LOCUS       NM_201410               2293 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A6B
            (Ugt1a6b), mRNA.
ACCESSION   NM_201410
VERSION     NM_201410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087801.69 and AC087780.19.
            
            On Jan 22, 2010 this sequence version replaced NM_201410.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189682.121798.1, AW701598.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC087801.69        77069-77190         c
            123-981             AC087801.69        72648-73506         c
            982-1113            AC087780.19        163865-163996       c
            1114-1201           AC087780.19        163158-163245       c
            1202-1421           AC087780.19        162683-162902       c
            1422-2293           AC087780.19        160042-160913       c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.51 cM"
     gene            1..2293
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A6B"
                     /db_xref="GeneID:394435"
                     /db_xref="MGI:MGI:3580629"
     exon            1..122
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     exon            123..981
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1719
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /note="UDP glycosyltransferase 1 family polypeptide A9"
                     /codon_start=1
                     /product="UDP glucuronosyltransferase 1 family,
                     polypeptide A6B precursor"
                     /protein_id="NP_958812.3"
                     /db_xref="CCDS:CCDS48313.1"
                     /db_xref="GeneID:394435"
                     /db_xref="MGI:MGI:3580629"
                     /translation="MACLLPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKE
                     IVEHLSERGHDIVVLVPEVNLLLGESKYYRRKIFSVPYSLEELQTRFRTFGRNQFVPG
                     APLMGPLREYRNSMLTLEMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILA
                     EYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILE
                     NYLYYCLYSKYEIIVTDLLKRDVSLPSLHQNSLWLLRYDFVFEYPRPIMPNMIFIGGI
                     NCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWR
                     YTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLF
                     GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPI
                     EPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCC
                     AYGCRKCFGGKGRVKKSHKSKTH"
     exon            982..1113
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1201
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1421
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..2293
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="Ugt1a6b"
                     /gene_synonym="A9'; Ugt1a9"
                     /note="major polyA site"
ORIGIN      
        1 gaattcagat gctggctgat ggtggctgac tggaaaccga cttccagatt tcttactctt
       61 gctcaagggc cctcatcacg tgctacctag aggcacaggt ctctaacctt actatctgac
      121 aggatggctt gccttcttcc tgctgctcag acacttcctg cagggtttct cttcctagtg
      181 ctttgggcct cagttctagg tgacaagctg ctggtggtcc cccaggatgg aagccactgg
      241 cttagcatga aggagatagt ggagcatctc agtgaacgag gacatgacat tgtggtccta
      301 gtgccagaag tcaatttgct tttgggagaa tccaaatact acaggaggaa aattttctca
      361 gttccctaca gcctagaaga actacagacc cgttttcgca cctttggacg caaccagttt
      421 gttcctggtg cccccctgat gggtcctcta agagagtaca ggaacagcat gcttacattg
      481 gagatgttct tttccaactg ccagagcctc ctgaaggact ctgccaccct cagcttcctc
      541 agggagaaca agtttgatgc tctgttcaca gacccagcca tgccctgtgg tgtgatcctg
      601 gctgagtatc tcaacctgcc ctctgtctac ctcttcagag gtttcccatg ctctctggaa
      661 cacatgcttg gtcaaagccc aagccctgtg tcctatgtgc ccagattcta caccaaattc
      721 tcagaccaca tgacatttcc ccaacggctg gccaacttca ttgttaacat cttggaaaac
      781 tacctatatt attgtctgta ttcaaagtat gaaatcattg tcacagacct cctcaagaga
      841 gatgtgtccc taccttcctt acaccagaat tctctgtggc tgttacggta cgattttgtg
      901 ttcgaatatc ccaggccaat catgcccaac atgatcttca ttggagggat caactgtaag
      961 aagaagggaa agctgactca ggaatttgaa gcctatgtca acgcctctgg ggagcatggc
     1021 atcgttgttt tctctttggg atccatggtc tcagagattc cggagaagaa agccatggaa
     1081 attgctgagg ctttgggcag aattcctcag acggtcctgt ggcgctacac cggaactaga
     1141 ccatcgaatc ttgcaaagaa cacaattctt gtcaaatggc taccccaaaa tgatctgctt
     1201 ggtcatccaa agactcgggc attcatcaca cactctggct cccatggtat ttatgaagga
     1261 atatgcaatg gagttccgat ggtgatgatg cccctatttg gcgatcagat ggacaatgcc
     1321 aagcgcatgg aaactcgggg agctggggtg accctgaatg tccttgaaat gactgctgat
     1381 gatttggaaa atgcccttaa aactgtcatc aacaacaaga gctacaagga gaacatcatg
     1441 cgcctctcca gccttcacaa ggaccgtcct atagagcctc tggacctggc tgtgttctgg
     1501 gtggaatacg tgatgaggca caagggggca ccacacctgc gcccggccgc ccatgacctc
     1561 acctggtatc agtaccactc cttggatgtg attggcttcc tcctggccat tgtgttgaca
     1621 gtggtcttca ttgtctttaa atgttgtgcc tatggctgcc ggaaatgctt tgggggaaag
     1681 gggcgagtga agaaatcaca caaatccaag acccattgag aagtgggggg aagtgaagga
     1741 gaagtattag ttcattatct gatcagttga aacttggaaa caagtgttaa atccatattg
     1801 tttttgttag ggaaataatt caccatacat tatacattca gcacatttaa aaataataat
     1861 aataacaatc taattgctgg ccacacccat cagggaaggt tctagtatat gtgatgtgct
     1921 tttccagtat cttcagtcta gacaactctt gccatctgtt ggtaatttac agaaagtctg
     1981 gcactctgct ttcagtgaca gccccacagt ttcccctgct cccgccagct gacggctttc
     2041 tcccctggat tctcagactg ccgtggcctt ctccagtgtt agtcattctt cattgtgttc
     2101 atgcattatg ggtggcaaga cctttggagc tttgggagaa gagatgaggc tgtgacactg
     2161 atggccctgt gtttgagata ataattgttg cttgtgccgg aatttgatga aaaccaaagt
     2221 atgttctaag gcaagtacat cttctattgt gttcccaaac caagaactta tcaataaatt
     2281 catataaatt gta
//
