LOCUS       NM_010931               3502 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus ubiquitin-like, containing PHD and RING finger
            domains, 1 (Uhrf1), transcript variant 1, mRNA.
ACCESSION   NM_010931 XM_914309
VERSION     NM_010931.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Tan,L., Yin,T., Xiang,H., Wang,L., Mudgal,P., Chen,J., Ding,Y.,
            Wang,G., Lim,B.J.W., Huang,Y., Huang,D., Liang,Y., Alexander,P.B.,
            Xiang,K., Wang,E., Yan,C., Ma,Z., Tan,M., Li,Q.J. and Wang,X.F.
  TITLE     Aberrant cytoplasmic expression of UHRF1 restrains the
            MHC-I-mediated anti-tumor immune response
  JOURNAL   Nat Commun 15 (1), 8569 (2024)
   PUBMED   39362877
  REMARK    GeneRIF: Aberrant cytoplasmic expression of UHRF1 restrains the
            MHC-I-mediated anti-tumor immune response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Vakayil,M., Madani,A.Y., Agha,M.V., Majeed,Y., Hayat,S.,
            Yonuskunju,S., Mohamoud,Y.A., Malek,J., Suhre,K. and Mazloum,N.A.
  TITLE     The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and
            limits fibrosis by suppressing GPNMB-mediated TGF-beta signaling
  JOURNAL   Sci Rep 14 (1), 11886 (2024)
   PUBMED   38789534
  REMARK    GeneRIF: The E3 ubiquitin-protein ligase UHRF1 promotes
            adipogenesis and limits fibrosis by suppressing GPNMB-mediated
            TGF-beta signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Cheng,S., Guo,H., Bai,M., Cui,Y., Tian,H. and Mei,X.
  TITLE     Inhibition of UHRF1 Improves Motor Function in Mice with Spinal
            Cord Injury
  JOURNAL   Cell Mol Neurobiol 44 (1), 39 (2024)
   PUBMED   38649645
  REMARK    GeneRIF: Inhibition of UHRF1 Improves Motor Function in Mice with
            Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3502)
  AUTHORS   Miura,M., Watanabe,H., Sasaki,T., Tatsumi,K. and Muto,M.
  TITLE     Dynamic changes in subnuclear NP95 location during the cell cycle
            and its spatial relationship with DNA replication foci
  JOURNAL   Exp Cell Res 263 (2), 202-208 (2001)
   PUBMED   11161719
REFERENCE   7  (bases 1 to 3502)
  AUTHORS   Uemura,T., Kubo,E., Kanari,Y., Ikemura,T., Tatsumi,K. and Muto,M.
  TITLE     Temporal and spatial localization of novel nuclear protein NP95 in
            mitotic and meiotic cells
  JOURNAL   Cell Struct Funct 25 (3), 149-159 (2000)
   PUBMED   10984098
REFERENCE   8  (bases 1 to 3502)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3502)
  AUTHORS   Fujimori,A., Matsuda,Y., Takemoto,Y., Hashimoto,Y., Kubo,E.,
            Araki,R., Fukumura,R., Mita,K., Tatsumi,K. and Muto,M.
  TITLE     Cloning and mapping of Np95 gene which encodes a novel nuclear
            protein associated with cell proliferation
  JOURNAL   Mamm Genome 9 (12), 1032-1035 (1998)
   PUBMED   9880673
REFERENCE   10 (bases 1 to 3502)
  AUTHORS   Muto,M., Utsuyama,M., Horiguchi,T., Kubo,E., Sado,T. and
            Hirokawa,K.
  TITLE     The characterization of the monoclonal antibody Th-10a, specific
            for a nuclear protein appearing in the S phase of the cell cycle in
            normal thymocytes and its unregulated expression in lymphoma cell
            lines
  JOURNAL   Cell Prolif 28 (12), 645-657 (1995)
   PUBMED   8634372
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026385.19.
