LOCUS       NM_019449               2230 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus unc-93 homolog B1, TLR signaling regulator (Unc93b1),
            transcript variant 1, mRNA.
ACCESSION   NM_019449
VERSION     NM_019449.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Rael,V.E., Yano,J.A., Huizar,J.P., Slayden,L.C., Weiss,M.A.,
            Turcotte,E.A., Terry,J.M., Zuo,W., Thiffault,I., Pastinen,T.,
            Farrow,E.G., Jenkins,J.L., Becker,M.L., Wong,S.C., Stevens,A.M.,
            Otten,C., Allenspach,E.J., Bonner,D.E., Bernstein,J.A.,
            Wheeler,M.T., Saxton,R.A., Liu,B., Majer,O. and Barton,G.M.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Large-scale mutational analysis identifies UNC93B1 variants that
            drive TLR-mediated autoimmunity in mice and humans
  JOURNAL   J Exp Med 221 (8) (2024)
   PUBMED   38780621
  REMARK    GeneRIF: Large-scale mutational analysis identifies UNC93B1
            variants that drive TLR-mediated autoimmunity in mice and humans.
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Wolf,C., Lim,E.L., Mokhtari,M., Kind,B., Odainic,A.,
            Lara-Villacanas,E., Koss,S., Mages,S., Menzel,K., Engel,K.,
            Duckers,G., Bernbeck,B., Schneider,D.T., Siepermann,K., Niehues,T.,
            Goetzke,C.C., Durek,P., Minden,K., Dorner,T., Stittrich,A.,
            Szelinski,F., Guerra,G.M., Massoud,M., Bieringer,M., de Oliveira
            Mann,C.C., Beltran,E., Kallinich,T., Mashreghi,M.F., Schmidt,S.V.,
            Latz,E., Klughammer,J., Majer,O. and Lee-Kirsch,M.A.
  TITLE     UNC93B1 variants underlie TLR7-dependent autoimmunity
  JOURNAL   Sci Immunol 9 (92), eadi9769 (2024)
   PUBMED   38207055
  REMARK    GeneRIF: UNC93B1 variants underlie TLR7-dependent autoimmunity.
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Ni,H., Wang,Y., Yao,K., Wang,L., Huang,J., Xiao,Y., Chen,H.,
            Liu,B., Yang,C.Y. and Zhao,J.
  TITLE     Cyclical palmitoylation regulates TLR9 signalling and systemic
            autoimmunity in mice
  JOURNAL   Nat Commun 15 (1), 1 (2024)
   PUBMED   38169466
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Kotov,D.I., Lee,O.V., Fattinger,S.A., Langner,C.A., Guillen,J.V.,
            Peters,J.M., Moon,A., Burd,E.M., Witt,K.C., Stetson,D.B.,
            Jaye,D.L., Bryson,B.D. and Vance,R.E.
  TITLE     Early cellular mechanisms of type I interferon-driven
            susceptibility to tuberculosis
  JOURNAL   Cell 186 (25), 5536-5553 (2023)
   PUBMED   38029747
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Acevedo Ospina,H., Guay-Vincent,M.M. and Descoteaux,A.
  TITLE     Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming
            Induced by Leishmania donovani Require Lipophosphoglycan and Type I
            Interferon Signaling
  JOURNAL   mBio 13 (6), e0257822 (2022)
   PUBMED   36222510
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Cook,M.C., Vinuesa,C.G. and Goodnow,C.C.
  TITLE     ENU-mutagenesis: insight into immune function and pathology
  JOURNAL   Curr Opin Immunol 18 (5), 627-633 (2006)
   PUBMED   16889948
  REMARK    Review article
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Janssen,E., Tabeta,K., Barnes,M.J., Rutschmann,S., McBride,S.,
            Bahjat,K.S., Schoenberger,S.P., Theofilopoulos,A.N., Beutler,B. and
            Hoebe,K.
