LOCUS       NM_153131               3988 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus unc-5 netrin receptor A (Unc5a), transcript variant 1,
            mRNA.
ACCESSION   NM_153131
VERSION     NM_153131.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3988)
  AUTHORS   Akkermans,O., Delloye-Bourgeois,C., Peregrina,C.,
            Carrasquero-Ordaz,M., Kokolaki,M., Berbeira-Santana,M., Chavent,M.,
            Reynaud,F., Raj,R., Agirre,J., Aksu,M., White,E.S., Lowe,E., Ben
            Amar,D., Zaballa,S., Huo,J., Pakos,I., McCubbin,P.T.N.,
            Comoletti,D., Owens,R.J., Robinson,C.V., Castellani,V., Del Toro,D.
            and Seiradake,E.
  TITLE     GPC3-Unc5 receptor complex structure and role in cell migration
  JOURNAL   Cell 185 (21), 3931-3949 (2022)
   PUBMED   36240740
  REMARK    GeneRIF: GPC3-Unc5 receptor complex structure and role in cell
            migration.
REFERENCE   2  (bases 1 to 3988)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3988)
  AUTHORS   Brignani,S., Raj,D.D.A., Schmidt,E.R.E., Dudukcu,O., Adolfs,Y., De
            Ruiter,A.A., Rybiczka-Tesulov,M., Verhagen,M.G., van der Meer,C.,
            Broekhoven,M.H., Moreno-Bravo,J.A., Grossouw,L.M., Dumontier,E.,
            Cloutier,J.F., Chedotal,A. and Pasterkamp,R.J.
  TITLE     Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic
            Neuron Migration and Dopaminergic Substantia Nigra Development
  JOURNAL   Neuron 107 (4), 684-702 (2020)
   PUBMED   32562661
REFERENCE   4  (bases 1 to 3988)
  AUTHORS   Varadarajan,S.G., Kong,J.H., Phan,K.D., Kao,T.J., Panaitof,S.C.,
            Cardin,J., Eltzschig,H., Kania,A., Novitch,B.G. and Butler,S.J.
  TITLE     Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is
            Required for Axon Guidance in the Spinal Cord
  JOURNAL   Neuron 94 (4), 790-799 (2017)
   PUBMED   28434801
REFERENCE   5  (bases 1 to 3988)
  AUTHORS   Shcherbakova,A., Tiemann,B., Buettner,F.F. and Bakker,H.
  TITLE     Distinct C-mannosylation of netrin receptor thrombospondin type 1
            repeats by mammalian DPY19L1 and DPY19L3
  JOURNAL   Proc Natl Acad Sci U S A 114 (10), 2574-2579 (2017)
   PUBMED   28202721
  REMARK    GeneRIF: Mannosylation by DPY19L1 but not DPY19L3 is required for
            transport of UNC5A from the endoplasmic reticulum to the cell
            surface. In vertebrates, a new C-mannosyltransferase has apparently
            evolved to increase glycosylation of TSRs, potentially to increase
            the stability of the structurally essential tryptophan ladder or to
            provide additional adhesion functions.
REFERENCE   6  (bases 1 to 3988)
  AUTHORS   Williams,M.E., Strickland,P., Watanabe,K. and Hinck,L.
  TITLE     UNC5H1 induces apoptosis via its juxtamembrane region through an
            interaction with NRAGE
  JOURNAL   J Biol Chem 278 (19), 17483-17490 (2003)
   PUBMED   12598531
  REMARK    GeneRIF: a mechanism for UNC5H1-mediated apoptosis that requires an
            interaction with the MAGE protein NRAGE
REFERENCE   7  (bases 1 to 3988)
  AUTHORS   Jarjour,A.A., Manitt,C., Moore,S.W., Thompson,K.M., Yuh,S.J. and
            Kennedy,T.E.
  TITLE     Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in
            the embryonic spinal cord
  JOURNAL   J Neurosci 23 (9), 3735-3744 (2003)
   PUBMED   12736344
REFERENCE   8  (bases 1 to 3988)
  AUTHORS   Engelkamp,D.