            
            On Oct 31, 2022 this sequence version replaced NM_010931.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (A). Variants 1 and 2
            encode isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF274046.1, BC022167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC026385.19        182640-182796
            158-322             AC026385.19        184321-184485
            323-565             AC026385.19        188572-188814
            566-726             AC026385.19        189911-190071
            727-942             AC026385.19        191289-191504
            943-1046            AC026385.19        192099-192202
            1047-1257           AC026385.19        192276-192486
            1258-1381           AC026385.19        194427-194550
            1382-1489           AC026385.19        194634-194741
            1490-1594           AC026385.19        195012-195116
            1595-1701           AC026385.19        196239-196345
            1702-1861           AC026385.19        197226-197385
            1862-1999           AC026385.19        197482-197619
            2000-2120           AC026385.19        199397-199517
            2121-2266           AC026385.19        199632-199777
            2267-2371           AC026385.19        201256-201360
            2372-3502           AC026385.19        201591-202721
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.26 cM"
     gene            1..3502
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /note="ubiquitin-like, containing PHD and RING finger
                     domains, 1"
                     /db_xref="GeneID:18140"
                     /db_xref="MGI:MGI:1338889"
     exon            1..157
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            158..322
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2518
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /EC_number="2.3.2.27"
                     /note="isoform A is encoded by transcript variant 1;
                     nuclear protein 95; E3 ubiquitin-protein ligase UHRF1;
                     nuclear zinc finger protein Np95; ubiquitin-like PHD and
                     RING finger domain-containing protein 1; mUhrf1; RING-type
                     E3 ubiquitin transferase UHRF1; ubiquitin-like-containing
                     PHD and RING finger domains protein 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UHRF1 isoform A"
                     /protein_id="NP_035061.3"
                     /db_xref="CCDS:CCDS28903.1"
                     /db_xref="GeneID:18140"
                     /db_xref="MGI:MGI:1338889"
                     /translation="MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEEVFHVEPQLQR
                     LFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHS
                     ESDKSSTHGEGAAEADDKTVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRAL
                     SEDEPCSSSAVKTSEDDIMYHVKYDDYPEHGVDIVKAKNVRARARTVIPWENLEVGQV
                     VMANYNVDYPRKRGFWYDVEICRKRQTRTARELYGNIRLLNDSQLNNCRIMFVDEVLM
                     IELPKERRPLIASPSQPPPALRNTGKSGPSCRFCKDDENKPCRKCACHVCGGREAPEK
                     QLLCDECDMAFHLYCLKPPLTSVPPEPEWYCPSCRTDSSEVVQAGEKLKESKKKAKMA
                     SATSSSRRDWGKGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPH
                     VAGIHGRSNDGAYSLVLAGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSDQKLTN
                     NNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVV
                     KYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLEALANKEK
                     SRKRPAKALEQGPSSSKTGKSKQKSTGPTLSSPRASKKSKLEPYTLSEQQANLIKEDK
                     GNAKLWDDVLTSLQDGPYQIFLSKVKEAFQCICCQELVFRPVTTVCQHNVCKDCLDRS
                     FRAQVFSCPACRFELDHSSPTRVNQPLQTILNQLFPGYGSGR"
     exon            323..565
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            566..726
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            727..942
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1046
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1257
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1381
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1489
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1594
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1701
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1861
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1999
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2120
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2266
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2371
