LOCUS       NM_145079               3302 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A6A
            (Ugt1a6a), mRNA.
ACCESSION   NM_145079
VERSION     NM_145079.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Carmean,C.M., Yokoi,N., Takahashi,H., Oduori,O.S., Kang,C.,
            Kanagawa,A., Kirkley,A.G., Han,G., Landeche,M., Hidaka,S.,
            Katoh,M., Sargis,R.M. and Seino,S.
  TITLE     Arsenic modifies serotonin metabolism through glucuronidation in
            pancreatic beta-cells
  JOURNAL   Am J Physiol Endocrinol Metab 316 (3), E464-E474 (2019)
   PUBMED   30562058
  REMARK    GeneRIF: This study provides evidence that UGT1A6A, acting on the
            serotonin pathway, regulates glucose induced insulin secretion
            under both normal and pathological conditions.
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Uchihashi,S., Nishikawa,M., Sakaki,T. and Ikushiro,S.
  TITLE     Comparison of serotonin glucuronidation activity of
            UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence
            for the preferential expression of Ugt1a6a in the mouse brain
  JOURNAL   Drug Metab Pharmacokinet 28 (3), 260-264 (2013)
   PUBMED   23089803
  REMARK    GeneRIF: the difference in expression levels between Ugt1a6a and
            Ugt1a6b in the hippocampus led us to speculate that Ugt1a6a is
            likely the predominant catalyst of serotonin glucuronidation in the
            mouse brain.
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Linster,C.L. and Van Schaftingen,E.
  TITLE     Glucuronate, the precursor of vitamin C, is directly formed from
            UDP-glucuronate in liver
  JOURNAL   FEBS J 273 (7), 1516-1527 (2006)
   PUBMED   16689937
REFERENCE   5  (bases 1 to 3302)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   6  (bases 1 to 3302)
  AUTHORS   Braun,L., Kardon,T., El Koulali,K., Csala,M., Mandl,J. and
            Banhegyi,G.
  TITLE     Different induction of gulonolactone oxidase in aromatic
            hydrocarbon-responsive or -unresponsive mouse strains
  JOURNAL   FEBS Lett 463 (3), 345-349 (1999)
   PUBMED   10606751
REFERENCE   7  (bases 1 to 3302)
  AUTHORS   Vasiliou,V., Reuter,S.F. and Nebert,D.W.
  TITLE     Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP
            glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and
            hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice
  JOURNAL   Biochem Biophys Res Commun 233 (3), 631-636 (1997)
   PUBMED   9168903
REFERENCE   8  (bases 1 to 3302)
  AUTHORS   Molla,A., Rouard-Talbot,L. and Block,M.R.
  TITLE     Cotranscription of two RNA coding for the cell adhesion regulator
            and its variant in Reh leukemia cells
  JOURNAL   Biochim Biophys Acta 1315 (1), 6-8 (1996)
   PUBMED   8611648
REFERENCE   9  (bases 1 to 3302)
  AUTHORS   Koiwai,O., Hasada,K., Yasui,Y., Sakai,Y., Sato,H. and Watanabe,T.
  TITLE     Isolation of cDNAs for mouse phenol and bilirubin
            UDP-glucuronosyltransferases and mapping of the mouse gene for
            phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by
            restriction fragment length variations
  JOURNAL   Biochem Genet 33 (3-4), 111-122 (1995)
   PUBMED   7677729
REFERENCE   10 (bases 1 to 3302)
  AUTHORS   Lamb,J.G., Straub,P. and Tukey,R.H.
  TITLE     Cloning and characterization of cDNAs encoding mouse Ugt1.6 and
            rabbit UGT1.6: differential induction by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   Biochemistry 33 (34), 10513-10520 (1994)
   PUBMED   8068691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087801.69 and AC087780.19.
