LOCUS       NM_001419330            3536 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus ubiquitin-like, containing PHD and RING finger domains
            2 (Uhrf2), transcript variant 3, mRNA.
ACCESSION   NM_001419330
VERSION     NM_001419330.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Zhuang,Y., Li,C., Zhao,F., Yan,Y., Pan,H., Zhan,J. and Behnisch,T.
  TITLE     E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in
            Social Behavior and Synaptic Plasticity in the Hippocampus
  JOURNAL   Int J Mol Sci 25 (3), 1543 (2024)
   PUBMED   38338822
  REMARK    GeneRIF: E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role
            in Social Behavior and Synaptic Plasticity in the Hippocampus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Sano,T., Ueda,K., Minakawa,K., Mori,T., Hashimoto,Y., Koseki,H.,
            Takeishi,Y., Ikeda,K. and Ikezoe,T.
  TITLE     Impaired Repopulating Ability of Uhrf2-/- Hematopoietic Progenitor
            Cells in Mice
  JOURNAL   Genes (Basel) 14 (8), 1531 (2023)
   PUBMED   37628583
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Slabber,C.F., Bachofner,M., Speicher,T., Kuklin,A., Fearon,A.E.,
            Padrissa-Altes,S., Bogorad,R., Horvath Rudigier,C., Wust,D.,
            Krautbauer,S., Horing,M., Liebisch,G., Anderson,D.G., Wolfrum,C.,
            Auf dem Keller,U. and Werner,S.
  TITLE     The ubiquitin ligase Uhrf2 is a master regulator of cholesterol
            biosynthesis and is essential for liver regeneration
  JOURNAL   Sci Signal 16 (787), eade8029 (2023)
   PUBMED   37253089
  REMARK    GeneRIF: The ubiquitin ligase Uhrf2 is a master regulator of
            cholesterol biosynthesis and is essential for liver regeneration.
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Wang,X., Sarver,A.L., Han,Q., Seiler,C.L., Xie,C., Lu,H.,
            Forster,C.L., Tretyakova,N.Y. and Hallstrom,T.C.
  TITLE     UHRF2 regulates cell cycle, epigenetics and gene expression to
            control the timing of retinal progenitor and ganglion cell
            differentiation
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35285483
  REMARK    GeneRIF: UHRF2 regulates cell cycle, epigenetics and gene
            expression to control the timing of retinal progenitor and ganglion
            cell differentiation.
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Pichler,G., Wolf,P., Schmidt,C.S., Meilinger,D., Schneider,K.,
            Frauer,C., Fellinger,K., Rottach,A. and Leonhardt,H.
  TITLE     Cooperative DNA and histone binding by Uhrf2 links the two major
            repressive epigenetic pathways
  JOURNAL   J Cell Biochem 112 (9), 2585-2593 (2011)
   PUBMED   21598301
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Mori,T., Li,Y., Hata,H. and Kochi,H.
  TITLE     NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP,
            a PEST-containing nuclear protein
  JOURNAL   FEBS Lett 557 (1-3), 209-214 (2004)
   PUBMED   14741369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111048.8 and AC162613.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.852228.1,
                                           SRR13422600.1616787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AC111048.8         170605-171016
            413-646             AC111048.8         179149-179382
            647-906             AC111048.8         196320-196579
            907-1125            AC111048.8         211328-211546
            1126-1238           AC111048.8         213976-214088
            1239-1425           AC111048.8         215169-215355
            1426-1549           AC111048.8         218099-218222
            1550-1657           AC111048.8         218625-218732
            1658-1762           AC111048.8         219924-220028
            1763-1869           AC111048.8         222819-222925
            1870-2032           AC111048.8         226331-226493
            2033-2173           AC111048.8         227261-227401
            2174-2270           AC111048.8         228564-228660
