LOCUS       NM_029692               2202 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus uridine phosphorylase 2 (Upp2), transcript variant 3,
            mRNA.
ACCESSION   NM_029692
VERSION     NM_029692.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Zhao,H., Han,G., Jiang,Z., Gao,D., Zhang,H., Yang,L., Ma,T.,
            Gao,L., Wang,A., Chao,H.W., Li,Q., Jin,Y. and Chen,H.
  TITLE     Identification of BMAL1-Regulated circadian genes in mouse liver
            and their potential association with hepatocellular carcinoma: Gys2
            and Upp2 as promising candidates
  JOURNAL   Biochem Biophys Res Commun 696, 149422 (2024)
   PUBMED   38183795
  REMARK    GeneRIF: Identification of BMAL1-Regulated circadian genes in mouse
            liver and their potential association with hepatocellular
            carcinoma: Gys2 and Upp2 as promising candidates.
REFERENCE   2  (bases 1 to 2202)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   3  (bases 1 to 2202)
  AUTHORS   Roosild,T.P., Castronovo,S., Villoso,A., Ziemba,A. and Pizzorno,G.
  TITLE     A novel structural mechanism for redox regulation of uridine
            phosphorylase 2 activity
  JOURNAL   J Struct Biol 176 (2), 229-237 (2011)
   PUBMED   21855639
REFERENCE   4  (bases 1 to 2202)
  AUTHORS   Mollah,M.B. and Ishikawa,A.
  TITLE     A wild derived quantitative trait locus on mouse chromosome 2
            prevents obesity
  JOURNAL   BMC Genet 11, 84 (2010)
   PUBMED   20860848
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2202)
  AUTHORS   Zhang,Y., Repa,J.J., Inoue,Y., Hayhurst,G.P., Gonzalez,F.J. and
            Mangelsdorf,D.J.
  TITLE     Identification of a liver-specific uridine phosphorylase that is
            regulated by multiple lipid-sensing nuclear receptors
  JOURNAL   Mol Endocrinol 18 (4), 851-862 (2004)
   PUBMED   14715930
REFERENCE   6  (bases 1 to 2202)
  AUTHORS   Johansson,M.
  TITLE     Identification of a novel human uridine phosphorylase
  JOURNAL   Biochem Biophys Res Commun 307 (1), 41-46 (2003)
   PUBMED   12849978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY133124.1, AK149444.1, AW112009.1 and AL844163.7.
            
            On Jan 25, 2014 this sequence version replaced NM_029692.2.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 3, which lacks an internal segment and is shorter, compared
            to isoform 1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149444.1, AY152393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY133124.1         2-15
            15-2081             AK149444.1         13-2079
            2082-2198           AW112009.1         1-117               c
            2199-2202           AL844163.7         126627-126630
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.16 cM"
     gene            1..2202
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /note="uridine phosphorylase 2"
                     /db_xref="GeneID:76654"
                     /db_xref="MGI:MGI:1923904"
     exon            1..239
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..357
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..516
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..631
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..841
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..988
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..2202
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /note="hexamer: AATAAA"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /note="hexamer: AATATA"
     polyA_site      2199
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
     polyA_site      2202
                     /gene="Upp2"
                     /gene_synonym="1700124F02Rik; UDRPASE2; UP2; UPASE2"
                     /note="major polyA site"
ORIGIN      
        1 gacattgtca gaggagttca aaatactcag ggaagatttt agaggaaatt tcagaaggaa
       61 acctaagttt gaagggaagg tggtattctg acttgaagct gcatcattgt gattagctct
      121 gtaatttaac agcagcctct aatattgctt tttcctgcta tctgcccacc gcagagtatg
      181 gcttccattt tgcctgcttc taatagatcc atgagacctg acaagaatac atacgagaga
      241 aaacggtctg tgtatgttaa gaatccatac ctggaaggca tggacgaaga cattctctat
      301 cacttggatt taggaaccaa aacacacaac ctaccagcaa tgtttgggga tgtaaagttt
      361 gtctgcgttg gtgggagccc gaacagaatg aaggcatttg cacagtttat gcacaaggaa
      421 ctccggttgg agggagatgg agaagacatt gaagacatct gtgcggggac agacagatac
      481 tgcatgttca aaacaggccc cgtgctctcc gtcagtcacg ggatgggcat cccctccatt
      541 tccattatgc tccacgaact catcaaatta ctccaccatg cacactgctg tgatgttacc
      601 atcatcagaa ttggaacgtc agggggaatt gggattgcac caggctccgt tgtaataaca
      661 gatacagctg tagactcctt cttcaagcct cgatttgagc aggtcatctt ggataacgtg
      721 gtcacccgaa gcactgagct tgacaaagaa ctggctaatg atctgttcaa ctgtagcaga
      781 gaaatcccca atgttccaac cctcatcgga cacacgatgt gtacctatga cttttatgaa
      841 ggccaaggtc gcctagatgg ggcgttatgc tccttttcga gagagaaaaa gctagactac
      901 ttgaagagag catacagagc tggtgtcagg aacattgaaa tggaatcgac tgtgttcgca
      961 gccatgtgtg gcctgtgtgg cctgagagct gctgtggtct gtgtgacact tcttgacaga
     1021 ctcgagagtg accaaatcaa tttgtcccat gatgtcctgg tggagtacca gcaacggcca
     1081 cagcttctaa tctcaaattt catcaaaaaa cagcttggac tttgtgacca gatgtcataa
     1141 ctccgaatcc cgccaccctc ctgagagttg ctacacagag ctgcaacgat ggagccatgt
     1201 gttgttcata acattcttat gtaattccca tccttgggct aaaatcataa aagattttta
     1261 tgaaatcttt tatcttaaag ttcaatttat tgtaagagaa tttaatactc atgcgaaatt
     1321 caaatcccat tttggaacga gttaacgaaa gcagtctaat aattaatatt ttaaactcat
     1381 gaaatgtgac atttggagtt tcacatgcag cattaattaa gcttacatca aaatcagcca
     1441 tttgtagatg gttaccagtt gcttgctgaa gcagatccag aagtgtatgt taggatggtg
     1501 tcagcacttc taggtgttgg acaagtgaca aaaattgatc atgcacattc aaaatattta
     1561 caaaaatgtg ccagtgtaat ataggctggt atggaagaat tatcctcggg gaaatatggc
     1621 catccctttc ctcctgtccc tgtacaattt cagtgcacac agaataaaat tagacgctat
     1681 gaatgtatgc tctgcaagaa tcacagaaca tcacagtttg agatcacaca ttttttctca
     1741 aatgaaaacc attggtcatg caaagacctt tattccctgc cctcccccag aaatcagaag
     1801 tgactcaatt gccttctcac aatctttttt atttctataa agaaatatgt catgagaaag
     1861 ctgtatttgt tgtttcaata agaaccgaat aagctgtaga attggttaac aaccaaattt
     1921 taaaagatca agatagtgat cgagtccttc tgtttaactt tggggtaggt ctcattctag
     1981 gcctgcacct cagactcccc tggttgaact cgcatgcagc agaggctcca ggagttgatc
     2041 tcaccttcaa ggttcttttg aacatttaaa aattggagag tctggttggg gtaagagtgg
     2101 aggaggtttt gcaaatatgt atagtatgta atgttgtgtg tgtatatttt tttttatatg
     2161 gatggggaac gaataaaata tatctctcac catgctgcag aa
//
