LOCUS       NM_177465               5091 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus uromodulin-like 1 (Umodl1), mRNA.
ACCESSION   NM_177465
VERSION     NM_177465.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5091)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5091)
  AUTHORS   Wang,W., Tang,Y., Ni,L., Kim,E., Jongwutiwes,T., Hourvitz,A.,
            Zhang,R., Xiong,H., Liu,H.C. and Rosenwaks,Z.
  TITLE     Overexpression of Uromodulin-like1 accelerates follicle depletion
            and subsequent ovarian degeneration
  JOURNAL   Cell Death Dis 3 (11), e433 (2012)
   PUBMED   23190605
  REMARK    GeneRIF: Overexpression of Umodl1 accelerates follicle depletion
            and subsequent ovarian degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5091)
  AUTHORS   Wang,S.Z., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Transcription factor ATF5 is required for terminal differentiation
            and survival of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), 18589-18594 (2012)
   PUBMED   23090999
REFERENCE   4  (bases 1 to 5091)
  AUTHORS   Sammeta,N., Hardin,D.L. and McClintock,T.S.
  TITLE     Uncx regulates proliferation of neural progenitor cells and
            neuronal survival in the olfactory epithelium
  JOURNAL   Mol Cell Neurosci 45 (4), 398-407 (2010)
   PUBMED   20692344
REFERENCE   5  (bases 1 to 5091)
  AUTHORS   Yu,T., Clapcote,S.J., Li,Z., Liu,C., Pao,A., Bechard,A.R.,
            Carattini-Rivera,S., Matsui,S., Roder,J.C., Baldini,A.,
            Mobley,W.C., Bradley,A. and Yu,Y.E.
  TITLE     Deficiencies in the region syntenic to human 21q22.3 cause
            cognitive deficits in mice
  JOURNAL   Mamm Genome 21 (5-6), 258-267 (2010)
   PUBMED   20512340
REFERENCE   6  (bases 1 to 5091)
  AUTHORS   Yu,T.T., McIntyre,J.C., Bose,S.C., Hardin,D., Owen,M.C. and
            McClintock,T.S.
  TITLE     Differentially expressed transcripts from phenotypically identified
            olfactory sensory neurons
  JOURNAL   J Comp Neurol 483 (3), 251-262 (2005)
   PUBMED   15682396
  REMARK    GeneRIF: At age 3 weeks, Umodl1 (N8) mRNA shows a smooth gradation
            from high apical to low basal within the layer of mature olfactory
            sensory neuron layer of the mouse olfactory epithelium.  Whether
            this is due to cell position or cell age is not known.
REFERENCE   7  (bases 1 to 5091)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   8  (bases 1 to 5091)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 5091)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   10 (bases 1 to 5091)
  AUTHORS   Akeson,E.C., Lambert,J.P., Narayanswami,S., Gardiner,K.,
            Bechtel,L.J. and Davisson,M.T.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051427.1 and AY771617.1.
            
            On Sep 21, 2006 this sequence version replaced NM_177465.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.45912.1,
                                           SRR9219382.108889.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1701              BC051427.1         1-1701
            1702-2526           AY771617.1         1706-2530
            2527-5091           BC051427.1         2182-4746
FEATURES             Location/Qualifiers
     source          1..5091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..5091
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /note="uromodulin-like 1"
                     /db_xref="GeneID:52020"
