LOCUS       NM_172569               3763 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus unkempt family zinc finger (Unk), transcript variant
            1, mRNA.
ACCESSION   NM_172569
VERSION     NM_172569.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3763)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3763)
  AUTHORS   Baskaran,P., Mihaylov,S.R., Vinsland,E., Shah,K., Granat,L.,
            Ultanir,S.K., Tee,A.R., Murn,J. and Bateman,J.M.
  TITLE     Phosphorylation of the novel mTOR substrate Unkempt regulates
            cellular morphogenesis
  JOURNAL   J Biol Chem 299 (1), 102788 (2023)
   PUBMED   36509146
  REMARK    GeneRIF: Phosphorylation of the novel mTOR substrate Unkempt
            regulates cellular morphogenesis.
REFERENCE   3  (bases 1 to 3763)
  AUTHORS   Vinsland,E., Baskaran,P., Mihaylov,S.R., Hobbs,C., Wood,H.,
            Bouybayoune,I., Shah,K., Houart,C., Tee,A.R., Murn,J., Fernandes,C.
            and Bateman,J.M.
  TITLE     The zinc finger/RING domain protein Unkempt regulates cognitive
            flexibility
  JOURNAL   Sci Rep 11 (1), 16299 (2021)
   PUBMED   34381067
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3763)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3763)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3763)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 3763)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3763)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 3763)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3763)
  AUTHORS   Mohler,J., Weiss,N., Murli,S., Mohammadi,S., Vani,K., Vasilakis,G.,
            Song,C.H., Epstein,A., Kuang,T., English,J. et al.
  TITLE     The embryonically active gene, unkempt, of Drosophila encodes a
            Cys3His finger protein
  JOURNAL   Genetics 131 (2), 377-388 (1992)
   PUBMED   1339381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619163.1, AK046395.1 and BC033048.1.
            
            On Oct 26, 2013 this sequence version replaced NM_172569.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077635.1, AK046395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BB619163.1         2-7
            7-2133              AK046395.1         2-2128
            2134-3763           BC033048.1         334-1963
FEATURES             Location/Qualifiers
     source          1..3763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..3763
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /note="unkempt family zinc finger"
                     /db_xref="GeneID:217331"
                     /db_xref="MGI:MGI:2442456"
     exon            1..176
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2505
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCCH type containing 5; zinc finger CCCH type
                     domain containing 5; RING finger protein unkempt homolog;
                     zinc finger CCCH domain-containing protein 5"
                     /codon_start=1
                     /product="RING finger protein unkempt homolog isoform 1"
                     /protein_id="NP_766157.1"
                     /db_xref="CCDS:CCDS25655.1"
                     /db_xref="GeneID:217331"
                     /db_xref="MGI:MGI:2442456"
                     /translation="MSKGPGPGGSAASSAPPAATAQVLQAQPEKPQHYTYLKEFRTEQ
                     CPLFVQHKCTQHRPYTCFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLCPE
                     GDECPFLHRTTGDTERRYHLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPV
