LOCUS       NM_001029873            7983 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus unc-13 homolog A (Unc13a), mRNA.
ACCESSION   NM_001029873 XM_356087
VERSION     NM_001029873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7983)
  AUTHORS   Kim,O., Okamoto,Y., Kaufmann,W.A., Brose,N., Shigemoto,R. and
            Jonas,P.
  TITLE     Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration
            of synaptic vesicle pools and channel-vesicle coupling at
            hippocampal mossy fiber boutons
  JOURNAL   PLoS Biol 22 (11), e3002879 (2024)
   PUBMED   39556620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7983)
  AUTHORS   Papantoniou,C., Laugks,U., Betzin,J., Capitanio,C., Ferrero,J.J.,
            Sanchez-Prieto,J., Schoch,S., Brose,N., Baumeister,W., Cooper,B.H.,
            Imig,C. and Lucic,V.
  TITLE     Munc13- and SNAP25-dependent molecular bridges play a key role in
            synaptic vesicle priming
  JOURNAL   Sci Adv 9 (25), eadf6222 (2023)
   PUBMED   37343100
REFERENCE   3  (bases 1 to 7983)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7983)
  AUTHORS   Elizarova,S., Chouaib,A.A., Shaib,A., Hill,B., Mann,F., Brose,N.,
            Kruss,S. and Daniel,J.A.
  TITLE     A fluorescent nanosensor paint detects dopamine release at axonal
            varicosities with high spatiotemporal resolution
  JOURNAL   Proc Natl Acad Sci U S A 119 (22), e2202842119 (2022)
   PUBMED   35613050
REFERENCE   5  (bases 1 to 7983)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   6  (bases 1 to 7983)
  AUTHORS   Varoqueaux,F., Sigler,A., Rhee,J.S., Brose,N., Enk,C., Reim,K. and
            Rosenmund,C.
  TITLE     Total arrest of spontaneous and evoked synaptic transmission but
            normal synaptogenesis in the absence of Munc13-mediated vesicle
            priming
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 9037-9042 (2002)
   PUBMED   12070347
REFERENCE   7  (bases 1 to 7983)
  AUTHORS   Rosenmund,C., Sigler,A., Augustin,I., Reim,K., Brose,N. and
            Rhee,J.S.
  TITLE     Differential control of vesicle priming and short-term plasticity
            by Munc13 isoforms
  JOURNAL   Neuron 33 (3), 411-424 (2002)
   PUBMED   11832228
REFERENCE   8  (bases 1 to 7983)
  AUTHORS   Rhee,J.S., Betz,A., Pyott,S., Reim,K., Varoqueaux,F., Augustin,I.,
            Hesse,D., Sudhof,T.C., Takahashi,M., Rosenmund,C. and Brose,N.
  TITLE     Beta phorbol ester- and diacylglycerol-induced augmentation of
            transmitter release is mediated by Munc13s and not by PKCs
  JOURNAL   Cell 108 (1), 121-133 (2002)
   PUBMED   11792326
REFERENCE   9  (bases 1 to 7983)
  AUTHORS   Duncan,R.R., Betz,A., Shipston,M.J., Brose,N. and Chow,R.H.
  TITLE     Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo
  JOURNAL   J Biol Chem 274 (39), 27347-27350 (1999)
   PUBMED   10488064
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
REFERENCE   10 (bases 1 to 7983)
  AUTHORS   Augustin,I., Rosenmund,C., Sudhof,T.C. and Brose,N.
  TITLE     Munc13-1 is essential for fusion competence of glutamatergic
            synaptic vesicles
  JOURNAL   Nature 400 (6743), 457-461 (1999)
   PUBMED   10440375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ106055.1, AK147408.1, CB250050.1 and CJ250255.1.
            
            On Jan 14, 2010 this sequence version replaced NM_001029873.1.