            
            On Apr 25, 2007 this sequence version replaced NM_145079.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16818.1, BC069940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC087801.69        45512-45638         c
            128-986             AC087801.69        41116-41974         c
            987-1118            AC087780.19        163865-163996       c
            1119-1206           AC087780.19        163158-163245       c
            1207-1426           AC087780.19        162683-162902       c
            1427-3302           AC087780.19        159038-160913       c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.52 cM"
     gene            1..3302
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A6A"
                     /db_xref="GeneID:94284"
                     /db_xref="MGI:MGI:2137698"
     exon            1..127
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            128..986
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1724
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 1 family, polypeptide A6;
                     UDP-glucuronosyltransferase 1-6; phenol
                     UDP-glucuronosyltransferase; UDP-glucuronosyltransferase
                     1A6"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A6 precursor"
                     /protein_id="NP_659545.2"
                     /db_xref="CCDS:CCDS48314.1"
                     /db_xref="GeneID:94284"
                     /db_xref="MGI:MGI:2137698"
                     /translation="MACLLPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKE
                     IVEHLSERGHDIMVLVPEVNLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPG
                     ASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILA
                     EYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILE
                     NYLYYCLYSKYEIIASDLLKRDVSLPSLHQNSLWLLRYDFVFEYPRPVMPNMIFLGGI
                     NCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWR
                     YTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLF
                     GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPI
                     EPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCC
                     AYGCRKCFGGKGRVKKSHKSKTH"
     exon            987..1118
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1206
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1426
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..3302
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /note="hexamer: AATAAA"
     polyA_site      2298
                     /gene="Ugt1a6a"
                     /gene_synonym="UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6;
                     Ugt1a7"
                     /note="major polyA site"
ORIGIN      
        1 acccagaatt cagatgctgg ctgatggtgg ctgactggaa accgacttcc agatttctta
       61 ctcttgctca agggccctca tcacgtgcta cctagaggca caggtctcta accttactat
      121 ctgacaggat ggcttgcctt cttcctgctg ctcagacact tcctgcaggg tttctcttcc
      181 tagtgctttg ggcctcagtt ctaggtgaca agctgctggt ggtcccccag gatggaagcc
      241 actggcttag catgaaggag atagtagaac atctcagtga acgaggacat gacattatgg
      301 tcctagtgcc agaagtcaat ttgcttttgg gagaatccaa atactacagg aggaaaatct
      361 tctcagttac ctacagccta gaagaactgc agacccgttt tcgcaccttt ggaaacaacc
      421 actttcttcc cggtgcctcc ctgatgggtc ctctaagaga gtacaggaac aacatgattg
      481 tcgtggacat gttcttttcc aactgccaga gcctcctgaa ggactctgcc accctcagct
