LOCUS       NM_001081153            8867 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus unc-13 homolog C (Unc13c), mRNA.
ACCESSION   NM_001081153 XM_006510933 XM_146948
VERSION     NM_001081153.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8867)
  AUTHORS   Kim,O., Okamoto,Y., Kaufmann,W.A., Brose,N., Shigemoto,R. and
            Jonas,P.
  TITLE     Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
            of synaptic vesicle pools and channel-vesicle coupling at
            hippocampal mossy fiber boutons
  JOURNAL   PLoS Biol 22 (11), e3002879 (2024)
   PUBMED   39556620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8867)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8867)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   5  (bases 1 to 8867)
  AUTHORS   Hilton,B.J., Husch,A., Schaffran,B., Lin,T.C., Burnside,E.R.,
            Dupraz,S., Schelski,M., Kim,J., Muller,J.A., Schoch,S., Imig,C.,
            Brose,N. and Bradke,F.
  TITLE     An active vesicle priming machinery suppresses axon regeneration
            upon adult CNS injury
  JOURNAL   Neuron 110 (1), 51-69 (2022)
   PUBMED   34706221
REFERENCE   6  (bases 1 to 8867)
  AUTHORS   Lalonde,R. and Strazielle,C.
  TITLE     Spontaneous and induced mouse mutations with cerebellar
            dysfunctions: behavior and neurochemistry
  JOURNAL   Brain Res 1140, 51-74 (2007)
   PUBMED   16499884
  REMARK    Review article
REFERENCE   7  (bases 1 to 8867)
  AUTHORS   Schoch,S., Mittelstaedt,T., Kaeser,P.S., Padgett,D., Feldmann,N.,
            Chevaleyre,V., Castillo,P.E., Hammer,R.E., Han,W., Schmitz,F.,
            Lin,W. and Sudhof,T.C.
  TITLE     Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered
            neurotransmitter release
  JOURNAL   EMBO J 25 (24), 5852-5863 (2006)
   PUBMED   17124501
REFERENCE   8  (bases 1 to 8867)
  AUTHORS   Caqueret,A., Boucher,F. and Michaud,J.L.
  TITLE     Laminar organization of the early developing anterior hypothalamus
  JOURNAL   Dev Biol 298 (1), 95-106 (2006)
   PUBMED   16860307
REFERENCE   9  (bases 1 to 8867)
  AUTHORS   Varoqueaux,F., Sons,M.S., Plomp,J.J. and Brose,N.
  TITLE     Aberrant morphology and residual transmitter release at the
            Munc13-deficient mouse neuromuscular synapse
  JOURNAL   Mol Cell Biol 25 (14), 5973-5984 (2005)
   PUBMED   15988013
REFERENCE   10 (bases 1 to 8867)
  AUTHORS   Augustin,I., Korte,S., Rickmann,M., Kretzschmar,H.A., Sudhof,T.C.,
            Herms,J.W. and Brose,N.
  TITLE     The cerebellum-specific Munc13 isoform Munc13-3 regulates
            cerebellar synaptic transmission and motor learning in mice
  JOURNAL   J Neurosci 21 (1), 10-17 (2001)
   PUBMED   11150314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132267.3, AC124451.4, AC112267.4, AC153359.4 and AC131722.4.
