LOCUS       NM_029975               1819 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus UL16 binding protein 1 (Ulbp1), mRNA.
ACCESSION   NM_029975 XM_486491
VERSION     NM_029975.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1819)
  AUTHORS   Legroux L, Moratalla AC, Laurent C, Deblois G, Verstraeten SL and
            Arbour N.
  TITLE     NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a
            Mouse Model of Multiple Sclerosis
  JOURNAL   Front Immunol 10, 154 (2019)
   PUBMED   30787931
  REMARK    GeneRIF: Our data support the notion that endogenous CD8 T cells
            contribute to passive EAE pathobiology in a NKG2D-dependent manner.
            Collectively, our results point to the deleterious role of NKG2D
            and its MULT1 in the pathobiology of a MS mouse model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1819)
  AUTHORS   Belting L, Homberg N, Przewoznik M, Brenner C, Riedel T, Flatley A,
            Polic B, Busch DH, Rocken M and Mocikat R.
  TITLE     Critical role of the NKG2D receptor for NK cell-mediated control
            and immune escape of B-cell lymphoma
  JOURNAL   Eur J Immunol 45 (9), 2593-2601 (2015)
   PUBMED   26151313
  REMARK    GeneRIF: The results show that NK cells and the NKG2D receptor play
            a role in control of lymphomas, and that selection of NKG2D-ligand
            (MULT1) loss mutants provides a mechanism for tumor escape.
REFERENCE   3  (bases 1 to 1819)
  AUTHORS   Spada R, Rojas JM, Perez-Yague S, Mulens V, Cannata-Ortiz P,
            Bragado R and Barber DF.
  TITLE     NKG2D ligand overexpression in lupus nephritis correlates with
            increased NK cell activity and differentiation in kidneys but not
            in the periphery
  JOURNAL   J Leukoc Biol 97 (3), 583-598 (2015)
   PUBMED   25583577
  REMARK    GeneRIF: An increased expression of the NKG2D ligand MICA in
            systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and
            Mult-1 in various murine SLE models, is reported.
REFERENCE   4  (bases 1 to 1819)
  AUTHORS   Tietje A, Li J, Yu X and Wei Y.
  TITLE     MULT1E/mIL-12: a novel bifunctional protein for natural killer cell
            activation
  JOURNAL   Gene Ther 21 (5), 468-475 (2014)
   PUBMED   24572784
  REMARK    GeneRIF: Although the study is preliminary, the data suggest that
            the MULT1E/mIL-12 bi-functional fusion protein is an effective
            activator of NK cells for cancer treatment.
REFERENCE   5  (bases 1 to 1819)
  AUTHORS   Hansen CH, Holm TL, Krych L, Andresen L, Nielsen DS, Rune I, Hansen
            AK and Skov S.
  TITLE     Gut microbiota regulates NKG2D ligand expression on intestinal
            epithelial cells
  JOURNAL   Eur J Immunol 43 (2), 447-457 (2013)
   PUBMED   23136011
REFERENCE   6  (bases 1 to 1819)
  AUTHORS   Nice TJ, Deng W, Coscoy L and Raulet DH.
  TITLE     Stress-regulated targeting of the NKG2D ligand Mult1 by a
            membrane-associated RING-CH family E3 ligase
  JOURNAL   J Immunol 185 (9), 5369-5376 (2010)
   PUBMED   20870941
  REMARK    GeneRIF: These results identify Mult1 as a target for the MARCH
            family of E3 ligases
REFERENCE   7  (bases 1 to 1819)
  AUTHORS   Lenac T, Budt M, Arapovic J, Hasan M, Zimmermann A, Simic H,
            Krmpotic A, Messerle M, Ruzsics Z, Koszinowski UH, Hengel H and
            Jonjic S.
  TITLE     The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands
            MULT-1 and H60
  JOURNAL   J Exp Med 203 (8), 1843-1850 (2006)
   PUBMED   16831899
  REMARK    GeneRIF: Mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a
            rapid down-regulation of NKG2D ligands murine UL16-binding protein
            like transcript (MULT)-1 and H60 from the cell surface.
REFERENCE   8  (bases 1 to 1819)
  AUTHORS   Diefenbach A, Hsia JK, Hsiung MY and Raulet DH.
  TITLE     A novel ligand for the NKG2D receptor activates NK cells and
            macrophages and induces tumor immunity
  JOURNAL   Eur J Immunol 33 (2), 381-391 (2003)
   PUBMED   12645935
REFERENCE   9  (bases 1 to 1819)
  AUTHORS   Carayannopoulos LN, Naidenko OV, Fremont DH and Yokoyama WM.
  TITLE     Cutting edge: murine UL16-binding protein-like transcript 1: a
            newly described transcript encoding a high-affinity ligand for
            murine NKG2D
  JOURNAL   J Immunol 169 (8), 4079-4083 (2002)
   PUBMED   12370332
  REMARK    GeneRIF: MULT1 (UL16-binding protein-like transcript 1) is
            expressed in adult parenchyma, possesses MHC class I-like alpha 1
            and alpha 2 domains and a large cytoplasmic domain, and binds NKG2D
            with high affinity. (MULT1)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132072.1.