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..3502
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="Uhrf1"
                     /gene_synonym="ICBP90; Np95; RNF106"
                     /note="major polyA site"
ORIGIN      
        1 aaaaagtcct agcagctgga aggaacccgc gctctagtgc tcacttgggt cttcagccac
       61 tcacgcggct cccttctggg tcacccagcc gcagagccct agcctagaac caggcgttcc
      121 aagggagagg agagtgcgga tcgccgccgt gagagagtac atcggcatca tgtggatcca
      181 ggttcgaact atggatggga aggagaccca caccgtgaac tctctgtcca ggttgaccaa
      241 ggtgcaggag ctgaggaaaa agattgagga agtgtttcac gtggaacccc aactacagag
      301 actcttttat aggggcaaac agatggagga tggccacaca ctcttcgatt atgatgtgcg
      361 cctcaatgac acaatccagc tgctcgtgcg ccagagtctg gcactgcctc tcagtacaaa
      421 agaacgggac tcggagctct cagactctga ctctggctat ggtgtgggtc acagtgaatc
      481 agacaagtcg tccacgcatg gtgaaggggc agctgaagcg gatgacaaga ctgtgtggga
      541 ggacacggac ctggggctgt acaaggtcaa tgagtatgtg gacgtgcgtg acaatatctt
      601 cggtgcatgg tttgaggccc aggtggtcca ggtacagaag agagccctat ctgaggacga
      661 gccctgtagc tccagtgccg ttaagacctc ggaggatgac atcatgtacc atgtcaagta
      721 tgatgactat ccagagcatg gagtggacat tgtcaaagcc aagaatgtcc gtgctcgtgc
      781 tcgcactgtg ataccatggg agaacctgga ggtgggtcag gtggtcatgg ccaactataa
      841 cgtggactac cccaggaaac gcggcttctg gtatgatgtt gagatctgta ggaagcgcca
      901 aaccaggacg gcacgtgagc tatacggcaa catcaggctc ttgaatgact ctcagctcaa
      961 caactgtcgg atcatgtttg tggatgaagt cttgatgatt gagctcccta aagagaggag
     1021 gcctttgatc gctagcccct cgcaaccccc tcctgccctc cggaacacag ggaagagcgg
     1081 cccatcctgc cggttctgca aggatgatga aaacaaacca tgtcgaaagt gtgcctgcca
     1141 tgtgtgtggt gggcgcgagg ctcctgagaa acagctgttg tgtgatgagt gtgacatggc
     1201 cttccacctg tactgcctga agccaccgct cacctctgtc ccccctgagc cggagtggta
     1261 ctgccccagc tgccgcactg actcaagtga ggtggtacaa gcaggggaga agctgaagga
     1321 gagcaagaag aaggcaaaga tggcatcagc cacttcctcc tcccggcggg actggggcaa
     1381 gggcatggca tgtgtgggcc gcaccacaga gtgtaccatt gtgcccgcca accacttcgg
     1441 gcccatccct ggtgtccctg tgggcaccat gtggcgcttc agagtccagg tcagtgagtc
     1501 cggtgtgcat cggcctcatg tggcaggcat ccatggccgg agcaacgacg gtgcctactc
     1561 attggtcctg gctggtggct atgaggatga tgtggacaat ggcaattact tcacatacac
     1621 agggagtggt ggccgagacc tctctggcaa caagcgtaca gcaggccagt cctctgacca
     1681 gaagctcact aataacaata gggctctggc actcaattgc cactccccaa tcaatgagaa
     1741 aggtgcggag gctgaagact ggcgccaagg gaagccagtg cgtgtggtcc ggaacatgaa
     1801 gggcgggaaa cacagcaagt acgctcctgc agagggcaac cgctatgatg gcatctacaa
     1861 ggtggtgaag tactggccag agagagggaa atctggcttc ctcgtgtggc gttatctcct
     1921 tcgacgagat gacacagagc ctgagccctg gacccgggag ggcaaggacc gcactcgaca
     1981 gctggggctc actatgcagt accctgaagg ctacttggag gccttggcta acaaggagaa
     2041 gagcaggaag cgcccggcca aggccttgga gcagggaccc tcatcttcca agacaggcaa
     2101 aagcaagcag aagtccacag ggccaaccct ctccagcccc cgtgcctcta agaagagcaa
     2161 gctggagccg tacacactct cagagcagca ggctaacctc atcaaagagg acaagggcaa
     2221 cgccaagctg tgggatgatg tgctaacttc acttcaggat gggccgtacc agatcttcct
     2281 gagcaaggtg aaagaggctt tccagtgcat ctgctgccag gagctggtgt tccggccagt
     2341 caccaccgtg tgtcagcaca acgtctgtaa ggactgtctg gacaggtcct tccgggccca
     2401 ggtgttcagc tgcccagcct gtcgctttga gctggaccac agctccccaa cccgggtgaa
     2461 ccagcccttg cagaccattc tcaaccagct cttccctggc tatggcagcg gccggtgatg
     2521 ctgagaccca ggcagagggc tcatggttcc aacttcatag tgtgtttagc ttgaaggtgt
     2581 tgtccttcac gtctgcctgt ggcaactctt ctgatctggt caccagttaa ccaggcatct
     2641 ataggaatcc catgttctgg ctaccagttg gacttctgtt tttcatccct ccaccccctt
     2701 tctataacaa agcctgcgat ttattgtcca agagaaggaa aaaaatgttt ttgtttttgt
     2761 tttttttttt ttgagatggg tttagaaacc gttgagtttc ataccaggcc tcatgtcatg
     2821 ctggtaggag ttctccccac accagctgcc tagaaaccat ctgcacccat ctttgaaaag
     2881 cccagacatg tcttcctggc agctatctgt gtgcttcatt ccaggggtgg cccctgcagc
     2941 tgcccctcag accttcatag atgccctggc ccgcgccatt cactgacatg attgcagagg
     3001 ggagttggct gtggcctcag gccaggggac cagctgggct gaagctgcat gtgccttggg
     3061 ctggccactt cttcactccc ctcaccactg agcattggat gtctaccttg aaagcctggt
     3121 tttcagagag tgcactgact gggtgtcatg gaaggcagag atgtgttatc agttccatct
     3181 catttttaac tcagcaacag aattctgagg gtttctgtat tatgggtttt tttattttta
     3241 ttttttaaag cgagataaat gggtttcctc gatgaatttc ttttgtagtt acagcctgta
     3301 ctgaggaaga tgttttcctt ggtaggtttt gtttcttttg taactttacc aaagtgtgca
     3361 ggtgtgtctc atggaaacta aaccatttac tacaggcaga ctggacagca cagttctaag
     3421 ggttgtgttt tgttttgtgt ggggtatttt ttccttgtta gattgttaac atattgcaat
     3481 aaaataaaat tctggccggg ca
//