  TITLE     Cloning of three mouse Unc5 genes and their expression patterns at
            mid-gestation
  JOURNAL   Mech Dev 118 (1-2), 191-197 (2002)
   PUBMED   12351186
  REMARK    GeneRIF: Unc5h1 was cloned; its expression is restricted to the
            central nervous system in developing mouse
REFERENCE   9  (bases 1 to 3988)
  AUTHORS   Bloch-Gallego,E., Ezan,F., Tessier-Lavigne,M. and Sotelo,C.
  TITLE     Floor plate and netrin-1 are involved in the migration and survival
            of inferior olivary neurons
  JOURNAL   J Neurosci 19 (11), 4407-4420 (1999)
   PUBMED   10341242
REFERENCE   10 (bases 1 to 3988)
  AUTHORS   Leonardo,E.D., Hinck,L., Masu,M., Keino-Masu,K., Ackerman,S.L. and
            Tessier-Lavigne,M.
  TITLE     Vertebrate homologues of C. elegans UNC-5 are candidate netrin
            receptors
  JOURNAL   Nature 386 (6627), 833-838 (1997)
   PUBMED   9126742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154610.3.
            
            On Oct 24, 2022 this sequence version replaced NM_153131.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ487852.1, SRR7652917.620608.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC154610.3         163057-163370       c
            315-536             AC154610.3         121687-121908       c
            537-680             AC154610.3         116848-116991       c
            681-784             AC154610.3         116525-116628       c
            785-965             AC154610.3         116204-116384       c
            966-1133            AC154610.3         115428-115595       c
            1134-1298           AC154610.3         114708-114872       c
            1299-1487           AC154610.3         113264-113452       c
            1488-1790           AC154610.3         112864-113166       c
            1791-1878           AC154610.3         110235-110322       c
            1879-2047           AC154610.3         109787-109955       c
            2048-2281           AC154610.3         109372-109605       c
            2282-2431           AC154610.3         109097-109246       c
            2432-2596           AC154610.3         108846-109010       c
            2597-2775           AC154610.3         108132-108310       c
            2776-3988           AC154610.3         106770-107982       c
FEATURES             Location/Qualifiers
     source          1..3988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..3988
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /note="unc-5 netrin receptor A"
                     /db_xref="GeneID:107448"
                     /db_xref="MGI:MGI:894682"
     exon            1..314
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2941
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; netrin receptor UNC5A; protein unc-5 homolog A;
                     protein unc-5 homolog 1"
                     /codon_start=1
                     /product="netrin receptor UNC5A isoform 1 precursor"
                     /protein_id="NP_694771.1"
                     /db_xref="CCDS:CCDS26537.1"
                     /db_xref="GeneID:107448"
                     /db_xref="MGI:MGI:894682"
                     /translation="MAVRPGLWPALLGIVLTAWLRGSGAQQSATVANPVPGANPDLLP
                     HFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTM
                     EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEV
                     SLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN
                     YTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLN
                     GGAFCEGQNVQKTACATLCPVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEEC
