LOCUS       NM_001122829            4657 bp    mRNA    linear   ROD 19-DEC-2023
DEFINITION  Mus musculus UPF1 RNA helicase and ATPase (Upf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001122829
VERSION     NM_001122829.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Gao C, Xu YJ, Meng ZX, Gu S, Zhang L and Zheng L.
  TITLE     BMSC-Derived Exosomes Carrying lncRNA-ZFAS1 Alleviate Pulmonary
            Ischemia/Reperfusion Injury by UPF1-Mediated mRNA Decay of FOXD1
  JOURNAL   Mol Neurobiol 60 (5), 2379-2396 (2023)
   PUBMED   36652050
  REMARK    GeneRIF: BMSC-Derived Exosomes Carrying lncRNA-ZFAS1 Alleviate
            Pulmonary Ischemia/Reperfusion Injury by UPF1-Mediated mRNA Decay
            of FOXD1.
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Qian B, Li Y, Yan R, Han S, Bu Z, Gong J, Zheng B, Yuan Z, Ren S,
            He Q, Zhang J, Xu C, Wang R, Sun Z, Lin M, Zhou J and Ye L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Kurosaki T, Sakano H, Proschel C, Wheeler J, Hewko A and Maquat LE.
  TITLE     NMD abnormalities during brain development in the Fmr1-knockout
            mouse model of fragile X syndrome
  JOURNAL   Genome Biol 22 (1), 317 (2021)
   PUBMED   34784943
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Sun Y, Eshov A, Zhou J, Isiktas AU and Guo JU.
  TITLE     C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA
            decay via translational repression
  JOURNAL   Nat Commun 11 (1), 3354 (2020)
   PUBMED   32620797
  REMARK    GeneRIF: C9orf72 arginine-rich dipeptide repeats inhibit
            UPF1-mediated RNA decay via translational repression.
            Erratum:[Nat Commun. 2022 Jan 6;13(1):279. PMID: 34992216]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Yaojia Cheng YX, Lu Q, Shi N, Zhou Q, Rong J, Li L, Wang L and Liu
            C.
  TITLE     Aberrant expression of the UPF1 RNA surveillance gene disturbs
            keratinocyte homeostasis by stabilizing AREG
  JOURNAL   Int J Mol Med 45 (4), 1163-1175 (2020)
   PUBMED   32124941
  REMARK    GeneRIF: Aberrant expression of the UPF1 RNA surveillance gene
            disturbs keratinocyte homeostasis by stabilizing AREG.
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Frischmeyer-Guerrerio PA, Montgomery RA, Warren DS, Cooke SK, Lutz
            J, Sonnenday CJ, Guerrerio AL and Dietz HC.
  TITLE     Perturbation of thymocyte development in nonsense-mediated decay
            (NMD)-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10638-10643 (2011)
   PUBMED   21670277
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Banihashemi L, Wilson GM, Das N and Brewer G.
  TITLE     Upf1/Upf2 regulation of 3' untranslated region splice variants of
            AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA
            decay
  JOURNAL   Mol Cell Biol 26 (23), 8743-8754 (2006)
   PUBMED   17000771
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Ciaudo C, Bourdet A, Cohen-Tannoudji M, Dietz HC, Rougeulle C and
            Avner P.
  TITLE     Nuclear mRNA degradation pathway(s) are implicated in Xist
            regulation and X chromosome inactivation
  JOURNAL   PLoS Genet 2 (6), e94 (2006)
   PUBMED   16789828
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Medghalchi SM, Frischmeyer PA, Mendell JT, Kelly AG, Lawler AM and
            Dietz HC.
  TITLE     Rent1, a trans-effector of nonsense-mediated mRNA decay, is
            essential for mammalian embryonic viability
  JOURNAL   Hum Mol Genet 10 (2), 99-105 (2001)
   PUBMED   11152657
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Perlick HA, Medghalchi SM, Spencer FA, Kendzior RJ Jr and Dietz HC.
  TITLE     Mammalian orthologues of a yeast regulator of nonsense transcript
            stability
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10928-10932 (1996)
   PUBMED   8855285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158553.13, BC056442.1, BC052149.1 and BE456815.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001122829.3.
