LOCUS       NP_001371035            4285 aa            linear   ROD 24-DEC-2024
DEFINITION  protein unc-13 homolog B isoform 4 [Mus musculus].
ACCESSION   NP_001371035
VERSION     NP_001371035.1
DBSOURCE    REFSEQ: accession NM_001384106.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 4285)
  AUTHORS   Kim,O., Okamoto,Y., Kaufmann,W.A., Brose,N., Shigemoto,R. and
            Jonas,P.
  TITLE     Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
            of synaptic vesicle pools and channel-vesicle coupling at
            hippocampal mossy fiber boutons
  JOURNAL   PLoS Biol 22 (11), e3002879 (2024)
   PUBMED   39556620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 4285)
  AUTHORS   Zhang,H., Lei,M., Zhang,Y., Li,H., He,Z., Xie,S., Zhu,L., Wang,S.,
            Liu,J., Li,Y., Lu,Y. and Ma,C.
  TITLE     Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE
            complex assembly and neurotransmitter release
  JOURNAL   Sci Adv 10 (20), eadi7024 (2024)
   PUBMED   38758791
  REMARK    GeneRIF: Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated
            SNARE complex assembly and neurotransmitter release.
REFERENCE   3  (residues 1 to 4285)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 4285)
  AUTHORS   Papantoniou,C., Laugks,U., Betzin,J., Capitanio,C., Ferrero,J.J.,
            Sanchez-Prieto,J., Schoch,S., Brose,N., Baumeister,W., Cooper,B.H.,
            Imig,C. and Lucic,V.
  TITLE     Munc13- and SNAP25-dependent molecular bridges play a key role in
            synaptic vesicle priming
  JOURNAL   Sci Adv 9 (25), eadf6222 (2023)
   PUBMED   37343100
REFERENCE   5  (residues 1 to 4285)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    GeneRIF: Munc13 supports fusogenicity of non-docked vesicles at
            synapses with disrupted active zones.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 4285)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (residues 1 to 4285)
  AUTHORS   Varoqueaux,F., Sigler,A., Rhee,J.S., Brose,N., Enk,C., Reim,K. and
            Rosenmund,C.
  TITLE     Total arrest of spontaneous and evoked synaptic transmission but
            normal synaptogenesis in the absence of Munc13-mediated vesicle
            priming
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 9037-9042 (2002)
   PUBMED   12070347
REFERENCE   8  (residues 1 to 4285)
  AUTHORS   Rosenmund,C., Sigler,A., Augustin,I., Reim,K., Brose,N. and
            Rhee,J.S.
  TITLE     Differential control of vesicle priming and short-term plasticity
            by Munc13 isoforms
  JOURNAL   Neuron 33 (3), 411-424 (2002)
   PUBMED   11832228
REFERENCE   9  (residues 1 to 4285)
  AUTHORS   Rhee,J.S., Betz,A., Pyott,S., Reim,K., Varoqueaux,F., Augustin,I.,
            Hesse,D., Sudhof,T.C., Takahashi,M., Rosenmund,C. and Brose,N.
  TITLE     Beta phorbol ester- and diacylglycerol-induced augmentation of
            transmitter release is mediated by Munc13s and not by PKCs
  JOURNAL   Cell 108 (1), 121-133 (2002)
   PUBMED   11792326
REFERENCE   10 (residues 1 to 4285)
  AUTHORS   Augustin,I., Rosenmund,C., Sudhof,T.C. and Brose,N.
