LOCUS       NM_001159402            1269 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus uridine phosphorylase 1 (Upp1), transcript variant 2,
            mRNA.
ACCESSION   NM_001159402
VERSION     NM_001159402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   2  (bases 1 to 1269)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   3  (bases 1 to 1269)
  AUTHORS   Harada,N., Nagasaki,H., Yamamoto,H., Matsubara,K., Suzuki,T.,
            Gomori,A., Yokogawa,T., Matsuo,K. and Miyadera,K.
  TITLE     Depletion of plasma thymidine results in growth retardation and
            mitochondrial myopathy in mice overexpressing human thymidine
            phosphorylase
  JOURNAL   J Biol Chem 299 (3), 103002 (2023)
   PUBMED   36773803
REFERENCE   4  (bases 1 to 1269)
  AUTHORS   Okamura,E., Tam,O.H., Posfai,E., Li,L., Cockburn,K., Lee,C.Q.E.,
            Garner,J. and Rossant,J.
  TITLE     Esrrb function is required for proper primordial germ cell
            development in presomite stage mouse embryos
  JOURNAL   Dev Biol 455 (2), 382-392 (2019)
   PUBMED   31315026
REFERENCE   5  (bases 1 to 1269)
  AUTHORS   de Soysa,T.Y., Ranade,S.S., Okawa,S., Ravichandran,S., Huang,Y.,
            Salunga,H.T., Schricker,A., Del Sol,A., Gifford,C.A. and
            Srivastava,D.
  TITLE     Single-cell analysis of cardiogenesis reveals basis for organ-level
            developmental defects
  JOURNAL   Nature 572 (7767), 120-124 (2019)
   PUBMED   31341279
REFERENCE   6  (bases 1 to 1269)
  AUTHORS   Cao,D., Russell,R.L., Zhang,D., Leffert,J.J. and Pizzorno,G.
  TITLE     Uridine phosphorylase (-/-) murine embryonic stem cells clarify the
            key role of this enzyme in the regulation of the pyrimidine salvage
            pathway and in the activation of fluoropyrimidines
  JOURNAL   Cancer Res 62 (8), 2313-2317 (2002)
   PUBMED   11956089
REFERENCE   7  (bases 1 to 1269)
  AUTHORS   Pugmire,M.J. and Ealick,S.E.
  TITLE     Structural analyses reveal two distinct families of nucleoside
            phosphorylases
  JOURNAL   Biochem J 361 (Pt 1), 1-25 (2002)
   PUBMED   11743878
  REMARK    Review article
REFERENCE   8  (bases 1 to 1269)
  AUTHORS   Cao,D., Nimmakayalu,M.A., Wang,F., Zhang,D., Handschumacher,R.E.,
            Bray-Ward,P. and Pizzorno,G.
  TITLE     Genomic structure, chromosomal mapping, and promoter region
            analysis of murine uridine phosphorylase gene
  JOURNAL   Cancer Res 59 (19), 4997-5001 (1999)
   PUBMED   10519414
REFERENCE   9  (bases 1 to 1269)
  AUTHORS   Saijoh,Y., Fujii,H., Meno,C., Sato,M., Hirota,Y., Nagamatsu,S.,
            Ikeda,M. and Hamada,H.
  TITLE     Identification of putative downstream genes of Oct-3, a pluripotent
            cell-specific transcription factor
  JOURNAL   Genes Cells 1 (2), 239-252 (1996)
   PUBMED   9140067
REFERENCE   10 (bases 1 to 1269)
  AUTHORS   Watanabe,S., Hino,A., Wada,K., Eliason,J.F. and Uchida,T.
