LOCUS       NM_011674               3772 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus UDP galactosyltransferase 8A (Ugt8a), transcript
            variant 1, mRNA.
ACCESSION   NM_011674
VERSION     NM_011674.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Gacem,N., Kavo,A., Zerad,L., Richard,L., Mathis,S., Kapur,R.P.,
            Parisot,M., Amiel,J., Dufour,S., de la Grange,P., Pingault,V.,
            Vallat,J.M. and Bondurand,N.
  TITLE     ADAR1 mediated regulation of neural crest derived melanocytes and
            Schwann cell development
  JOURNAL   Nat Commun 11 (1), 198 (2020)
   PUBMED   31924792
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Kennedy,A.J., Rahn,E.J., Paulukaitis,B.S., Savell,K.E.,
            Kordasiewicz,H.B., Wang,J., Lewis,J.W., Posey,J., Strange,S.K.,
            Guzman-Karlsson,M.C., Phillips,S.E., Decker,K., Motley,S.T.,
            Swayze,E.E., Ecker,D.J., Michael,T.P., Day,J.J. and Sweatt,J.D.
  TITLE     Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory
            Function
  JOURNAL   Cell Rep 16 (10), 2666-2685 (2016)
   PUBMED   27568567
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3772)
  AUTHORS   Lau,C.G. and Marikawa,Y.
  TITLE     Morphology-based mammalian stem cell tests reveal potential
            developmental toxicity of donepezil
  JOURNAL   Mol Reprod Dev 81 (11), 994-1008 (2014)
   PUBMED   25269881
REFERENCE   5  (bases 1 to 3772)
  AUTHORS   Yu,Y., Chen,Y., Kim,B., Wang,H., Zhao,C., He,X., Liu,L., Liu,W.,
            Wu,L.M., Mao,M., Chan,J.R., Wu,J. and Lu,Q.R.
  TITLE     Olig2 targets chromatin remodelers to enhancers to initiate
            oligodendrocyte differentiation
  JOURNAL   Cell 152 (1-2), 248-261 (2013)
   PUBMED   23332759
REFERENCE   6  (bases 1 to 3772)
  AUTHORS   Hennet,T., Dinter,A., Kuhnert,P., Mattu,T.S., Rudd,P.M. and
            Berger,E.G.
  TITLE     Genomic cloning and expression of three murine UDP-galactose:
            beta-N-acetylglucosamine beta1,3-galactosyltransferase genes
  JOURNAL   J Biol Chem 273 (1), 58-65 (1998)
   PUBMED   9417047
REFERENCE   7  (bases 1 to 3772)
  AUTHORS   Coetzee,T., Fujita,N., Dupree,J., Shi,R., Blight,A., Suzuki,K.,
            Suzuki,K. and Popko,B.
  TITLE     Myelination in the absence of galactocerebroside and sulfatide:
            normal structure with abnormal function and regional instability
  JOURNAL   Cell 86 (2), 209-219 (1996)
   PUBMED   8706126
REFERENCE   8  (bases 1 to 3772)
  AUTHORS   Bosio,A., Binczek,E. and Stoffel,W.
  TITLE     Molecular cloning and characterization of the mouse CGT gene
            encoding UDP-galactose ceramide-galactosyltransferase (cerebroside
            synthetase)
  JOURNAL   Genomics 35 (1), 223-226 (1996)
   PUBMED   8661124
REFERENCE   9  (bases 1 to 3772)
  AUTHORS   Coetzee,T., Li,X., Fujita,N., Marcus,J., Suzuki,K., Francke,U. and
            Popko,B.
  TITLE     Molecular cloning, chromosomal mapping, and characterization of the
            mouse UDP-galactose:ceramide galactosyltransferase gene
  JOURNAL   Genomics 35 (1), 215-222 (1996)
   PUBMED   8661123
REFERENCE   10 (bases 1 to 3772)
  AUTHORS   Citron,B.A., Ratzlaff,K.T., Smirnova,I.V. and Festoff,B.W.
  TITLE     Protease nexin I (PNI) in mouse brain is expressed from the same
            gene as in seminal vesicle
  JOURNAL   J Mol Neurosci 7 (3), 183-191 (1996)
   PUBMED   8906614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111106.10, AK137364.1 and AK144005.1.
