LOCUS       NM_009476                890 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus uroplakin 2 (Upk2), mRNA.
ACCESSION   NM_009476
VERSION     NM_009476.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Lopes,F.M., Roberts,N.A., Zeef,L.A., Gardiner,N.J. and Woolf,A.S.
  TITLE     Overactivity or blockade of transforming growth factor-beta each
            generate a specific ureter malformation
  JOURNAL   J Pathol 249 (4), 472-484 (2019)
   PUBMED   31400222
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Liu,C., Tate,T., Batourina,E., Truschel,S.T., Potter,S., Adam,M.,
            Xiang,T., Picard,M., Reiley,M., Schneider,K., Tamargo,M., Lu,C.,
            Chen,X., He,J., Kim,H. and Mendelsohn,C.L.
  TITLE     Pparg promotes differentiation and regulates mitochondrial gene
            expression in bladder epithelial cells
  JOURNAL   Nat Commun 10 (1), 4589 (2019)
   PUBMED   31597917
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Schafer,F.M., Algarrahi,K., Savarino,A., Yang,X., Seager,C.,
            Franck,D., Costa,K., Liu,S., Logvinenko,T., Adam,R. and Mauney,J.R.
  TITLE     Mode of Surgical Injury Influences the Source of Urothelial
            Progenitors during Bladder Defect Repair
  JOURNAL   Stem Cell Reports 9 (6), 2005-2017 (2017)
   PUBMED   29173895
  REMARK    GeneRIF: Conversely, repair of focal mucosal defects not only
            employs this mechanism, but in parallel host intermediate cell
            daughters expressing uroplakin 2 give rise to themselves and are
            also contributors to superficial cells in neotissues.
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Lee,A.J., Polgar,N., Napoli,J.A., Lui,V.H., Tamashiro,K.K.,
            Fujimoto,B.A., Thompson,K.S. and Fogelgren,B.
  TITLE     Fibroproliferative response to urothelial failure obliterates the
            ureter lumen in a mouse model of prenatal congenital obstructive
            nephropathy
  JOURNAL   Sci Rep 6, 31137 (2016)
   PUBMED   27511831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Oostergetel,G.T., Keegstra,W. and Brisson,A.
  TITLE     Structure of the major membrane protein complex from urinary
            bladder epithelial cells by cryo-electron crystallography
  JOURNAL   J Mol Biol 314 (2), 245-252 (2001)
   PUBMED   11718558
  REMARK    GeneRIF: structure of the major membrane protein complex from
            urinary bladder epithelial cells by cryo-electron crystallography
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Zhang,Z.T., Pak,J., Huang,H.Y., Shapiro,E., Sun,T.T., Pellicer,A.
            and Wu,X.R.
  TITLE     Role of Ha-ras activation in superficial papillary pathway of
            urothelial tumor formation
  JOURNAL   Oncogene 20 (16), 1973-1980 (2001)
   PUBMED   11360181
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Lin,J.H., Zhao,H. and Sun,T.T.
  TITLE     A tissue-specific promoter that can drive a foreign gene to express
            in the suprabasal urothelial cells of transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 679-683 (1995)
   PUBMED   7846036
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Ryan,A.M., Womack,J.E., Yu,J., Lin,J.H., Wu,X.R., Sun,T.T.,
            Clarke,V. and D'Eustachio,P.
  TITLE     Chromosomal localization of uroplakin genes of cattle and mice
  JOURNAL   Mamm Genome 4 (11), 656-661 (1993)
   PUBMED   8281015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104260.1, CX565093.1, AC122428.4 and AW491716.1.
            
            On Jan 12, 2007 this sequence version replaced NM_009476.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08030.1, DQ358978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               BC104260.1         1-435
            436-481             CX565093.1         646-691
            482-702             AC122428.4         31668-31888
            703-890             AW491716.1         1-188               c
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..890
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /note="uroplakin 2"
                     /db_xref="GeneID:22269"
                     /db_xref="MGI:MGI:98913"
     exon            1..137
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..616
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /note="UP2; uroplakin II"
                     /codon_start=1
                     /product="uroplakin-2 precursor"
                     /protein_id="NP_033502.2"
                     /db_xref="CCDS:CCDS23112.1"
                     /db_xref="GeneID:22269"
                     /db_xref="MGI:MGI:98913"
                     /translation="MASTLPVQTLPLILILLAVLAPGTADFNISSLSGLLSPALTESL
                     LIALPPCHLTGGNATLMVRRANDSKVVKSDFVVPPCRGRRELVSVVDSGSGYTVTRLS
                     AYQVTNLTPGTKYYISYRVQKGTSTESSPETPMSTLPRKNMESIGLGMARTGGMVVIT
                     VLLSVAMFLLVVGLIVALALGARK"
     exon            138..269
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            270..408
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            409..479
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /inference="alignment:Splign:2.1.0"
     exon            480..874
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      845..850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /note="hexamer: AATAAA"
     polyA_site      867
                     /gene="Upk2"
                     /gene_synonym="UPII"
                     /note="major polyA site"
ORIGIN      
        1 attggcccca ggaaacccca gcctgtcagc acctgttcca ggatccagtt cccagcgcag
       61 tatggcatcc acactgcctg tccagacctt gcccctgatc ctgattctgc tggctgtcct
      121 ggctccgggg actgcagact tcaacatctc aagcctctct ggtctgctgt ctccggcgct
      181 aacagaaagc ctgttaattg ccttgccccc atgtcacctc acgggaggta atgccacatt
      241 gatggtccgg agagccaacg acagcaaagt ggttaagtca gactttgtgg tgcctccatg
      301 tcgcgggcgc agggagcttg tgagcgtggt ggacagtggg tctggctaca ccgtcacaag
      361 gctcagcgca tatcaggtga caaacctaac accaggaacc aaatactaca tatcctaccg
      421 agtacagaag gggacatcca ccgagtccag tccagagact cccatgtcca cgcttcctcg
      481 aaaaaacatg gagtctattg ggttaggaat ggcccggaca ggagggatgg tggtcatcac
      541 agtgctgctg tctgtggcca tgttcctgtt ggtcgtgggt cttattgttg ccctggcact
      601 gggtgcccgc aaatgagaag ggctctcctg catcccaggc tcctccaaga agtccagcct
      661 gcctcctgcc aggctgtagt cactggcttc tcagtggctt ttcttccctc tccccgcccc
      721 ctcctcgagt ccactcctga cagtgccccc tccctgctcc ctgtctcacc ttgcagcact
      781 ccctgctagc cccactgcaa tcctgccaac actgatttat ctcttaactg tacttaattc
      841 tcacaataaa ggctgaccca cgtagtatgt ctcaaaaaaa aaaaaaaaaa
//