  TITLE     Purification, cloning, and expression of murine uridine
            phosphorylase
  JOURNAL   J Biol Chem 270 (20), 12191-12196 (1995)
   PUBMED   7744869
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA493594.1, AK136474.1 and BX527866.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136474.1, SRR5189685.31254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               CA493594.1         39-158
            121-1249            AK136474.1         2-1130
            1250-1269           BX527866.1         495-514
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 6.13 cM"
     gene            1..1269
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /note="uridine phosphorylase 1"
                     /db_xref="GeneID:22271"
                     /db_xref="MGI:MGI:1097668"
     exon            1..154
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            155..230
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            231..296
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1185
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /EC_number="2.4.2.3"
                     /note="UPase 1; urdPase 1"
                     /codon_start=1
                     /product="uridine phosphorylase 1"
                     /protein_id="NP_001152874.1"
                     /db_xref="CCDS:CCDS24432.1"
                     /db_xref="GeneID:22271"
                     /db_xref="MGI:MGI:1097668"
                     /translation="MAATGTEAKDLENHHNDCFIQLSNPNIAAMKEDVLYHFNLSTST
                     HDFPAMFGDVKFVCVGGSSSRMNTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKAG
                     PVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAV
                     NECFKPEFEQIVLGKRVIRNTNLDAQLVQELVQCSSDLNEFPMVVGNTMCTLDFYEGQ
                     GRLDGALCSYTEKDKQSYLRAAHAAGVRNIEMESSVFATMCSACGLKAAVVCVTLLDR
                     LQGDQINTPHDVLVEYQQRPQRLVGHFIKKSLGRA"
     exon            297..414
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            415..573
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            574..688
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            689..898
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1045
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1255
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /note="hexamer: AATAAA"
     polyA_site      1253
                     /gene="Upp1"
                     /gene_synonym="UdRPase; Up; UPase; Upp"
                     /note="major polyA site"
ORIGIN      
        1 aaagccaggc ggtgacctct gggcggggct gcgggagaca gatcagggga ggcgagcctg
       61 ccgacagcta ggttctcctt tctggtcctt ttaaaagctc tggtgcgctg cttctctctc
      121 acagtgctcc agcgcggcca acggggactg agcggtcttg acgaagtgat tgactggtgg
      181 tctctgacac tctggaagcc ttctcgcgac gtggacatcg gtctctgaca gtcctcctac
      241 agtgagaaca tggcagctac aggaactgaa gcaaaggacc ttgaaaacca tcacaatgac
      301 tgcttcatcc aactttcaaa tccaaacata gcagcaatga aggaagacgt gctctaccat
      361 ttcaacctca gcactagcac acacgatttc cctgctatgt ttggagacgt gaagtttgtg
      421 tgtgttggtg gaagctcttc ccggatgaac accttcatca agtatgtggc tgcagagctg
      481 ggccttgacc atccagggaa ggaatatccc aacatctgtg caggcactga ccgctacgcc
      541 atgtataaag ccgggcccgt gctgtctgtg agccatggca tgggcattcc ttccatcggc
      601 atcatgttgc acgagctcat caagatgctg taccatgcca ggtgctccaa catcaccatc
      661 atccgcattg gcacttcagg cgggataggt ctggagcctg gctctgttgt catcacgcag
      721 caggcagtga atgagtgctt caagccggag tttgagcaga ttgtcctggg aaaacgggtg
      781 attcgcaaca ccaacctgga cgcgcagctg gttcaggagt tggtgcagtg ctcctcagac
      841 ctgaatgagt tccccatggt tgtgggcaac accatgtgca ccttggactt ctatgagggg
      901 caaggccgtc tggatggcgc cctctgctcc tacacagaga aagacaaaca gtcttatctg
      961 cgtgcagccc atgccgcggg tgtccgaaat atcgagatgg aatcttcggt gtttgccacc
     1021 atgtgcagtg cctgtggcct gaaagcggct gtggtgtgtg tcacccttct ggaccgtctg
     1081 caaggagacc agatcaacac tccccacgat gtgcttgtgg aataccagca gagaccacag
     1141 cggctagtgg gccacttcat caagaagagc ctgggacggg cctgagccct gtgcctttcc
     1201 gccccggaga agcctctgca actcctgggc aataaatcta ttttttcata acacaaaaaa
     1261 aaaaaaaaa
//
