LOCUS       NM_201644               3216 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A9
            (Ugt1a9), mRNA.
ACCESSION   NM_201644
VERSION     NM_201644.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Xu,H., Chen,M., Yu,F., Zhang,T. and Wu,B.
  TITLE     Circadian Clock Component Rev-erbalpha Regulates Diurnal Rhythm of
            UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice
  JOURNAL   Drug Metab Dispos 48 (8), 681-689 (2020)
   PUBMED   32527940
  REMARK    GeneRIF: Circadian Clock Component Rev-erbalpha Regulates Diurnal
            Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation
            in Mice.
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Shi,R., Wu,J., Meng,C., Ma,B., Wang,T., Li,Y. and Ma,Y.
  TITLE     Cyp3a11-mediated testosterone-6beta-hydroxylation decreased, while
            UGT1a9-mediated propofol O-glucuronidation increased, in mice with
            diabetes mellitus
  JOURNAL   Biopharm Drug Dispos 37 (7), 433-443 (2016)
   PUBMED   27514509
  REMARK    GeneRIF: Diabetes mellitus caused a decrease in the activity of
            Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in
            the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an
            increase in the activity of UGT1a9-mediated propofol
            O-glucuronidation in db/db mice
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Kong,A.N., Ma,M., Tao,D. and Yang,L.
  TITLE     Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol
            family of UDP-glucuronosyltransferases (mUGTBr/p)
  JOURNAL   Pharm Res 10 (3), 461-465 (1993)
   PUBMED   8464825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087801.69, AC087780.19 and AY227200.1.
            
            On Apr 26, 2007 this sequence version replaced NM_201644.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227200.1, BC019434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-900               AC087801.69        108769-109668       c
            901-1032            AC087780.19        163865-163996       c
            1033-2211           AY227200.1         1012-2190
            2212-3216           AC087780.19        159038-160042       c
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.5 cM"
     gene            1..3216
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A9"
                     /db_xref="GeneID:394434"
                     /db_xref="MGI:MGI:3576092"
     exon            1..900
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1032
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1120
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1340
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..3216
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2192..2197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /note="hexamer: AATAAA"
     polyA_site      2212
                     /gene="Ugt1a9"
                     /gene_synonym="mUGTBr/P; UDPGT; UDPGT 1-9; UGT1-09;
                     UGT1.9; Ugt1a12; UGTP4"
                     /note="major polyA site"
ORIGIN      
        1 agaaaatctt gcagtcatag tgacaggatt actctgggct ctgattttac catggctcct
       61 gtagcctttc ccacctcctt ttttctctgt ctgcttctgg cctctggctt ggcccaggca
      121 ggcaggctgc tggtggtgcc catggatgga agccactggt tcaccatgca gatggttgtg
      181 gagaaactca ttcacagagg gcatgaggtt gtggtagtca tcccagaggt gagttggcag
      241 ctggggaaat cactgaattg tacagtgaag acttactcaa tttctcacac tctggaagac
      301 ctggacagag agttcaagta tttatcttac actcaatgga aaactccaga acacagtata
      361 cgttctttct tgactggttc agccagaggt ttctttgaac taacattttc acactgcagg
