LOCUS       NM_025924               1402 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UPF3 regulator of nonsense transcripts homolog A
            (yeast) (Upf3a), mRNA.
ACCESSION   NM_025924 XM_356061 XM_907935 XM_978843
VERSION     NM_025924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Ma,X., Li,Y., Chengyan,C., Shen,Y., Wang,H. and Li,T.
  TITLE     Spatial expression of the nonsense-mediated mRNA decay factors
            UPF3A and UPF3B among mouse tissues
  JOURNAL   J Zhejiang Univ Sci B 24 (11), 1062-1068 (2023)
   PUBMED   37961809
  REMARK    GeneRIF: Spatial expression of the nonsense-mediated mRNA decay
            factors UPF3A and UPF3B among mouse tissues.
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Chen,C., Shen,Y., Li,L., Ren,Y., Wang,Z.Q. and Li,T.
  TITLE     UPF3A is dispensable for nonsense-mediated mRNA decay in mouse
            pluripotent and somatic cells
  JOURNAL   Life Sci Alliance 6 (6), e202201589 (2023)
   PUBMED   36997282
  REMARK    GeneRIF: UPF3A is dispensable for nonsense-mediated mRNA decay in
            mouse pluripotent and somatic cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Shum,E.Y., Jones,S.H., Shao,A., Chousal,J.N., Krause,M.D.,
            Chan,W.K., Lou,C.H., Espinoza,J.L., Song,H.W., Phan,M.H.,
            Ramaiah,M., Huang,L., McCarrey,J.R., Peterson,K.J., De Rooij,D.G.,
            Cook-Andersen,H. and Wilkinson,M.F.
  TITLE     The Antagonistic Gene Paralogs Upf3a and Upf3b Govern
            Nonsense-Mediated RNA Decay
  JOURNAL   Cell 165 (2), 382-395 (2016)
   PUBMED   27040500
  REMARK    GeneRIF: Analysis revealed that UPF3A is a broadly acting
            nonsense-mediated RNA decay inhibitor. This discovery implies that
            UPF3A and UPF3B do not primarily work in a complementary or
            redundant manner as previously supposed; instead, they oppose each
            other, allowing this paralog pair to serve as a molecular rheostat
            to modulate the level of gene expression during development.
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Jolly,L.A., Homan,C.C., Jacob,R., Barry,S. and Gecz,J.
  TITLE     The UPF3B gene, implicated in intellectual disability, autism, ADHD
            and childhood onset schizophrenia regulates neural progenitor cell
            behaviour and neuronal outgrowth
  JOURNAL   Hum Mol Genet 22 (23), 4673-4687 (2013)
   PUBMED   23821644
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Song,H.W., Dann,C.T., McCarrey,J.R., Meistrich,M.L., Cornwall,G.A.
            and Wilkinson,M.F.
  TITLE     Dynamic expression pattern and subcellular localization of the
            Rhox10 homeobox transcription factor during early germ cell
            development
  JOURNAL   Reproduction 143 (5), 611-624 (2012)
   PUBMED   22393026
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Ciaudo,C., Bourdet,A., Cohen-Tannoudji,M., Dietz,H.C., Rougeulle,C.
            and Avner,P.