            
            On Sep 20, 2017 this sequence version replaced NM_011674.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144005.1, AK137364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC111106.10        52646-52747
            103-3701            AK137364.1         2-3600
            3702-3772           AK144005.1         3600-3670
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 54.68 cM"
     gene            1..3772
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="UDP galactosyltransferase 8A"
                     /db_xref="GeneID:22239"
                     /db_xref="MGI:MGI:109522"
     exon            1..200
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     exon            201..1024
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1828
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /EC_number="2.4.1.47"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP-glucuronosyltransferase 8;
                     UDP-galactose-ceramide galactosyltransferase 8A;
                     2-hydroxyacylsphingosine 1-beta-galactosyltransferase;
                     cerebroside synthase; ceramide UDP-galactosyltransferase"
                     /codon_start=1
                     /product="2-hydroxyacylsphingosine
                     1-beta-galactosyltransferase isoform 1 precursor"
                     /protein_id="NP_035804.2"
                     /db_xref="CCDS:CCDS17821.1"
                     /db_xref="GeneID:22239"
                     /db_xref="MGI:MGI:109522"
                     /translation="MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASA
                     LHERGHHTVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVE
                     LVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFST
                     GLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERI
                     MQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDL
                     QRWVSGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNN
                     TKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQA
                     KGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDY
                     ILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKIKSLWS
                     KNEHSTVNGHYQNGIRNGKYKGNGRVKHEKKVR"
     exon            1025..1167
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1244
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1464
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3772
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3504
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="major polyA site"
     regulatory      3513..3518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="hexamer: AATAAA"
     polyA_site      3534
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="major polyA site"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="hexamer: AATAAA"
     regulatory      3693..3698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="hexamer: ATTAAA"
     polyA_site      3706
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
     polyA_site      3724
                     /gene="Ugt8a"
                     /gene_synonym="Cgt; mCerGT; Ugt8"
                     /note="major polyA site"
ORIGIN      
        1 ccggcggagg agcaggcgcg ctgcggcccc gagggggggc accgcggagc atcgcctgcc
       61 ctagagcgcc cgtcttaagc ccggcaggcg cgccgcagct tccctcacgc ccagcctccg
      121 agggcgacga cgcgcgctcc acagaccccg tccggcggca gaggcgctct ccaactcccg
      181 cgcggcagcc gaaggacgcg ctatgaagtc ttacactcca tatttcatgc tcctgtggag
      241 tgctgttgga atagcaaggg ctgctaaaat catcattgtg ccgccaatta tgtttgaaag
      301 ccatttgtac attttcaaga cactagcatc ggccttgcac gagagaggcc atcacaccgt
      361 gctcctcctc tcagaaggca gagacattgc cccatctaat cactacagcc tccagcggta
      421 cccaggcatc ttcaacagta ccacctcaga tgctttcctg cagtctaaaa tgaggaatat
      481 tttttctggg agattgacag cagttgaact ggttgacata ctggatcact atactaagaa
      541 ttgtgacatg atggttggca accaagccct aatccagggt ttaaaaaaag aaaagtttga