  TITLE     Efficient T cell activation via a Toll-Interleukin 1
            Receptor-independent pathway
  JOURNAL   Immunity 24 (6), 787-799 (2006)
   PUBMED   16782034
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Tabeta,K., Hoebe,K., Janssen,E.M., Du,X., Georgel,P., Crozat,K.,
            Mudd,S., Mann,N., Sovath,S., Goode,J., Shamel,L., Herskovits,A.A.,
            Portnoy,D.A., Cooke,M., Tarantino,L.M., Wiltshire,T.,
            Steinberg,B.E., Grinstein,S. and Beutler,B.
  TITLE     The Unc93b1 mutation 3d disrupts exogenous antigen presentation and
            signaling via Toll-like receptors 3, 7 and 9
  JOURNAL   Nat Immunol 7 (2), 156-164 (2006)
   PUBMED   16415873
  REMARK    GeneRIF: identified 'triple D' (3d), a recessive
            N-ethyl-N-nitrosourea-induced mutation and phenotype in which no
            signaling occurs via the intracellular Toll-like receptors 3, 7 and
            9
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133523.3.
            
            On Apr 1, 2022 this sequence version replaced NM_019449.2.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018388.1, AK165060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC133523.3         172103-172233
            132-273             AC133523.3         172643-172784
            274-427             AC133523.3         173150-173303
            428-589             AC133523.3         178401-178562
            590-722             AC133523.3         178766-178898
            723-816             AC133523.3         179230-179323
            817-941             AC133523.3         179575-179699
            942-1124            AC133523.3         180410-180592
            1125-1398           AC133523.3         180904-181177
            1399-1517           AC133523.3         183888-184006
            1518-2230           AC133523.3         185509-186221
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.65 cM"
     gene            1..2230
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /note="unc-93 homolog B1, TLR signaling regulator"
                     /db_xref="GeneID:54445"
                     /db_xref="MGI:MGI:1859307"
     exon            1..131
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1832
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /note="isoform a is encoded by transcript variant 1;
                     protein unc-93 homolog B1"
                     /codon_start=1
                     /product="protein unc-93 homolog B1 isoform a"
                     /protein_id="NP_062322.3"
                     /db_xref="CCDS:CCDS29404.2"
                     /db_xref="GeneID:54445"
                     /db_xref="MGI:MGI:1859307"
                     /translation="MEVEPPLYPVAGAAGPQGDEDRHGVPDGPEAPLDELVGAYPNYN
                     EEEEERRYYRRKRLGVVKNVLAASTGVTLTYGVYLGLLQMQLILHYDETYREVKYGNM
                     GLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYT
                     LVPSAVALGMAIVPLWASMGNYITRMSQKYYEYSHYKEQDEQGPQQRPPRGSHAPYLL
                     VFQAIFYSFFHLSFACAQLPMIYFLNNYLYDLNHTLINVQSCGTKSQGILNGFNKTVL
                     RTLPRSKNLIVVESVLMAVAFLAMLMVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKH
                     VRDFRLRHLVPFFIYSGFEVLFACTGFALGYGVCSMGLERLAYLLIAYSLGASASSVL
                     GLLGLWLPRSVPLVAGAGLHLLLTLSLFFWAPAPRVLQHSWIFYFVAALWGVGSALNK
                     TGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFVVYLGSSLPMKAKLAVLLVTLVAAA
                     ASYLWMEQKLQQGLVPRQPRIPKPQHKVRGYRYLEEDNSDESDMEGEQGQGDCAEDEA
                     PQAGPLGAEPAGPCRKPCPYEQALGGDGPEEQ"
     exon            132..273