                     RGADLDTRNCTSDLCLHTSSGPEDVALYIGLVAVAVCLILLLLVLVLIYCRKKEGLDS
                     DVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQL
                     SNGHLLSPLGSGRHTLHHSSPTSEAEDFVSRLSTQNYFRSLPRGTSNMAYGTFNFLGG
                     RLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGV
                     LLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEESPSHLYYCQLEAGAC
                     YVFTEQLGRFALVGEALSVAATKRLRLLLFAPVACTSLEYNIRVYCLHDTHDALKEVV
                     QLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGT
                     QQYLHCTFTLERVNASTSDLACKVWVWQVEGDGQSFNINFNITKDTRFAEMLALESEG
                     GVPALVGPSAFKIPFLIRQKIITSLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPT
                     AMILNLWEARHFPNGNLGQLAAAVAGLGQPDAGLFTVSEAEC"
     exon            315..536
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..680
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..784
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..965
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1133
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1298
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1487
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1790
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1878
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2047
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2281
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2431
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2596
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2775
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..3988
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3963..3968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /note="hexamer: AATAAA"
     regulatory      3968..3973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /note="hexamer: ATTATA"
     polyA_site      3985
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
     polyA_site      3988
                     /gene="Unc5a"
                     /gene_synonym="mKIAA1976; Unc5h1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggcggc tggctcggtg cgcggcgcgg ctggcgctgc gctccgcccc ggctgcattg
       61 ctgcgctccg ggtgcccagg ggagccacgc gccgcgtgcg ccccgcagcc ggccgcccgg
      121 aggcagcgct gtcctctggc atgggccccg ggggcgcccc gaggtggggc tctcggctga
      181 ggcgctgaca gcctctctcc cgcccgcggg gcccctagtc cagcccgctc gtccgcccgc
      241 ggccatggcc gtccggcccg gcctgtggcc agcgctcctg ggcatagtcc tcactgcctg
      301 gcttcgtggt tcgggtgccc agcagagtgc cacagtggcc aacccagtgc ctggtgccaa
      361 cccggacctg ctgccccact tcctggtaga gccggaggac gtgtacattg tcaagaacaa
      421 gcccgtgctg ctggtgtgca aggctgtgcc cgccacccag atcttcttca agtgcaacgg
      481 ggaatgggtt cgccaggtcg atcacgtcat tgaacgcagc actgacggca gcagcggatt
      541 gccaaccatg gaggtccgga tcaacgtatc aaggcagcag gtcgagaaag tgtttgggct
      601 ggaggagtac tggtgccagt gtgtggcatg gagctcctca ggaaccacca aaagccagaa
      661 ggcctacatc cggattgcct atttgcgcaa gaactttgag caggagccgc tggccaagga
      721 agtgtcactg gagcaaggca ttgtgctacc ttgtcgcccc ccggaaggaa tccccccagc
      781 tgaggtggag tggctccgaa atgaggacct cgtggacccc tccctcgacc ccaatgtgta
      841 catcacacgg gagcacagcc tagtcgtgcg gcaggcccgc ctggccgaca ctgccaacta
      901 cacctgcgtg gccaagaaca tcgtggcccg tcgccgaagc gcctctgcgg ccgtcattgt
      961 ttatgtgaac ggtgggtggt cgacgtggac cgagtggtcc gtctgcagtg ccagctgtgg
     1021 gcgtggctgg cagaaacgga gccggagctg caccaacccg gcacctctca acgggggcgc
     1081 cttctgtgag gggcagaatg tccagaaaac agcctgcgcc actctgtgcc cagtggatgg