      421 agtttgttta acgacaagaa gttagtggag tacttgaagc agagattttt tgatgcagtg
      481 tttctggatc ctttcgatgt gtgtggatta attgtcgcca aatatttctc gctcccatca
      541 gtgatctttg caagaggtgt attttgtgac tatcttgaag agggtgccca gtgcccaagt
      601 cttccttcct atgttcctag acttttctca aaatacacag acaccatgac tttcaaggag
      661 agagtgtgga accatcttat ctacattgaa gaacatgcat tttgctccta ctttttaaga
      721 actgctgttg aagttgcatc tgaaattctt cagaccccag tgactatgac agacctcttt
      781 agcccagtgt ctatttggtt gttacgcact gactttgtgt tggagttccc caggcctgtg
      841 atgcctaaca tggtctttat tggtgggatc aactgcctcc agaagaagtc actttccaag
      901 gaatttgaag cctatgtcaa cgcctctggg gagcatggca tcgttgtttt ctctttggga
      961 tccatggtct cagagattcc ggagaagaaa gccatggaaa ttgctgaggc tttgggcaga
     1021 attcctcaga cggtcctgtg gcgctacacc ggaactagac catcgaatct tgcaaagaac
     1081 acaattcttg tcaaatggct accccaaaat gatctgcttg gtcatccaaa gactcgggca
     1141 ttcatcacac actctggctc ccatggtatt tatgaaggaa tatgcaatgg agttccgatg
     1201 gtgatgatgc ccctatttgg cgatcagatg gacaatgcca agcgcatgga aactcgggga
     1261 gctggggtga ccctgaatgt ccttgaaatg actgctgatg atttggaaaa tgcccttaaa
     1321 actgtcatca acaacaagag ctacaaggag aacatcatgc gcctctccag ccttcacaag
     1381 gaccgtccta tagagcctct ggacctggct gtgttctggg tggaatacgt gatgaggcac
     1441 aagggggcac cacacctgcg cccggccgcc catgacctca cctggtatca gtaccactcc
     1501 ttggatgtga ttggcttcct cctggccatt gtgttgacag tggtcttcat tgtctttaaa
     1561 tgttgtgcct atggctgccg gaaatgcttt gggggaaagg ggcgagtgaa gaaatcacac
     1621 aaatccaaga cccattgaga agtgggggga agtgaaggag aagtattagt tcattatctg
     1681 atcagttgaa acttggaaac aagtgttaaa tccatattgt ttttgttagg gaaataattc
     1741 accatacatt atacattcag cacatttaaa aataataata ataacaatct aattgctggc
     1801 cacacccatc agggaaggtt ctagtatatg tgatgtgctt ttccagtatc ttcagtctag
     1861 acaactcttg ccatctgttg gtaatttaca gaaagtctgg cactctgctt tcagtgacag
     1921 ccccacagtt tcccctgctc ccgccagctg acggctttct cccctggatt ctcagactgc
     1981 cgtggccttc tccagtgtta gtcattcttc attgtgttca tgcattatgg gtggcaagac
     2041 ctttggagct ttgggagaag agatgaggct gtgacactga tggccctgtg tttgagataa
     2101 taattgttgc ttgtgccgga atttgatgaa aaccaaagta tgttctaagg caagtacatc
     2161 ttctattgtg ttcccaaacc aagaacttat caataaattc atataaattg tatcactact
     2221 cttcttttca ttggtgttat atttatttgt tgtcaaagta tatcctctaa ttgtaaaagc
     2281 actacatgat catgatgcag aacttgaaaa ctagaacaga ttcacacagg tatacataca
     2341 cacaagaaag gaaccagctg taattacagt gctcatgaat aaccatggct gctgcctagt
     2401 ttgattctga gtcttccaaa ggtgcattgg ctgatggctt gcagccttgc tgatgctcag
     2461 cctgtgatat cactgggaag ttgtgcaacc attaagtggc agtctagtgt gagaaagcta
     2521 ggtctctgga ggtgttcctt tgaaggagat acagggatag aggtaccttc tctttctttg
     2581 ttcccatact atcctgaaac aagaaggttc ccggacagtc tctttgagta ttctcttatc
     2641 ttacacaggt cccaaagcaa cataaccaca tgatcaggga tgaaaagtct atagctagcc
     2701 caaaataaac ctttgctcat gagttgctac atctcaggta tttgttacag taacataaag
     2761 tttattaaca tacctattgt tttgacaaat acacataaaa cattacagac attctgtatt
     2821 agtcagtttt gcatcagcat aatgaaataa ccaaagcaag taagttaaaa gagagaaggg
     2881 ctgtttaact tagaggttat cttgctttgg ctcagttctg tgagggtaac agaaggtggc
     2941 atatcaaaca ggagcatgta catgaacaaa ccatgaatta tatcttgagg caggaacagg
     3001 gagctagagt ctgggctgtc acaatcctct ttgaggaaga tctttaatga cctatgggca
     3061 ttttaatagg ccctacctga aaaaaaaagt tttccctgct tctcaatagc acacactgaa
     3121 gaccaagctt ttatcacatg gctctttggg ggcatttcag attcaagcta tatattctga
     3181 ccaaaagttc caaaagttca tgtccatttc gcaatt
//
