LOCUS       NM_009471               3484 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus uridine monophosphate synthetase (Umps), transcript
            variant 1, mRNA.
ACCESSION   NM_009471
VERSION     NM_009471.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3484)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3484)
  AUTHORS   Garavito,M.F., Narvaez-Ortiz,H.Y. and Zimmermann,B.H.
  TITLE     Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens
            and Cellular Development
  JOURNAL   J Genet Genomics 42 (5), 195-205 (2015)
   PUBMED   26059768
  REMARK    Review article
REFERENCE   3  (bases 1 to 3484)
  AUTHORS   Rainger,J., Bengani,H., Campbell,L., Anderson,E., Sokhi,K., Lam,W.,
            Riess,A., Ansari,M., Smithson,S., Lees,M., Mercer,C., McKenzie,K.,
            Lengfeld,T., Gener Querol,B., Branney,P., McKay,S., Morrison,H.,
            Medina,B., Robertson,M., Kohlhase,J., Gordon,C., Kirk,J.,
            Wieczorek,D. and Fitzpatrick,D.R.
  TITLE     Miller (Genee-Wiedemann) syndrome represents a clinically and
            biochemically distinct subgroup of postaxial acrofacial dysostosis
            associated with partial deficiency of DHODH
  JOURNAL   Hum Mol Genet 21 (18), 3969-3983 (2012)
   PUBMED   22692683
REFERENCE   4  (bases 1 to 3484)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 3484)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   6  (bases 1 to 3484)
  AUTHORS   Qumsiyeh,M.B. and Suttle,D.P.
  TITLE     Localization of the adenosine deaminase, transferrin, and UMP
            synthetase genes on Chinese hamster chromosomes 4 and 6 by in situ
            hybridization
  JOURNAL   J Hered 81 (2), 111-116 (1990)
   PUBMED   2338490
REFERENCE   7  (bases 1 to 3484)
  AUTHORS   Suttle,D.P., Bugg,B.Y., Winkler,J.K. and Kanalas,J.J.
  TITLE     Molecular cloning and nucleotide sequence for the complete coding
            region of human UMP synthase
  JOURNAL   Proc Natl Acad Sci U S A 85 (6), 1754-1758 (1988)
   PUBMED   3279416
REFERENCE   8  (bases 1 to 3484)
  AUTHORS   Ohmstede,C.A., Langdon,S.D., Chae,C.B. and Jones,M.E.
  TITLE     Expression and sequence analysis of a cDNA encoding the
            orotidine-5'-monophosphate decarboxylase domain from Ehrlich
            ascites uridylate synthase
  JOURNAL   J Biol Chem 261 (9), 4276-4282 (1986)
   PUBMED   2419341
REFERENCE   9  (bases 1 to 3484)
  AUTHORS   Hisata,T. and Tatibana,M.
  TITLE     Control of de novo pyrimidine biosynthesis in mammalian tissues.
            Levels and turnover of early intermediates in mouse spleen in vivo
  JOURNAL   Eur J Biochem 105 (1), 155-161 (1980)
   PUBMED   6154574
REFERENCE   10 (bases 1 to 3484)
  AUTHORS   Kavipurapu,P.R. and Jones,M.E.
  TITLE     Purification, size, and properties of the complex of orotate
            phosphoribosyltransferase: orotidylate decarboxylase from mouse
            Ehrlich ascites carcinoma
  JOURNAL   J Biol Chem 251 (18), 5589-5599 (1976)
   PUBMED   965379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165079.2, AK035821.1 and BM219105.1.