            
            On Sep 8, 2016 this sequence version replaced NM_001122829.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056442.1, AK148196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC158553.13        111365-111370
            7-4165              BC056442.1         1-4159
            4166-4619           BC052149.1         4065-4518
            4620-4657           BE456815.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..4657
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /note="UPF1 RNA helicase and ATPase"
                     /db_xref="GeneID:19704"
                     /db_xref="MGI:MGI:107995"
     exon            1..502
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..3661
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /EC_number="3.6.4.13"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 1;
                     ATP-dependent helicase RENT1; regulator of nonsense
                     transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1)
                     (Up-frameshift suppressor 1 homolog); UPF1 regulator of
                     nonsense transcripts homolog"
                     /codon_start=1
                     /product="regulator of nonsense transcripts 1 isoform a"
                     /protein_id="NP_001116301.1"
                     /db_xref="CCDS:CCDS52572.1"
                     /db_xref="GeneID:19704"
                     /db_xref="MGI:MGI:107995"
                     /translation="MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQT
                     QTPPGGPGGAGGPGGAGAGGAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEE
                     DEEDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKC
                     KEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDIN
                     WDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLE
                     KPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNK
                     KRIAFFTLPKTDSGNEDLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDN
                     YGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHK
                     LLGHEVEDVVIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTS
                     ATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLA
                     LHNQIRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCV
                     GAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAA
                     KAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKG
                     FDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGI
                     ITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGI
                     GFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKEQKALVEGPLNNLRE
                     SLMQFSKPRKLVNTVNPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSNMYFQTHDQI
                     SMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRGTPKTKTGRGGRQKNR
                     FGLPGPSQTTLPNSQASQDVASQPFSQGALTQGYVSMSQPSQMSQPGLSQPELSQDSY
                     LGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY"
     exon            503..642
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            643..732
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            733..900
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1081
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1243
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1361
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1460
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1569
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1729
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1848
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2013
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2128
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2272
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2486
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2604
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2761
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2904
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3079
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3161
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3323
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3541
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3664
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..4651
                     /gene="Upf1"
                     /gene_synonym="B430202H16Rik; NORF1; PNORF-1; Rent1;
                     Upflp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacggcgg ttcctgtcca ggggtctgag agcggcggtc ggctttgagg cgagcagcgt
       61 tacggagggg cgcggcggcg gcggcggcgg cggcggcggc ggcggcggcg gcggcaactc
      121 agagctcaga accggcggcc cggctctgct ttcggaggcc gactcggagc ccgcccggct
      181 ctcagggcgg cggcagcggc tactccggat tacggcctag gcctagccga agcctcgggc
      241 tcgagtgcgg tgaggcgccc gctgaaggcg cggcccgggc ggcaggatga gtgtggaggc
      301 gtacggcccc agctcgcaaa cactcacctt cttggacact gaggaggccg agctgctcgg
      361 cgccgacacc cagggctccg agttcgaatt caccgacttc acccttccca gccagacgca
      421 gacgcccccc ggcggccccg gcggcgcggg aggcccgggc ggagcgggcg caggcggcgc
