LOCUS       NM_001416410            2099 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus UDP glycosyltransferases 3 family, polypeptide A1
            (Ugt3a1), transcript variant 2, mRNA.
ACCESSION   NM_001416410 XM_011245349
VERSION     NM_001416410.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Meech,R., Rogers,A., Zhuang,L., Lewis,B.C., Miners,J.O. and
            Mackenzie,P.I.
  TITLE     Identification of residues that confer sugar selectivity to
            UDP-glycosyltransferase 3A (UGT3A) enzymes
  JOURNAL   J Biol Chem 287 (29), 24122-24130 (2012)
   PUBMED   22621930
  REMARK    GeneRIF: Mouse Ugt3a2 was able to conjugate 4-methylumbelliferone
            and ursodeoxycholic acid with UDP-Glc, although to a lesser extent
            than Ugt3a1, and it was also inactive with UDP-GlcNAc.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132893.23.
            
            On Feb 1, 2023 this sequence version replaced XM_011245349.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.124530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC132893.23        86579-86783
            206-304             AC132893.23        89641-89739
            305-839             AC132893.23        112443-112977
            840-1071            AC132893.23        116141-116372
            1072-1291           AC132893.23        118243-118462
            1292-2099           AC132893.23        121062-121869
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 4.01 cM"
     gene            1..2099
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="UDP glycosyltransferases 3 family, polypeptide A1"
                     /db_xref="GeneID:223337"
                     /db_xref="MGI:MGI:2145969"
     exon            1..205
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..304
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..839
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1568
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /EC_number="2.4.1.17"
                     /note="isoform 2 is encoded by transcript variant 2; UDP
                     glucuronosyltransferase 3 family, polypeptide A2;
                     UDP-glucuronosyltransferase 3A2; UDPGT 3A2; UDP
                     glycosyltransferases 3 family, polypeptide A2"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 3A2 isoform 2"
                     /protein_id="NP_001403339.1"
                     /db_xref="GeneID:223337"
                     /db_xref="MGI:MGI:2145969"
                     /translation="MDFLKNENFDLVLLDSMDLCSLLIVEKLGKRFVSFLPFQFSYMD
                     FGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREILSQYDSTIQEHFVE
                     GSQPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLENFISQ
                     FGDSGFVLVALGSIVSMIQSKEIIKEMNSAFAHLPQGVLWTCKTSHWPKDVSLAPNVK
                     IMDWLPQTDLLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKN
                     LGVSIQLQTLKAESFALTMKKIIEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHIL
                     QTGGAAHLKPYAFQQPWHEQYMLDVFLFLLGLMLGTLWLSVKVLVAVTRYLSIATKVK
                     EA"
     exon            840..1071
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1291
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2099
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="hexamer: AATAAT"
     polyA_site      2099
                     /gene="Ugt3a1"
                     /gene_synonym="Ugt3a2"
                     /note="major polyA site"
ORIGIN      
        1 agtccatctg aggcaacaga cagtgctttg tgacagaggc ttacagggtc ccttagtggg
       61 gcacagctct ttaggtgtgc aacctgtgtc agggctccac atattctaca gatggcagca
      121 catcggcgtt ggcttctcat gagcttcctt ttccttgagg ttattctctt ggaggctgca
      181 aaaatcctga ctatatctac actgagtgca agccattata tagtgataag ccgtgtgtcg
      241 caagttcttc atgaaggtgg ccacaatgtg accaaacttc tttatgaaag tgctaatatc
      301 ccaggtccaa acatcacacc cttctaaaga tccatcaata ctttggggac ttatgcagtc
      361 aattattaag cagaaaggac atcatggact tcttaaaaaa tgagaacttt gacctagtac
      421 ttcttgattc aatggatctc tgttctttgc taattgttga aaagcttggg aaacgatttg
      481 tgtcctttct tccctttcaa tttagctata tggactttgg gttaccaagc gcccccttgt
      541 cctatgctcc agtgtatggt tctggtctaa ctgaccaaat ggacttctgg ggccgagtga
      601 agaactttct gatgttcctt gatttctcca tgaagcaaag ggaaatcctt tctcagtatg
      661 acagcactat ccaggagcat tttgtggaag gctctcagcc agtgttgtct gaccttctac
      721 tgaaagctga gctgtggttt gtcaactctg actttgcttt ggattttgct cgtcccctgt
      781 ttcccaacac agtctatgtg ggaggtttac tggacaaacc tgttcagcca ataccccaag
      841 acttggagaa ttttatctct cagtttggag actcaggttt tgtccttgtg gccctgggct
      901 ctatagtgag catgattcag tccaaggaaa ttattaagga gatgaacagt gcctttgctc
      961 acctccctca aggggtgcta tggacatgta agacttctca ttggcccaaa gatgtcagtt
     1021 tggccccaaa tgtcaaaatc atggattggc ttccacagac tgaccttcta gctcacccta
     1081 gcattcgtct gtttgtcact catggaggga tgaacagtgt gatggaggct gtccatcatg
     1141 gagtacccat ggtggggatt ccattttttt ttgaccaacc tgaaaacatg gtccgagtag
     1201 aagcaaagaa ccttggtgtt tctattcagc tacagacgct caaggcagag tcatttgcgc
     1261 tcaccatgaa aaaaatcata gaagacaaga ggtacaagtc tgcagcaatg gcctccaaga
     1321 ttatcaggca ctcccaccca ctgacccctg cccagaggct tttgggctgg atagatcata
     1381 tcttgcagac agggggtgca gcacatctca agccatatgc tttccagcag ccatggcatg
     1441 agcagtacat gcttgatgtc ttcctctttc tcctagggct catgctgggt actttgtggc
     1501 ttagtgtaaa ggttcttgtt gctgtaacca ggtatctgag tatagcaacg aaggtcaagg
     1561 aggcataatg ctgaaatgct gggcttggct ctggtgtagg gatgggaggt ctgtggctct
     1621 tcagaggcct tccgtaattc agcacagaga aactctagca ttctctgcct ccatcttcta
     1681 ctgatgcacc cgagttagta cctcactact tttggccctg ttttcctctt atgatcttca
     1741 ttcctactta gatataaacc acttgcatca tgtgttcctc ctctcactca tttatcctaa
     1801 acacactgct tcaataggct gtttgcccca tggctcctta tgttcttcct ctctttatcc
     1861 cttctatcat ttggggttaa aaccatagtt ggacattttt tctcatgttc tttttttttt
     1921 tttatataaa cattctttag agctcagaac acctgctctg ccttactcca ctgtttccct
     1981 aagatctgga caataatcat tctatattgt gaatgaattt atctaagaat atatgaagta
     2041 gaaaaatata ataattattg tttggtaata atcagaataa aaataatatg caactaaaa
//