            
            On or before Feb 12, 2019 this sequence version replaced
            XM_006510933.3, NM_001081153.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               AC132267.3         43536-44079         c
            545-3757            AC132267.3         5639-8851           c
            3758-3780           AC124451.4         50913-50935         c
            3781-3845           AC124451.4         50288-50352         c
            3846-3924           AC112267.4         179721-179799       c
            3925-3930           AC112267.4         179074-179079       c
            3931-4002           AC112267.4         177457-177528       c
            4003-4222           AC112267.4         170604-170823       c
            4223-4450           AC112267.4         157639-157866       c
            4451-4592           AC112267.4         155526-155667       c
            4593-4762           AC112267.4         120223-120392       c
            4763-4878           AC112267.4         115993-116108       c
            4879-5042           AC112267.4         114327-114490       c
            5043-5199           AC112267.4         101459-101615       c
            5200-5268           AC153359.4         295-363
            5269-5358           AC153359.4         2208-2297
            5359-5487           AC153359.4         4189-4317
            5488-5621           AC153359.4         30670-30803
            5622-5707           AC153359.4         40621-40706
            5708-5834           AC153359.4         91360-91486
            5835-5931           AC153359.4         95750-95846
            5932-6075           AC153359.4         97380-97523
            6076-6153           AC131722.4         227073-227150       c
            6154-6231           AC131722.4         221993-222070       c
            6232-6320           AC131722.4         209027-209115       c
            6321-6470           AC131722.4         203287-203436       c
            6471-6594           AC131722.4         196962-197085       c
            6595-6651           AC131722.4         193968-194024       c
            6652-6732           AC131722.4         189006-189086       c
            6733-6880           AC131722.4         180293-180440       c
            6881-6973           AC131722.4         147936-148028       c
            6974-7133           AC131722.4         146672-146831       c
            7134-8867           AC131722.4         142476-144209       c
FEATURES             Location/Qualifiers
     source          1..8867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.8 cM"
     gene            1..8867
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /note="unc-13 homolog C"
                     /db_xref="GeneID:208898"
                     /db_xref="MGI:MGI:2149021"
     exon            1..544
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            545..3757
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     CDS             787..7419
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /note="unc13 homolog 3"
                     /codon_start=1
                     /product="protein unc-13 homolog C"
                     /protein_id="NP_001074622.1"
                     /db_xref="CCDS:CCDS40690.1"
                     /db_xref="GeneID:208898"
                     /db_xref="MGI:MGI:2149021"
                     /translation="MVASLFKSLILAYIHKLCKGMFTKKLGNTTKKKENRQQKKDQDF
                     PTAGHTKPPKLSNALKSTVKKIAKCSSTRNFSIEDEEGHKDFSLSPTFSYRVAIANGL
                     QTAVTNSDEDLLQELSSIESSYSESFNELRSSTENQVQSTHTMPVRRNRKSSSSLAPS
                     EGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTVKKTWGIRSKSLDRTARNP
                     KTNVLEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKYSIDEISS
                     SVEVVQSEIEQLRTGFVQARRETRDIHDYIKHLGHMGSKVSLRFLNVPEERHEYVESV
                     VYQILIDKMGFSDVPNAIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSY
                     KLKGTGIGISTDILTYDIRERKEKGVLPSSQTYESMDMKLSTPEPKAKKNAWLSPNDS
