccgatacatt caactcctgg tttctcataa ccctgcttca
      721 tgtctggatg tgtctagtcc gaatgaagca ggaaggccgg actgggaagt acatgtgccg
      781 gatcatagtt catttcatgt gggaagatgt ggagcagcgc ggccgcgtca tgggggttaa
      841 ttcctatatc ctaaagaaga acatggccct catgacgaac aatttctatg cagcaatctt
      901 gggatacgat gaggggatcc tttcagatga ccatggcctg gctgctgcgc tctggaggac
      961 cttcttcaac cagaaatgtg aggaccctcg acagcttgaa ttgctggtgg aatatgtgag
     1021 gaaacagatg caatacctgg actccatgaa cggtgaggat ctgctgctga caggggaagt
     1081 gagatggcgc cctctggtgg agaagaatcc acaaagcatc ttgaagcccc atgctcctac
     1141 ttacaatgat gagggccttt gagagactgg tccctccgga cagctggctg gctggctttg
     1201 aggaccttcc atggaagaag tgcctgtttg ccccaggacc ctgaagaagg tggcctgaac
     1261 tgacttgtga acagtacctg ttgaatactc agcccactcg tgttgagttt cttcttcctg
     1321 atctggtggg gttactgggg aggtcctctt gctctttgac aggtcccctc cctcaagaga
     1381 agccccaggc acacttccca agtcccctca gcaccacacg tgactgagag ctttttccga
     1441 aggctgagga agggatgggt aggttagaag ggggtgcctt cactcagaaa cccctgtgct
     1501 tggagcagtt tattaagttc caaagtcaca gtgggtaacc atatactgtt ccccctctgt
     1561 gagccatggg gttgaagtag ccattaaaaa gagagactta tttctgccat ggtttttctt
     1621 tgttccaagg tcttttagaa acatagttaa agcccagtgt agtggtgcat gtctttagtc
     1681 caagtatttg ggaagcagag gcagatgact ctagctaggt tctaggtcag catgatctac
     1741 agagtgaatt acagggcagg cagagctaca cagagaaagc ctgtcttgaa aaaacaagag
     1801 aaaagaaaag tgcaggtgag gccgtgggtt ctccaagctc agggaataac tgcagctcag
     1861 ttagaggcag cacggagagg agcggagagg agaggagagg agaagaggcc aggggctctc
     1921 tgctgctact cctgtcccca ggtcacagag aggagtcact gtctgggcaa ggtacagtct
     1981 gccaggcatg ttcactgaga tccaggaggt ctcaggacca aggggcttgt cacatcctaa
     2041 gtcatttaga aagaacaaaa gtccctttgt cacccacagt gaactgggga aggaacacac
     2101 tctccgcact tggcctctct ttacgtgaga tactgtggcg tgctggtacc atccaagcct
     2161 cggcccggtg tctatcccct ccccaagttc taaagcacgg gctgtgatgg gaacttgagg
     2221 ggccttttct ctctgggcac ttgaagggtc tgttctctct cccccgagac tttgggtcat
     2281 ctcttggaag gttttctgaa attgaggaac gggggtgggg cccgtctcct ccctcccttc
     2341 ccccacccag cttccttcat tgaacttgct ataaaatgag tcatatgaag aaaccctata
     2401 ctgtgaggta tgcgccactt ctgtgaaaac attacaaatc aagccgcctt ctcagtttat
     2461 ttaagatgct tttgttgcaa gcggggctct ggagtgaggc gtcctctgtg agcatgagat
     2521 aatagcacct tgtaactcat tacatctggg cactatttac ataaaccaga ggcgagccag
     2581 gcagggattt gctgattaat ttatttttaa tggactgaag tatgccatgc accaaaataa
     2641 actttactgt gtgtacctaa ctgctcct
//