            
            On Jun 10, 2007 this sequence version replaced NM_029975.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132072.1, AK084712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10"
     gene            1..1819
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /note="UL16 binding protein 1"
                     /db_xref="GeneID:77777"
                     /db_xref="MGI:MGI:1925027"
     exon            1..224
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1141
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /note="UL16-binding protein-like transcript 1"
                     /codon_start=1
                     /product="NKG2D ligand 1 precursor"
                     /protein_id="NP_084251.1"
                     /db_xref="CCDS:CCDS56691.1"
                     /db_xref="GeneID:77777"
                     /db_xref="MGI:MGI:1925027"
                     /translation="MELTASNKVLSCCLSLLCLLSVCLCPRIEETASLCNIYKVNRSE
                     SGQHSHEVQGLLNRQPLFVYKDKKCHAIGAHRNSMNATKICEKEVDTLKDGIDIFKGL
                     LLHIVQETNTTGKPLTLQAEVCGQYEVDKHFTGYAIVSLNGKNIFRVDTSTGNWTQLD
                     HEFEKFIEMCKEDKVLAAFLKKTTEGDCRTWLDELMLHWKEHLEPAGSFSTLMIILCV
                     IAIAFLGLIFGVSCKLRHLRTKKIGLQSSPPPLLDDSLTVPTSPQSSVCGTMIQCLCP
                     RKLKSPVFMQIDLQSSAPPLLDDSLTVPETCSVKKEDEFPTASQNSVLLTSDDIDGIP
                     "
     exon            225..479
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..755
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..859
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..994
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1819
                     /gene="Ulbp1"
                     /gene_synonym="A430108B07Rik; MULT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattgcctt gatcccccag ccaaggttca aaaactttct gtggtcagga ccattatcag
       61 gaagtgatca agatcgtccc tccctttcag acagttaaaa tcgtgccttt ggccgccaga
      121 gtctagagaa gcagctatgg agctgactgc cagtaacaag gtcctttcct gctgcttgtc
      181 cctgctgtgc ctgctgtctg tctgtctgtg tccaaggata gaagagactg cttctctttg
      241 taacatttac aaggttaaca ggtcagagtc tggacaacat agtcatgaag ttcaaggcct
      301 actcaacaga cagcctcttt ttgtctacaa ggataaaaag tgtcatgcca ttggtgctca
      361 taggaacagc atgaatgcta caaagatctg tgaaaaagag gttgacactc tgaaagatgg
      421 aattgacatt ttcaaaggtc tgctgcttca catagtgcag gagactaaca caaccggaaa
      481 gcccctcact ctgcaggctg aggtgtgtgg ccagtatgaa gtagacaaac atttcacagg
      541 atacgccatt gttagcctca atggaaagaa tatattccgt gttgacacaa gcactggcaa
      601 ctggacccaa ctggatcatg aattcgagaa gtttatagaa atgtgcaagg aagacaaggt
      661 tttagctgcc tttttaaaga agactacaga gggcgactgc aggacctggc ttgatgagct
      721 catgttgcac tggaaagaac atctggagcc tgcaggatct ttcagtacct tgatgattat
      781 tctatgcgtg attgcaattg cctttctcgg attgatcttc ggagtctctt gtaaattaag
      841 acatttacgt acaaaaaaga ttggcctgca gtcctcacca ccacctctct tggatgactc
      901 tttgacagtg cctacttcac cacaatccag tgtatgtgga actatgattc aatgtctctg
      961 tcctcggaag ttgaagtcac ctgtgtttat gcagattgat ctgcagtcct cagcaccacc
     1021 tctgttggat gactctttga cagtgcctga gacgtgttca gtaaagaaag aagatgaatt
     1081 tccgacagca tctcagaatt ctgtgctgtt gacttcagac gatattgatg ggatcccatg
     1141 agactgatgg ccgacagagc ctcacgcacc agggcatcag agtgcactag gctgttgcca
     1201 ccaggggctt cctcttgctc tgttcctttc ctttctcatt cttacatgat agtgctgtgg
     1261 agatcaagca gggcatggct ctaagtttct tctcactgtg caaaaacaat gatttgtcct
     1321 gagtgattcc attttacaag cagcacttgg ctcccttctg agtgcaatgc agacattgga
     1381 ggacagggca ccttaattta aacatagata catgtcagcc aggtaccatc catgatgcag
     1441 gtgttgataa ttaacttaat ccccaaggta aaaaaatatg cctcccatgc acttatcaaa
     1501 atagatttga agtcatgaac acatgtgcat ctcaaattat atcagagaac taggtctgag
     1561 aatttatctc accctcacct ggtcccctaa agaagccacc tagccctgca atgctcatgg
     1621 cccccacaaa cttgcccctg tctgtttgtg tgtcaaggaa ccttcagaca gaggactcct
     1681 ggccatctta aggcttcagc tccatccaca atgctaaagc ctcctgcttg aaacgctgtc
     1741 tgacagttca tctgctgctc catgttaatg tgggtctgca tctcacctgc tggatcctgg
     1801 ggtcctgcac ctcacctct
//