      481 ggccggccag ctcgacgcac aagttggacc agagggcatc ttgcaaaatg gggctgtgga
      541 tgacagtgtg gccaagacca gccagctgct agctgagctg aacttcgagg aagatgaaga
      601 ggacacatac tacactaagg acctcccagt ccacgcctgc agttactgtg gaatccatga
      661 tcctgcctgc gtggtttact gtaataccag caagaagtgg ttctgcaatg gccgaggaaa
      721 tacttctggc agccacattg tgaatcacct cgtgagggca aaatgcaagg aagtgacgct
      781 gcacaaggac gggcctctgg gcgagaccgt gctggagtgc tacaactgtg gctgccgcaa
      841 cgtcttcctg ctgggcttca tccctgcgaa ggccgactct gtggtggtgc tgttgtgcag
      901 gcagccctgt gccagccaga gcagcctgaa ggacatcaac tgggacagct cacagtggca
      961 gcccctaatc caggaccggt gctttctgtc atggctggtc aagattccct ctgagcagga
     1021 gcagctgcga gcacggcaga tcacggcaca gcagatcaac aagctggaag agctctggaa
     1081 ggaaaatcct tcagccactc tggaggacct ggagaagcca ggcgtagacg aggagccaca
     1141 gcacgtgctc ctgcgttacg aggatgctta ccagtaccag aacatcttcg ggccactggt
     1201 caagctggag gctgactatg acaagaagtt gaaggagtca cagactcaag ataacatcac
     1261 ggtcaggtgg gacctgggcc ttaacaagaa gagaatcgcc ttcttcactt tgcccaagac
     1321 tgactctggt aatgaggatt tagtcataat ttggttaaga gacatgcggc tcatgcaggg
     1381 tgatgagatc tgtctgcggt acaaagggga tctggcgccc ctgtggaagg ggattggcca
     1441 cgtcatcaag gttcctgata attatggtga tgagattgct attgagctcc gcagcagcgt
     1501 gggtgcccct gtggaagtga cccacaactt ccaagtggat tttgtgtgga agtcaacctc
     1561 ttttgatagg atgcagagtg cactgaagac cttcgctgtg gacgagacct ctgtgtcagg
     1621 gtatatttac cacaagctgc tgggccacga ggtggaggat gtggtcatca agtgccagct
     1681 gccaaagcgc ttcacagctc aggggctccc tgacctcaac cactctcagg tgtatgctgt
     1741 gaagaccgtg ctgcagagac cactcagcct catccagggc cctccaggca caggcaagac
     1801 tgtgacatca gccactattg tctaccacct tgctcggcag ggcaatgggc ctgtactggt
     1861 ttgtgctcca agtaacatcg ctgtggacca gctcacagag aagatccacc agacaggact
     1921 gaaggtcgta cgcctctgtg ccaagagccg tgaggccatt gactccccag tgtccttcct
     1981 ggctttgcac aaccagatca ggaacatgga cagcatgcct gagctgcaga agctgcagca
     2041 gctaaaggat gagacaggcg agctgtcatc tgcagatgag aagcggtacc gggcgcttaa
     2101 gcgcacagct gagagagaac ttctcatgaa tgcagatgtc atatgctgca catgtgtggg
     2161 tgctggtgac ccgaggctgg ccaagatgca gttccgttcc atcctcattg acgagagcac
     2221 ccaggccact gagcctgagt gcatggtgcc tgtagtcctt ggggccaagc agctaatcct
     2281 cgtcggtgac cactgccagc tgggcccagt ggtgatgtgc aagaaggcag ccaaggccgg
     2341 actgtcacaa tcgctcttcg agcgcttggt ggtgctgggc atccggccca tccgcctgca
     2401 ggtgcaatac cgcatgcacc ctgcactcag cgcctttccg tccaacatct tctacgaggg
     2461 ctcattgcag aatggcgtca ctgcagcgga tcgtgtcaaa aaaggctttg acttccagtg
     2521 gccacaacct gacaagccta tgttcttcta cgtgacgcag ggccaggagg agattgccag
     2581 ctctggcaca tcctacctca acaggacgga ggcagccaat gtggagaaga taactacgaa
     2641 gctgttgaag gcaggtgcaa agcctgacca gatcggcatc atcaccccct acgagggcca
     2701 gcgctcttac ttggtgcagt acatgcagtt cagcggctcc ctgcacacaa agctctacca
     2761 ggaagtggaa attgccagtg tggacgcctt ccagggccgg gagaaggact tcatcattct
     2821 gtcctgcgtg cgcgccaatg aacatcaggg cattgggttc ctaaacgacc cccggcgtct
     2881 gaatgtggct ctcaccagag caagatatgg cgtgatcatt gtgggtaacc caaaggccct
     2941 gtcgaagcag cccctgtgga atcacctgct gagctactac aaggaacaga aggcgctagt
     3001 ggaagggccg ctcaacaacc tacgtgagag cctcatgcag ttcagcaagc ctcgcaaact
     3061 tgtcaacact gtcaacccgg gtgcccgctt catgactact gccatgtacg atgcccgtga
     3121 ggccatcatc cccgggtctg tctatgaccg cagcagccag ggccggccct cgaacatgta
     3181 cttccagacc catgaccaga ttagtatgat cagcgcaggc cccagccacg tggctgccat
     3241 gaacatccct attcccttca acttggtcat gcctcccatg ccgccacctg gctacttcgg
     3301 acaggccaac gggccggcag ctggtcgggg caccccaaaa accaagactg gccgtggggg
     3361 ccgccagaag aaccgctttg ggcttcctgg gcccagccag accacccttc ccaacagcca
     3421 ggccagccag gacgtggcct cccagccctt ttcacagggt gccctcacac agggttacgt
     3481 gtccatgagc cagccctctc agatgagcca gcctggcctc tcccagccag aactgtccca
     3541 ggacagctac ctcggtgatg agtttaaatc acagattgac gtggcactct cacaagactc
     3601 cacataccag ggagagcggg cataccagca cggcggggtc accgggctgt cccagtacta
     3661 gaaggtagcg gaggaagagc taagctatgt ggcttagtct atcagcatct tattctgggt
     3721 aataaaaaat aaaaataaat ggatacctgt tttccactgc taaaactgaa gcaccactgt
     3781 gtgagcagcc gaggagagga gaggaaagag gagcgagagc gagcagagag cggccaggga
     3841 ggacgacaga gcggagcgcc gaggagcggg cgccccctgt gggcggcgag aggagagagg
     3901 cccgcaccgc tgcgaggccg gcccagcgcc gtgcccgcca gagggagagg cctcgccagg
     3961 accggccccg ctgttctttt tctttgtttc tcgtgattga ggggctacgt tttagcagga
     4021 cgaacttcgc gtttctgtgc ccaagcgggc ggccaggagc atcagtgcgc ggtcccagcg
     4081 ctaaggggtt tcatttaaag aaaatacggt gtttggggtt tttctggttt ttcttttttt
     4141 tttctttttt ttggtttttt ttttttgttt gtttgtttgg tttttttttt ttttcttttt
     4201 ggttttcctt tcctcccccc tacccccttc aaagattctt tcaaaggagt atgggaagta
     4261 cttggatcgg tttgtctcta gagacctgac tgttaaacct gagagatgcg agaagcttcc
     4321 gggaaaggca gcgctgagaa gcctgagccc cgcagcctgg gatcaccgcc tgcaccgcag
     4381 ccggaggatt tgtttttgag tttgagcttc agaggccaca ggcgaactcg tgagcacggc
     4441 ctgcgggttc ttccccatcg agggtggagg cctcattgct gggcgccctg ccccggaccc
     4501 ccacctcccg cggcagccac ccaaccccta cccaggcaca cctgcgccaa cgcaatggaa
     4561 cttaattttt agtcaaattt gttttaagct ttttgtcacc aataaaacat gaacaaacag
     4621 tccctgcttt tgcgtggggc ggtccctgaa aaaaaaa
//