                     DRELESDLSRSSYADSPAKGSSSKSSSKSHSARSKNKAANSRTSQKSDYNKRPSQPPA
                     SSTPEKQTPHYVEATPPLWHSQSDFFTLKLSRSESDFSKLCQSYSEDFSESQFFCRTN
                     GSSLLSSSDRELWQRKQEGMPALYHRLQDQGLDETIPAVPGQAEIENTETVDSGMSNS
                     MVCASGDRSNYSGSQLSLHEDLSPWKEWNQAGQGTDDVGLDSSTQEPFDYDTNSLSDQ
                     QLDLSSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQEA
                     NSNDLYPNQSHPSMMYRSQSELQSDDSEGAQPKSWHSRLSIDLSDKTFKFPKFGSTLQ
                     RAKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYK
                     AEEEEDYCEPVADSETDYVEVMEQVLAKLENRTSITEVNEHIKDYDHPSYETPYETPQ
                     DEGYDGQADDIISEGELETLNEPAVEMELAEDENQNLPAESLEVMKPKRIRPSFKEAA
                     LRAYKKQMAELEEKILAGDSSSMDEKARIVSGNDLDASKFSALQVFGGAGRGLYGIDS
                     MPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFRKTLQALIYPI
                     SSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQR
                     AAEKSSKHGAEDKTQTIITAMKERMKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAK
                     QSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPV
                     WDEKFFFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMD
                     VWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGS
                     VKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGVESIYQAMTHFSCLSSKYMCPGVPAV
                     MSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYR
                     ENFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKY
                     IFDNCHELYSQLIDPSKKQDVPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVL
                     NQFPQELNMGKISAEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYV
                     RELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFS
                     CSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLVQYAAIVSNDFSSYC
                     DKETVPCILMNNIQQLRVQLEKMFESMGGKELDPEASTILKELQIKLNGVLDALSITY
                     GESFQLTIEECIKQMGAELNQMRANGNSTANKNSAAMDAEIVLRPLMDFLDKTLSLSA
                     KICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHM
                     IREDAKGLTPRQCAIVEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQT
                     TDALIKKFIETQGSQSRSSKDAVGQISVHVDVTTTPGTGDHKVTVKVIAINDLNWQTT
                     AMFRPFVEVCMLGPSLGDKKRKQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLS
                     VKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNLSMDETGLTILRILSQRTSD
                     DVAKEFVRLKSETRSIEESA"
     exon            3758..3780
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3845
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3924
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..3930
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4002
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4222
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..4450
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4592
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4762
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4763..4878
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..5042
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5199
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5268
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5269..5358
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5359..5487
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5621
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5622..5707
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..5834
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5835..5931
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6075
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6076..6153
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6231
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6232..6320
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6321..6470
