LOCUS       NM_144845               2214 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus UDP glycosyltransferases 3 family, polypeptide A1
            (Ugt3a1), transcript variant 1, mRNA.
ACCESSION   NM_144845 NM_181069 XM_001052103 XM_001052104
VERSION     NM_144845.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2214)
  AUTHORS   Meech,R., Rogers,A., Zhuang,L., Lewis,B.C., Miners,J.O. and
            Mackenzie,P.I.
  TITLE     Identification of residues that confer sugar selectivity to
            UDP-glycosyltransferase 3A (UGT3A) enzymes
  JOURNAL   J Biol Chem 287 (29), 24122-24130 (2012)
   PUBMED   22621930
  REMARK    GeneRIF: Mouse Ugt3a2 was able to conjugate 4-methylumbelliferone
            and ursodeoxycholic acid with UDP-Glc, although to a lesser extent
            than Ugt3a1, and it was also inactive with UDP-GlcNAc.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132893.23.
            
            On Feb 1, 2023 this sequence version replaced NM_144845.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022134.1, AK143815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC132893.23        86579-86783
            206-304             AC132893.23        89641-89739
            305-419             AC132893.23        102095-102209
            420-954             AC132893.23        112443-112977
            955-1186            AC132893.23        116141-116372
            1187-1406           AC132893.23        118243-118462
            1407-2214           AC132893.23        121062-121869
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 4.01 cM"
     gene            1..2214
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="UDP glycosyltransferases 3 family, polypeptide A1"
                     /db_xref="GeneID:223337"
                     /db_xref="MGI:MGI:2145969"
     exon            1..205
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1683
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /EC_number="2.4.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP glucuronosyltransferase 3 family,
                     polypeptide A2; UDP-glucuronosyltransferase 3A2; UDPGT
                     3A2; UDP glycosyltransferases 3 family, polypeptide A2"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 3A2 isoform 1
                     precursor"
                     /protein_id="NP_659094.1"
                     /db_xref="CCDS:CCDS27375.1"
                     /db_xref="GeneID:223337"
                     /db_xref="MGI:MGI:2145969"
                     /translation="MAAHRRWLLMSFLFLEVILLEAAKILTISTLSASHYIVISRVSQ
                     VLHEGGHNVTKLLYESANIPDFRKEKPSYQVINWRPPEDQEKKFADLRHRLTEEITYG
                     RSKHHTLLKIHQYFGDLCSQLLSRKDIMDFLKNENFDLVLLDSMDLCSLLIVEKLGKR
                     FVSFLPFQFSYMDFGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREIL
                     SQYDSTIQEHFVEGSQPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPV
                     QPIPQDLENFISQFGDSGFVLVALGSIVSMIQSKEIIKEMNSAFAHLPQGVLWTCKTS
                     HWPKDVSLAPNVKIMDWLPQTDLLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFF
                     DQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKIIEDKRYKSAAMASKIIRHSHPLT
                     PAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFLLGLMLGTLWLSVKVLV
                     AVTRYLSIATKVKEA"
     exon            206..304
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..419
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..954
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1186
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1406
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2214
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2197..2202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="hexamer: AATAAT"
     polyA_site      2214
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="major polyA site"
ORIGIN      
        1 agtccatctg aggcaacaga cagtgctttg tgacagaggc ttacagggtc ccttagtggg
       61 gcacagctct ttaggtgtgc aacctgtgtc agggctccac atattctaca gatggcagca
      121 catcggcgtt ggcttctcat gagcttcctt ttccttgagg ttattctctt ggaggctgca
      181 aaaatcctga ctatatctac actgagtgca agccattata tagtgataag ccgtgtgtcg
      241 caagttcttc atgaaggtgg ccacaatgtg accaaacttc tttatgaaag tgctaatatc
      301 ccagatttta gaaaggaaaa accatcatat caagttatta attggcgtcc acctgaagat
      361 caggaaaaga aatttgctga tcttaggcat cgacttacag aagaaataac ttatggcagg
      421 tccaaacatc acacccttct aaagatccat caatactttg gggacttatg cagtcaatta
      481 ttaagcagaa aggacatcat ggacttctta aaaaatgaga actttgacct agtacttctt
      541 gattcaatgg atctctgttc tttgctaatt gttgaaaagc ttgggaaacg atttgtgtcc
      601 tttcttccct ttcaatttag ctatatggac tttgggttac caagcgcccc cttgtcctat
      661 gctccagtgt atggttctgg tctaactgac caaatggact tctggggccg agtgaagaac
      721 tttctgatgt tccttgattt ctccatgaag caaagggaaa tcctttctca gtatgacagc
      781 actatccagg agcattttgt ggaaggctct cagccagtgt tgtctgacct tctactgaaa
      841 gctgagctgt ggtttgtcaa ctctgacttt gctttggatt ttgctcgtcc cctgtttccc
      901 aacacagtct atgtgggagg tttactggac aaacctgttc agccaatacc ccaagacttg
      961 gagaatttta tctctcagtt tggagactca ggttttgtcc ttgtggccct gggctctata
     1021 gtgagcatga ttcagtccaa ggaaattatt aaggagatga acagtgcctt tgctcacctc
     1081 cctcaagggg tgctatggac atgtaagact tctcattggc ccaaagatgt cagtttggcc
     1141 ccaaatgtca aaatcatgga ttggcttcca cagactgacc ttctagctca ccctagcatt
     1201 cgtctgtttg tcactcatgg agggatgaac agtgtgatgg aggctgtcca tcatggagta
     1261 cccatggtgg ggattccatt tttttttgac caacctgaaa acatggtccg agtagaagca
     1321 aagaaccttg gtgtttctat tcagctacag acgctcaagg cagagtcatt tgcgctcacc
     1381 atgaaaaaaa tcatagaaga caagaggtac aagtctgcag caatggcctc caagattatc
     1441 aggcactccc acccactgac ccctgcccag aggcttttgg gctggataga tcatatcttg
     1501 cagacagggg gtgcagcaca tctcaagcca tatgctttcc agcagccatg gcatgagcag
     1561 tacatgcttg atgtcttcct ctttctccta gggctcatgc tgggtacttt gtggcttagt
     1621 gtaaaggttc ttgttgctgt aaccaggtat ctgagtatag caacgaaggt caaggaggca
     1681 taatgctgaa atgctgggct tggctctggt gtagggatgg gaggtctgtg gctcttcaga
     1741 ggccttccgt aattcagcac agagaaactc tagcattctc tgcctccatc ttctactgat
     1801 gcacccgagt tagtacctca ctacttttgg ccctgttttc ctcttatgat cttcattcct
     1861 acttagatat aaaccacttg catcatgtgt tcctcctctc actcatttat cctaaacaca
     1921 ctgcttcaat aggctgtttg ccccatggct ccttatgttc ttcctctctt tatcccttct
     1981 atcatttggg gttaaaacca tagttggaca ttttttctca tgttcttttt ttttttttat
     2041 ataaacattc tttagagctc agaacacctg ctctgcctta ctccactgtt tccctaagat
     2101 ctggacaata atcattctat attgtgaatg aatttatcta agaatatatg aagtagaaaa
     2161 atataataat tattgtttgg taataatcag aataaaaata atatgcaact aaaa
//