                     /db_xref="MGI:MGI:1929785"
     exon            1..144
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..4112
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /note="olfactorin"
                     /codon_start=1
                     /product="uromodulin-like 1 precursor"
                     /protein_id="NP_803416.2"
                     /db_xref="CCDS:CCDS37543.1"
                     /db_xref="GeneID:52020"
                     /db_xref="MGI:MGI:1929785"
                     /translation="MMSRTVRLVLLALACTVDLSQASGFTENGLSLLSYQLCSYPVTR
                     SVQKLQAVQTSHTAYVYCGGWIPWKKCPKTVYRTQYLAMDVPESRNVTDCCAGFEQLG
                     LYCVLSLNRSREFASRPGVCPTAEAEPLSPSCSLDTDCSGLQKCCSWPGGRHCVSPTP
                     TGTEKSMVSWYNVTVLVKVGFEDLQREDPGLRNHTRLLYSLVTSALQPLNPAVHYLTS
                     TGGKDTFTTVSWLLMGFPRLMTVANVSVMLDDMVNRVYEVVSIQVQDVNECLHSELQA
                     CSVREQCRNLEGSYQCVSSQRLNHTDEDCPPIRDFVALNVTSSSFHVSWSLNSTQNYN
                     FHIQVYKGKEILRSAWTRGHTMAVSDLEAGVLYRVRTSYLGCGANVSATLVVKTDAQV
                     FQVTIRIMDRNLTEQILDCSSGEFWNFSRQLFHEVQNSFPQAISDLYRQGRLRMQIVS
                     LQAGSLVVTLRLTLQDPDFSVGVHTLTPMLPVLSVSNVFQVDQQRTFVQDWDECAHSS
                     EHDCHPSARCINLEGSYTCQCLTARDASPSRAGRVCEGDMVIPTGDELSVTTKVTVPA
                     ASTGITTFGPETLTESLSSKHPRSTPARSQTWTPVPPSVRDGGSIVRQDRNSTGQGME
                     VPNVTPNLGKTHRSTSGVTSSVPWAPGQTHGTHQGTTDAPLHTTRESQELITKDPPFL
                     TATTTGYVVWHSSPTWKTPPNSTRLQNEDPRSSSFPGPPSAPTDVTPESPACVPGPIG
                     KVTVSNVTSTSFSLEWPADIRLSPAFHLTLVSPRGPAMTMETQNNNVTLSGLEWGTLY
                     LVEIVAKVCGKEGARTQLKVRTVAQKLAGNVRITSMQYSESFLNTSSREHREFVELFF
                     RTVRDSLPATLRQHMDAGRIRVDIINITNGSIVVEFNLLMTADLDVREVSAGFLNALQ
                     NTSMLEVVRGKTFMQDYNECDMKEDDCAPGTCRNTFGSFTCSCDEGGPDSQVEYSGRS
                     CDGDPSGNMTQTPGSEWSPTPAGTRGVPVPIASSTAQDLPLRLNLMDAVSVSCEIETV
                     IITIQKRFLQQAAIPEASLYLGEPSCNVSRSNSTHVFLVAGWGECGTILQSNMTTTVV
                     TTTLRNNLSPEGVIHHPQFLSPIHCAFQNDVLTSSGYTPQWGVYTVIEDLHGTGNFVT
                     EMQLYIGDSPIPQNYSVSASDEIKIEVGLHRQKSSLKVVLTECWATPSSNAKDPVTFS
                     FINNSCPVPNTYTSVIQNGHSSKAQFKLRIFSFINNSIVYLHCKLRVCMENPRNSCRI
                     SCNDFRSLRSSEALHQMTWGPLHRTEGAQACTKPVLGTGYIILLAAAALLVVAGATTL
                     LILRYQRVRQKYNLRIQTDDFSYQVFSQ"
     exon            145..387
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            388..549
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            550..668
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            669..858
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            859..975
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1230
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1343
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1563
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1701
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2268
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2526
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2639
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2853
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2988
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3308
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3454
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3691
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3851