            
            CCDS Note: The coding region has been updated to represent a splice
            pattern that is more supported by the available transcript and
            protein data. The update results in a protein that is shorter,
            changes the splice pattern reflected by the CDS, and changes the
            sequence of the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY753536.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               CJ106055.1         1-489
            490-6465            AK147408.1         3-5978
            6466-6571           CB250050.1         548-653
            6572-7934           AK147408.1         6085-7447
            7935-7983           CJ250255.1         427-475
FEATURES             Location/Qualifiers
     source          1..7983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..7983
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /note="unc-13 homolog A"
                     /db_xref="GeneID:382018"
                     /db_xref="MGI:MGI:3051532"
     exon            1..132
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..162
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..262
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..380
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..504
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..578
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..633
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..666
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..874
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1420
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1529
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1576
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1655
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1661
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1733
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1953
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2181
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2323
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2493
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2609
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2773
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2924
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..2993
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3083
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3218
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3352
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3438
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3565
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3662
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..3806
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3890
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..3968
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4057
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4210
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4334
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4340
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4379
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4409
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4410..4466
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4547
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4695
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4788
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4789..4948
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..7960
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5737
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /note="major polyA site"
     regulatory      6184..6189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /note="hexamer: TATAAA"
     polyA_site      6208
                     /gene="Unc13a"
                     /gene_synonym="2410078G03Rik; Munc13-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggcgct gtccgcgccc ccggtgctga agcgacatgg ccggcggccg ggccccggca
       61 taagccctga gccccgcgct gcacccgccg cgctctagcc gcctggagtc atgtctctgc
      121 tgtgcgtggg agtcaaaaaa gccaagtttg acggtgccca agagaagttc aacacatacg
      181 tgacgctgaa ggtgcagaac gtgaagagca ctaccatagc tgtacgtggc agccagccca
      241 gctgggagca ggacttcatg tttgagatca accgcctgga tctaggcctg accgtggagg
      301 tgtggaacaa gggtctcatc tgggacacga tggtgggtac tgtgtggatc ccgctgcgga
      361 ccatccgcca gtccaatgag gagggcccag gagagtggct cacactggac tctcaggcca
      421 tcatggcgga cagtgagatc tgtgggacca aggaccccac cttccatcgc atcctcctgg
      481 acgctcattt cgagctgccg ttggacatcc ctgaggagga ggcacgctac tgggccaaga
      541 agctggagca gctgaatgcc atgcgtgacc aggatgagta ctccttccag gaccagcagg
      601 acaagccgct gccagtgccc agcagccagt gctgcaactg gaattacttt ggctggggag
      661 aacagaatga cgaccccgac agtgcggtgg atgaccggga cagtgactat aggagtgaga
      721 ccagcaacag catcccaccg ccctactata cgacttcgca gcccaacgcc tctgtgcacc
      781 agtactccgt gcgaccgccc cctctggggt cccgggagtc ctacagtgac tccatgcaca
      841 gctatgagga gttctctgag ccgcgggcgc tcagccccac aggcagcagc cgctatgctt
      901 cttccgggga gctgagccag ggaagctcac agctgagcga ggacttcgac cctgatgagc
      961 acagcctgca gggctcggag ctggatgacg agagggaccg cgattcttat cactcctgtc
     1021 acagctccgt gagttaccac aaggactcac cccgctggga ccaggacgat gaggacctgg
     1081 aggacctgga ggacctggaa gatgaggagc tgcccgagga ggaggaggag ttggaggagg
     1141 agggggagga ggaattggag gaagaggatt tggaggagga ggaggaggtg cctgatgacc
     1201 tggccagcta cacccagcag gaggacacca ctgtggctga gcccaaagag ttcaagcgga
     1261 tcagcttccc aacggctgcg cctcagaagg atgacaaggt ttcagctgtg cctacagagg
     1321 cccccgaggt ggccaaaggc atccccaaag cagccacacc cgaggagaag gcagctgcag
     1381 agcgtgcgca ggaagccgag ccccccaagt ctgaggagag tttcagatct cgagaggagg
     1441 aagagggcca ggaagggcag gatgccatgt ccagagccaa agccaactgg ttgcgagcct
     1501 tcaacaaggt gcgcatgcag ctgcaggagg cccgaggaga aggggatatg tctaagtctc
     1561 tatggttcaa aggcggtcct ggtggtggcc ttatcatcat tgacagcatg ccagacatca
     1621 ggaaacggaa gcccattccc ctcgtgagcg acctggctat gtcattggtg cagtctcgga
     1681 aggcaggcat cacctcggcc ttggcctcca gcacgttgaa caatgaagag ctgaaaaatc
     1741 acgtttacaa gaagaccctg caagccttaa tctaccccat ctcctgcacc acgccgcaca
     1801 atttcgaggt gtggacggcc accacgccca cctactgcta tgagtgcgag gggctgctgt
     1861 ggggcatcgc gcggcagggc atgcgatgca ccgagtgcgg cgttaagtgc cacgagaagt
     1921 gccaggacct gctcaatgcg gattgcctgc agcgggcggc tgagaagagt tccaagcatg
     1981 gcgctgaaga ccgcacgcag aacatcatca tggtgctgaa ggaccgcatg aagatccgcg
     2041 agcgcaacaa gcctgagatc ttcgagctta tccaagagat cttcgcggtc accaagagcg
     2101 cacacacaca gcagatgaaa gctgtcaagc agagtgtgct ggacggcaca tccaagtggt
     2161 ctgccaaaat tagcatcaca gtggtctgtg cccagggctt gcaggccaag gacaagacag
     2221 gatccagtga cccttatgtc accgtccagg ttgggaagac caagaaaagg acaaaaacca
     2281 tctacgggaa cctcaaccca gtgtgggaag agaattttca ttttgaatgt cacaactcct
     2341 ctgaccggat caaggttcgt gtttgggatg aagatgacga cataaaatcc cgtgtgaaac