            
            On Feb 8, 2017 this sequence version replaced NM_009471.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035821.1, SRR7345562.4708028.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC165079.2         81125-81159         c
            36-3254             AK035821.1         2-3220
            3255-3484           BM219105.1         1-230               c
FEATURES             Location/Qualifiers
     source          1..3484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.26 cM"
     gene            1..3484
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /note="uridine monophosphate synthetase"
                     /db_xref="GeneID:22247"
                     /db_xref="MGI:MGI:1298388"
     exon            1..213
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1503
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /EC_number="2.4.2.10"
                     /EC_number="4.1.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uridine 5'-monophosphate synthase; UMP synthase"
                     /codon_start=1
                     /product="uridine 5'-monophosphate synthase isoform 1"
                     /protein_id="NP_033497.1"
                     /db_xref="CCDS:CCDS28136.1"
                     /db_xref="GeneID:22247"
                     /db_xref="MGI:MGI:1298388"
                     /translation="MEVASQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIV
                     SRPRLLSQVADILFQTAKNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKD
                     YGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGK
                     DKLQAQGIRLHAVCTLSQMLEILQQQEKIDADMVGRVKRFIQENVFSAANHNGLPPPE
                     KKACKELSFGARAELPGTHPLASKLLRLMQKKETNLCLSADVSEARELLQLADALGPS
                     ICMLKTHVDILNDFTLDVMEELTALAKRHEFLIFEDRKFADIGNTVKKQYESGTFKIA
                     SWADIVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGNYTKAAVGMAEE
                     HCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVIGKRGSDVIIVG
                     RGILAAANRLEAAEMYRKAAWEAYLSRLAVQ"
     exon            214..367
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1039
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1215
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1330
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..3484
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1670
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /note="major polyA site"
     polyA_site      1710
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3482
                     /gene="Umps"
                     /gene_synonym="1700095D23Rik"
ORIGIN      
        1 gggtgacgtc acgggcccca agcccctcgg cttccagagc gaactgagcg cgcgagaatg
       61 gaggtcgcca gccaagccct gggccccttg gtcaccgagc tgtatgacgt gcaggctttc
      121 aagttcggga gcttcgtcct gaagagcggg ctctcctccc cagtctacat cgacctgcgg
      181 ggcatcgtgt cacgcccgcg tcttctcagt caggtcgcag acattttatt ccagactgca
      241 aaaaatgcgg ggatcagttt tgacagtgtg tgtggagttc cttatacagc gttaccactg
      301 gcgacagtta tctgctcagc caatcacatt cccatgctca ttaggaggaa ggaaacaaag
      361 gattatggta ccaagcgcct tgtagaagga gagattaatc cgggccagac ctgtctggtc
      421 attgaggacg tcgtcaccag cggagccagt gttttggaga ctgtggaagt tcttcagaag
      481 gagggtctaa aggtaactga tgccatagtg ctgttggacc gggagcaggg aggcaaggac
      541 aagctgcagg cccaggggat ccgcctccac gccgtgtgca cgctctccca aatgctggag
      601 attctccagc agcaggaaaa gatcgacgct gacatggtcg ggagagtgaa gaggttcatt
      661 caggagaacg ttttctcagc agctaatcat aacggtctcc cccctcctga gaagaaagcg