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3930
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4136
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..5043
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5021..5026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /note="hexamer: AATAAA"
     polyA_site      5043
                     /gene="Umodl1"
                     /gene_synonym="D17Ertd488e"
                     /note="major polyA site"
ORIGIN      
        1 agcctggctt aggactcagg ccactgcagt agaagtcgaa agccctgcct gcacaccacc
       61 acgggatgat gtccaggacc gtgaggctgg tcctgttggc tttggcctgt actgtggacc
      121 tgagccaggc cagtggcttt acagaaaatg gcctctccct gctgagctac cagctctgca
      181 gctacccggt gacccgaagt gtccagaagc tgcaggctgt gcagacctct cacacagcct
      241 acgtgtactg tggaggatgg atcccctgga aaaagtgccc caagactgtg taccggaccc
      301 agtacctagc gatggatgtc cctgagtcca ggaatgtgac cgactgctgt gcgggctttg
      361 agcagcttgg cctctactgc gttctgtccc tgaaccggtc ccgggagttt gcatcgaggc
      421 ccggggtctg cccgactgct gaagcagagc cacttagccc ttcatgcagc ttggacacag
      481 actgctctgg acttcagaag tgctgttcct ggccaggggg ccgccactgt gtgtccccca
      541 cacccacagg tacagagaag agcatggtga gctggtacaa cgtgactgtg ctggtgaagg
      601 tgggcttcga ggacctgcag cgagaggacc ctgggctccg gaaccacacg cgcctgctct
      661 actctttggt taccagtgcc ttgcagcctc tgaacccagc tgtacactac ctgacctcga
      721 ctggtggcaa ggacacattc accactgtgt catggctact gatgggcttt ccacggctca
      781 tgacggtagc caatgtctcc gtcatgttgg atgacatggt gaatcgggtc tatgaggtgg
      841 tcagcatcca ggtgcaagac gtgaacgagt gtcttcacag tgagctgcaa gcctgctctg
      901 taagagagca gtgtcggaac ctggagggct cctaccaatg tgtgtcttcc cagcggctga
      961 accacacaga tgaagattgc cctccaatcc gagatttcgt ggcacttaat gtcaccagca
     1021 gcagtttcca tgtgtcctgg agtttgaatt ccactcagaa ctacaatttc cacattcaag
     1081 tgtacaaagg caaagagata ctcagaagcg cttggacaag gggccacact atggctgtgt
     1141 ctgacttgga ggctggagta ctttacagag tgaggactag ctacctgggg tgcggggcca
     1201 atgtctctgc cacactggtt gtcaagacag atgcccaggt tttccaagtc acaatacgga
     1261 tcatggaccg taacctgaca gagcagattc ttgactgcag cagcggggaa ttctggaact
     1321 tttctcgaca gctgtttcat gaggtgcaaa actccttccc ccaagccatc tctgacctgt
     1381 acagacaagg gaggctgagg atgcagatcg tgtctctgca ggcagggagt ctagtggtga
     1441 cgcttagact caccctgcaa gaccctgact tttcagtggg ggtccacaca ctgacgccta
     1501 tgctgcccgt cctgtctgtg agcaacgtgt tccaggttga ccagcagagg acattcgtgc
     1561 aagactggga tgagtgtgca cacagctcgg agcatgactg ccacccgagc gcacgctgca
     1621 tcaacctgga gggctcctac acgtgccagt gcctcacagc cagggatgcc agcccctcca
     1681 gggctggcag ggtctgcgag ggtgacatgg tgatccccac aggagatgaa ctgtctgtaa
     1741 caacgaaggt cacagtccca gctgccagta cgggaataac aacctttggc ccagagaccc
     1801 tcaccgagtc actaagttcc aagcacccaa ggagcacccc agcaagaagt caaacctgga
     1861 ccccagtgcc cccatcagtg agagatgggg gtagcatagt caggcaggat aggaatagca
     1921 cgggacaagg tatggaggtg cccaacgtga ccccaaacct gggcaaaacc cacagaagta
     1981 ccagtggggt gacaagctct gttccctggg ctccaggaca gacccatgga acccatcagg
     2041 ggaccacaga tgccccactg cacaccactc gagagtcaca ggaacttatc accaaagatc
     2101 cacccttcct gactgctaca accacgggct atgttgtgtg gcactccagt cccacttgga
     2161 agacacctcc gaactccaca agactacaga atgaagaccc tcgatcttcc tccttcccag
     2221 gcccgccatc ggccccaacc gatgtgactc cagagtcccc tgcctgtgtt cctggaccca
     2281 ttggaaaggt cacggtctct aacgtgacca gtaccagctt ctccctcgag tggcctgcag
