LOCUS       NM_026815               1308 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus uroplakin 1A (Upk1a), mRNA.
ACCESSION   NM_026815 XM_485904
VERSION     NM_026815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Munipalli,S.B. and Yenugu,S.
  TITLE     Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity,
            Decreased Bacterial Clearance Capacity, and Drastic Changes in the
            Testicular Transcriptome
  JOURNAL   Reprod Sci 30 (3), 914-927 (2023)
   PUBMED   36042152
  REMARK    GeneRIF: Uroplakin 1a Knockout Mice Display Marginal Reduction in
            Fecundity, Decreased Bacterial Clearance Capacity, and Drastic
            Changes in the Testicular Transcriptome.
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Deuper,L., Meuser,M., Thiesler,H., Jany,U.W.H., Rudat,C.,
            Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric
            mesenchyme by balancing SHH and BMP4 signaling
  JOURNAL   Development 149 (17) (2022)
   PUBMED   36094016
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Liu,C., Tate,T., Batourina,E., Truschel,S.T., Potter,S., Adam,M.,
            Xiang,T., Picard,M., Reiley,M., Schneider,K., Tamargo,M., Lu,C.,
            Chen,X., He,J., Kim,H. and Mendelsohn,C.L.
  TITLE     Pparg promotes differentiation and regulates mitochondrial gene
            expression in bladder epithelial cells
  JOURNAL   Nat Commun 10 (1), 4589 (2019)
   PUBMED   31597917
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Oostergetel,G.T., Keegstra,W. and Brisson,A.
  TITLE     Structure of the major membrane protein complex from urinary
            bladder epithelial cells by cryo-electron crystallography
  JOURNAL   J Mol Biol 314 (2), 245-252 (2001)
   PUBMED   11718558
  REMARK    GeneRIF: structure of the major membrane protein complex from
            urinary bladder epithelial cells by cryo-electron crystallography
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Zhou,G., Mo,W.J., Sebbel,P., Min,G., Neubert,T.A., Glockshuber,R.,
            Wu,X.R., Sun,T.T. and Kong,X.P.
  TITLE     Uroplakin Ia is the urothelial receptor for uropathogenic
            Escherichia coli: evidence from in vitro FimH binding
  JOURNAL   J Cell Sci 114 (Pt 22), 4095-4103 (2001)
   PUBMED   11739641
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Yabe,D., Nakamura,T., Kanazawa,N., Tashiro,K. and Honjo,T.
  TITLE     Calumenin, a Ca2+-binding protein retained in the endoplasmic
            reticulum with a novel carboxyl-terminal sequence, HDEF
  JOURNAL   J Biol Chem 272 (29), 18232-18239 (1997)
   PUBMED   9218460
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Ryan,A.M., Womack,J.E., Yu,J., Lin,J.H., Wu,X.R., Sun,T.T.,
            Clarke,V. and D'Eustachio,P.
  TITLE     Chromosomal localization of uroplakin genes of cattle and mice
  JOURNAL   Mamm Genome 4 (11), 656-661 (1993)
   PUBMED   8281015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK004014.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004014.1, DV043876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1308              AK004014.1         2-1309
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.78 cM"
     gene            1..1308
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /note="uroplakin 1A"
                     /db_xref="GeneID:109637"
                     /db_xref="MGI:MGI:98911"
     exon            1..21
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            22..109
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..802
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /note="UP1a; UPIa; UPKa; uroplakin Ia"
                     /codon_start=1
                     /product="uroplakin-1a"
                     /protein_id="NP_081091.1"
                     /db_xref="CCDS:CCDS21103.1"
                     /db_xref="GeneID:109637"
                     /db_xref="MGI:MGI:98911"
                     /translation="MASAATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQ
                     YRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIV
                     YIFECASCITSYTHRDYMVSNPSLITKQMLTYYSADTDQGQELTRLWDRIMIEQECCG
                     TSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCF
                     EHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL"
     exon            110..310
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..385
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..493
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..673
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..757
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1308
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1308
                     /gene="Upk1a"
                     /gene_synonym="1110031P12Rik; Tspan21; Upk1"
                     /note="putative"
ORIGIN      
        1 agagaggctt ctgtagagaa gcaggaagat ggcttctgca gcgacagagg gagagaaggg
       61 gtctcctgtg gtggtggggc tgctggtcgt gggcaacatc attattttgc tgtcaggcct
      121 ggccctgttt gcggagacag tgtgggtaac agctgaccag taccgcgtgt acccactgat
      181 gggcgtctca ggcaaggatg atgtcttcgc tggcgcctgg attgccatct tctgcggctt
      241 ctccttcttc gtcgtggcca gctttggtgt aggagctgcg ctctgtcgtc gtcggtacat
      301 gatcctcacg tacctgctgc tgatgctcat cgtctacatc ttcgagtgtg cctcctgcat
      361 cacatcctac acccaccgcg actatatggt gtccaaccca tccctgataa ccaagcaaat
      421 gttgacctac tacagtgcag acactgacca gggccaggag ctaacccgac tctgggaccg
      481 gatcatgatt gagcaagagt gttgtggcac atctggcccc atggactggg tgaattacac
      541 atcagccttc cgggcagcca ccccggaagt ggtgttcccg tggcccccac tgtgctgtcg
      601 tcggacaggc aacttcatcc ccatcaatga agatggctgc cgagtaggcc acatggacta
      661 cctgtttacc aagggttgct tcgagcacat cggccatgcc attgatagct acacgtgggg
      721 catatcgtgg tttggctttg ccatcttgat gtggaccctc cctgtgatgt tgatagccat
      781 gtatttctac accactctct gaggaggaag gggaggccat agatgcacct tggcctgaag
      841 ctcctgcctc gctgctgcac atgcttggac agcctcaacc tcctccccat cccacctccg
      901 tgtacctcag cctcaaccca ccccatccac ctccctccat tttcccttct tgtgatccca
      961 acatcccttt ctagatgtag gagctgcctc gggccctccc tgtacccctg ggcctggatt
     1021 tgtgtgccca gaacctcttg accctgcttc acttggctga ctacggacaa caacatatct
     1081 tgtccttaga ggcccttccg ctgctcctaa caacccatcc tgccccgaac tgtggcttcc
     1141 ataacttctt gcaggtgtag ccactgctgc tcagtagttt taagctctta tacgcctagg
     1201 tagcgaaaag aggagggtga cacgttctgc cgtggtcatt gtgggggttc ccatcatcac
     1261 cccaacatgt gtctgagcgt tggctggaca cccaataaat actggctg
//