            2271-2428           AC111048.8         229271-229428
            2429-2527           AC162613.2         103476-103574
            2528-3536           AC162613.2         104153-105161
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 24.73 cM"
     gene            1..3536
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /note="ubiquitin-like, containing PHD and RING finger
                     domains 2"
                     /db_xref="GeneID:109113"
                     /db_xref="MGI:MGI:1923718"
     exon            1..412
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2674
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     Np95-like ring finger protein; E3 ubiquitin-protein ligase
                     UHRF2; nuclear zinc finger protein Np97; ubiquitin-like
                     PHD and RING finger domain-containing protein 2;
                     ubiquitin-like-containing PHD and RING finger domains
                     protein 2; nuclear protein 97; RING-type E3 ubiquitin
                     transferase UHRF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UHRF2 isoform 3"
                     /protein_id="NP_001406259.1"
                     /db_xref="GeneID:109113"
                     /db_xref="MGI:MGI:1923718"
                     /translation="MWIQVRTIDGSQTRTIEDVSRKATIEELRERVWALFDVRPECQR
                     LFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDSSLPSTSKQNDAQVKPSSHNPPKVKK
                     TARGGSSSQPSTSARTCLIDPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHS
                     RGKTPLKNGSSYKRTNGNVNHNSKENTNKLDNVPSTSNSDSVAADEDVIYHIEYDEYP
                     ESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTIS
                     RTKKEVRVKVFLGRGSEGTLNDCRVMSVDEIFKIEKPGAHPISFADGKFLRKNDPECD
                     LCGGDPDKTCHMCSCHKCGEKRDPNMQLLCDECNMAYHIYCLSPPLDKVPEEEYWYCP
                     SCKTDSSEVVKAGERLKLSKKKAKMPSASTESRRDWGRGMACVGRTKECTIVPSNHYG
                     PIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFEDEVDRGDEFT
                     YTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRV
                     IRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTS
                     EGIERSRRLCLRLQYPAGYPSEKEGKKTKGQSKKQGSEATKRPASDDECPGDSKVLKA
                     SDSTDAVEAFQLTPQQQRLIREDCQNQKLWDEVLASLVEGPNFLKKLEQSFMCVCCQE
                     LVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYVMVLNETLQTLLDLFFP
                     GYSKGR"
     exon            413..646
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            647..906
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1125
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1238
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1425
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1549
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1657
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1762
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1869
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2032
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2173
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2270
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2428
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2527
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..3536
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3513..3518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="Uhrf2"
                     /gene_synonym="2310065A22Rik; D130071B19Rik; Nirf"
                     /note="major polyA site"
ORIGIN      
        1 atggctcctt cctatttgtg aggcgcgggc tgcgctcgca cctcgggcgg gttccggttt
       61 ccttccaccg aggaggggcg ggcgggcggt cgcgcggtct aagagcgtca gtcctcgccc
      121 gcacccgcgt tcgccgagtc gccgccgcag agaaccggat cctcccgggg aggcggcggg
      181 gaccgggcgg ggcgcggcgc ggcggcccga gcgcagggcc agacaaaggg gcttggtccc
      241 ctgtccccgt gccgccgcga tgtggatcca ggtccgcacc atcgacggct cccagacgcg
      301 caccatcgag gacgtttctc gcaaagccac catcgaggag ctgcgcgagc gggtctgggc