     2401 aaaggtttaa gagggagtct gatgacttcc tagggcagac aatcatcgag gtgcggacgc
     2461 ttagcggcga gatggatgtg tggtacaatc tggacaagag aacggacaag tcggcggtgt
     2521 cgggggccat ccggcttcac atcagtgtgg agatcaaagg ggaggagaag gtggcgccct
     2581 accatgtcca gtacacctgt ctgcatgaga acctgttcca ctttgtgacg gacgtgcaga
     2641 acaatggtgt ggtgaagatt cccgatgcca agggtgacga cgcctggaag gtttactacg
     2701 atgagacggc ccaggagatc gtggatgagt ttgccatgcg ctatggtgtt gagtccatct
     2761 accaagccat gacccacttt gcctgcctct cctccaagta tatgtgccct ggggtacccg
     2821 ctgtcatgag caccctgctt gccaacatca acgcctacta cgcacacacc accgcctcca
     2881 ccaacgtgtc tgcctctgac cgcttcgctg cctctaattt cgggaaagag cgctttgtga
     2941 aacttctgga ccagctacac aattctctgc ggatcgacct gtccatgtac cggaacaact
     3001 tcccagccag cagccctgag cggctgcagg atctcaagtc cacggtggac ctgctcacca
     3061 gcatcacctt cttccggatg aaggttcagg aactgcagag cccgccgcgt gccagccagg
     3121 tagtgaaaga ctgtgtgaag gcctgcctca actccaccta tgagtacatc ttcaacaact
     3181 gccatgagct ctatggccgg gagtaccaaa cggatccggc caagaagggg gaggttcccc
     3241 cagaggagca aggccctagc atcaagaacc tggatttctg gtccaagctg atcaccctca
     3301 tcgtgtctat catcgaggag gataagaatt cttacacacc ctgcctcaat cagtttcccc
     3361 aggagctcaa tgtggggaag atcagtgctg aggtgatgtg gagcctattt gcccaagaca
     3421 tgaagtacgc catggaggaa catgacaaac accggctgtg taagagcgca gattacatga
     3481 acctgcactt caaggtgaag tggctgtaca atgagtacgt ggccgagctg cccaccttca
     3541 aggaccgtgt gcctgagtac cctgcgtggt ttgagccctt cgtcatccag tggttggatg
     3601 agaatgagga ggtgtcccgg gacttcctgc atggtgccct cgagcgggac aagaaggacg
     3661 ggttccagca gacctcagag cacgccctgt tctcttgctc agtggtggac gtcttctccc
     3721 agcttaacca gagtttcgag atcatcaaga agctggagtg tcctgacccc cagatcgtgg
     3781 gccattacat gcggcgtttt gccaagacca ttagcaatgt gcttctccag tatgcagaca
     3841 tcgtttccaa ggacttcgcc tcctactgct ccaaggagaa ggagaaagtg ccctgcatcc
     3901 tcatgaacaa cacacagcaa ctacgagtgc agctggagaa gatgtttgag gcgatgggcg
     3961 ggaaggagct ggatgccgag gccagtggca ccctgaagga gctgcaggtg aaactcaaca
     4021 atgtcctgga tgaactcagc catgtgtttg ccaccagctt ccagccacac attgaggaat
     4081 gcgtcagaca gatgggtgac atcctgagcc aggtgaaggg cacaggcaat gtacctgcca
     4141 gtgcctgcag cagcgtggcc caggatgcag acaatgtgct gcagcccatc atggatcttc
     4201 tggacagcaa cctcaccctg tttgccaaaa tctgtgagaa gacagttctg aagcgggtgc
     4261 tgaaggagct ctggaagctg gtgatgaaca caatggagaa gaccatcgtc ctgccaccgc
     4321 tcactgacca gacgatgatt ggcaccctct tgagaaaaca tggcaagggc ctagaaaagg
     4381 gcagggtgaa actgccaagc cactcagacg ggacacaaat gatcttcaat gctgccaagg
     4441 agctgggcca gctgtccaaa cttaaggatc acatggtgcg ggaagaagcc aagagcttga
     4501 ccccgaagca gtgtgctgtt gttgaactgg ccctggacac catcaagcaa tacttccacg
     4561 cggggggcgt tggcctcaag aagaccttcc tggagaagag cccggacctc cagtccctgc
     4621 gctacgccct gtcgctctac acgcaagcca ccgacctgct catcaaaacc ttcgtgcaga
     4681 cgcagtcagc gcagggctct ggtgtggagg accctgtagg tgaagtgtcc gtccacgtgg
     4741 agctgttcac acatccagga actggggaac agaaggtcac agtgaaggtg gtggccgcca
     4801 atgacctcaa gtggcagact tctggcatct tccgcccgtt catcgaggtc aacatcgttg
     4861 gacctcagct tagcgacaag aaacgcaagt tcgccaccaa atccaaaaac aacagctggg
     4921 cgcccaagta taacgagagc ttccagttct ccctgagcgc cgacgcgggc cccgagtgct
     4981 acgagctgca ggtgtgcgtg aaggactact gctttgcgcg cgaagaccgc acggtggggc
     5041 tggcggtgct gcaactgcga gagctggccc agcgcgggag cgccgcgtgc tggcttccac
     5101 tcggccgccg catccacatg gacgacacgg ggctcacagt gctgcgcatc ctgtcgcagc
     5161 gcagcaacga tgaggtggcc aaggaattcg tcaagctcaa gtcggacacg cgctcagccg
