LOCUS       NM_011307               2936 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ubiquitin interaction motif containing 1 (Uimc1),
            transcript variant 1, mRNA.
ACCESSION   NM_011307 XM_127378
VERSION     NM_011307.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Tang,H., Lu,Y.F., Zeng,R., Liu,C., Shu,Y., Wu,Y., Su,J., Di,L.,
            Qian,J., Zhang,J., Tian,Y., Lu,X., Pei,X.H., Zhu,Q. and Zhu,W.G.
  TITLE     DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to
            elicit DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2320804121 (2024)
   PUBMED   39172790
  REMARK    GeneRIF: DOT1L-mediated RAP80 methylation promotes BRCA1
            recruitment to elicit DNA repair.
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Jiang,Q., Foglizzo,M., Morozov,Y.I., Yang,X., Datta,A., Tian,L.,
            Thada,V., Li,W., Zeqiraj,E. and Greenberg,R.A.
  TITLE     Autologous K63 deubiquitylation within the BRCA1-A complex licenses
            DNA damage recognition
  JOURNAL   J Cell Biol 221 (9) (2022)
   PUBMED   35938958
  REMARK    GeneRIF: Autologous K63 deubiquitylation within the BRCA1-A complex
            licenses DNA damage recognition.
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Kakarougkas,A., Ismail,A., Katsuki,Y., Freire,R., Shibata,A. and
            Jeggo,P.A.
  TITLE     Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1
            and RAP80 to resection
  JOURNAL   Nucleic Acids Res 41 (22), 10298-10311 (2013)
   PUBMED   24013561
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Yin,Z., Menendez,D., Resnick,M.A., French,J.E., Janardhan,K.S. and
            Jetten,A.M.
  TITLE     RAP80 is critical in maintaining genomic stability and suppressing
            tumor development
  JOURNAL   Cancer Res 72 (19), 5080-5090 (2012)
   PUBMED   22896338
  REMARK    GeneRIF: Data indicate that RAP80-deficiency promotes genomic
            instability and causes an increase in cancer risk consistent with
            the concept that RAP80 exhibits a tumor suppressor function.
REFERENCE   5  (bases 1 to 2936)
  AUTHORS   Hu,X., Paul,A. and Wang,B.
  TITLE     Rap80 protein recruitment to DNA double-strand breaks requires
            binding to both small ubiquitin-like modifier (SUMO) and ubiquitin
            conjugates
  JOURNAL   J Biol Chem 287 (30), 25510-25519 (2012)
   PUBMED   22689573
  REMARK    GeneRIF: a model in which SUMO and Ub modification is coordinated
            to recruit Rap80 and BRCA1 to DNA damage sites.
REFERENCE   6  (bases 1 to 2936)
  AUTHORS   Wu,J., Huen,M.S., Lu,L.Y., Ye,L., Dou,Y., Ljungman,M., Chen,J. and
            Yu,X.
  TITLE     Histone ubiquitination associates with BRCA1-dependent DNA damage
            response
  JOURNAL   Mol Cell Biol 29 (3), 849-860 (2009)
   PUBMED   19015238
REFERENCE   7  (bases 1 to 2936)
  AUTHORS   Kim,H., Chen,J. and Yu,X.
  TITLE     Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage
            response
  JOURNAL   Science 316 (5828), 1202-1205 (2007)
   PUBMED   17525342
REFERENCE   8  (bases 1 to 2936)
  AUTHORS   Kim,Y.S., Nakanishi,G., Oudes,A.J., Kim,K.H., Wang,H.,
            Kilpatrick,D.L. and Jetten,A.M.
  TITLE     Tsp57: a novel gene induced during a specific stage of
            spermatogenesis
  JOURNAL   Biol Reprod 70 (1), 106-113 (2004)
   PUBMED   12954732
REFERENCE   9  (bases 1 to 2936)
  AUTHORS   Yan,Z., Kim,Y.S. and Jetten,A.M.
  TITLE     RAP80, a novel nuclear protein that interacts with the
            retinoid-related testis-associated receptor
  JOURNAL   J Biol Chem 277 (35), 32379-32388 (2002)
   PUBMED   12080054
REFERENCE   10 (bases 1 to 2936)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160926.1 and AK052704.1.