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6471..6594
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6595..6651
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6652..6732
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6733..6880
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6881..6973
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            6974..7133
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     exon            7134..8867
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8836..8841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /note="hexamer: AATAAA"
     polyA_site      8867
                     /gene="Unc13c"
                     /gene_synonym="1500037O19Rik; D9Ertd414e; Munc13-3;
                     Unc13h3"
                     /note="major polyA site"
ORIGIN      
        1 agagggagcc tggactccaa gggaggaggc taggagctca ggtctctgct gcaatcggag
       61 gatcccgggc tgcagccgct gtgtgaagtt cccagcacac actcctcggc tgctgctctg
      121 cactgtcaat tgtgggtgag ccaggacaac aacaaggaga gggatcccat tttgccttct
      181 tagagaaagg gctgagaaat gagccgccca aggaatctgg caaggagagg agtgaaaggc
      241 agattcctgc cagcagctaa gttgtaaaat tgctttggag gctacccagg gagcgcgata
      301 gaattgataa gagcagcgcg caagccgggt tcctgagcaa aggcatgccc ggctgcactt
      361 gagtctgggc gggcgcagga acgctgcctg cgcctcctgc aactatctgt ggctggaata
      421 aaggaaaaga gcctaggaac acaattgcaa gggggattcc tggacggaaa atacatctac
      481 cctcaaagga ggggaacaac aacccagctg gcctgtgtgc gtttttagaa ggagaatccc
      541 tcagatacat catgaagtta catggacatg aaagcgctgt aaaacttccc ttccagaaag
      601 gtggaggagc taagctggtg gagtccacag acccttgacc ttccacagga gcgccatcca
      661 ctttcctgcc ccttctggtg attgatggca ccagagaaca gtgatgctgg ccttgggttt
      721 acagactacc atcccagtgc cttgttcact tccttggatt agagaaactc ccactcattg
      781 ctctccatgg tggccagtct ctttaagagc ttgattttag cttatataca taagctttgc
      841 aaaggaatgt ttacaaagaa attgggaaat acaaccaaaa agaaagagaa tcgtcagcag
      901 aaaaaagatc aagattttcc aactgctggc cacaccaaac cccctaaatt gtcaaatgcc
      961 ctgaaaagca ctgtaaaaaa gattgcaaag tgctcatcta cccggaactt ctccatagaa
     1021 gacgaagagg gtcacaaaga cttctccctg tcacccacat tcagttaccg agttgctatc
     1081 gccaatggcc tgcaaacagc cgtgaccaac agcgatgagg atctgctcca ggagctgtct
     1141 tccatcgaga gctcgtactc tgaatccttc aatgagctaa ggagcagcac ggaaaaccag
     1201 gtccaatcaa cacacaccat gcctgtccga cgtaacagga agagctcgag cagtttggca
     1261 ccttctgagg gcagctcaga tggggagcgc accctccaca ccttaaaact gggtgctcta
     1321 cggaaactga ggaaatggaa gaagagccaa gagtgcgtct cctcagactc ggagttgagc
     1381 accgtcaaga aaacctgggg cataagaagc aaatcattag atagaactgc ccggaaccca
     1441 aagacaaatg tcttagagcc agggttcagc tcctctggct gcattagcca aacccacgat
     1501 gtcatggaaa tgatctttaa agagcttcag ggtataagtc agatcgaaac agaactttcc
     1561 gaactccgag ggcacgtgaa tgctctcaag tactctatcg atgaaatctc cagcagtgtg
     1621 gaggtagtcc agagcgagat cgaacagctt cgaacagggt ttgtccaggc tcgaagggaa
     1681 actcgagaca tccacgatta cattaaacac ttgggtcaca tggggagtaa ggtaagcctg
     1741 agatttttaa atgtgcctga agaaagacac gagtacgtgg aaagtgtggt gtaccaaatt
     1801 cttatagata aaatgggttt ctcagatgta ccgaatgcta ttaaaattga atttgctcag
     1861 aggatagggc agcaaaggga ctgcccaaat gcaaaacctc gacccatcct agtgtacttt
     1921 gaaacccctc agcaaaggga ttctgtctta aagaaatcgt ataagctgaa aggtacaggc
     1981 atcgggatct ccacagatat tctaacttat gatatcagag aacggaaaga aaaaggggta
     2041 ttgccatctt cccagacata cgaaagcatg gatatgaagt tatccacgcc agagcccaaa
     2101 gccaagaaga acgcttggct gtcacccaat gacagtgaca gagagctgga gtcagacctc
     2161 agcagaagca gctatgctga ctctccggca aagggaagtt cttctaaatc cagctcaaag
     2221 tcacacagtg ctcggtccaa gaacaaagca gctaacagca gaacatcaca gaagtcagac
     2281 tacaataaac ggccctccca accgccagca tcaagtaccc cagaaaagca aacacctcac
     2341 tatgtggagg ccacaccacc actctggcat tcacagagtg acttcttcac tcttaaactt
     2401 agtcgctccg aatcggattt ctccaaattg tgtcaatctt attcagagga tttttctgaa
     2461 agccagtttt tctgtcgaac taatgggagc tccctccttt cctcgtctga ccgggaactt