     5221 aggagggcgg tgccgcgcct gcgccctagc gcgcgtttcg gtggcggggc ggggcctggg
     5281 aacggatgag accccgcctt ccgtaggcca ccgtctctcc agaggccacg cccctgcacc
     5341 tcagtggcct tggctggtga ggccctgcct cctgcccctg gaaaagccat agagggtccg
     5401 gtgccctggg catgggctgg gcaggcctgc ctgggaggcc gggtcgtagc ctctggtgtc
     5461 tgtgcaaaat acagtgtggg atgggctctc aaaagcacac gcgccctcgg cgcacacctg
     5521 gggctgaggg cgcctctctc cgcggacccc gccctcagca gcgggcccat tggcagctgg
     5581 cgacaccctg ctcgtgccac acacggtggg ctgagctccg acgaaaggct cagcccccat
     5641 cgctgctaaa tacccgattt agaatctccc tgattcttcc ccgagggccc cacaggccag
     5701 gcgccccctc cccccaattg aaccggttgc caaacaagtt tctgtccttg cccttccttc
     5761 tgggacttta gtcggaaccg gcctagtcaa gaaggggggg ggtgtcccag agccaagggc
     5821 ccccatccca tcttttctcc aaatccagtc aggaaataag agatcagaaa ctaggtagga
     5881 gggagaaagc gagaatatga acgtgcattt ctgagtgtcc tgtgcttgtg ataaagggat
     5941 gacccttttc taattggctt tgaaccacag catgtcccct gaatgtcacg tgcagtgaca
     6001 gggtagaatt caggctctta cataggatcc aagtttcatc catggacagg gagttcagag
     6061 gctacattcc atacattgag gggggacttg atcccgacca cactggagct caggagggag
     6121 tgatttacac tttagggcaa caaacatggc taaaggggaa gtggtctaac cagagatcaa
     6181 tcatataaag tttctacatt gctggcaaga atgtgggggt ttgtgtgact gacagagcca
     6241 agatagtttt ggtgacctct gcacatgtgt gtgtgtggct gtgtgtgtgt tttctagccc
     6301 cagaatgttg aaggaagtac atgggagtgt ttgtttaggg aattgttctg actcccaggc
     6361 taggactgtt tgaaatttcc ttttatttac ctagagacct cctattcatc cctctgcacc
     6421 cattacaacc ctgtcacacc cccactcccg tacaaaaatc attactcaag gaattcccca
     6481 gtattctttc cctcttctga tttggccctg atgtcatgag actgaggtgt ctgcctggct
     6541 ctggctaaat tccaggctga ggctttaagg gagccccaag cttccccaga ataagcaggt
     6601 cacagtcatt gaaggaaggt cgtgctgact tgaattgtat gagagtggct gacggtctgc
     6661 atgtgacccc aattcacatg catggttttc attacagttc ccccccgact tgacagatac
     6721 ccctatgtgg gaggtgtcca agctgagccc aggacacaat agatggaagt agagcagagg
     6781 gctgagctct gatctcagga cagccccaga tatagcaatg tcctgaaagg aagttactcc
     6841 agggcctggc tggttgagtt ctcaccacct cccctggtgg cccctcgctg ctggagtcct
     6901 acattaaaac atactggggt gcagctccag aatccacagg tcaaggacgg ttggagactg
     6961 gttagcctcg ccttcagaag gcaggaagaa gccacagccc cacccacagg agaggcagat
     7021 gccaaggggt gagggaggct gcagtgtggg cagaagaggg aggaggaagc gcaagtggaa
     7081 ggggctgggg tccaggcttg tctataccct acctagactt cctcagtcag gggcctaggg
     7141 tggagctcag cacctgccaa tcatgcatcg ttctaggttt ctttcccaat gctgaaaatt
     7201 ttaaaaggcc ctgcagtcag ctcaccatgt ctgggcaagt ctgcactcca gtctgtttca
     7261 ggccccaggg cctgtcccct cacctgcccc atcagacatg caaaaaatca agtgcaccca
     7321 gaactcctgg ggacctctct cagcctggac cgcagacctc tcaggtctca agggcagccc
     7381 tgctgggggt ggggcaaggg ccagggtcgg cttgattctg cccactctac ccatctaccc
     7441 cagcatcttt caggaccaaa gctggctctg cgaacccacc tccctctcct ctttacatct
     7501 tattgtttta aaaatcaaat tcggctgagc tgttggatcc gggtgacaca ggtgacaagc
     7561 aagagtcccc tgcaccccag aaggttcctg accccagccc ctgccatgca gcccagggag
     7621 cccctctgac tcgcctttct tagcatgtga ctgcaaaggt agaatcccag tatcgtgctt
     7681 ttggtttttc ggggttttgt ttttggtttt tttttttttt tggagggttt tttaggtcta
     7741 ccccgttagt ccagcatctt tcaagatgcc ctcaattctc agtcaacacg tgacttggga
     7801 cacatacccg gggagtgttc atgagtgcat ggcgttgaga tgttttgcac tattttgact
     7861 ttttggtctc tgtaaaaaat attttattaa cattaaaaaa aaaaacaaaa agaaaaacaa
     7921 aacaaaaaac aaacaaacaa aaaacacaga atccctgaaa aaaaaaaaaa aaaaaaaaaa
     7981 aaa
//