     1141 gagctggagc ccatggagta agtggtcagc ctgcgggctt gactgcaccc actggcggag
     1201 ccgggagtgc tccgacccag cgccccgcaa cggaggtgag gagtgccggg gtgctgacct
     1261 ggacacccgc aactgtacca gtgacctctg cctgcacacc tcttccggcc ccgaggacgt
     1321 ggctctctac atcggcctcg tcgccgtggc cgtgtgcctc atcttgctgc tgctggtcct
     1381 cgtcctcatc tactgccgca agaaggaagg actggactca gacgtggctg actcatccat
     1441 ccttacctca ggcttccagc ctgtcagcat caagcccagc aaagcagaca atccccatct
     1501 gctcaccatc caaccggacc tcagcaccac cacgaccacc taccagggca gcctgtgtcc
     1561 ccggcaggat ggacccagcc ccaagttcca gctctctaat ggtcacctgc tcagcccact
     1621 gggcagtggc cgccatacgc tgcaccacag ctcccccacc tctgaggctg aggacttcgt
     1681 ctcccgcctc tccacccaaa actactttcg ttctctgccc cgcggtacca gcaacatggc
     1741 ctatgggacc ttcaacttcc tcgggggccg gctgatgatc cctaacacag gaatcagcct
     1801 cctcataccc ccggacgcca tcccccgagg aaagatctac gagatctacc tcactctgca
     1861 caagccagaa gacgtgaggt tgcccctagc tggctgtcag accctgctga gtcctatcgt
     1921 tagctgtggg cccccaggag tcctgctcac ccggccagtc atccttgcca tggaccactg
     1981 cggggagccc agtcccgaca gctggagcct gcgcctcaaa aagcagtcct gtgagggcag
     2041 ctgggaggac gtgctgcacc ttggtgagga gtcgccctct catctctact actgccagct
     2101 ggaggccggg gcctgctatg tcttcaccga gcagctaggc cgctttgccc tggtgggaga
     2161 ggccctcagc gtggctgcca ccaagcgcct caggctcctt ctgtttgccc ctgtggcctg
     2221 tacgtccctc gagtacaaca tccgagtgta ctgcctgcac gacacccacg atgctctcaa
     2281 ggaggtggtg cagctggaga agcagctggg tggacagctg atccaggagc cccgtgtcct
     2341 gcacttcaaa gacagttacc acaacctacg tctgtccatc cacgacgtgc ccagctccct
     2401 gtggaagagc aagctccttg tcagctacca ggagatccct ttttaccaca tctggaatgg
     2461 cactcagcag tatctgcact gcaccttcac cctggagcgc gtcaatgcca gcaccagcga
     2521 cctggcctgc aaggtgtggg tgtggcaggt ggagggagat ggacagagct tcaacatcaa
     2581 ctttaacatc actaaggaca cgaggtttgc tgaaatgctg gctctggaga gtgaaggggg
     2641 ggtcccagcc ctggtgggcc ccagtgcctt caagatcccc ttcctcattc ggcaaaagat
     2701 cattaccagc ctggacccac cctgcagccg gggcgccgac tggcgaactc tagcccagaa
     2761 acttcacctg gacagccatc ttagcttctt tgcctccaag cccagcccta cagccatgat
     2821 cctcaaccta tgggaggcgc ggcacttccc caacggcaac ctcggccagc tggccgcagc
     2881 tgtggccgga ctgggccagc cagatgctgg cctcttcacc gtgtcagagg ccgagtgctg
     2941 agaccagcca ggccggtcac gcctacactc tcaccagctt tggcacctgc cagggacagg
     3001 caaaagccag acaggggccc tacccccaca cccggggaga gctgcttgga caggcccccc
     3061 tcctggctga agttgtccct cgatgctggt ccttcagacc ctgcccaaac tccatccctc
     3121 catggcctgc ctggccaggt tggtttagcc acctgttctc gctctgccct ggtcccgggg
     3181 cccagagtgg acagtgcctg gagcctgggc tgagcccagc ccatctgtgt gtgtgtgtgt
     3241 atgtgtgtga tgctacctct cttcctgtcc cttgccaggg gccccgcata cacacagcat
     3301 gcgcacacat gctgggcttg ggacacggcc cccagagctc ctgcctgagg tgggccttat
     3361 gcaaacattt ctgtgcctgc tgggtagggg tctatttgag gggcctggct tcaagcctgg
     3421 ggggactaag ggtcccagct ggacaggggc tggcccttgg attcaggcac acgatcacca
     3481 cacaggcgtg tgttcatgca tgcctcgtgt gctcatctca cacgcacccc tctcccaggt
     3541 catgcaggac ccctcccccc accacacaca catctcatgc tgtgcacccg gaggctgctc
     3601 acgtctctca cacccggtgt cggtgtcggt acacatctgc ctctcacatg ctgcccttct
     3661 cccacccacc cagggacacc cgacggctcc tccctgatcc tttccctgta ccccggcctc
     3721 gaggtgccct gcccagcggg gcgtgtgaat atgcaatggg agtcccgggc tgtacaatgg
     3781 caagtgtgtg tgccgtggcg tgcccgttcc tggggctggc caatgcccct gtgtggggcc
     3841 tgttgtgtga agcttgtgtc ctgactctgt cttaagtgca ttcctgcact tacacttggc
     3901 cttatgtaca cagccttgcc cggctgccgg ggcacgtagg gattttagcg gatgtgaatg
     3961 taaataaatt atatatatat attgctaa
//