  TITLE     Munc13-1 is essential for fusion competence of glutamatergic
            synaptic vesicles
  JOURNAL   Nature 400 (6743), 457-461 (1999)
   PUBMED   10440375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672276.9, AL772176.6 and AL732504.23.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849374, SAMN00849375
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4285
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.0 cM"
     Protein         1..4285
                     /product="protein unc-13 homolog B isoform 4"
                     /note="protein unc-13 homolog B; unc13 homolog 1; munc13;
                     UNC-13 homolog 1"
                     /calculated_mol_wt=478495
     Region          1..127
                     /region_name="C2A_Munc13"
                     /note="C2 domain first repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08394"
                     /db_xref="CDD:176040"
     Site            order(23,25,27,31..34,63,65,71..74)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:176040"
     Region          3154..3235
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(3178..3184,3192..3196,3199)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          3295..3421
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(3311,3317,3363,3365,3382)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          3613..4099
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          4133..4252
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..4285
                     /gene="Unc13b"
                     /gene_synonym="Munc13-1; Munc13-2; Unc13a; Unc13h1;
                     Unc13h2"
                     /coded_by="NM_001384106.1:312..13169"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:22249"
                     /db_xref="MGI:MGI:1342278"
ORIGIN      
        1 msllcvrvkr akfqgspdkf ntyvtlkvqn vksttvavrg dqpsweqdfm feisrldlgl
       61 svevwnkgli wdtmvgtvwi alktirqsde egpgewstle aetlmkddei cgtknptphk
      121 illdtrfelp fdipeeeary wtykleqina laddneyssq eesqrkplpt aaaqcsfedp
      181 dsavddrdsd yrsetsnsap ppyhtttqpn asvhqfpvpv rlpqqlflqg sshdscndsm
      241 qsydldyper ralrypqkyn tidrrrkkpl yshsednerw hyntksnskc afpdtensap
      301 yhiekkklny pilcpykngf vksstwntdl egydyglpyc lrnygnvsgs ncsvtnftpl
      361 difddstsst seeilgspis deqesmsptw hssnvnhmgd fseeyyvans vlplqrmncn
      421 vntvgdlsrc smedmtpsfv egpkekyvdt mdelqclvet vseylaekee einrfgslsk
      481 tkephehnta vanaeqktse nqtspltvtq nakakaisfp elngvkcavg slfssltekv
      541 gsgtkhltts veklvhsvpe kketqnqtet vslgpnpsai sllekdlsaq pllscqttdd
      601 kdavrhgrts enehlgdktk gesfqdstet irkdsapqtq ssivksvfsk lnplkifsek
      661 eetksedhsk vsrrestegc gsesnqsedl ldnqssslad lirskretad lqmqeredlp
      721 slqvadepsn vassigkkgg mesqlegkpc velslskdqp qqsakdtver cgvagstfan
      781 qesstkalee dkvtsdedfl eplrksfsql lftspesckk etssesvtil kleedgqerd
      841 akkdghsfsf srklhipffn ilshsekhqd vkekgsifpl fkfpltdshs tvnnqsfhss
      901 vattdkevqq nchmdtrlss vksssfpnih nhleklgste efskndqinc pedvkcnslk
      961 sssisnihnd peklnsieef nksdqtycse dekhntmrsd stssinsdfg kcgslaelnp
     1021 sshaavehye kadpddvlke qhitvalsee gvnltqvafp lmsdsslgli satskstlvn
     1081 dinedkvene tsdkgtqrgf lsvilskfas lenmpsqqef nlksdsshhk nntsssllsg
     1141 ifnlitnssv ndynpveakl isledgrkhl stdevpadsw vtsenlrsqv ennvassfik
     1201 nslslsketm pssdgwdsnh icpptwenqe sekhcpseni lccteqdple ksltkrptpn
     1261 hileiklher snklsspiqn tnilsksnhy qafdedclew gpdikdfsrn srrlqpvyhl
     1321 lnqntfpsad aflwpdsenp vinlcqkdqn anifewgtnp nsviscdlpy esfdqlafne
     1381 gyllrgdmwa adscgnsgyl pvnetknsle elpidlsyss dyekimcsll qqqslgmden