     2341 acatccgcct ctcccctgcc ttccacctca cattggtctc tcctcggggt cctgccatga
     2401 ccatggagac ccagaacaat aatgtgacat tgtcaggact ggaatgggga accttgtatc
     2461 tggtggagat tgtggctaag gtgtgtggga aagaaggtgc cagaacacag ctgaaagtgc
     2521 ggacagtggc ccagaaactt gccggtaacg tccggatcac gagcatgcag tattcggaat
     2581 ccttcctcaa taccagcagc agggagcacc gagagttcgt agagttgttc ttcagaacgg
     2641 tgcgggactc tctgccagcc acgctgcgtc agcacatgga tgcaggcagg atccgtgtgg
     2701 acatcattaa catcacaaat ggcagcatcg tggtggagtt taatctgcta atgacagcag
     2761 accttgatgt cagggaggtg tctgctggct tcctcaatgc cttacagaac acatcgatgc
     2821 tggaggtggt cagaggcaaa acttttatgc aagattacaa cgagtgtgac atgaaagagg
     2881 atgactgtgc ccctgggaca tgcaggaaca ctttcgggtc ttttacatgt agctgtgatg
     2941 agggaggacc tgactcacag gtggaatatt ctggaaggtc ctgtgatggt gacccttctg
     3001 gcaacatgac ccagacccca ggctcagagt ggtctcctac cccagcagga actaggggtg
     3061 tccctgtgcc aattgccagc tccacagccc aggaccttcc cctgcggctg aacctgatgg
     3121 acgctgttag cgtgtcctgt gagatcgaga cggtgatcat caccatccag aagcgctttc
     3181 tgcagcaggc ggccatacct gaggcctccc tgtacctggg agagccatcc tgcaatgtga
     3241 gcagaagcaa cagcacacac gtgtttctgg tggctggctg gggcgagtgt gggaccatct
     3301 tacagagtaa catgaccacc acagtggtga cgaccacgct gaggaacaac ctgtccccag
     3361 agggtgtcat ccaccaccca cagttcctca gtcctatcca ctgtgccttc cagaatgacg
     3421 ttctgacttc ctcgggctac accccacagt ggggggtcta caccgtcatc gaagacctcc
     3481 acgggactgg aaattttgtc acagaaatgc agttgtacat tggcgattct cccatacctc
     3541 agaactatag cgtgtccgcc agcgatgaga tcaagattga ggtggggctt cacaggcaga
     3601 agagcagtct gaaggtcgtg ctgactgagt gctgggccac cccctccagc aacgccaagg
     3661 accccgtaac cttcagcttc atcaacaaca gctgccctgt tcccaacacc tacaccagcg
     3721 tgattcagaa tggccactcc agcaaggccc agttcaagct gagaatcttc tccttcatca
     3781 acaactccat cgtctacctg cactgcaagc tgagagtgtg catggagaac cccaggaact
     3841 cgtgcaggat aagctgcaac gacttccggt cgctgagaag tagtgaagcc ttgcaccaga
     3901 tgacctgggg gcccctccat cggactgaag gtgcacaggc atgtacaaag ccagtcctgg
     3961 ggaccggtta catcattctc ctagcggcag ctgcacttct ggtagtggca ggggccacaa
     4021 cccttctgat cttgcgttac cagagagtaa ggcagaaata caatcttcgg atccagaccg
     4081 acgacttcag ctaccaggtg ttctctcaat agaagaccca actgaccagg agatggagca
     4141 ccctgtaaat aacatccagt ggctaattca tcgaacattg acgggagtcc aactctgtat
     4201 agtgccgtgc cagcacttga ggacgagacc cttcgatgac agcaaacctc tgtctgcccc
     4261 caagatcctg aagacacaga gtaccaccca ccaggctggt gatgggcctg ctgaagctgt
     4321 gggcagagcc ctggagtggc cttcatcctc aaacccagca caaacatggc cccacttacc
     4381 acagccttcc aagctttgac atccaagctg ctctgtgact cctgttctct gacaatgaca
     4441 tcctcacaga catttcccat gatgctcgtt cacgaatgga tccctccgat aaactctccg
     4501 agggtggttt tccatgaaca aacactaact cagctctcct tatcagcatg agtctcatag
     4561 ttgcctggca gtgactcagg acaacctagg tgaaaccgga acgctttcta acgagtcgca
     4621 gtcatatgat gtgtatgtaa cacctcttgc atgtttccca gcacatccat ggacattttt
     4681 catgtaattc catggagaga aggtgtgatt ttttcccccc actctatcac aaggaatcag
     4741 ggaagaggtg ggggaggtgc gtaccatgct aacaggtcct ctactttgtt gatttgaaag
     4801 atggccattg gttacatagt tatcacctga gacaatagtg ttctccctag ggaatataaa
     4861 agcataacag ggttgtagca tttaattaat gtgcttgctt atgttgaatg tgactgtcac
     4921 ttatacagat catctggggg aaacgagtct ttcgattttt tgcatattct tgcgggtaag
     4981 aatgacaacc gggagtctgt gtggctagcc acctttgagc aataaatttt tcctggcact
     5041 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
