LOCUS       NM_023478               1106 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus uroplakin 3A (Upk3a), mRNA.
ACCESSION   NM_023478
VERSION     NM_023478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Ortega,M.A., Villiger,R.K., Harrison-Chau,M., Lieu,S.,
            Tamashiro,K.K., Lee,A.J., Fujimoto,B.A., Patwardhan,G.Y., Kepler,J.
            and Fogelgren,B.
  TITLE     Exocyst inactivation in urothelial cells disrupts autophagy and
            activates non-canonical NF-kappaB signaling
  JOURNAL   Dis Model Mech 15 (10) (2022)
   PUBMED   36004645
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Deuper,L., Meuser,M., Thiesler,H., Jany,U.W.H., Rudat,C.,
            Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric
            mesenchyme by balancing SHH and BMP4 signaling
  JOURNAL   Development 149 (17) (2022)
   PUBMED   36094016
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Guo,C., Zhang,Y., Tan,R., Tang,Z., Lam,C.M., Ye,X., Wang,Z. and
            Li,X.
  TITLE     Arid1a regulates bladder urothelium formation and maintenance
  JOURNAL   Dev Biol 485, 61-69 (2022)
   PUBMED   35283102
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Kim,E., Choi,S., Kang,B., Kong,J., Kim,Y., Yoon,W.H., Lee,H.R.,
            Kim,S., Kim,H.M., Lee,H., Yang,C., Lee,Y.J., Kang,M., Roh,T.Y.,
            Jung,S., Kim,S., Ku,J.H. and Shin,K.
  TITLE     Creation of bladder assembloids mimicking tissue regeneration and
            cancer
  JOURNAL   Nature 588 (7839), 664-669 (2020)
   PUBMED   33328632
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Jones,L.K., Lam,R., McKee,K.K., Aleksandrova,M., Dowling,J.,
            Alexander,S.I., Mallawaarachchi,A., Cottle,D.L., Short,K.M.,
            Pais,L., Miner,J.H., Mallett,A.J., Simons,C., McCarthy,H.,
            Yurchenco,P.D. and Smyth,I.M.
  TITLE     A mutation affecting laminin alpha 5 polymerisation gives rise to a
            syndromic developmental disorder
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32439764
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Kong,X.T., Deng,F.M., Hu,P., Liang,F.X., Zhou,G., Auerbach,A.B.,
            Genieser,N., Nelson,P.K., Robbins,E.S., Shapiro,E., Kachar,B. and
            Sun,T.T.
  TITLE     Roles of uroplakins in plaque formation, umbrella cell enlargement,
            and urinary tract diseases
  JOURNAL   J Cell Biol 167 (6), 1195-1204 (2004)
   PUBMED   15611339
REFERENCE   7  (bases 1 to 1106)
  AUTHORS   Hu,P., Meyers,S., Liang,F.X., Deng,F.M., Kachar,B., Zeidel,M.L. and
            Sun,T.T.
  TITLE     Role of membrane proteins in permeability barrier function:
            uroplakin ablation elevates urothelial permeability
  JOURNAL   Am J Physiol Renal Physiol 283 (6), F1200-F1207 (2002)
   PUBMED   12388410
REFERENCE   8  (bases 1 to 1106)
  AUTHORS   Hu,P., Deng,F.M., Liang,F.X., Hu,C.M., Auerbach,A.B., Shapiro,E.,
            Wu,X.R., Kachar,B. and Sun,T.T.
  TITLE     Ablation of uroplakin III gene results in small urothelial plaques,
            urothelial leakage, and vesicoureteral reflux
  JOURNAL   J Cell Biol 151 (5), 961-972 (2000)
   PUBMED   11085999
REFERENCE   9  (bases 1 to 1106)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
REFERENCE   10 (bases 1 to 1106)
  AUTHORS   Ryan,A.M., Womack,J.E., Yu,J., Lin,J.H., Wu,X.R., Sun,T.T.,
            Clarke,V. and D'Eustachio,P.
  TITLE     Chromosomal localization of uroplakin genes of cattle and mice
  JOURNAL   Mamm Genome 4 (11), 656-661 (1993)
   PUBMED   8281015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772308.4, BX512009.1, BY703997.1 and AV022830.1.