     1441 lifssfdyey qewlsyleng vwwpsedgny gyymfhdgqy iyslltdstg qyvylfipdy
     1501 yheylnynlq tdalpsimld dntisahslq vlgkednllw yaeeepvedp ldlsvtlprn
     1561 erslyvnlet fsqvfessfd qrdkpldfsg ynsqkfkrdf rsfigrpycs edlecildlr
     1621 nkpgtmsnht lnggtviqre mnwtlpkkss ahlsrfhfhq sssdepssli hpesmteslq
     1681 keetppvnkl tpvfsilgtl irsslnfdks dsvdglviqk tdqqselsep ihdslhslil
     1741 skqlschsik edeshpedle rqmvysvqqp eftdsikqef slhkndhmdk esllkagfqv
     1801 sqttlkaktd vedvkiitak sivdplapql skdehkncel lqdqfskesd ktlltsalkl
     1861 fgweegssvs tvtsekpasg ilnlfktrvn keespdleki gdkggkissq ekkessgvan
     1921 ffgtlgdffk tnvclmqtte nksvslvtde derrsspnpl hlahqdtgnf pplpvpskkk
     1981 vrirsltkqt tiddnglrep ltremqsngl nekevpvrdh qvqqstsppv stggskespr
     2041 dsskgtgavs tgtevprnnk sfdalsrrnt neqdnfpnqe wkfstatpas qqelpsrrni
     2101 fsfltgseks enkasaalpr arsqaeglft lpsffstasl stkkdasrss safslfnlsf
     2161 leekqqssee kqslsaiapv taqpcrrpvv svdtgdvmtk edstahkesi vhqvvyeeqm
     2221 apgvstnstt elttslvdkl hiektqekms sskggaegat afdfqvnqlp asvapllpef
     2281 qeqalgvapq eegvfhqets srdsaaesls rdnglnekln dldvctehqn erfttgllnl
     2341 plehgsdsls tqildlpasp dpghtgllqn qdadkledrs vlgskvemis gfvtkvksfs
     2401 gslieqpktf sgffstpksp kknsffsfss aassqplkte lfgifrspkp etnkqepsvs
     2461 tscfqsgssr dpvgsilpks lpgeaacagl nsesalsacs itvvdakses dpltddpkli
     2521 pemeknises iseppcfevl attssvsedd mgqgilslsd egdmgllqgt dteasleaeh
     2581 illptqlqsd paciaeelpp ssqpllelep epepepepep epepepepep epepepellt
     2641 astnqeyfgl vttsvetsis lfdeagasen ttletqgyhs cplqeepvlc lkesssihha
     2701 pkdppvapqe teqtrprfei pnmaswpklh fpstpdhgkt lssifnpsss sgnmaaetgl
     2761 msgfkklstl fegasegkgv ilgndpklvf gkkldlsfpw skenkgdpeq mpaksspvlv
     2821 vsddqdliis kankisessq vpsgspksan ictlpsgtte qlvakpsdca qelsksgeve
     2881 rqlefsapee hwgedsnlsg sarpsekhke ehcaqpakqe emsastssil nvgqlviped
     2941 tketvtnksp tsssrygssc nvsqgsslls eldqyheqdd dgrerdsihs shsygslskd
     3001 gqaglgeqek alevtcesek ektgeskemr ddatihppsd lvlhkdhvlg pqeslpeeta
     3061 sspftqarah wfravtkvrl qlqeisddgd pslpqwlpeg pagglygids mpdlrrkkpl
     3121 plvsdlslvq srkagitsam atrtslkdee lkshvykktl qaliypisct tphnfevwsa
     3181 ttptycyece gllwglarqg mrcsecgvkc hekcqdllna dclqraaeks skhgaedrtq
     3241 niimamkdrm kirernkpei fevirdvftv skvahvqqmk tvkqsvldgt skwsakitit
     3301 vvcaqglqak dktgssdpyv tvqvgktkkr tktifgnlnp vweekfhfec hnssdrikvr
     3361 vwdedddiks rvkqrlkres ddflgqtiie vrtlsgemdv wynlekrtdk savsgairlq
     3421 isveikgeek vapyhvqytc lhenlfhylt diqgsggvwi peargddawk vyfdetaqei
     3481 vdefamrygi esiyqamthf aclsskymcp gvpavmstll aninayyaht tastnvsasd
     3541 rfaasnfgke rfvklldqlh nslridlsty rnnfpagspe rlqdlkstvd lltsitffrm
     3601 kvqelqsppr asqvvkdcvk aclnstyeyi fnnchdlysh qyqlqeqple epgpsirnld
     3661 fwpklitliv siieedknsy tpvlsqfpqe lnvgkvsaev mwhlfaqdmk yaleehekdr
     3721 lcksadymnl hfkvkwlhne yvrdlpalqg qvpeypawfe qfvlqwlden edvsleflrg
     3781 alerdkkdgf qqtsehalfs csvvdvftql nqsfeiirkl ecpdpnilah ymrrfaktig
     3841 kvlmqyadil sknfpayctk erlpcilmnn mqqlrvqlek mfeamggkel dseaadslke
     3901 lqvklntvld elsmvfgnsf qvridecvrq madilgqvrg tgnaspnara svaqdadsvl
     3961 rplmdfldgn ltlfatvcek tvlkrvlkel wrvvmntmer vivlppltdq tgtqliltaa
     4021 kelsqlsklk dhmvreetrn ltpkqcavld laldtikqyf haggnglkkt flekspdlqs
     4081 lryalslytq ttdtliktfv rsqtaqgagv ddpvgevsiq vdlfthpgtg ehkvtvkvva
     4141 andlkwqtag mfrpfvevtm vgphqsdkkr kfttksksnn wtpkynetfh fllgneegpe
     4201 ayelqicvkd ycfaredrvi glavmplrdv aakgscacwc plgrkihmde tgmtilrils
     4261 qrsndevare fvklksesrs teegs
//