                     YDIRELQAMEALQNGQTTVEGSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKT
                     EPCKKPPRLCRQGYACPYYHNSKDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGD
                     ACQYCHTRTEQQFHPEIYKSTKCNDMQQAGSCPRGPFCAFAHIEPPPLSDDVQPSSAV
                     SSPTQPGPVLYMPSAAGDSVPVSPSSPHAPDLSALLCRNSGLGSPSHLCSSPPGPSRK
                     ASNLEGLVFPGESSLAPGSYKKAPGFEREDQVGAEYLKNFKCQAKLKPHSLEPRSQEQ
                     PLLQPKQDVLGILPVGSPLTSSISSSITSSLAATPPSPAGTNSTPGMNANALPFYPTS
                     DTVESVIESALDDLDLNEFGVAALEKTFDNSAVPHPSSVTIGGSLLQSSAPVNIPGSL
                     GSSASFHSASPSPPVSLSSHFLQQPQGHLSQSENTFLGTSASHGSLGLNGMNSSIWEH
                     FASGSFSPGTSPAFLSGPGAAELARLRQELDEANGTIKQWEESWKQAKQACDAWKKEA
                     EEAGERASAAGAECELAREQRDALELRVKKLQEELERLHTVPEAQTLPAAPDLEALSL
                     STLYSIQKQLRVHLEQVDKAVFHMQSVKCLKCQEQTRAVLPCQHAVLCELCAEGSECP
                     VCQPSRAHALQS"
     exon            177..386
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            387..563
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            564..694
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..830
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            831..948
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1033
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1176
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1377
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1443
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1618
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1720
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1909
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2091
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2349
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3741
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3724..3729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /note="hexamer: AATAAA"
     polyA_site      3741
                     /gene="Unk"
                     /gene_synonym="B230379M23Rik; mKIAA1753; Unkh; Zc3h5;
                     Zc3hdc5"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtcttc ggcgcggacc gcgcagactg aataataaaa ggggagcggc gaagaggcag
       61 gaagacagga ccatgtcgaa gggccccggg cccggcggct cggcagcttc ctcggcgccc
      121 ccggccgcta ccgctcaggt gctgcaggca cagcccgaga aaccgcagca ctacacgtac
      181 ctgaaggaat tccgcacaga gcagtgccca ctcttcgtgc agcacaaatg cacacagcat
      241 cggccctata cctgcttcca ctggcacttt gtgaaccagc gtcgccgccg ttccatccgc
      301 cgacgggatg gcaccttcaa ctacagtcca gatgtctact gcacgaagta tgacgaggct
      361 acaggcctct gccccgaggg cgacgagtgc ccattcctgc acagaaccac tggggacact
      421 gagcgcaggt atcaccttcg ttactataaa actggaatct gcatccatga gacagactca
      481 aaaggcaact gcaccaaaaa tggcctgcac tgcgcttttg cccacgggcc tcatgacctc
      541 cgctcccctg tttacgacat cagggagctc caggccatgg aggccttgca gaatggccag
      601 actacagtag agggcagcat agaaggccag tcagctgggg ctgcaagcca tgccatgata
      661 gaaaaaatcc tcagtgagga accccggtgg caagagactg cttatgtgct ggggaactat
      721 aagacggagc cgtgcaagaa gcctccacgg ctgtgccgcc agggctatgc ctgtccctac
      781 taccacaaca gcaaggaccg gcgtcggagt ccccggaagc acaaatacag gtcgtctccg
      841 tgtccaaacg tcaagcatgg ggatgagtgg ggagaccctg gcaagtgtga aaacggagac
      901 gcctgccagt attgccacac acgcacagag cagcagttcc acccagagat ctacaagtcc
      961 accaagtgta atgacatgca gcaggcgggc agctgccccc gaggaccttt ctgcgccttc