     2521 tggcagagga aacaggaggg catgcctgcc ttgtaccacc gtcttcagga ccagggtttg
     2581 gatgagacta ttccagcagt gccagggcag gctgaaattg agaatacaga aacagtagac
     2641 agcggtatga gcaacagcat ggtgtgtgca tctggagacc gaagcaatta cagcggttct
     2701 cagctctcat tgcacgagga cctgtctcca tggaaggagt ggaatcaagc agggcaagga
     2761 actgatgatg ttggcttaga ttcatctacc caggaacctt ttgactacga taccaacagt
     2821 ttgtctgacc aacagctgga tctctctagc aaagacctag atgaccttgg caagtgccac
     2881 agcgacctgc aagatgactc tgaaagctat gatttaaccc aggatgacaa ctcctctcca
     2941 tgccctggat tggataatga accacaaggc cagtgggttg gccagtacga ctcttatcag
     3001 gaagccaatt ctaatgacct gtatcccaac caaagccatc catccatgat gtatagaagt
     3061 caaagcgaac tgcaaagtga tgattcagag ggggcccagc ccaagtcctg gcacagtcgg
     3121 ctaagcattg acctttctga taagactttt aagttcccca aatttggatc tactcttcag
     3181 agagcaaagt cagccctgga agtggtgtgg aacaagagca cacagagtct cagtgggtgt
     3241 gaggacagcg gctcttcctt aatggggaga tttcggacat tatcacaatc caccgcgaac
     3301 gagtcaagta ccacccttga ctctgatatc tacacggaac cctattacta taaagccgag
     3361 gaagaggagg actactgtga accagtggct gacagtgaga cagattatgt tgaagtgatg
     3421 gagcaggtcc tagctaagct agaaaacagg actagtatca ctgaagtaaa cgaacacatt
     3481 aaagactatg accacccttc ctatgaaact ccttacgaga ccccgcaaga tgagggctat
     3541 gatgggcagg ctgatgacat cattagtgaa ggagaactgg aaaccttaaa tgaaccagca
     3601 gttgaaatgg aattagcaga agatgagaac caaaacctcc ctgcagagtc actggaggtc
     3661 atgaagccaa agagaatcag gccttccttc aaagaagcag ctttaagggc ctataagaag
     3721 cagatggcag agctggaaga gaagatcctg gctggagata gcagctctat ggatgaaaag
     3781 gctcgaatag taagtggcaa tgatttggat gcttccaaat tctccgcact ccaggtgttc
     3841 ggtggggctg ggcgtggact gtatggtatt gatagcatgc ctgacctccg caggaaaaag
     3901 acattgccta ttgtgcggga tgtggccatg accctggctg cccggaaatc tggtctctcc
     3961 cttgctatgg ttatcaggac atcactgaat aatgaggagc tgaaaatgca tgtcttcagg
     4021 aagaccttgc aggcattgat ctaccccatt tcttccacca ctccccacaa cttcgaggtc
     4081 tggacggcta ccacacccac ctactgctat gaatgtgaag ggctcctgtg gggcatcgca
     4141 aggcaaggca tgaagtgtct ggagtgtggg gtgaaatgcc acgagaagtg tcaggacctg
     4201 ctcaacgccg actgtctgca gcgagcagca gagaagagct ctaagcacgg tgcggaggac
     4261 aagacccaga ctatcatcac agccatgaaa gaaagaatga agatcaggga gagaaacaga
     4321 ccagaggtgt ttgaagtcat tcaggaaatg ttccagatct ccaaagagga ttttgtgcag
     4381 tacacaaagg ctgccaagca gagcgtgctg gatgggacgt cgaagtggtc tgcaaaaatt
     4441 accattacag tggtttccgc acaaggcttg caggcaaaag acaaaacagg gtccagcgac
     4501 ccatatgtga cagttcaagt tggcaaaaat aaaagaagaa cgaaaactat ctttggaaac
     4561 ttgaatccag tgtgggacga gaagttcttc tttgagtgtc ataactcgac agatcgaatc
     4621 aaggtcagag tatgggatga agatgatgac attaaatcca gagttaagca gcacttcaag
     4681 aaggagtcgg atgactttct gggacagacg attgtggaag tcaggactct aagtggtgag
     4741 atggatgtct ggtacaactt agagaaacgg acagataagt cagctgtgtc tggggccatc
     4801 cgactaaaaa tcaatgtgga gataaaggga gaagagaagg tcgcaccata ccatatacaa
     4861 tacacttgtt tacacgagaa cctgttccat tacctgacgg aagtgaagtc taatggcagt
     4921 gtaaaaatac cagaggtcaa gggcgatgaa gcctggaagg ttttctttga tgatgcgtct
     4981 caggaaatag tggatgaatt tgccatgcgt tatggggttg agtccattta tcaagctatg
     5041 acgcactttt catgtctgtc ttctaagtac atgtgcccgg gtgtccctgc agtcatgagc
     5101 gccctgctgg cgaacatcaa tgccttctat gctcatacaa ctgtctccac taacgtgcag
     5161 gtttctgcct ctgatcgctt tgctgctaca aactttggga gggaaaaatt cataaaacta
     5221 ctggaccagt tgcataactc cttaaggatt gacctgtcaa agtacaggga aaactttcca
     5281 gccagcaaca gtgagagact acaggaccta aagtccactg tggacctgtt gaccagcatc
     5341 accttcttcc ggatgaaggt cctggagctg cagagccccc caaaggccag tgcagttgtg
     5401 aaggactgtg tcagggcttg tctggattcc acatacaagt atatcttcga caactgccat
     5461 gaactctatt ctcagctgat agacccgagc aagaagcagg atgtccctcg agaagaccag
     5521 ggaccaacca ccaagaacct ggacttctgg ccacagttga ttacactgat ggtcactatt
     5581 attgatgagg ataaaactgc ctacacccct gttctcaatc agtttccaca agaactaaac
     5641 atggggaaga taagtgcaga aatcatgtgg tctctttttg ctctcgatat gaaatatgct