            
            On Jan 18, 2018 this sequence version replaced NM_011307.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052704.1, BC040808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK160926.1         2-6
            6-2936              AK052704.1         2-2932
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..2936
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="ubiquitin interaction motif containing 1"
                     /db_xref="GeneID:20184"
                     /db_xref="MGI:MGI:103185"
     exon            1..104
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            105..259
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2296
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA1-A complex subunit RAP80; receptor-associated protein
                     80; ubiquitin interaction motif-containing protein 1;
                     retinoid X receptor interacting protein 110"
                     /codon_start=1
                     /product="BRCA1-A complex subunit RAP80 isoform 1"
                     /protein_id="NP_035437.1"
                     /db_xref="CCDS:CCDS36671.1"
                     /db_xref="GeneID:20184"
                     /db_xref="MGI:MGI:103185"
                     /translation="MPRRKKKIKEASESQNLEKKDLETSSCVSIKKKRRLEDLLIVIS
                     DSDGEETKEENGLQKTKTKQSNRSKCLAKRKVAHMSEEEQFALALKMSEQEAREVNNQ
                     EEKEEELLRKAIAESLNSCWSSAASATRSRPLAAELSSHSHQENTKDSGTTEGVWQLV
                     PPSLCKGSHVSQGNEAEQRKEPWDHNENTEEEPVSGSSGSWDQSSQPVFENENVKCFD
                     RCTGHLAEHTQCGKPQESTGSGYAFSKAVQGRGDTSRQCLPIPADTKGLQDTGGTVHY
                     YWGIPFCPAGVDPNQYTNVILCQLEVYQKSLKMAQRQLVKKRGFGEPVLPRPPFLIQN
                     ECGQEDQTSDKNEGISEDMGDEAKEERQESRASVWHSETKDFQKSPIKSLKQKLLLEE
                     EPTTSRGQSSQGLFVEETSEEGLKSSEGDNSVPTTQSIAALTSKRSLVLMPESSAEET
                     TVCPETQLSFLEPLDLNREDSPDSRELPIEVRMAVGDKQVANREDCMKENPPPAVSSS
                     TRVSCPLCNQDFPPTKIEQHAMYCNGLMEQETVLTRRRREAKNKSDGRTAAQPALDAN
                     RKEKCYLCKSLVPLGEYQCHVEACLQLAKVDREDGIEGTRRPRVCAPVEGKQQQRLKK
                     SKDKGHSQGRLLSLLEQSEHRTTGVEKKPKYSEVRTFRMPSPEVEEASCSREMQSTLS
                     QLNLNESPIKSFVPVSEATNCLVDFKEQFAFRSRTKSGRGRRRKS"
     exon            260..344
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            345..469
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            470..575
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1312
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1398
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1475
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1579
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1733
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1812
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1990
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2054
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2097
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2936
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="hexamer: AATATA"
     polyA_site      2532
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="major polyA site"
     polyA_site      2621
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="hexamer: AATGAA"
     polyA_site      2660
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
     regulatory      2910..2915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
                     /note="hexamer: AATAGA"
     polyA_site      2936
                     /gene="Uimc1"
                     /gene_synonym="9430016E08Rik; D330018D10Rik;
                     D630032M02Rik; RIP110; Rxrip110"
ORIGIN      
