LOCUS       NM_178924               1769 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus uroplakin 1B (Upk1b), mRNA.
ACCESSION   NM_178924
VERSION     NM_178924.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Qasrawi,F., Meuser,M., Lehnhoff,F., Schulte,M. and Kispert,A.
  TITLE     S100A1 expression characterizes terminally differentiated
            superficial cells in the urothelium of the murine bladder and
            ureter
  JOURNAL   Histochem Cell Biol 158 (4), 389-399 (2022)
   PUBMED   35648290
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Deuper,L., Meuser,M., Thiesler,H., Jany,U.W.H., Rudat,C.,
            Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric
            mesenchyme by balancing SHH and BMP4 signaling
  JOURNAL   Development 149 (17) (2022)
   PUBMED   36094016
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Kurita,T., Medina,R.T., Mills,A.A. and Cunha,G.R.
  TITLE     Role of p63 and basal cells in the prostate
  JOURNAL   Development 131 (20), 4955-4964 (2004)
   PUBMED   15371309
REFERENCE   7  (bases 1 to 1769)
  AUTHORS   Oostergetel,G.T., Keegstra,W. and Brisson,A.
  TITLE     Structure of the major membrane protein complex from urinary
            bladder epithelial cells by cryo-electron crystallography
  JOURNAL   J Mol Biol 314 (2), 245-252 (2001)
   PUBMED   11718558
  REMARK    GeneRIF: structure of the major membrane protein complex from
            urinary bladder epithelial cells by cryoelectron crystallography
REFERENCE   8  (bases 1 to 1769)
  AUTHORS   Webb,G.C., Finch,J.L. and Cowled,P.A.
  TITLE     Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16
            bands B5-C2 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 37-38 (1999)
   PUBMED   10343097
REFERENCE   9  (bases 1 to 1769)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
REFERENCE   10 (bases 1 to 1769)
  AUTHORS   Ryan,A.M., Womack,J.E., Yu,J., Lin,J.H., Wu,X.R., Sun,T.T.,
            Clarke,V. and D'Eustachio,P.
  TITLE     Chromosomal localization of uroplakin genes of cattle and mice
  JOURNAL   Mamm Genome 4 (11), 656-661 (1993)
   PUBMED   8281015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053004.1, AK086926.1, AK083101.1, BB427704.2 and D18653.1.
            
            On May 15, 2008 this sequence version replaced NM_178924.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046604.1, AK083101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK053004.1         2-3
            3-1319              AK086926.1         2-1318
            1320-1363           AK083101.1         1320-1363
            1364-1761           BB427704.2         289-686
            1762-1769           D18653.1           62-69
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.87 cM"
     gene            1..1769
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /note="uroplakin 1B"
                     /db_xref="GeneID:22268"
                     /db_xref="MGI:MGI:98912"
     exon            1..56
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..144
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..858
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /note="UP1b; uroplakin Ib"
                     /codon_start=1
                     /product="uroplakin-1b"
                     /protein_id="NP_849255.2"
                     /db_xref="CCDS:CCDS28174.1"
                     /db_xref="GeneID:22268"
                     /db_xref="MGI:MGI:98912"
                     /translation="MAKDDSTVRCFQGLLIFGHVIVGMCGIALTAECIFFVSDQHSLY
                     PLLEATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFIMMFIVYGFE
                     VASCITAATQRDFFTTNLFLKQMLMRYQNNSPPTNDDEWKNNGVTKTWDRLMLQDHCC
                     GVNGPSDWQKYTSAFRVENNDADYPWPRQCCVMDKLKEPLNLDACKLGVPGYYHSQGC
                     YELISGPMDRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY"
     exon            145..345
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..420
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..543
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..723
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..807
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1769
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1283..1288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /note="hexamer: AAGAAA"
     polyA_site      1317
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="Upk1b"
                     /gene_synonym="Tspan20; UPIb; Upk1"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtgag tctgtgcagc accggagaag aaggcagagg agaccaggca gccggtcttt
       61 tagaaaatcc tgaagatggc caaagacgat tccactgttc gttgcttcca gggcctgttg
      121 atttttggac acgtaattgt tggtatgtgt ggcatcgccc tgacagcaga gtgtatcttc
      181 tttgtatctg accaacacag tctttaccca cttctcgaag ccaccaacaa tgatgatatc
      241 ttcggggcag cttggatagg catgttcgtg ggcatctgcc tcttctgctt gtccgttcta
      301 gccatagtag gaattatgaa gtccaacagg aaaatcctct tggcgtactt catcatgatg
      361 tttatagtgt acggttttga agtggcatct tgcatcacag cagcaacaca acgcgacttt
      421 ttcacaacca acctcttcct gaagcagatg ctgatgaggt atcaaaacaa cagtccccca
      481 accaatgacg acgaatggaa gaacaacggg gtcaccaaga cctgggatag gctcatgctg
      541 caggaccact gctgtggtgt aaacggtccg tcagactggc agaaatacac ctctgccttc
      601 cgggtggaga ataacgatgc tgactacccc tggcctcggc agtgctgcgt catggacaag
      661 cttaaagagc ctctcaacct ggacgcttgc aaacttggag tgcctggtta ttaccacagt
      721 cagggctgct atgaactgat ctctggacca atggaccggc atgcctgggg agttgcctgg
      781 tttggatttg ccatcctctg ctggactttt tgggttctcc tgggcaccat gttctactgg
      841 agcagaattg aatattaagc acagacagtg tctccaccat acctccctcc ctccctgggt
      901 gactctgaat ttggtgctgg aacctgctgt ttcgtgacac gccctctgtg tgctctgccc
      961 cgtgactcgt gcttgtttct ctcaaatgcc agttccggtg gaatgggctt cctttaggct
     1021 ttcaagatgc tgcaatcctt agcagaaata tttctcatcc ttgcctaaga ttccgaaatg
     1081 tatttatata ctataagaca gaaggtgtac tatatatgta ctatatataa tatagtactt
     1141 acgtgtacta tataagacag aaagtttgga gaatggagac gactctcatt cctgtctatg
     1201 tttaatgtgg aggcacaatg atattcaaag gaacctgctt caccattcat tataagctct
     1261 gtctgtattg agcagcaaat tcaagaaaca gagagcccat ctctctattt tcttcaacct
     1321 tgaaagactt ttgtttgtca ctgtgtaggc tgggggagga gggttgcact gtgaaagagg
     1381 aggaaatggc agtcatgctt tcttctgcct ctggttctgc tgtgacttct gtctgcagtg
     1441 ttcctcacac ttttggatgc ttttagtctc cagtacaacc cttgattttc agatttcctc
     1501 tcatgccctg tggagtgatg tgcattgagt gtatggaaac tttgggggtg tcggccgtgc
     1561 ccgatttaca tcagctcagt ctttgccctc agaggtttca accggaaaca cttcccaaac
     1621 cgcgggatcc atgccagcta ttcaaacaag tgatttatag ggtcttttgt ttgctgtcaa
     1681 aatagtttgc tcacattaac gatcctgaag gaagtcctga caagtcacca tttgtttgcc
     1741 tatccataaa taaaggagcc cataaaata
//