  TITLE     Nuclear mRNA degradation pathway(s) are implicated in Xist
            regulation and X chromosome inactivation
  JOURNAL   PLoS Genet 2 (6), e94 (2006)
   PUBMED   16789828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC116988.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XM_356061.3, XM_907935.2, XM_978843.1, NM_025924.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116988.1, AK011127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.38 cM"
     gene            1..1402
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /note="UPF3 regulator of nonsense transcripts homolog A
                     (yeast)"
                     /db_xref="GeneID:67031"
                     /db_xref="MGI:MGI:1914281"
     exon            1..270
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1338
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /codon_start=1
                     /product="regulator of nonsense transcripts 3A"
                     /protein_id="NP_080200.1"
                     /db_xref="CCDS:CCDS40235.1"
                     /db_xref="GeneID:67031"
                     /db_xref="MGI:MGI:1914281"
                     /translation="MRSEEGAGGLGAALAARGPSWREKLSSSETHCRRESPRKESAAP
                     PAPTLSESGAGKPREEKRTALSKVVLRRLPPGLTKEQLEEQLRPLPAHDYFEVVAADL
                     SLYPHVYSRAYINFRNPDDILLFRDRFDGYIFIGNKGLEYPAVVEFAPFQKIAKKKLK
                     KKDAKTGSIEDDPEYKQFLESYSLEEEKTSASPETLLGEIEAKTRELLARRTTPLLEY
                     IKNRKLEKQRLREEKREERRRRELEKKRLREEEKRKRREEDRCKRKEAERHKRAEKDV
                     RIKLLKKLETGEEVATEKPKERGEAVGAGDEKQEDRLVASQPETAGERLQDTSDKEPR
                     DKRSREKDPETSRCHPDTCRKHSSHSEFARFSRRNEDEAKWGKGFAQDRGKKGQDGSV
                     PMDVAERSGKEHKEYDSLGPRKDRLGHKAQ"
     exon            271..377
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..484
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..583
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..694
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            695..750
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..906
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1040
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1402
                     /gene="Upf3a"
                     /gene_synonym="2600001C03Rik; 4930546M19Rik; RENT3A; UPF3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggggctg cctagtcctc gcgaggcttc gttctcgcgg aggtggcggc ggccggccgg
       61 ccggtgggga tgcgctcgga agagggggcc ggaggcttag gcgcagccct ggctgcgcgg
      121 ggcccgagct ggagggagaa actatcgagc tcagagaccc actgccgccg cgagtcaccg
      181 cggaaggagt cggcggcgcc tccggccccg accctaagtg agagcggggc cggcaagcct
      241 cgcgaggaga agaggacagc cctgagcaag gtggtcctcc ggcgtctgcc cccgggcctc
      301 accaaagagc agctggaaga gcaactgcgc cccctgccgg cgcacgatta cttcgaggtg
      361 gtggctgcgg acctcagcct ttatcctcat gtctactcca gagcatacat taattttagg
      421 aaccctgatg acatcctgct gttcagagac cgttttgacg gctatatctt cattggcaat
      481 aaaggcctgg agtatcctgc tgtggtggag tttgctccat tccagaagat tgccaaaaag
      541 aagctgaaga aaaaagatgc caagaccgga agcattgaag atgacccaga atataaacag
      601 ttcctggagt cgtacagcct ggaggaggag aagaccagcg ctagtcccga gacgctgctg
      661 ggagagatag aagccaagac gagagagctc ctggctagaa ggaccacccc tcttttggaa
      721 tatattaaaa acagaaaatt agaaaagcag agactccggg aagaaaagcg cgaggagcgg
      781 aggaggaggg agctagaaaa gaagcgtctg cgggaagaag agaagaggaa gaggagagag
      841 gaggaccgct gtaagaggaa ggaggcggag aggcacaaga gagcggagaa ggacgtgagg
      901 atcaagcttc ttaaaaaact ggaaacggga gaggaagtgg ccacagagaa acccaaagaa
      961 agaggtgaag ctgttggtgc tggagacgag aagcaggaag accggctggt agcgagccag
     1021 ccagagacag ctggggagag gctacaggat accagtgata aagagccaag ggacaagaga
     1081 tctcgagaga aagaccctga aacttctaga tgtcatccgg acacctgcag gaagcacagc
     1141 agtcactcag agtttgccag gttctccaga aggaatgaag acgaggcaaa gtgggggaaa
     1201 ggcttcgccc aggacagagg gaagaagggc caggatggca gtgtccccat ggacgtggca
     1261 gagagaagcg gcaaggagca caaggagtat gacagcctgg ggccaagaaa ggatcgcctg
     1321 ggacacaagg cccagtagac catgggccat cgtccctgtt gatgtgctct gcagccacac
     1381 agccatgttc cccgggtaga aa
//