            
            On Jul 8, 2009 this sequence version replaced NM_023478.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125338.1, AF222750.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL772308.4         15450-15580
            132-194             AL772308.4         16335-16397
            195-716             BX512009.1         2-523
            717-1040            BY703997.1         228-551
            1041-1041           AL772308.4         20804-20804
            1042-1093           BY703997.1         552-603
            1094-1106           AV022830.1         303-315
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.25 cM"
     gene            1..1106
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /note="uroplakin 3A"
                     /db_xref="GeneID:22270"
                     /db_xref="MGI:MGI:98914"
     exon            1..131
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..943
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /note="uroplakin-3a; uroplakin III; proplakin IIIa;
                     uroplakin 3"
                     /codon_start=1
                     /product="uroplakin-3a precursor"
                     /protein_id="NP_075967.2"
                     /db_xref="CCDS:CCDS27716.1"
                     /db_xref="GeneID:22270"
                     /db_xref="MGI:MGI:98914"
                     /translation="MLLLWALLALGCLRCGWTVNLQPQLASVTFATNNPTLTTVALEK
                     PLCMFDSSEPLSGSYEVYLYAMVDSAMSRNVSVQDSAGVPLSTTFRQTQGGRSGPYKA
                     AAFDLTPCGDLPSLDAVGDVTQASEILNAYLVRVGNNGTCFWDPNFQGLCNPPLTAAT
                     EYRFKYVLVNMSTGLVQDQTLWSDPIWTNRPIPYSAIDTWPGRRSGGMIVITSILGSL
                     PFFLLVGFAGAIILSFVDMGSSDGEMTHDSQITQEAVPKTLGTSEPSYSSVNRGPPLD
                     RAEVFSSKLQD"
     exon            132..287
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     exon            288..567
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..650
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..783
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1106
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1076..1081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /note="hexamer: AATAAA"
     polyA_site      1095
                     /gene="Upk3a"
                     /gene_synonym="1110017C07Rik; UP3a; UPIII; Upk3"
                     /note="major polyA site"
ORIGIN      
        1 ctggtgacag gtgagcggag ctgcagggag caggtgcgcg ttctcaggca gagtgcatcg
       61 cgaaggctca tctcgggcga tgctcctgct ctgggccctg ctggctctcg gatgcctgcg
      121 gtgtggctgg actgtgaacc tccagcccca actggccagt gtgacctttg ccaccaacaa
      181 ccctaccctc accaccgtgg ccttggagaa gcctctgtgc atgtttgata gctcagagcc
      241 actcagcggc tcttacgagg tttacctcta tgctatggtc gactcagcca tgtccaggaa
      301 tgtgtctgta caggacagcg ctggcgtccc actgagcacc actttccggc aaacccaggg
      361 tgggaggtca ggcccctata aagctgcggc ctttgacctg accccttgtg gtgacttgcc
      421 cagcctggat gctgttggag atgtgaccca ggcctcagag atcctgaacg catacctagt
      481 cagggtgggc aacaacggga cctgtttttg ggaccccaac ttccagggcc tctgcaaccc
      541 acccctgaca gcggccactg agtacagatt caagtatgtc ctggtcaaca tgtccacagg
      601 cttggtgcag gaccagacac tatggtcaga tcccatctgg accaaccggc ccatccccta
      661 ctcggccatc gacacgtggc ccggccggcg gagtggaggc atgattgtca tcacgtccat
      721 tctgggctcc ctgcccttct tcctgctcgt gggtttcgct ggagccatca tcctcagctt
      781 tgtggacatg ggcagttctg atggggaaat gacacacgac tcacagatca cccaggaggc
      841 tgttcccaag accctgggga cttctgagcc ttcctactca tctgtgaacc ggggcccacc
      901 cctagacaga gcagaggtgt tctccagcaa gcttcaagac tgaaacaagc caagccccgg
      961 caccaagcca tggccacttt tcaacttggc cctgtggttg gcagtgatgg tgtttatgct
     1021 ctgactggac cagatgtgaa acatgacatc ttggtccaac ctcatgaaaa agctaaataa
     1081 aatcttaagt gttaatgtcc agagtg
//
