LOCUS       NM_011676               1332 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus unc-119 lipid binding chaperone (Unc119), transcript
            variant 2, mRNA.
ACCESSION   NM_011676 XM_001004307 XM_001004311 XM_001004313 XM_001004316
            XM_001004318
VERSION     NM_011676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Fehlhaber,K.E., Majumder,A., Boyd,K.K., Griffis,K.G.,
            Artemyev,N.O., Fain,G.L. and Sampath,A.P.
  TITLE     A Novel Role for UNC119 as an Enhancer of Synaptic Transmission
  JOURNAL   Int J Mol Sci 24 (9), 8106 (2023)
   PUBMED   37175812
  REMARK    GeneRIF: A Novel Role for UNC119 as an Enhancer of Synaptic
            Transmission.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Nancy,V., Callebaut,I., El Marjou,A. and de Gunzburg,J.
  TITLE     The delta subunit of retinal rod cGMP phosphodiesterase regulates
            the membrane association of Ras and Rap GTPases
  JOURNAL   J Biol Chem 277 (17), 15076-15084 (2002)
   PUBMED   11786539
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Kubota,S., Kobayashi,A., Mori,N., Higashide,T., McLaren,M.J. and
            Inana,G.
  TITLE     Changes in retinal synaptic proteins in the transgenic model
            expressing a mutant HRG4 (UNC119)
  JOURNAL   Invest Ophthalmol Vis Sci 43 (2), 308-313 (2002)
   PUBMED   11818371
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Kobayashi,A., Higashide,T., Hamasaki,D., Kubota,S., Sakuma,H.,
            An,W., Fujimaki,T., McLaren,M.J., Weleber,R.G. and Inana,G.
  TITLE     HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal
            degeneration in a transgenic model
  JOURNAL   Invest Ophthalmol Vis Sci 41 (11), 3268-3277 (2000)
   PUBMED   11006213
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Swanson,D.A., Chang,J.T., Campochiaro,P.A., Zack,D.J. and Valle,D.
  TITLE     Mammalian orthologs of C. elegans unc-119 highly expressed in
            photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 39 (11), 2085-2094 (1998)
   PUBMED   9761287
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Schorpp,M., Hofmann,M., Dear,T.N. and Boehm,T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY772605.1, AK131955.1 and
            BE950651.1.
            
            On Sep 19, 2015 this sequence version replaced NM_011676.2.
            
            Summary: The protein encoded by this gene is multifunctional,
            affecting trafficking of transducin in rod photoreceptors,
            interacting with src-type tyrosine kinases through SH2 and SH3
            interacting domains, and aiding the uptake of bacteria through
            endocytosis. In addition, the encoded protein acts as a
            lipid-binding chaperone to help localize some myristoylated
            proteins correctly. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction in the 3' end compared to variant 1. The resulting
            isoform (2) has the same N- and C-termini but is shorter compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001990.1, AK131955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY772605.1         1-22
            23-1308             AK131955.1         1-1286
            1309-1332           BE950651.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1332
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /note="unc-119 lipid binding chaperone"
                     /db_xref="GeneID:22248"
                     /db_xref="MGI:MGI:1328357"
     exon            1..292
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..795
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein unc-119 homolog A; retinal protein 4; retinal gene
                     4"
                     /codon_start=1
                     /product="protein unc-119 homolog A isoform 2"
                     /protein_id="NP_035806.1"
                     /db_xref="CCDS:CCDS25101.1"
                     /db_xref="GeneID:22248"
                     /db_xref="MGI:MGI:1328357"
                     /translation="MKVKKGGGGTGSGAEPVPGASNRSAEPTREPGAEAESGSESEPE
                     PGPGPRLGPLQGKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVL
                     FEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR
                     MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDS
                     FYFVDDRLVMHNKADYSYSGTP"
     exon            293..406
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /inference="alignment:Splign:2.1.0"
     exon            407..509
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /inference="alignment:Splign:2.1.0"
     exon            510..682
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1316
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /note="hexamer: AATAAA"
     polyA_site      1308
                     /gene="Unc119"
                     /gene_synonym="D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h"
                     /note="major polyA site"
ORIGIN      
        1 ttcccctggc tccagccggc gcaagcagcg gcggcggtgg cagcgggcga ggatctgcgg
       61 ccccgcgagg ccatgaaggt gaagaaaggc ggcggcggga ccgggtcggg ggcggagccc
      121 gttccagggg cctcgaaccg gagcgcggag cccacgcggg agcctggggc ggaagctgag
      181 tccgggtccg agtcggagcc ggagccaggc ccggggccca ggctggggcc gctgcagggc
      241 aagcagccca tcgggccgga ggatgtgctg gggctgcagc ggatcacggg tgactacctg
      301 tgctcccctg aggaaaatat ctacaagatt gacttcgtca ggttcaagat ccgtgacatg
      361 gactcaggga ctgtcctttt tgaaatcaag aagccccctg tttcggaacg gttgcccatc
      421 aaccggcggg acctggaccc caatgcaggg cgctttgttc gctaccagtt cacacctgcc
      481 ttcctccgcc taaggcaggt gggagccacg gtggagttca cagtgggaga caagccggtc
      541 aacaacttcc gcatgatcga gaggcactac tttcgaaacc agctcctcaa aagcttcgac
      601 ttccactttg gcttctgcat ccccagcagc aagaacacct gtgagcacat ctatgacttc
      661 cctcctctct ccgaggagct aatcagtgag atgattcgtc acccgtatga gacccagtct
      721 gacagcttct acttcgtgga tgaccggctg gtgatgcata acaaagcaga ctattcctac
      781 agtgggacac cctgacccct aatgctgccc ctgaggctct ggcctagacc ctgtgctgta
      841 acctctccga catcatctcc acttggggat ggatccggtg gctctggacc ctgagtcagt
      901 ctcgagagga aaggtgtcca gcatccctag gcaaacctct ggagctagtg ggaggggcag
      961 cagggggagg ctggctgtcc ccatgttcag gaaggcctcc tgcaagagga ggactcctgg
     1021 atgcctcgct aggtccactg ggcctgagtt tcagagtagt gcccccttct tgaccgtgac
     1081 tagatcaggt tagggaccat ttcctgtccc ttgcccacca cctccaggct atttatagtt
     1141 gtcggttcac agacaaagat ccacagtggg taccctgctc tgagccctgg cctcctccat
     1201 caggggccaa gaaactaccc gaggtgtgag aggggcgggt ccagatcgca gcctgtaaga
     1261 cctggacaaa ctgtatatag ttttcaataa accttttctg ttcttgggtg cggccaaaaa
     1321 aaaaaaaaaa aa
//
