LOCUS       NM_152823               2838 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus unc-5 family C-terminal like (Unc5cl), mRNA.
ACCESSION   NM_152823
VERSION     NM_152823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Heinz,L.X., Rebsamen,M., Rossi,D.C., Staehli,F., Schroder,K.,
            Quadroni,M., Gross,O., Schneider,P. and Tschopp,J.
  TITLE     The death domain-containing protein Unc5CL is a novel
            MyD88-independent activator of the pro-inflammatory IRAK signaling
            cascade
  JOURNAL   Cell Death Differ 19 (4), 722-731 (2012)
   PUBMED   22158417
  REMARK    GeneRIF: The death domain-containing protein Unc5CL is a novel
            MyD88-independent activator of the pro-inflammatory IRAK signaling
            cascade.
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Zhang,J., Xu,L.G., Han,K.J. and Shu,H.B.
  TITLE     Identification of a ZU5 and death domain-containing inhibitor of
            NF-kappaB
  JOURNAL   J Biol Chem 279 (17), 17819-17825 (2004)
   PUBMED   14769797
  REMARK    GeneRIF: Focuses on identification and characterization of human
            UNC5CL, but also identifies mouse Unc5cl.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165291.2.
            
            On Aug 8, 2009 this sequence version replaced NM_152823.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095959.1, AK144925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC165291.2         77967-78038
            73-518              AC165291.2         82605-83050
            519-819             AC165291.2         83551-83851
            820-1082            AC165291.2         85242-85504
            1083-1184           AC165291.2         86428-86529
            1185-1252           AC165291.2         86643-86710
            1253-1353           AC165291.2         87508-87608
            1354-1467           AC165291.2         87982-88095
            1468-2838           AC165291.2         90382-91752
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 24.14 cM"
     gene            1..2838
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /note="unc-5 family C-terminal like"
                     /db_xref="GeneID:76589"
                     /db_xref="MGI:MGI:1923839"
     exon            1..72
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            73..518
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1690
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /note="ZU5 and death domain-containing inhibitor of NF-kB;
                     protein unc-5 homolog C-like; ZU5 and death
                     domain-containing protein"
                     /codon_start=1
                     /product="UNC5C-like protein"
                     /protein_id="NP_690036.4"
                     /db_xref="CCDS:CCDS28870.1"
                     /db_xref="GeneID:76589"
                     /db_xref="MGI:MGI:1923839"
                     /translation="MSPQESSVQPSQFLLLVGIPVASALLLAQCLRWHCCQWLPGTCR
                     KLDDPEEPVSPSTPLPEYELPRQCPAPTLPEVAAFYQELHMPTQGQTVTRQMMHKLLV
                     FSAREVDHRGGCLILQDTGISLLIPPGAVTVGRQERVSLVLVWDLTDAPSLSHRQGLV
                     SPVVACGPHGASFLKPCTLTFKHCAQQPSQACAYSSNTSLLDAKDWKPLGQPGTHISR
                     DECRILLSHFSLYTCVLEAPLGQTARKWLQLAMFCSPLVPGQTHLQLRVYFLNNTPCA
                     LQWAITNEQPHGGRMRGPCQLFDFTGARADQCLKLKYISEGWENVDDSSSQLVPHLHI
                     WHGKCPFRSFCFRRKAANGNEECSALTNEIIVTMHTFQDGLETKYVEILRFQASEEET
                     WAVPPPVSQPPLCNRLPPELFEQLQMLLEPNSVTGNDWRRLASHLGLCGMKIRFLSCQ
                     RSPAAAILELFEEQNGSLQELHYLMTSMERLDCASAIQNYLNRSPRGSPDRLHGGTWE
                     NHGLELDEKL"
     exon            519..819
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1082
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1184
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1252
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1353
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1467