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            274..427
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            428..589
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            590..722
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            723..816
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            817..941
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1124
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1398
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1517
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2230
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /note="hexamer: AATAAA"
     polyA_site      2230
                     /gene="Unc93b1"
                     /gene_synonym="Unc-93B1; Unc93b"
                     /note="major polyA site"
ORIGIN      
        1 gcccagaact gcaagccctt gatctggatc tggtcatgga ggtggagcct ccgctctacc
       61 ctgtggccgg ggccgcgggt cctcaagggg atgaagaccg gcacggagtt cctgatgggc
      121 cagaggctcc cttggacgaa ctcgtgggtg cgtaccccaa ctacaatgag gaggaggaag
      181 agcgccgcta ctaccgccgc aagcgcctcg gagtggtcaa gaacgtgctg gcggccagca
      241 cgggtgtcac ccttacttac ggcgtctacc tgggcctcct gcagatgcaa ctgatcctgc
      301 actatgatga gacctacaga gaggtgaagt atggcaacat ggggctgccg gacatcgata
      361 gcaagatgct gatgggtatc aacgtgacgc ctatcgctgc cctgctctac acacctgtgc
      421 tcatcaggtt ttttggtacc aagtggatga tgttcttggc tgtgggcatc tatgccctct
      481 ttgtctctac caactactgg gaacgctact acacgctggt gccctctgct gtggctctgg
      541 gcatggccat tgtgcctctg tgggcctcca tgggcaacta tatcaccagg atgtcccaga
      601 agtactatga atactcccac tacaaggagc aagatgagca gggacctcag cagcgcccac
      661 cacgaggttc ccacgcaccc tatctcctgg ttttccaggc catcttctat agcttcttcc
      721 acttgagctt cgcgtgtgcc cagctgccca tgatttactt cctcaacaac tacctgtatg
      781 acctgaacca cacactgatc aacgtgcaga gctgcggtac taagagccaa ggcattctga
      841 atggcttcaa caagacggtc cttcggacgc tgccgcgcag caaaaacctt attgttgtag
      901 agagcgtgct catggcggtg gccttcttgg ccatgctgat ggtgctgggc ctgtgtggag
      961 ccgcttaccg gcccacggaa gagatcgacc tgcgcagcgt gggctggggc aacatcttcc
     1021 agctgccctt caaacacgtg cgtgactttc gcttacgcca tctggtgccc ttctttatct
     1081 acagtggctt tgaggtgctc tttgcctgca ctggttttgc cctgggctac ggcgtgtgct
     1141 ccatggggct ggagcgactg gcatacctgc tcatagctta cagcctgggt gcctcagcct
     1201 cctcggttct ggggctgctg ggactgtggc tgcctcgctc tgtcccgctc gtggctgggg
     1261 caggactgca cctactgctc acccttagcc tctttttctg ggctcctgct cctcgggtcc
     1321 tccagcacag ttggatcttt tacttcgtgg ctgccctctg gggtgtgggc agcgccctca
     1381 acaagaccgg acttagcaca ctcctgggca tcctatatga agacaaagag aggcaggact
     1441 tcatcttcac catctatcac tggtggcagg ccgtggccat ctttgttgtg tacctgggct
     1501 ccagcttgcc catgaaggcc aagctggcag tgttgctggt gaccctggta gcagcagcag
     1561 cctcatacct gtggatggag cagaagttgc agcaaggatt ggtcccgcgg cagccgcgca
     1621 ttccgaagcc acagcacaaa gtccgcggct accgctacct ggaggaggac aactcggatg
     1681 agagtgacat ggagggcgag cagggtcagg gggactgcgc agaggacgaa gcaccacagg
     1741 cagggcccct gggtgcagag ccagctggcc cctgccgcaa gccctgtccc tatgaacagg
     1801 ctctgggtgg cgatgggcct gaggagcagt gagagaacca gggtggccag cctggccctt
     1861 agactcagct ttctgccttc cagcctcagt ttactgtatc tcaggttgag ggtccccccc
     1921 ccccccgaat catgctccac ctgctagaag ggccttcttc ctcttcccag agcctggggt
     1981 cacctggaac ttcctccaag gagataaggg tcactctccg aaacccctat tcctgtttac
     2041 agaatatgcc tctgcctaaa tcagcgagat tcccttccgg cctgcctcgg ctcaggtcac
     2101 cctctgcccc tgtgttacaa ctagagcttt gcacatttct tgcccacagg ttccctaacc
     2161 tcagagcagg gggcttttat ttttattttt taatggaaaa taatcaataa agacttttgt
     2221 attttctgga
//