      721 tgcaaagaac tcagctttgg tgctcgagct gagctgcctg gaacccaccc gcttgcctca
      781 aagctgctcc ggctcatgca gaagaaggag accaatctgt gtctgtctgc cgatgtgtcg
      841 gaggccaggg agctgctgca gctcgcagac gccttgggac ccagcatctg catgctcaaa
      901 actcatgtcg acattctgaa tgattttact ctggatgtga tggaggagtt gacagccctg
      961 gcaaaacgcc acgagttctt aatatttgaa gacaggaaat tcgctgatat tggaaacaca
     1021 gttaaaaagc agtatgaaag tggcaccttt aaaatagctt catgggcaga tatagtgaat
     1081 gctcacgtcg tgccaggctc aggagttgtg aaaggcttac aggaagtggg tctgccttta
     1141 catcgagcct gcctgctcat tgcagaaatg agctctgctg gctccttggc cactggaaac
     1201 tacaccaagg cagcagtcgg gatggctgag gagcactgtg aatttgtcat tggcttcatt
     1261 tctggctccc gagtaagcat gaaaccagag tttcttcact tgaccccagg agttcagtta
     1321 gaaacaggag gggatcacct tggccagcag tacaatagtc cccaagaagt gatcgggaaa
     1381 cgcggttctg atgtcatcat tgtaggccgg ggaatacttg cagcggctaa ccgcctagaa
     1441 gcagctgaga tgtacaggaa ggctgcctgg gaggcatatc tgagtaggct tgctgttcag
     1501 tgagacagaa gacactgaaa atgggtggta tcccaaaagc cgctggcttc agagaccagt
     1561 gctcagggcc ctgcacaggg tctgtgaaga gagactctgc agcattgtat catggtctaa
     1621 cttgtaatca ctgcattggt actgtaatga gcagcccttt tgaaagcttt ctcaagactg
     1681 gtatttgttt ggcagctgcc acctttcaga ttccttgggc tatactgctt aattctttta
     1741 gttccagtgt gacttagtca cacacatcta atgttagccg cttacctcct tcagtgccat
     1801 gaagctggat cctttcgtgg agcaggagtt ctagttcatt ctactcagca gtcagtgtag
     1861 aaagtcaggc acagcttcct cttgccgcct ctgtatccaa gagagaacgg cagtaccagt
     1921 tccccactgt cattgtgtgt ttgctaataa cctgggggct catagtgaat ggctcagtgg
     1981 ttaagagcac tgttcctctt atgtaggatc agcatgtggt tcccagcacc cacattgtgt
     2041 ctcaaaacca tctgtaactc caattccagg ggatccagtt tcctcttata gcttccaggg
     2101 gctacatgca tgtgatacaa tgcaccttta ctttacaaag acagtctttg ccagtgctaa
     2161 gagggaaaat tttagtacag aaatatttgc tcacagactg agaaattggg tgcctcctac
     2221 agtgtgatct gaccgctctt taacacatag aacttagccg tgtccattgc aagtggaatt
     2281 cacagccccc gtaaacttga accagttgcc cctgtggtcc gcatgcttac tgagcaaagc
     2341 accaccaccc tagtttctgc cctccacaca tcatcagtgg taccttaagt cttattcctg
     2401 ccaaaaggaa agatccttta gcactcacag acagctgtat gtaaatagtc tagacttgag
     2461 ataactggtg agcgccagac agaatggtct gagagtatgt agcctgctaa cttccttagc
     2521 actgagtcag tacagcaccc ggtctacaca tctataagat tagcaactgc atacactcag
     2581 caagtaatgg tgcatcctgt agtaaagtgg aatcaaagta gcaatagcac gtgcttgaag
     2641 gagtccgact gcagcatggt cccatcgagt aaaagcataa caaggcatga gcctcaggtg
     2701 ggtttgagct aatgtctgag aaaagctgtc aggagctaat ggaacttccc ttctaggctt
     2761 tagcttagtc atagtctcca acagctatgt ggttccagga gtccaaggtc caggagttgt
     2821 aagatgcaga cctaaactga gaccctgaag ttaagtgcac acacacgctc tttagagcag
     2881 gcttttagga accaaaagga aaaatgcatt aagttctaca ctgttaactc agatcagtat
     2941 ttggggaaat aggaaacaaa gtcctcttga ggacgactta ctattccacc cattaaaact
     3001 aacaacagta cccttggcca aatcagttca tcaaaaataa tgttaaatgc tgtctgcttt
     3061 tccagatggc tgggcatggc agtttcataa ttaacagcta cataatttac ccaagaaaat
     3121 ggttttgtca ctggagatgt ctccaatgtt tactccataa ataagatgct ccccagtggc
     3181 atcttatctg ctcctgtcac aatggccttc ctataagcaa aaaacaaact atcatgagaa
     3241 aatatttatg tcctactgaa ggtggcagtt ttatgagttc ctcttgtaag ttcctcttta
     3301 aactcctgag ttcctctttg gcggtccatc agtgtgccaa gattgcacta tggacactcc
     3361 tgtgagggca ttttcttgtt taataatcct gtgaggtgga agagcccagt ccacaatggg
     3421 cagtgacacc cctattcaca tagtcttgaa ttatataaag gctaagcaag ccaataagaa
     3481 catc
//