      601 cctgctactg gttgacccca atgatatgtg tggatttgtg atcgcccatc ttttaggcgt
      661 taagtatgct gtattttcta ctggcctttg gtatcctgct gaagtaggag cacctgctcc
      721 tttagcttat gtcccagagt ttaactcact cctcacagac cgcatgaact tcctggaaag
      781 gatgaaaaat actggtgttt acctcatatc cagaataggg gttagctttc tggttctccc
      841 gaaatatgag aggataatgc agaagtacaa cctgctgcct gcaaagtcca tgtatgattt
      901 ggttcatggg tccagcctat ggatgttatg tactgacgta gcactggagt ttccaagacc
      961 aacgctgcct aatgttgtgt atgttggagg aatcctgaca aagccggcca gcccactgcc
     1021 agaagatctg cagaggtggg taagtggtgc tcaggaacat ggctttgtcc tggtgtcttt
     1081 tggagctggt gtcaagtatc tgtcagaaga cattgccaac aaactggcag gagctctggg
     1141 gagattgcct caaaaagtga tttggagatt ttctggaacc aaaccaaaga acctaggaaa
     1201 caacactaag ctcatagaat ggctgcctca aaatgacctg cttggccatt caaatatcag
     1261 agccttccta agccatggtg gtttgaacag tatatttgaa actatgtatc atggtgtccc
     1321 tgtagtggga atcccactgt ttggagacca ttatgatact atgactagag tacaggcaaa
     1381 aggcatgggg atcttgttag aatggaatac agttactgaa ggagagctgt atgatgccct
     1441 ggtgaaagtt atcaataatc ccagttatcg gcagagggct cagaagttat cggaaattca
     1501 caaggatcaa cccggccacc ctgtcaatcg gactacctat tggatagact acattcttcg
     1561 ccatgacgga gcccgtcacc tccgttctgc tgtccatcag atctctttct gccagtattt
     1621 cctactggat attgcctttg tgcttctgct tggtgctgtc ttgctctact tcatattgtc
     1681 ctatgtgaca aaatttatct atagaaaaat caaaagtcta tggtctaaaa atgagcatag
     1741 cacagttaat ggacattacc aaaatggaat ccgcaatggc aaatacaaag gcaatggtcg
     1801 tgttaaacac gaaaagaagg tgagatgatc cgacagccca ggtgaagggg ccaagtctgt
     1861 agtgctattc tttagtctaa cagctactaa aagtaaatgt cagcaaacag tcctaacatg
     1921 ccctcatcag atcttattaa tgagattcca tggataaaat gtctgtaaag agcacaaccc
     1981 taaatgcaaa aatgtatttt attctaatac tgatgcagag agttggcagt gaaccattta
     2041 gaagccttaa ttatttaaat caattaagtg acgtgtcaga ccttagtttt aaatgttatg
     2101 tatgtgttac aggtgaggga tggtgttttt ctcttgataa gatgtgtgta tgtttcctac
     2161 gtcattgagt tttagcttct atttgtattt agtttgtaac agtatttcaa aaactgtttc
     2221 ctaaactcgg tgtaaagtgg caagtgaaaa gatgggtggc acaatttttg tatttttgtt
     2281 tattatagac atttttattt tatttttatt ttttgtaaat gcttttttct taccaactat
     2341 agacacttgt gaaggaaaac atgcaatgaa gtaaatgagt gaaaaggttt tcacattttg
     2401 ctaatatttt tctcctacca atgatttttc tctggaagaa ttttctaatt aggacagagc
     2461 aacaaagctc ttacttttgt tcaaagtact gaagattatt gcttaaatag cacttggaag
     2521 cagagccatg tgtaaatgct tatttgactt agatattcca gaatttgagt tttgagtatt
     2581 caggtatcac ttctaaagtt ttaactttag aataatcacc tttcattcct tttattatct
     2641 gggccacaat atagtatata gtatataggt gccaacgtat ccttcttcca aacagaacat
     2701 ttgcagttct ccttgctgcc tgctttagct gcaggagttt gaggtttgtc agcaaataag
     2761 actttacctg ctacacagaa atgacagaaa ttgtaccacc catttgtgca aatgagtttc
     2821 cattccctcc tcactacatc agcccaactc agtagccttt tttgtcattg tgcttgacat
     2881 gggacaatga cagtatctgt ttggaacatg gagacaagtc acaactttca taaattcagg
     2941 acctccatgt tgaaccactt actaaatggc actgtaagct tattctatgt cactctgttt
     3001 actgagcatt tgcactgcac atgctctgtg tgtgcattat ttatttgtgg ttggaaatcc
     3061 catatttgac acttgagagt agagaaatga aatatttact taatgtcact cactaacatg
     3121 gcagagttgt gaaaaatcta gaatgctgta aatccttgtc atacactgtg acatacaact
     3181 ttgtgacact cccaccagga gccagtctca tatacttaga tttaatatca atagtttttt
     3241 aatgcacaat gcatacagcg tactgctttc tgaatacttg aaatggtatc tatacaaacc
     3301 tgttagttac accttttcac aatcttatca caacattgcc attcaaagag gaaaatgatc
     3361 aggcaatgaa tggtgggtgg taacagagca tagagtgtat gaatgagttg attttacttt
     3421 tggcatttgg taaagttgac aatagacact aactggatga ttaagcataa gttaatttcc
     3481 actgtggttt aaaaaaaaaa gaaacttaaa acaataaaca aagttgaaaa tagagaaatg
     3541 ttgttggaat aaaattttta ttcagatttt atttcacagt attatataaa ggtatattta
     3601 cattataaac atgtttctaa ggcctcccaa cttttgtatg tatatatgaa tgtgaaaaca
     3661 atgtattaaa tgtgagaaca tatttaataa aaattaaatg cagggattta tcctttaaag
     3721 tacatcaaca cggatcttta agttctatcc cagaattaag aatgttaagt ac
//