        1 ctgccgcctc gcgccgccgc gcgggctctc ctctttctaa agagttgcgg ccgctcgcga
       61 cccccagcgt tcaggaggcg ctgggcggcg ctgccagatc cgcggtaaaa ggatgccacg
      121 aaggaagaaa aaaattaaag aggcctctga aagccagaac ttggagaaga aggatctgga
      181 aacaagcagt tgtgtcagta taaagaagaa gcgtagactt gaggacttac tcatagtgat
      241 atccgatagc gatggagagg aaacaaaaga ggagaatgga ttgcagaaaa cgaagacaaa
      301 acagtcgaac agatcaaagt gtttggctaa aagaaaagtt gcacacatgt cagaagaaga
      361 acaatttgct ttggctctca agatgagtga gcaggaagct agggaggtga ataaccagga
      421 ggagaaagaa gaggagctct tgcggaaagc cattgctgaa agcctgaata gttgctggtc
      481 ttctgctgct tctgctacca gatctcgacc tctggctgct gaactatctt cacattccca
      541 tcaagagaac accaaagact ctgggaccac tgaaggcgta tggcagctgg tacctccatc
      601 actgtgtaaa ggctcacatg tcagtcaggg aaacgaggct gagcaaagaa aggagccctg
      661 ggaccacaat gaaaacactg aagaggagcc ggtctctggc agctcaggaa gctgggacca
      721 gtcaagccag ccagtgtttg agaatgagaa cgttaaatgt tttgacagat gtactggcca
      781 cttggctgag cacacacagt gtgggaagcc acaggaaagt actgggagtg gttatgcttt
      841 ttccaaagct gtccagggta ggggggacac gtctaggcaa tgccttccta tcccagcaga
      901 cacaaaaggt ctccaggaca ctgggggcac tgtgcactac tactggggta ttccattctg
      961 ccctgctgga gtagatccca atcaatacac caatgtcatt ctctgccagt tagaggttta
     1021 tcagaagagc ctgaaaatgg ctcagagaca gcttgttaaa aaaagagggt ttggggaacc
     1081 agtgttacct agacctcctt ttctgatcca gaatgaatgt ggccaagaag atcagactag
     1141 tgacaaaaat gaaggcatct cagaagatat gggagatgaa gccaaagagg aaaggcagga
     1201 atctagggca tctgtctggc actcagaaac caaggatttt caaaaaagtc caattaaaag
     1261 cttgaaacag aaacttttgt tggaggaaga accaacaacc agtcgtggtc agtcttccca
     1321 aggtctgttt gttgaagaaa cctctgaaga aggtctgaag agttctgaag gagacaactc
     1381 tgtgcccacc acgcaaagca ttgcagcttt gaccagtaag agaagtttag ttcttatgcc
     1441 ggaaagttct gcagaagaaa ccactgtttg ccctgagaca cagttaagtt tccttgaacc
     1501 ccttgacctc aatagagaag actctccaga tagcagagag ctccccattg aagtaaggat
     1561 ggcagtgggc gataagcagg ttgctaatag ggaagattgt atgaaggaaa accctcctcc
     1621 tgcagtctca tctagtaccc gggtatcctg cccactgtgt aaccaagact ttcctcccac
     1681 aaagattgaa cagcatgcca tgtactgcaa tggtctgatg gagcaggaaa cagtgttgac
     1741 tcggagacga agagaggcca agaacaagag tgacggtcgg acagctgcac agccggctct
     1801 ggatgccaac aggaaggaga agtgttatct atgtaagtcc ctggttccac ttggggagta
     1861 tcagtgccat gtggaggcct gtctccagct tgcaaaggtt gacagagaag atgggattga
     1921 agggacaagg agaccaaggg tgtgtgcacc tgtggagggg aaacaacagc agcggctgaa
     1981 gaagtcaaag gacaaaggcc atagtcaagg ccgactcctc agtctcttgg agcagtctga
     2041 gcataggacc acaggtgtag agaaaaaacc caagtattcg gaagtaagaa ccttcaggat
     2101 gccctcacca gaggtggaag aggctagctg cagcagagag atgcagagta ccctctcaca
     2161 gctcaactta aatgagtctc ccatcaagtc ttttgttcct gtttcagaag ctacaaattg
     2221 cttagtggac tttaaagaac agtttgcttt ccggtcacga actaaatcag gcagaggaag
     2281 gaggagaaaa tcttgaattt cttgagactg gaagttgacc agaacacaca tcgttgggtt
     2341 gatcgtgttc attaagtata gtggtctcta gtttgttgtg agagttctga ccctgttgtt
     2401 atcaccacca gcacccattc agtatcctgg ctttatattt tataagatca gttcagacaa
     2461 ctgtgaatat tattctgttt gaatttgctt atagttaaaa tttaaatata tttatctttg
     2521 tatgaaatct tatttcaata gatggaagtg tttttttttt catttctgtt ttaagctttg
     2581 gggtagggat atttcagttg aagaggcagt ttcactcata agctatgtgt tcctgaatga
     2641 atttcattgc taatctttga cacactactc aaattcattt aaattacact gcacaattct
     2701 gaacattgac tgaacctgac atcactttgg ctgtgccaaa tgtatttaat cccaatacta
     2761 actgttatcc ctttcattca gtgacctgct cacccagtta agacttctca gctaagacct
     2821 gtggctatat agaaggagga gtgccgttct tcccctggaa tttttaagtg aacactgttg
     2881 tattagtgtc tatgcatttt tttcttcaaa atagatttac cagtgggagt accagg
//