      541 tcctcaggga gaacaagttt gatgctctgt tcacagaccc agccatgccc tgtggtgtga
      601 tcctggctga gtatctcaac ctgccctctg tctacctctt cagaggtttc ccatgctctc
      661 tggaacacat gcttggtcaa agcccaagcc ctgtgtccta tgtgcccaga ttctacacca
      721 aattctcaga ccacatgacg tttccccaac ggctggccaa cttcattgtt aacatcttgg
      781 aaaactacct atattattgt ctgtattcaa agtatgaaat cattgcctca gacctcctca
      841 agagagatgt gtccctacct tccttacacc agaattctct gtggctgtta cggtacgatt
      901 ttgtgttcga atatcccagg ccggtcatgc ccaacatgat cttcctagga gggatcaact
      961 gtaagaagaa gggaaagctg actcaggaat ttgaagccta tgtcaacgcc tctggggagc
     1021 atggcatcgt tgttttctct ttgggatcca tggtctcaga gattccggag aagaaagcca
     1081 tggaaattgc tgaggctttg ggcagaattc ctcagacggt cctgtggcgc tacaccggaa
     1141 ctagaccatc gaatcttgca aagaacacaa ttcttgtcaa atggctaccc caaaatgatc
     1201 tgcttggtca tccaaagact cgggcattca tcacacactc tggctcccat ggtatttatg
     1261 aaggaatatg caatggagtt ccgatggtga tgatgcccct atttggcgat cagatggaca
     1321 atgccaagcg catggaaact cggggagctg gggtgaccct gaatgtcctt gaaatgactg
     1381 ctgatgattt ggaaaatgcc cttaaaactg tcatcaacaa caagagctac aaggagaaca
     1441 tcatgcgcct ctccagcctt cacaaggacc gtcctataga gcctctggac ctggctgtgt
     1501 tctgggtgga atacgtgatg aggcacaagg gggcaccaca cctgcgcccg gccgcccatg
     1561 acctcacctg gtatcagtac cactccttgg atgtgattgg cttcctcctg gccattgtgt
     1621 tgacagtggt cttcattgtc tttaaatgtt gtgcctatgg ctgccggaaa tgctttgggg
     1681 gaaaggggcg agtgaagaaa tcacacaaat ccaagaccca ttgagaagtg gggggaagtg
     1741 aaggagaagt attagttcat tatctgatca gttgaaactt ggaaacaagt gttaaatcca
     1801 tattgttttt gttagggaaa taattcacca tacattatac attcagcaca tttaaaaata
     1861 ataataataa caatctaatt gctggccaca cccatcaggg aaggttctag tatatgtgat
     1921 gtgcttttcc agtatcttca gtctagacaa ctcttgccat ctgttggtaa tttacagaaa
     1981 gtctggcact ctgctttcag tgacagcccc acagtttccc ctgctcccgc cagctgacgg
     2041 ctttctcccc tggattctca gactgccgtg gccttctcca gtgttagtca ttcttcattg
     2101 tgttcatgca ttatgggtgg caagaccttt ggagctttgg gagaagagat gaggctgtga
     2161 cactgatggc cctgtgtttg agataataat tgttgcttgt gccggaattt gatgaaaacc
     2221 aaagtatgtt ctaaggcaag tacatcttct attgtgttcc caaaccaaga acttatcaat
     2281 aaattcatat aaattgtatc actactcttc ttttcattgg tgttatattt atttgttgtc
     2341 aaagtatatc ctctaattgt aaaagcacta catgatcatg atgcagaact tgaaaactag
     2401 aacagattca cacaggtata catacacaca agaaaggaac cagctgtaat tacagtgctc
     2461 atgaataacc atggctgctg cctagtttga ttctgagtct tccaaaggtg cattggctga
     2521 tggcttgcag ccttgctgat gctcagcctg tgatatcact gggaagttgt gcaaccatta
     2581 agtggcagtc tagtgtgaga aagctaggtc tctggaggtg ttcctttgaa ggagatacag
     2641 ggatagaggt accttctctt tctttgttcc catactatcc tgaaacaaga aggttcccgg
     2701 acagtctctt tgagtattct cttatcttac acaggtccca aagcaacata accacatgat
     2761 cagggatgaa aagtctatag ctagcccaaa ataaaccttt gctcatgagt tgctacatct
     2821 caggtatttg ttacagtaac ataaagttta ttaacatacc tattgttttg acaaatacac
     2881 ataaaacatt acagacattc tgtattagtc agttttgcat cagcataatg aaataaccaa
     2941 agcaagtaag ttaaaagaga gaagggctgt ttaacttaga ggttatcttg ctttggctca
     3001 gttctgtgag ggtaacagaa ggtggcatat caaacaggag catgtacatg aacaaaccat
     3061 gaattatatc ttgaggcagg aacagggagc tagagtctgg gctgtcacaa tcctctttga
     3121 ggaagatctt taatgaccta tgggcatttt aataggccct acctgaaaaa aaaagttttc
     3181 cctgcttctc aatagcacac actgaagacc aagcttttat cacatggctc tttgggggca
     3241 tttcagattc aagctatata ttctgaccaa aagttccaaa agttcatgtc catttcgcaa
     3301 tt
//