      361 gctcttcgat gtaaggcccg agtgccagcg cctgttctac cggggcaagc agttggaaaa
      421 tggatatact ttatttgact acgacgttgg actgaatgat ataattcagc tgctagttcg
      481 tccagactcc agtcttccta gcacatctaa gcagaatgat gctcaggtta aaccctcttc
      541 tcataatccg cctaaagtaa agaaaacagc aagaggggga tcttccagtc agccatctac
      601 atcagctcgc acttgtctta ttgaccctgg ctttggacta tataaggtaa atgaattggt
      661 ggatgccaga gatgtcggcc ttggtgcttg gtttgaagca catatacata gtgttactag
      721 agcttctgat ggacattcac gtggcaaaac tccactgaag aatggcagtt cttataaaag
      781 gactaatgga aatgtaaatc ataattccaa agagaacaca aataaattgg acaatgtacc
      841 ctctacgtct aattcagact cagttgctgc tgatgaagac gttatttatc atatcgagta
      901 tgatgaatat ccagaaagtg gtatactaga gatgaatgtt aaggatcttc gaccacgagc
      961 aaggaccatt ttaaaatgga atgaactaaa tgttggtgat gtggtaatgg ttaattacaa
     1021 tgtagaaaat ccaggcaaaa gaggattttg gtatgatgct gaaattacca cactgaagac
     1081 aatatcaagg accaaaaagg aagttcgtgt gaaagttttc ctgggcaggg gctctgaagg
     1141 cacattaaat gactgccgag tgatgtctgt agatgaaatc ttcaagattg agaagcctgg
     1201 agcccatccc atttcctttg cagatggaaa gtttttaagg aaaaatgacc ctgaatgtga
     1261 cctgtgtggt ggagacccag ataagacctg tcacatgtgt tcgtgtcata agtgtggaga
     1321 gaagcgggac cccaacatgc agctgctgtg tgacgagtgc aatatggcct atcacattta
     1381 ctgcctgagc ccacctctgg acaaagtccc ggaagaggaa tactggtatt gtccttcctg
     1441 taaaactgac tccagtgagg tggtaaaggc tggagagaga ctcaagctga gtaagaagaa
     1501 agcgaagatg ccctcagcca gtactgagag ccggagggac tggggcaggg gaatggcttg
     1561 tgttggtcgt acaaaagaat gtactattgt cccttcaaat cattatggac caatccctgg
     1621 tattcctgtt ggatcaactt ggagattcag agttcaggtg agcgaagcag gtgttcatcg
     1681 gccacatgtt ggtggaattc atggtcgcag caatgatggg gcttattctc ttgtcctggc
     1741 tggaggattt gaagatgaag ttgaccgagg tgatgagttc acgtatactg gaagcggtgg
     1801 taaaaatctt gctggtaata aaagaattgg agctccatcg gctgaccaga cactaacaaa
     1861 catgaacagg gcattggccc taaactgtga tgctccattg gatgataaaa ttggagcaga
     1921 gtctcggaat tggagagctg gtaagcccgt cagagtgata cgcagtttta aagggaggaa
     1981 gatcagcaaa tatgctccag aagaaggcaa cagatatgat ggcatttata aggtggtaaa
     2041 atactggcca gagatttcat ccagccatgg cttcttggtt tggcgttatc ttttaagaag
     2101 agatgatgtt gaacctgctc cttggacctc agaaggaatc gaacgatcaa ggagactgtg
     2161 tctgcgattg cagtacccag caggttaccc ctcggaaaag gaaggcaaga agaccaaggg
     2221 gcagtcaaag aagcagggca gtgaggccac caaaaggcca gcttcagatg atgagtgtcc
     2281 aggtgactcc aaagtgctga aggcatcaga ttcaacagat gctgtagagg ctttccagct
     2341 cacgcctcag cagcagcgcc tgatcagaga agactgtcag aaccagaagc tgtgggatga
     2401 agtacttgca tctcttgtag aaggaccgaa ttttctgaag aaattggaac aatcttttat
     2461 gtgtgtgtgc tgccaagaac tagtttacca gcctgtcaca actgaatgct ttcacaacgt
     2521 ctgtaaggat tgcttacagc gctcctttaa ggcccaggtt ttctcctgcc ctgcttgccg
     2581 ccatgatctc gggcagaatt atgtcatggt tctaaatgag accctccaaa ctctgcttga
     2641 cctcttcttc cctggctaca gcaaaggccg gtgatctgcg cgtgctgtgt ggttcctgct
     2701 ggagtcctgg acagtaacaa gtcttacaat gagtgggagg ggtaaagcag agctggacca
     2761 tgtctttcgt ccgaaagcag cagtacctct tttcccacag ccatcctcct gtgtgtgtag
     2821 taagaggccc attctcaact gtcttttaga tagcaacagg tagttcttct cagtaacaac
     2881 tcattttcat gaatgaagac ttaacgcctc cactgtagtt gattacccaa tttatgattt
     2941 attttgcaac tacctcagga cagaaaagat ttacggggat tttaaaaatc attgactaat
     3001 tagttaaatg aaattttagc tacacactgc ctcccaagta ttagttgtgc ctgttccttg
     3061 tacttcgctt gtccaggaaa gaaggcagat ggattgttgg ggcgagtgag tgcagcttct
     3121 gtaatatgca tactacattt tttaatgtca gtttccatca ccatgcgtgt tttgcaagaa
     3181 catgttcatt ttttaactca tttgtgatct ccattgtgac ttttttctgg tgttttatgc
     3241 aaattgacta ctaatggcta atgagaacaa tatgaatgca ttgttgctgc attagtgtaa
     3301 tgtggtgttt tcttgccatg acagagatgt ccgaagcgct agtagtaaat gtttctgaaa
     3361 agccgctctg tcctcatctg gcgtgcagga attcctccta gtggtctcca tctgcagatt
     3421 aggagggctg tgctggcttt tgagaagatt aaaattgctt cacattgtga tcctacattt
     3481 tatattcact atattcctta agagtatacc ttaataaata ttttatgatc agaaaa
//