     5701 ctagaggaac atgagaagca acgcttatgc aagagcaccg attatatgaa tttgcatttc
     5761 aaagtgaaat ggttttataa tgagtatgta cgagaacttc ctgccttcaa ggatgctgtt
     5821 ccagaatatt ccctgtggtt tgagcctttt gttatgcaat ggctagatga aaatgaagat
     5881 gtgtccatgg agttccttca tggagcactg ggaagagaca aaaaagatgg attccagcag
     5941 acatcggacc acgccctttt ctcctgttct gtggttgatg tctttgctca gcttaaccag
     6001 agctttgaga tcattaagaa actggaatgc cccaatcctg aagccctatc acacttaatg
     6061 agacgatttg caaagaccat caataaggtt ctggtccagt acgctgcgat cgtatcaaat
     6121 gacttcagtt catactgcga taaggagaca gtgccttgca tattgatgaa caacatccaa
     6181 caactgcggg tccagctgga aaaaatgttt gaatccatgg gtgggaaaga gctagaccct
     6241 gaagctagca ctattctgaa agaacttcaa atcaaactca acggggttct ggatgcactc
     6301 agcatcactt atggagaaag tttccaactt acaattgaag agtgtataaa gcagatgggt
     6361 gccgagctga atcagatgcg agccaacggg aacagcacag cgaataagaa cagtgcggcg
     6421 atggatgcag agattgtgct gaggccgctc atggacttct tggataagac attaagtctt
     6481 tcagcaaaaa tttgtgagaa aacggtcctg aagcgagttc tgaaggagct ctggaaatta
     6541 gtacttaaca agatagagaa gcagattgtt ctccctccac tgacagacca aacggggcct
     6601 cagatgatct tcattgctgc taaagatctt ggacagttat ccaaactgaa ggagcatatg
     6661 attcgagaag atgccaaggg tctgacacca agacaatgtg caatagtgga ggtggtcttg
     6721 gccactataa agcaatattt tcatgcagga ggaaatggcc tgaagaagaa ttttctggag
     6781 aaaagcccag atcttcattc cctgagatac gctctcagcc tctacacaca aactactgat
     6841 gctttgatca agaagttcat agagacacag ggctcacaga gtcgttcctc caaagatgct
     6901 gtaggccaga tctctgtcca tgtggatgtc accaccaccc cagggactgg agaccataaa
     6961 gtcactgtga aagtaattgc gatcaatgac ctaaactggc agaccaccgc catgttccgc
     7021 ccctttgtgg aagtgtgcat gctgggaccc agcctagggg acaagaagag aaaacaaggg
     7081 acaaagacaa aaagcaacac atggtcaccg aagtacaatg aaaccttcca gttcattctg
     7141 ggtaacgaga accgcccagg agcctatgaa cttcacctct cggttaagga ctactgcttt
     7201 gcccgagaag atcgaataat tggaatgaca gtcattcagt tacagaacat agcagagaaa
     7261 gggagctacg gggcatggta ccctcttctg aaaaatctct ctatggatga aactggttta
     7321 accatcctca gaatactctc tcagaggacc agcgacgatg tcgctaaaga gtttgtgaga
     7381 cttaagtcag aaacgaggtc tattgaagag agtgcctgaa acaaagactt ccaaatactg
     7441 tctttgagaa ttcataaact cttgttgttt gaccctcaca tgcatgtgga aatacatggg
     7501 aatgtttaaa cccaccgtgt tttgatgttt gccagtgatc aaccacagtg tctacaacgt
     7561 atgtgaaaaa cttttatacc agtctggtct ttgagaaata aatgttccat gaagtgccaa
     7621 aatatgatgt aaagtgaaat atcaaggcta tcttttacaa tgttcttctc attaccaatt
     7681 tctcctccat gaagaaaaca aaaaaaaaaa aaaaaacaaa caaaaaaacc aaaacaaaca
     7741 aacattcttg agtttgtcca ttggttgtcc ttgttagatt catttgatca acctatccga
     7801 aagcatcttt gactgaactt ctgttctgtt tagccttacc ttattgtaga caccctgcag
     7861 atccagtttt ctaccacacc tagaaatgca gcgacttcta gaaagtttgt aattttatag
     7921 ttgcagatat attgtgatga tttttgcata caaattacaa tagaaaaggt gggaaatatt
     7981 ttatgctgac cagttcctaa cctttctaaa atatcactgt gaagaaatgc tttcgaagca
     8041 aacttacaca aagcaatgct aaatagtttg ttaatgttta atatattgat gaaactgtgt
     8101 tctttaaaac tgccaagccc ccaaccatca catttgtaat ttaaaaaaaa aaagaaaaaa
     8161 aatggtaacc tgatgagttt gctgtgtagc attatgtctc agctttaccc tacttcattc
     8221 tttggaaagt catggaatgc aagataagta acttgttaga aggaaaatac taacaatata
     8281 cttatgacta cttaactcta catccagatg tctcttttaa aaatattcaa tggtttatgc
     8341 tgaatgcagc actactgtag attgcagaaa accaaagtca caacttcgta tatatttagg
     8401 agggaaaaat gtaaaataaa ctaaaagtaa atggctcatg attttgtaac tcgtgttctt
     8461 tatatgcccc aaatgcaact tggttacaga tacttgcgtt gtctggattt tgttatctga
     8521 ctttccaggg tctgtattta aatatttggc tgcaaagcat cattttgtca ttgtaactca
     8581 cagccacggc tgtgaggaga ttccccactt ggccaggatt gagaagctgt cctgttgact
     8641 gtgttatata aacatgctgg tctaatatgt gaggagcaga agtgatttag tgccatctct
     8701 ctcaaccatt ctgcttctgg gtctgaaaac acacaagctg gtgagattgg ctaatttgtg
     8761 ttcaaatctt aggcgactgc tttgttaatg acttttctaa atgcctagta tgacgcaatt
     8821 gctgacatat gcattaataa atggatgtgt attgaactca tgcaaaa
//