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2838
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2808..2813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /note="hexamer: AATAAA"
     polyA_site      2838
                     /gene="Unc5cl"
                     /gene_synonym="2510009H09Rik; Zud"
                     /note="major polyA site"
ORIGIN      
        1 agacctctct gtttcttaga gagggaacta ttgcttctgg acgggcctag tgggtggcaa
       61 gccgacatta aggcccttga ccttggctgg tgtaggggtg cgggagagcc agcagcattg
      121 agtgaccagg cggatgagcc cccaggagag ctctgttcaa ccttcccagt tcctcctgtt
      181 ggtggggatc cctgtggcca gtgctctcct tctggctcag tgtcttcgat ggcactgctg
      241 tcagtggctg ccagggacct gccggaagct ggatgatcca gaggagccag tgtccccatc
      301 cactccatta ccagagtatg agctcccgag gcagtgccca gcccccacac taccggaggt
      361 ggctgcgttc taccaggaac tccacatgcc tacccagggc cagactgtca cccgccagat
      421 gatgcataag ctactggtgt tttctgctcg agaggtggat caccgtggtg gatgcctgat
      481 cctgcaggac acaggcatct ccctgctcat cccgccaggt gctgtgaccg tgggtcgcca
      541 ggagagggtg tccttggttc tggtgtggga cctgacagat gccccgtcac tgtctcacag
      601 acagggacta gtgagtcctg tggtggcctg tggccctcac ggggcctctt tcctgaagcc
      661 ttgcaccctc acgttcaagc actgcgccca acagcccagt caagcctgtg cctacagcag
      721 caatacctcc ttgctggatg ccaaggactg gaaacccctg ggtcagccgg ggactcatat
      781 ctccagggac gagtgtcgta tcctgctctc tcacttcagt ctctacacct gcgttctgga
      841 ggcccccctg ggccagacag cccgcaagtg gctgcagctg gccatgttct gctccccact
      901 ggtgccaggg cagacacacc tgcagctgcg cgtctacttc ctgaacaaca ctccctgcgc
      961 cctgcagtgg gctatcacca atgaacagcc gcacggggga cgcatgcgcg ggccgtgcca
     1021 gctcttcgac ttcactgggg ccagagcaga ccagtgcctg aagctcaagt acatctctga
     1081 gggttgggag aatgtggatg atagcagtag ccagctggtt ccacatctcc acatctggca
     1141 tggaaagtgc cccttccgtt ctttctgctt ccggagaaag gcagccaatg ggaatgaaga
     1201 gtgctcggca ttaaccaatg agatcattgt caccatgcac accttccagg atggcttgga
     1261 aaccaaatac gttgaaatcc tcagattcca ggcatcggag gaagagacct gggcagtgcc
     1321 ccctcctgtc tcccagccac ccctgtgcaa caggctgccc ccagagctct ttgagcagct
     1381 gcagatgttg ttggagccca acagtgtcac tgggaatgac tggcgcagac tggcctccca
     1441 cctgggtctc tgtggcatga aaatccggtt cttgtcctgc cagcgcagtc ccgccgcggc
     1501 cattctggaa ttgttcgagg aacagaatgg cagcttgcag gagctgcact atctcatgac
     1561 ctccatggag cggctggact gcgcctctgc catccagaac tacctaaacc ggtctccccg
     1621 gggcagccct gacaggttgc atggaggcac ctgggagaac catggcctag agctggatga
     1681 gaaactctaa gcagactcca cggctgtgca gggtgcttca agaggccatg ccataccgtg
     1741 ccatgccttt gagctcagga tcaatgccac agtctcaggt ggaccgaact ggaacccgca
     1801 gcaaagcccg acagccctgt catctgccct gcatcaggat agctcttaat cctgccggcc
     1861 aactttgtcc tgcgtgcaga ttccttcttg gtcggtaggg ggcgcgggag tctgggagat
     1921 ggtcacagcc aagcagcttc tgagatgctg cttaattttc ttgtggacct gtgggcagac
     1981 ctcagagact gctcagtcca caaatattca tggagcgccg agtctcagca ccaagctggg
     2041 atcatgagga acgtcggctt ctttggactt gtcttggagt ctgttctgcg aaatgaagat
     2101 gcactcccag ccggctgaga gcaacattct agacagtgtc tccctgtggt taggagatgt
     2161 cttgggtgtg taactttgtt gagaagggag ggccctgcgg tggactggaa caaagagaag
     2221 tctctataga gggtcttggg agagaacttt ggcgggggag ggggctcacc tcattgatgt
     2281 gaggaatggc ctcttctccc ttcatctctt cacttgcagc tcacactttg tcctcctcct
     2341 cagccttgtt tctctcatca cacaggaagc tgtgaagcct caggatgcgc gccctatgtc
     2401 tctccacctc cagctgagag tgttaagttt ctggctgcct tttcttgcac ttgcccagct
     2461 cagagttggc ctctttactg ttgctcatgt cttcacattg cttcgtctct atctagttat
     2521 ggaatcccat ctttgtgttt ctttttctat taggaaaaaa aaaatcagtc actccctcag
     2581 gcaagtgtct gagctaatgc tatgtatttc aaggctactg aaagagcttc ggctattcca
     2641 ggaatgaata agtagagaca tttctctcac agatcaagtt cctccttagg ggcaggatta
     2701 aaggaccccc accccgctcc gatccagtca gcagttctgg ctactgctac tcttgcttac
     2761 cgatagtttt gttcgtttgt ccaaaggtat acaatccctt tggagataat aaaatttcac
     2821 ttgcacattt aatgaaaa
//