     1021 gcccacatag aaccgccacc cttaagtgat gatgtgcagc cttcctcagc tgtgtccagc
     1081 cctacccagc caggtcccgt cttgtacatg ccatctgccg ctggagactc ggtccctgtg
     1141 agcccctcca gcccgcatgc ccctgacctc agcgccctcc tctgtaggaa tagtggcctg
     1201 ggcagtccgt ctcacctctg cagctcccca ccaggcccca gcaggaaggc ctcaaacctg
     1261 gagggtctgg tcttccctgg ggagtccagc cttgcccctg gcagctacaa gaaagctcct
     1321 ggcttcgaaa gggaagacca ggttggggca gagtacctga agaatttcaa gtgccaggct
     1381 aaattaaaac cccattcgct agagcccagg agtcaagagc agcctctgct tcaacccaaa
     1441 caggacgtgc tgggcatcct ccctgtgggc agccccctga cttccagcat ctcttccagt
     1501 attacctcca gcttggcagc cactcccccc agccctgcag gcaccaacag cacccctggc
     1561 atgaatgcaa atgctctgcc cttctaccca accagcgaca cggtagagtc ggtcatagag
     1621 tctgccttgg atgacctgga cctgaatgag tttggagtgg ctgccctaga gaagactttt
     1681 gataacagcg cagtgcccca ccccagcagc gtcacaatcg gtggcagttt gttgcagagc
     1741 tccgcgcctg tgaacatccc tggctccctg ggcagctcag cttccttcca ctctgcttct
     1801 ccatcccctc ccgtcagcct ctcctcacac ttcctgcagc agccccaggg ccacttgagt
     1861 cagtcagaaa acacgttttt ggggacctca gcatcacatg gatctttggg tctgaacggg
     1921 atgaacagca gcatctggga gcattttgcc tctggaagct tctccccagg cacttcccct
     1981 gccttcctat cagggccagg ggctgctgag ctggcccggc ttcggcaaga gctagatgaa
     2041 gctaacggca ccatcaagca gtgggaggag tcctggaagc aggccaagca ggcttgtgat
     2101 gcctggaaga aggaagcgga ggaggctggt gagcgggcca gtgcagccgg agcagagtgt
     2161 gagctggccc gggagcagcg ggatgccctg gagctgcggg tgaagaagct gcaggaggag
     2221 ctggagcggc tgcacacggt gccagaagcc cagaccctgc cagccgcccc tgacctggag
     2281 gcgctgtccc tctccaccct gtactccatc cagaagcagc tgcgggtcca cctggaacaa
     2341 gtggacaagg ctgtgttcca catgcagtca gtgaaatgcc ttaagtgtca ggagcagacc
     2401 cgggcagtgc tgccgtgcca acacgctgtt ctgtgtgagc tctgtgctga gggcagtgag
     2461 tgccccgtct gccagcccag ccgggcccat gccctccagt cgtgaccctg cagaccgggc
     2521 ccagctgggc ctagaccttt tcacctagga ctttttaaag tatatatatg tatgtatgta
     2581 tgtatgtacg tatgtatgta tatgtatatg attatgtaca tgtatacatt tctgtgtgca
     2641 gatgcgcgtg gtgccagcgt gtacagtgtc tgtgtgtatc tggacaggtg cagacacaca
     2701 ctttgaagca gacttaccaa gcacttttta aagaagagac tattttgcag tcctcctgtt
     2761 ccttccccat cctttctgct caaagacaac gtcccctctt ttcccactgg ccttttgaca
     2821 ctgaatatgt tttgtctcat tttttatgta ggaactaact atttttaact tcttcctggg
     2881 gccagagcag ggaaggctgg gaagctggaa gggcagctcc gttcaccctg cctttccagg
     2941 ccagaggcgt cagcgtggac tcaggtcccc acttcccagc tgtgagggct tcaggcaggt
     3001 ctgaaactct aaaccagact agctcctggg cttaccaaat atgtatttaa ctctggggac
     3061 agccacagag cagggaggcc aaagctacag gctagcccca ctcccacacc tgggcccttg
     3121 aagctcctca aggcctagtt ctgtccctca gtgttttgaa acctgggctt ctctttgatc
     3181 acttccttct ggaatcccta gatagcctct ttgaccccac agtcacttgt caggttggca
     3241 ctgccctcac ctgtccctgc ctccttccct ctggcacacg gccgtagagc cggccgctcc
     3301 ctccctctgg cagctagcag ggcaattgtt gggaggagtg cagtatgagg accaaggggc
     3361 acgagccctg cccttcttgc tgggaggagg tagtatgcat tccttggtgc tctcagagtg
     3421 cagctgacgt actgccgtgc tgggcagacg cctgtgtgca tgtgtgtgcg tgcctgtctg
     3481 atgtgtttag cttcaatttt aaaaattgtt ctgtacagag atgcagtgaa tcgggaaagc
     3541 agagtgggca gagggaggca gccctgttcc cagtactggg tgtccagagg gctcaagagg
     3601 gctacaaaga atctgcccca gtagaggccc ctcccttggg ctcagcacga aagggctttc
     3661 aatgaattac gtgaaaactt tctccttttt tacaaaaatg caaaaatcaa caaacttatt
     3721 ggaaataaac tatgaacttg caaaaaaaaa aaaaaaaaaa aaa
//
